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Protein

Polymerase basic protein 2

Gene

PB2

Organism
Influenza C virus (strain C/JJ/1950)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCap snatching, Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus, mRNA capping, mRNA processing, Viral transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase basic protein 2UniRule annotation
Alternative name(s):
RNA-directed RNA polymerase subunit P3UniRule annotation
Gene namesi
Name:PB2UniRule annotation
OrganismiInfluenza C virus (strain C/JJ/1950)
Taxonomic identifieri11560 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus C
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000788481 – 774Polymerase basic protein 2Add BLAST774

Interactioni

Subunit structurei

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus).UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP13877.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza viruses PB2 family.UniRule annotation

Family and domain databases

HAMAPiMF_04062. INV_PB2. 1 hit.
InterProiView protein in InterPro
IPR001591. INV_PB2.
PfamiView protein in Pfam
PF00604. Flu_PB2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001667. RNA_pol_PB2_orthomyxovir. 1 hit.

Sequencei

Sequence statusi: Complete.

P13877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLTIAKE YKRLCQDAKA AQMMTVGTVS NYTTFKKWTT SRKEKNPSLR
60 70 80 90 100
MRWAMSSKFP IIANKRMLEE AQIPKEHNNV ALWEDTEDVS KRDHVLASTS
110 120 130 140 150
CINYWNFCGP CANNSEVIKE VYKSRFGRLE RRKEIMWKEL RFTLVDRQRR
160 170 180 190 200
RVDTQPVEQR LRTGEIKDLQ MWTLFEDEAP LASKFILDNY GLVKEMRSKF
210 220 230 240 250
ANKPLNKEVV AHMLEKQFNP ESRFLPVFGA IRPERMELIH ALGGETWIQE
260 270 280 290 300
ANTAGISNVD QRKNDMRAVC RKVCLAANAS IMNAKSKLVE YIKSTSMRIG
310 320 330 340 350
ETERKLEELI LETDDVSPEV TLCKSALGGP LGKTLSFGPM LLKKISGSGV
360 370 380 390 400
KVKDTVYIQG VRAVQFEYWS EQEEFYGEYK SATALFSRKE RSLEWITIGG
410 420 430 440 450
GINEDRKRLL AMCMIFCRDG DYFKDAPATI TMADLSTKLG REIPYQYVMM
460 470 480 490 500
NWIQKSEDNL EALLYSRGIV ETNPGKMGSS MGIDGSKRAI KSLRAVTIQS
510 520 530 540 550
GKIDMPESKE KIHLELSDNL EAFDSSGRIV ATILDLPSDK KVTFQDVSFQ
560 570 580 590 600
HPDLAVLRDE KTAITKGYEA LIKRLGTGDN DIPSLIAKKD YLSLYNLPEV
610 620 630 640 650
KLMAPLIRPN RKGVYSRVAR KLVSTQVTTG HYSLHELIKV LPFTYFAPKQ
660 670 680 690 700
GMFEGRLFFS NDSFVEPGVN NNVFSWSKAD SSKIYCHGIA IRVPLVVGDE
710 720 730 740 750
HMDTSLALLE GFSVCENDPR APMVTRQDLI DVGFGQKVRL FIGQGSVRTF
760 770
KRTASQRAAS SDVNKNVKKI KMSN
Length:774
Mass (Da):87,825
Last modified:January 1, 1990 - v1
Checksum:iBF21307EB1A1088D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28061 Genomic RNA. Translation: AAA43815.1.
PIRiA34225. P3IV50.

Similar proteinsi

Entry informationi

Entry nameiPB2_INCJJ
AccessioniPrimary (citable) accession number: P13877
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: December 20, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families