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P13866

- SC5A1_HUMAN

UniProt

P13866 - SC5A1_HUMAN

Protein

Sodium/glucose cotransporter 1

Gene

SLC5A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei43 – 431Implicated in sodium couplingBy similarity
    Sitei300 – 3001Implicated in sodium couplingBy similarity
    Binding sitei457 – 4571GlucoseBy similarity
    Sitei460 – 4601Involved in sugar-binding/transport and inhibitor bindingBy similarity

    GO - Molecular functioni

    1. glucose:sodium symporter activity Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. glucose transport Source: MGI
    3. hexose transport Source: Reactome
    4. intestinal absorption Source: Ensembl
    5. small molecule metabolic process Source: Reactome
    6. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Sodium transport, Sugar transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19165. Na+-dependent glucose transporters.
    REACT_19188. Inositol transporters.
    REACT_9441. Hexose transport.

    Protein family/group databases

    TCDBi2.A.21.3.1. the solute:sodium symporter (sss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/glucose cotransporter 1
    Short name:
    Na(+)/glucose cotransporter 1
    Alternative name(s):
    High affinity sodium-glucose cotransporter
    Solute carrier family 5 member 1
    Gene namesi
    Name:SLC5A1
    Synonyms:NAGT, SGLT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:11036. SLC5A1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. brush border membrane Source: Ensembl
    3. cell-cell junction Source: Ensembl
    4. extracellular vesicular exosome Source: UniProt
    5. integral component of plasma membrane Source: ProtInc
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Congenital glucose/galactose malabsorption (GGM) [MIM:606824]: Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet.4 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281D → G in GGM. 1 Publication
    VAR_013630
    Natural varianti28 – 281D → N in GGM. 1 Publication
    VAR_007168
    Natural varianti135 – 1351R → W in GGM; loss of activity. 1 Publication
    VAR_021502
    Natural varianti318 – 3181G → R in GGM. 1 Publication
    VAR_021503
    Natural varianti468 – 4681A → V in GGM. 1 Publication
    VAR_021504

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi248 – 2481N → Q: Loss of N-glycosylation. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi606824. phenotype.
    Orphaneti35710. Glucose-galactose malabsorption.
    PharmGKBiPA308.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 664664Sodium/glucose cotransporter 1PRO_0000105366Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi248 – 2481N-linked (GlcNAc...)1 Publication
    Disulfide bondi255 ↔ 610By similarity

    Post-translational modificationi

    N-glycosylation is not necessary for the cotransporter function.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP13866.
    PaxDbiP13866.
    PRIDEiP13866.

    PTM databases

    PhosphoSiteiP13866.

    Expressioni

    Tissue specificityi

    Expressed mainly in intestine and kidney.

    Gene expression databases

    ArrayExpressiP13866.
    BgeeiP13866.
    CleanExiHS_SLC5A1.
    GenevestigatoriP13866.

    Organism-specific databases

    HPAiCAB015467.
    HPA051805.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EGFRP005333EBI-1772443,EBI-297353

    Protein-protein interaction databases

    BioGridi112414. 2 interactions.
    IntActiP13866. 1 interaction.
    STRINGi9606.ENSP00000266088.

    Structurei

    3D structure databases

    ProteinModelPortaliP13866.
    SMRiP13866. Positions 28-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 6415CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini86 – 10520ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 14216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini202 – 2087CytoplasmicSequence Analysis
    Topological domaini230 – 27748ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 31315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini335 – 38046ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini402 – 42322CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini445 – 45511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini477 – 4848CytoplasmicSequence Analysis
    Topological domaini506 – 52621ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini564 – 64380ExtracellularSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei527 – 56337HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 20123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei485 – 50521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei644 – 66421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4146.
    HOVERGENiHBG052859.
    InParanoidiP13866.
    KOiK14158.
    OMAiEMVKMGR.
    OrthoDBiEOG77126J.
    PhylomeDBiP13866.
    TreeFamiTF352855.

    Family and domain databases

    InterProiIPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00813. sss. 1 hit.
    PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P13866-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSSTWSPKT TAVTRPVETH ELIRNAADIS IIVIYFVVVM AVGLWAMFST    50
    NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAASGIAIGG 100
    FEWNALVLVV VLGWLFVPIY IKAGVVTMPE YLRKRFGGQR IQVYLSLLSL 150
    LLYIFTKISA DIFSGAIFIN LALGLNLYLA IFLLLAITAL YTITGGLAAV 200
    IYTDTLQTVI MLVGSLILTG FAFHEVGGYD AFMEKYMKAI PTIVSDGNTT 250
    FQEKCYTPRA DSFHIFRDPL TGDLPWPGFI FGMSILTLWY WCTDQVIVQR 300
    CLSAKNMSHV KGGCILCGYL KLMPMFIMVM PGMISRILYT EKIACVVPSE 350
    CEKYCGTKVG CTNIAYPTLV VELMPNGLRG LMLSVMLASL MSSLTSIFNS 400
    ASTLFTMDIY AKVRKRASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG 450
    QLFDYIQSIT SYLGPPIAAV FLLAIFWKRV NEPGAFWGLI LGLLIGISRM 500
    ITEFAYGTGS CMEPSNCPTI ICGVHYLYFA IILFAISFIT IVVISLLTKP 550
    IPDVHLYRLC WSLRNSKEER IDLDAEEENI QEGPKETIEI ETQVPEKKKG 600
    IFRRAYDLFC GLEQHGAPKM TEEEEKAMKM KMTDTSEKPL WRTVLNVNGI 650
    ILVTVAVFCH AYFA 664
    Length:664
    Mass (Da):73,498
    Last modified:January 1, 1990 - v1
    Checksum:i2B403376595EAB74
    GO
    Isoform 2 (identifier: P13866-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-127: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:537
    Mass (Da):60,097
    Checksum:iF7B5A898E54C9476
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti631 – 6311K → R in BAH14555. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281D → G in GGM. 1 Publication
    VAR_013630
    Natural varianti28 – 281D → N in GGM. 1 Publication
    VAR_007168
    Natural varianti51 – 511N → S.
    Corresponds to variant rs17683011 [ dbSNP | Ensembl ].
    VAR_029147
    Natural varianti135 – 1351R → W in GGM; loss of activity. 1 Publication
    VAR_021502
    Natural varianti318 – 3181G → R in GGM. 1 Publication
    VAR_021503
    Natural varianti411 – 4111A → T.
    Corresponds to variant rs17683430 [ dbSNP | Ensembl ].
    VAR_029148
    Natural varianti468 – 4681A → V in GGM. 1 Publication
    VAR_021504

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 127127Missing in isoform 2. 1 PublicationVSP_044782Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24847 mRNA. Translation: AAA60320.1.
    L29339
    , L29328, L29330, L29329, L29331, L29332, L29333, L29334, L29335, L29336, L29337, L29338 Genomic DNA. Translation: AAB59448.1.
    CR456579 mRNA. Translation: CAG30465.1.
    AK297665 mRNA. Translation: BAH12645.1.
    AK312948 mRNA. Translation: BAG35789.1.
    AK316184 mRNA. Translation: BAH14555.1.
    AL022321
    , Z74021, Z80998, Z83839, Z83849 Genomic DNA. Translation: CAI19810.1.
    Z74021
    , AL022321, Z80998, Z83839, Z83849 Genomic DNA. Translation: CAI18756.1.
    Z80998
    , AL022321, Z74021, Z83839, Z83849 Genomic DNA. Translation: CAI18759.1.
    Z83839
    , AL022321, Z74021, Z80998, Z83849 Genomic DNA. Translation: CAB06087.1.
    Z83849
    , AL022321, Z74021, Z80998, Z83839 Genomic DNA. Translation: CAI23589.1.
    CH471095 Genomic DNA. Translation: EAW60006.1.
    CCDSiCCDS13902.1. [P13866-1]
    CCDS58805.1. [P13866-2]
    PIRiA33545.
    RefSeqiNP_000334.1. NM_000343.3. [P13866-1]
    NP_001243243.1. NM_001256314.1. [P13866-2]
    UniGeneiHs.1964.

    Genome annotation databases

    EnsembliENST00000266088; ENSP00000266088; ENSG00000100170. [P13866-1]
    ENST00000543737; ENSP00000444898; ENSG00000100170. [P13866-2]
    GeneIDi6523.
    KEGGihsa:6523.
    UCSCiuc003amc.3. human. [P13866-1]

    Polymorphism databases

    DMDMi127803.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24847 mRNA. Translation: AAA60320.1 .
    L29339
    , L29328 , L29330 , L29329 , L29331 , L29332 , L29333 , L29334 , L29335 , L29336 , L29337 , L29338 Genomic DNA. Translation: AAB59448.1 .
    CR456579 mRNA. Translation: CAG30465.1 .
    AK297665 mRNA. Translation: BAH12645.1 .
    AK312948 mRNA. Translation: BAG35789.1 .
    AK316184 mRNA. Translation: BAH14555.1 .
    AL022321
    , Z74021 , Z80998 , Z83839 , Z83849 Genomic DNA. Translation: CAI19810.1 .
    Z74021
    , AL022321 , Z80998 , Z83839 , Z83849 Genomic DNA. Translation: CAI18756.1 .
    Z80998
    , AL022321 , Z74021 , Z83839 , Z83849 Genomic DNA. Translation: CAI18759.1 .
    Z83839
    , AL022321 , Z74021 , Z80998 , Z83849 Genomic DNA. Translation: CAB06087.1 .
    Z83849
    , AL022321 , Z74021 , Z80998 , Z83839 Genomic DNA. Translation: CAI23589.1 .
    CH471095 Genomic DNA. Translation: EAW60006.1 .
    CCDSi CCDS13902.1. [P13866-1 ]
    CCDS58805.1. [P13866-2 ]
    PIRi A33545.
    RefSeqi NP_000334.1. NM_000343.3. [P13866-1 ]
    NP_001243243.1. NM_001256314.1. [P13866-2 ]
    UniGenei Hs.1964.

    3D structure databases

    ProteinModelPortali P13866.
    SMRi P13866. Positions 28-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112414. 2 interactions.
    IntActi P13866. 1 interaction.
    STRINGi 9606.ENSP00000266088.

    Chemistry

    BindingDBi P13866.
    ChEMBLi CHEMBL4979.
    GuidetoPHARMACOLOGYi 915.

    Protein family/group databases

    TCDBi 2.A.21.3.1. the solute:sodium symporter (sss) family.

    PTM databases

    PhosphoSitei P13866.

    Polymorphism databases

    DMDMi 127803.

    Proteomic databases

    MaxQBi P13866.
    PaxDbi P13866.
    PRIDEi P13866.

    Protocols and materials databases

    DNASUi 6523.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266088 ; ENSP00000266088 ; ENSG00000100170 . [P13866-1 ]
    ENST00000543737 ; ENSP00000444898 ; ENSG00000100170 . [P13866-2 ]
    GeneIDi 6523.
    KEGGi hsa:6523.
    UCSCi uc003amc.3. human. [P13866-1 ]

    Organism-specific databases

    CTDi 6523.
    GeneCardsi GC22P032439.
    HGNCi HGNC:11036. SLC5A1.
    HPAi CAB015467.
    HPA051805.
    MIMi 182380. gene.
    606824. phenotype.
    neXtProti NX_P13866.
    Orphaneti 35710. Glucose-galactose malabsorption.
    PharmGKBi PA308.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4146.
    HOVERGENi HBG052859.
    InParanoidi P13866.
    KOi K14158.
    OMAi EMVKMGR.
    OrthoDBi EOG77126J.
    PhylomeDBi P13866.
    TreeFami TF352855.

    Enzyme and pathway databases

    Reactomei REACT_19165. Na+-dependent glucose transporters.
    REACT_19188. Inositol transporters.
    REACT_9441. Hexose transport.

    Miscellaneous databases

    GeneWikii SLC5A1.
    GenomeRNAii 6523.
    NextBioi 25375.
    PROi P13866.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13866.
    Bgeei P13866.
    CleanExi HS_SLC5A1.
    Genevestigatori P13866.

    Family and domain databases

    InterProi IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00813. sss. 1 hit.
    PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters."
      Hediger M.A., Turk E., Wright E.M.
      Proc. Natl. Acad. Sci. U.S.A. 86:5748-5752(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Structure of the human Na+/glucose cotransporter gene SGLT1."
      Turk E., Martin M.G., Wright E.M.
      J. Biol. Chem. 269:15204-15209(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GGM GLY-28.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Heart and Trachea.
    5. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Membrane topology of the human Na+/glucose cotransporter SGLT1."
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      Cited for: TOPOLOGY, MUTAGENESIS OF ASN-248, GLYCOSYLATION AT ASN-248.
    8. "Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter."
      Turk E., Zabel B., Mundlos S., Dyer J., Wright E.M.
      Nature 350:354-356(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GGM ASN-28.
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      Cited for: VARIANTS GGM ARG-318 AND VAL-468.
    10. "A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein."
      Kasahara M., Maeda M., Hayashi S., Mori Y., Abe T.
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      Cited for: VARIANT GGM TRP-135.

    Entry informationi

    Entry nameiSC5A1_HUMAN
    AccessioniPrimary (citable) accession number: P13866
    Secondary accession number(s): B2R7E2, B7Z4Q9, B7ZA69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 152 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3