Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myelomonocytic growth factor

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-GGA-449836. Other interleukin signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Myelomonocytic growth factor
Short name:
MGF
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000001559624 – 201Myelomonocytic growth factorAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 67By similarity
Disulfide bondi89 ↔ 99By similarity
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiENSGALG00000026420.
ExpressionAtlasiP13854. differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP13854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000017328.
HOVERGENiHBG005411.
KOiK05423.
OMAiKLCHPEE.
OrthoDBiEOG091G0NDU.
PhylomeDBiP13854.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
PfamiView protein in Pfam
PF16647. GCSF. 1 hit.
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiView protein in SMART
SM00126. IL6. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00254. INTERLEUKIN_6. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCCLTPVLAL ALVLGAPWQA LHGAPLAELS GDHDFQLFLH KNLEFTRKIR
60 70 80 90 100
GDVAALQRAV CDTFQLCTEE ELQLVQPDPH LVQAPLDQCH KRGFQAEVCF
110 120 130 140 150
TQIRAGLHAY HDSLGAVLRL LPNHTTLVET LQLDAANLSS NIQQQMEDLG
160 170 180 190 200
LDTVTLPAEQ RSPPPTFSGP FQQQVGGFFI LANFQRFLET AYRALRHLAR

L
Length:201
Mass (Da):22,374
Last modified:January 1, 1990 - v1
Checksum:i240A8DD21B4244E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85034 Genomic DNA. Translation: AAA48694.1.
X14477 mRNA. Translation: CAA32639.1.
PIRiA42247.
RefSeqiNP_990610.1. NM_205279.1.
UniGeneiGga.712.

Genome annotation databases

EnsembliENSGALT00000058288; ENSGALP00000044330; ENSGALG00000030907.
GeneIDi396216.
KEGGigga:396216.

Similar proteinsi

Entry informationi

Entry nameiMGF_CHICK
AccessioniPrimary (citable) accession number: P13854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 25, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families