P13845 (HBEAG_HHBV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
External core antigen

Alternative name(s):
HBeAg
Precore protein

Gene names

Name:

C

Organism

Heron hepatitis B virus (HHBV) [Complete proteome]

Taxonomic identifier

28300 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Hepadnaviridae › Avihepadnavirus

Virus host

Ardeidae (herons) [TaxID: 8899]

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May regulate immune response to the intracellular capsid in acting as a T cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T cells By similarity.
Subunit structure	Homodimerizes By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the avihepadnavirus precore antigen family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral immunoevasion
Cellular component	Secreted
Coding sequence diversity	Alternative initiation
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	evasion by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform External core antigen (identifier: P13845-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Capsid protein (identifier: P0C6K0-1)

The sequence of this isoform can be found in the external entry P0C6K0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 272	253	External core antigen		PRO_0000222307
	Propeptide	273 – 305	33	By similarity		PRO_0000324686
Sites
	Site	272 – 273	2	Cleavage; by host By similarity

Sequences

	Sequence		Length	Mass (Da)
	Isoform External core antigen [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 2B228EF44162CB06	FASTA	305	34,925
	10 20 30 40 50 60 MWSLRLHPSP FGAACQGIFT STSLLFLVTV PLVCTIVYDS CLYMDVNASR ALANVYDLPD 70 80 90 100 110 120 DFFPQIDDLV RDAKDALEPY WKAETIKKHV LIATHFVDLI EDFWQTTQGM SQIADALRAV 130 140 150 160 170 180 IPPTTVPVPE GFLITHSEAE EIPLNDLFSN QEERIVNFQP DYPITARIHT HLRVYTKLNE 190 200 210 220 230 240 QALDKARRLL WWHYNCLLWG EATVTNYISR LRTWLSTPEK YRGKDAPTIE AITRPIQVAQ 250 260 270 280 290 300 GGRNQTKGTR KPRGLEPRRR KVKTTVVYGR RRSKSRGRRS SPSQRAGSPL PRNRGNQTRS PSPRE
	Isoform Capsid protein [UniParc]. See P0C6K0.		–	–

References

[1]	"Isolation and characterization of a hepatitis B virus endemic in herons." Sprengel R., Kaleta E.F., Will H. J. Virol. 62:3832-3839(1988) [PubMed: 3418788] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M22056 Genomic DNA. Translation: AAA45737.1.
PIR	NKVLHH. C30082.
RefSeq	NP_040997.1. NC_001486.1.
3D structure databases
ProteinModelPortal	P13845.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703544.
Family and domain databases
InterPro	IPR002006. Viral_capsid_core_Hepatitis. [Graphical view]
Pfam	PF00906. Hepatitis_core. 1 hit. [Graphical view]
SUPFAM	SSF47852. Viral_capsid_core_Hepatitis. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HBEAG_HHBV

Accession

Primary (citable) accession number: P13845

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	September 21, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program