P13826 (CSP_PLAVS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Circumsporozoite protein Short name=CS
Organism	Plasmodium vivax (strain Salvador I)
Taxonomic identifier	126793 [NCBI]
Taxonomic lineage	Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Plasmodium)

Protein attributes

Sequence length	343 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host).
Domain	The C-terminal region is probably used for anchoring the protein to the cell membrane. The repeat sequences would be the surface antigen of the organism.
Sequence similarities	Belongs to the plasmodium circumsporozoite protein family. Contains 1 TSP type-1 domain.

Ontologies

Keywords
Developmental stage	Sporozoite
Disease	Malaria
Domain	Repeat
Gene Ontology (GO)
Cellular component	cell surface Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 343	›343	Circumsporozoite protein		PRO_0000217182
Regions
	Repeat	61 – 69	9	1
	Repeat	70 – 78	9	2
	Repeat	79 – 87	9	3
	Repeat	88 – 96	9	4
	Repeat	97 – 105	9	5
	Repeat	106 – 114	9	6
	Repeat	115 – 123	9	7
	Repeat	124 – 132	9	8
	Repeat	133 – 141	9	9
	Repeat	142 – 150	9	10
	Repeat	151 – 159	9	11
	Repeat	160 – 168	9	12
	Repeat	169 – 177	9	13
	Repeat	178 – 186	9	14
	Repeat	187 – 195	9	15
	Repeat	196 – 204	9	16
	Repeat	205 – 213	9	17
	Repeat	214 – 222	9	18
	Repeat	223 – 231	9	19
	Repeat	232 – 240	9	20
	Domain	269 – 321	53	TSP type-1
	Region	61 – 240	180	20 X 9 AA tandem repeats of [PA]-G-D-R-A-[DA]-G-Q-[PA]
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P13826-1 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 308EFD5BBC15DFC3	FASTA	343	34,156
	10 20 30 40 50 60 NGVNFNNVDA SSLGAAHVGQ SASRGRGLGE NPDDEEGDAK KKKDGKKAEP KNPRENKLKQ 70 80 90 100 110 120 PGDRADGQPA GDRADGQPAG DRADGQPAGD RADGQPAGDR AAGQPAGDRA DGQPAGDRAD 130 140 150 160 170 180 GQPAGDRADG QPAGDRADGQ PAGDRAAGQP AGDRAAGQPA GDRADGQPAG DRAAGQPAGD 190 200 210 220 230 240 RADGQPAGDR AAGQPAGDRA DGQPAGDRAA GQPAGDRAAG QPAGDRAAGQ AAGDRAAGQA 250 260 270 280 290 300 AGGNAGGQGQ NNEGANAPNE KSVKEYLDKV RATVGTEWTP CSVTCGVGVR VRRRVNAANK 310 320 330 340 KPEDLTLNDL ETDVCTMDKC AGIFNVVSNS LGLVILLVLA LFN

References

[1]	"Sequence of the immunodominant epitope for the surface protein on sporozoites of Plasmodium vivax." McCutchan T.F., Lal A.A., de la Cruz V.F., Miller L.H., Maloy W.L., Charoenvit Y., Beaudoin R.L., Guerry P., Wistar R. Jr., Hoffman S.L., Hockmeyer W.T., Collins W.E., Wirth D. Science 230:1381-1383(1985) [PubMed: 2416057] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Evolution of the immunodominant domain of the circumsporozoite protein gene from Plasmodium vivax. Implications for vaccines." de la Cruz V.F., Lal A.A., Welsh J.A., McCutchan T.F. J. Biol. Chem. 262:6464-6467(1987) [PubMed: 2437120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

3D structure databases
ProteinModelPortal	P13826.
ModBase	Search...
Family and domain databases
InterPro	IPR003067. Crcmsprzoite. IPR000884. Thrombospondin_1_rpt. [Graphical view]
Pfam	PF00090. TSP_1. 1 hit. [Graphical view]
PRINTS	PR01303. CRCMSPRZOITE.
SMART	SM00209. TSP1. 1 hit. [Graphical view]
SUPFAM	SSF82895. TSP1. 1 hit.
PROSITE	PS50092. TSP1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CSP_PLAVS

Accession

Primary (citable) accession number: P13826

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	August 10, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)