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P13810 (E2AA_ECOLX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat-labile enterotoxin IIA, A chain

Short name=LT-IIA
OrganismEscherichia coli
Taxonomic identifier562 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.

Subunit structure

Heterohexamer of one A chain and of five B chains.

Sequence similarities

Belongs to the enterotoxin A family.

Ontologies

Keywords
   DomainSignal
   Molecular functionEnterotoxin
Toxin
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncatalytic activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 259241Heat-labile enterotoxin IIA, A chain
PRO_0000019353

Regions

Nucleotide binding23 – 3715NAD By similarity

Sites

Active site1281 By similarity

Amino acid modifications

Disulfide bond203 ↔ 215 By similarity

Sequences

Sequence LengthMass (Da)Tools
P13810 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 996F311A32CABEAA

FASTA25929,242
        10         20         30         40         50         60 
MIKHVLLFFV FISFSVSAND FFRADSRTPD EIRRAGGLLP RGQQEAYERG TPININLYEH 

        70         80         90        100        110        120 
ARGTVTGNTR YNDGYVSTTV TLRQAHLIGQ NILGSYNEYY IYVVAPAPNL FDVNGVLGRY 

       130        140        150        160        170        180 
SPYPSENEFA ALGGIPLSQI IGWYRVSFGA IEGGMQRNRD YRGDLFRGLT VAPNEDGYQL 

       190        200        210        220        230        240 
AGFPSNFPAW REMPWSTFAP EQCVPNNKEF KGGVCISATN VLSKYDLMNF KKLLKRRLAL 

       250 
TFFMSEDDFI GVHGERDEL 

« Hide

References

[1]"Genetics of type IIa heat-labile enterotoxin of Escherichia coli: operon fusions, nucleotide sequence, and hybridization studies."
Pickett C.L., Weinstein D.L., Holmes R.K.
J. Bacteriol. 169:5180-5187(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SA53.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
JQ031711 Genomic DNA. Translation: AAA24093.1.
PIRA29831.

3D structure databases

ProteinModelPortalP13810.
SMRP13810. Positions 19-205.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP13810.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001144. Enterotoxin_A.
[Graphical view]
PfamPF01375. Enterotoxin_a. 1 hit.
[Graphical view]
PRINTSPR00771. ENTEROTOXINA.
ProtoNetSearch...

Entry information

Entry nameE2AA_ECOLX
AccessionPrimary (citable) accession number: P13810
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families