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P13810

- E2AA_ECOLX

UniProt

P13810 - E2AA_ECOLX

Protein

Heat-labile enterotoxin IIA, A chain

Gene
N/A
Organism
Escherichia coli
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    • Comment

    Functioni

    The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 3715NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. catalytic activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Enterotoxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat-labile enterotoxin IIA, A chain
    Short name:
    LT-IIA
    OrganismiEscherichia coli
    Taxonomic identifieri562 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Chaini19 – 259241Heat-labile enterotoxin IIA, A chainPRO_0000019353Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi203 ↔ 215By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP13810.

    Interactioni

    Subunit structurei

    Heterohexamer of one A chain and of five B chains.

    Structurei

    3D structure databases

    ProteinModelPortaliP13810.
    SMRiP13810. Positions 19-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the enterotoxin A family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR001144. Enterotoxin_A.
    [Graphical view]
    PfamiPF01375. Enterotoxin_a. 1 hit.
    [Graphical view]
    PRINTSiPR00771. ENTEROTOXINA.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13810-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKHVLLFFV FISFSVSAND FFRADSRTPD EIRRAGGLLP RGQQEAYERG    50
    TPININLYEH ARGTVTGNTR YNDGYVSTTV TLRQAHLIGQ NILGSYNEYY 100
    IYVVAPAPNL FDVNGVLGRY SPYPSENEFA ALGGIPLSQI IGWYRVSFGA 150
    IEGGMQRNRD YRGDLFRGLT VAPNEDGYQL AGFPSNFPAW REMPWSTFAP 200
    EQCVPNNKEF KGGVCISATN VLSKYDLMNF KKLLKRRLAL TFFMSEDDFI 250
    GVHGERDEL 259
    Length:259
    Mass (Da):29,242
    Last modified:January 1, 1990 - v1
    Checksum:i996F311A32CABEAA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JQ031711 Genomic DNA. Translation: AAA24093.1.
    PIRiA29831.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JQ031711 Genomic DNA. Translation: AAA24093.1 .
    PIRi A29831.

    3D structure databases

    ProteinModelPortali P13810.
    SMRi P13810. Positions 19-205.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P13810.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001144. Enterotoxin_A.
    [Graphical view ]
    Pfami PF01375. Enterotoxin_a. 1 hit.
    [Graphical view ]
    PRINTSi PR00771. ENTEROTOXINA.
    ProtoNeti Search...

    Publicationsi

    1. "Genetics of type IIa heat-labile enterotoxin of Escherichia coli: operon fusions, nucleotide sequence, and hybridization studies."
      Pickett C.L., Weinstein D.L., Holmes R.K.
      J. Bacteriol. 169:5180-5187(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SA53.

    Entry informationi

    Entry nameiE2AA_ECOLX
    AccessioniPrimary (citable) accession number: P13810
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3