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Protein

Heat-labile enterotoxin IIA, A chain

Gene
N/A
Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 37NADBy similarityAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-labile enterotoxin IIA, A chain
Short name:
LT-IIA
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001935319 – 259Heat-labile enterotoxin IIA, A chainAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi203 ↔ 215By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP13810.

Interactioni

Subunit structurei

Heterohexamer of one A chain and of five B chains.

Structurei

3D structure databases

ProteinModelPortaliP13810.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the enterotoxin A family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001144. Enterotoxin_A.
[Graphical view]
PfamiPF01375. Enterotoxin_a. 1 hit.
[Graphical view]
PRINTSiPR00771. ENTEROTOXINA.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKHVLLFFV FISFSVSAND FFRADSRTPD EIRRAGGLLP RGQQEAYERG
60 70 80 90 100
TPININLYEH ARGTVTGNTR YNDGYVSTTV TLRQAHLIGQ NILGSYNEYY
110 120 130 140 150
IYVVAPAPNL FDVNGVLGRY SPYPSENEFA ALGGIPLSQI IGWYRVSFGA
160 170 180 190 200
IEGGMQRNRD YRGDLFRGLT VAPNEDGYQL AGFPSNFPAW REMPWSTFAP
210 220 230 240 250
EQCVPNNKEF KGGVCISATN VLSKYDLMNF KKLLKRRLAL TFFMSEDDFI

GVHGERDEL
Length:259
Mass (Da):29,242
Last modified:January 1, 1990 - v1
Checksum:i996F311A32CABEAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ031711 Genomic DNA. Translation: AAA24093.1.
PIRiA29831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ031711 Genomic DNA. Translation: AAA24093.1.
PIRiA29831.

3D structure databases

ProteinModelPortaliP13810.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP13810.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR001144. Enterotoxin_A.
[Graphical view]
PfamiPF01375. Enterotoxin_a. 1 hit.
[Graphical view]
PRINTSiPR00771. ENTEROTOXINA.
ProtoNetiSearch...

Entry informationi

Entry nameiE2AA_ECOLX
AccessioniPrimary (citable) accession number: P13810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.