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Protein

Heat-labile enterotoxin IIA, A chain

Gene
N/A
Organism
Escherichia coli
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 37NADBy similarityAdd BLAST15

GO - Molecular functioni

Keywordsi

Molecular functionEnterotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-labile enterotoxin IIA, A chain
Short name:
LT-IIA
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001935319 – 259Heat-labile enterotoxin IIA, A chainAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi203 ↔ 215By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterohexamer of one A chain and of five B chains.

Structurei

3D structure databases

ProteinModelPortaliP13810
SMRiP13810
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the enterotoxin A family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR001144 Enterotoxin_A
PfamiView protein in Pfam
PF01375 Enterotoxin_a, 1 hit
PRINTSiPR00771 ENTEROTOXINA

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKHVLLFFV FISFSVSAND FFRADSRTPD EIRRAGGLLP RGQQEAYERG
60 70 80 90 100
TPININLYEH ARGTVTGNTR YNDGYVSTTV TLRQAHLIGQ NILGSYNEYY
110 120 130 140 150
IYVVAPAPNL FDVNGVLGRY SPYPSENEFA ALGGIPLSQI IGWYRVSFGA
160 170 180 190 200
IEGGMQRNRD YRGDLFRGLT VAPNEDGYQL AGFPSNFPAW REMPWSTFAP
210 220 230 240 250
EQCVPNNKEF KGGVCISATN VLSKYDLMNF KKLLKRRLAL TFFMSEDDFI

GVHGERDEL
Length:259
Mass (Da):29,242
Last modified:January 1, 1990 - v1
Checksum:i996F311A32CABEAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ031711 Genomic DNA Translation: AAA24093.1
PIRiA29831

Similar proteinsi

Entry informationi

Entry nameiE2AA_ECOLX
AccessioniPrimary (citable) accession number: P13810
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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