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P13810

- E2AA_ECOLX

UniProt

P13810 - E2AA_ECOLX

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Protein
Heat-labile enterotoxin IIA, A chain
Gene
N/A
Organism
Escherichia coli
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 3715NAD By similarity
Add
BLAST

GO - Molecular functioni

  1. catalytic activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-labile enterotoxin IIA, A chain
Short name:
LT-IIA
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818
Add
BLAST
Chaini19 – 259241Heat-labile enterotoxin IIA, A chain
PRO_0000019353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi203 ↔ 215 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP13810.

Interactioni

Subunit structurei

Heterohexamer of one A chain and of five B chains.

Structurei

3D structure databases

ProteinModelPortaliP13810.
SMRiP13810. Positions 19-205.

Family & Domainsi

Sequence similaritiesi

Belongs to the enterotoxin A family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001144. Enterotoxin_A.
[Graphical view]
PfamiPF01375. Enterotoxin_a. 1 hit.
[Graphical view]
PRINTSiPR00771. ENTEROTOXINA.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13810-1 [UniParc]FASTAAdd to Basket

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MIKHVLLFFV FISFSVSAND FFRADSRTPD EIRRAGGLLP RGQQEAYERG    50
TPININLYEH ARGTVTGNTR YNDGYVSTTV TLRQAHLIGQ NILGSYNEYY 100
IYVVAPAPNL FDVNGVLGRY SPYPSENEFA ALGGIPLSQI IGWYRVSFGA 150
IEGGMQRNRD YRGDLFRGLT VAPNEDGYQL AGFPSNFPAW REMPWSTFAP 200
EQCVPNNKEF KGGVCISATN VLSKYDLMNF KKLLKRRLAL TFFMSEDDFI 250
GVHGERDEL 259
Length:259
Mass (Da):29,242
Last modified:January 1, 1990 - v1
Checksum:i996F311A32CABEAA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JQ031711 Genomic DNA. Translation: AAA24093.1.
PIRiA29831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JQ031711 Genomic DNA. Translation: AAA24093.1 .
PIRi A29831.

3D structure databases

ProteinModelPortali P13810.
SMRi P13810. Positions 19-205.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P13810.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001144. Enterotoxin_A.
[Graphical view ]
Pfami PF01375. Enterotoxin_a. 1 hit.
[Graphical view ]
PRINTSi PR00771. ENTEROTOXINA.
ProtoNeti Search...

Publicationsi

  1. "Genetics of type IIa heat-labile enterotoxin of Escherichia coli: operon fusions, nucleotide sequence, and hybridization studies."
    Pickett C.L., Weinstein D.L., Holmes R.K.
    J. Bacteriol. 169:5180-5187(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SA53.

Entry informationi

Entry nameiE2AA_ECOLX
AccessioniPrimary (citable) accession number: P13810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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