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P13808

- B3A2_MOUSE

UniProt

P13808 - B3A2_MOUSE

Protein

Anion exchange protein 2

Gene

Slc4a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Plasma membrane anion exchange protein of wide distribution.

    GO - Molecular functioni

    1. chloride transmembrane transporter activity Source: UniProtKB
    2. inorganic anion exchanger activity Source: InterPro

    GO - Biological processi

    1. chloride transmembrane transport Source: GOC
    2. chloride transport Source: UniProtKB

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange protein 2
    Short name:
    AE 2
    Short name:
    Anion exchanger 2
    Alternative name(s):
    Band 3-related protein
    Short name:
    B3RP
    Non-erythroid band 3-like protein
    Solute carrier family 4 member 2
    Gene namesi
    Name:Slc4a2
    Synonyms:Ae2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:109351. Slc4a2.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12371237Anion exchange protein 2PRO_0000079216Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei112 – 1121PhosphoserineBy similarity
    Modified residuei131 – 1311PhosphoserineBy similarity
    Modified residuei144 – 1441Phosphoserine1 Publication
    Modified residuei170 – 1701Phosphoserine1 Publication
    Modified residuei172 – 1721Phosphoserine1 Publication
    Modified residuei253 – 2531Phosphothreonine1 Publication
    Modified residuei439 – 4391PhosphoserineBy similarity
    Glycosylationi855 – 8551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi866 – 8661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi878 – 8781N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1169 – 11691S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP13808.
    PRIDEiP13808.

    PTM databases

    PhosphoSiteiP13808.

    Expressioni

    Tissue specificityi

    Isoform a is widely expressed at similar levels in all tissues examined. Isoforms B1 and B2 are predominantly expressed in stomach although they are also detected at lower levels in other tissues. Isoform C1 is stomach-specific. Isoform C2 is expressed at slightly higher levels in lung and stomach than in other tissues.1 Publication

    Gene expression databases

    ArrayExpressiP13808.
    BgeeiP13808.
    GenevestigatoriP13808.

    Interactioni

    Protein-protein interaction databases

    IntActiP13808. 1 interaction.
    MINTiMINT-4088942.

    Structurei

    3D structure databases

    ProteinModelPortaliP13808.
    SMRiP13808. Positions 318-641, 688-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 703703CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini844 – 89653ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini915 – 92915CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei704 – 72724HelicalSequence AnalysisAdd
    BLAST
    Transmembranei733 – 77038HelicalSequence AnalysisAdd
    BLAST
    Transmembranei790 – 81223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei822 – 84322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei897 – 91418HelicalSequence AnalysisAdd
    BLAST
    Transmembranei930 – 95021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei984 – 100623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1032 – 105322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1087 – 113246HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1159 – 119537HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni704 – 1237534Membrane (anion exchange)Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 316312Pro-richAdd
    BLAST
    Compositional biasi73 – 8715His-richAdd
    BLAST
    Compositional biasi861 – 8655Poly-Ser

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268067.
    GeneTreeiENSGT00560000076933.
    HOGENOMiHOG000280683.
    HOVERGENiHBG004326.
    InParanoidiP13808.
    KOiK13855.
    OrthoDBiEOG7TMZR0.
    PhylomeDBiP13808.
    TreeFamiTF313630.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR001717. Anion_exchange.
    IPR002978. Anion_exchange_2.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF14. PTHR11453:SF14. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR00165. ANIONEXCHNGR.
    PR01188. ANIONEXHNGR2.
    PR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 2 hits.
    TIGRFAMsiTIGR00834. ae. 1 hit.
    PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: P13808-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEDELRT LGVERFEEIL     50
    QEAGSRGGEE PGRSYGEEDF EYHRQSSHHI HHPLSTHLPP DARRRKTPQG 100
    PGRKPRRRPG ASPTGETPTI EEGEEDEEEA SEAEGFRAPP QQPSPATTPS 150
    AVQFFLQEDE GAERKPERTS PSPPTQTPHQ EAAPRASKGA QTGTLVEEMV 200
    AVASATAGGD DGGAAGRPLT KAQPGHRSYN LQERRRIGSM TGVEQALLPR 250
    VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSTQAAREGR 300
    EPGPTPRARP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE 350
    EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ 400
    MVISDQIKAE DRANVLRALL LKHSHPSDEK EFSFPRNISA GSLGSLLGHH 450
    HAQGTESDPH VTEPLIGGVP ETRLEVDRER ELPPPAPPAG ITRSKSKHEL 500
    KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR 550
    FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE RDDLLTAINA 600
    FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGAGLEPKS 650
    AQDKALLQMV EVAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL 700
    DPQCLAAVIF IYFAALSPAI TFGGLLGEKT KDLIGVSELI MSTALQGVVF 750
    CLLGAQPLLV IGFSGPLLVF EEAFFSFCSS NELEYLVGRV WIGFWLVFLA 800
    LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI KIFQEHPLHG 850
    CSGSNDSEAG SSSSSNMTWA TTILVPDNSS ASGQSGQEKP RGQPNTALLS 900
    LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI 950
    EDTYTQKLSV PSGFSVTAPD KRGWVINPLG EKTPFPVWMM VASLLPAVLV 1000
    FILIFMETQI TTLIISKKER MLQKGSGFHL DLLLIVAMGG ICALFGLPWL 1050
    AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL LVALLVGLSM 1100
    VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY 1150
    VKKVRTMRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL 1200
    TRIFTEREMK CLDANEAEPV FDECEGVDEY NEMPMPV 1237
    Length:1,237
    Mass (Da):136,814
    Last modified:January 1, 1990 - v1
    Checksum:i1A0782C0071782EE
    GO
    Isoform B1 (identifier: P13808-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: MSSAPRRPASGADSLHT → MTQ

    Show »
    Length:1,223
    Mass (Da):135,452
    Checksum:iE03B373EAAA48119
    GO
    Isoform B2 (identifier: P13808-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: MSSAPRRPASGADSLHT → MDFLLRPQ

    Show »
    Length:1,228
    Mass (Da):136,092
    Checksum:i8EC77B1EF4AF52A2
    GO
    Isoform C1 (identifier: P13808-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-198: Missing.

    Show »
    Length:1,039
    Mass (Da):115,198
    Checksum:i5F6C9A0FC1FECBC6
    GO
    Isoform C2 (identifier: P13808-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-166: Missing.
         167-193: ERTSPSPPTQTPHQEAAPRASKGAQTG → MPAFQEWKSGGLREEAVFGAHGCSVCR

    Show »
    Length:1,071
    Mass (Da):118,705
    Checksum:i9BED064CDDEAB4E4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti205 – 2051A → G in AAG23154. (PubMed:11006093)Curated
    Sequence conflicti205 – 2051A → G in AAG23155. (PubMed:11006093)Curated
    Sequence conflicti205 – 2051A → G in AAG23156. (PubMed:11006093)Curated
    Sequence conflicti205 – 2051A → G in AAG23158. (PubMed:11006093)Curated
    Sequence conflicti205 – 2051A → G in AAG23157. (PubMed:11006093)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 198198Missing in isoform C1. CuratedVSP_000460Add
    BLAST
    Alternative sequencei1 – 166166Missing in isoform C2. CuratedVSP_000459Add
    BLAST
    Alternative sequencei1 – 1717MSSAP…DSLHT → MTQ in isoform B1. CuratedVSP_000458Add
    BLAST
    Alternative sequencei1 – 1717MSSAP…DSLHT → MDFLLRPQ in isoform B2. CuratedVSP_000457Add
    BLAST
    Alternative sequencei167 – 19327ERTSP…GAQTG → MPAFQEWKSGGLREEAVFGA HGCSVCR in isoform C2. CuratedVSP_000461Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04036 mRNA. Translation: AAA65505.1.
    AF255774 Genomic DNA. Translation: AAG23154.1.
    AF255774 Genomic DNA. Translation: AAG23155.1.
    AF255774 Genomic DNA. Translation: AAG23156.1.
    AF255774 Genomic DNA. Translation: AAG23158.1.
    AF255774 Genomic DNA. Translation: AAG23157.1.
    CCDSiCCDS19119.1. [P13808-1]
    PIRiA31789.
    RefSeqiNP_001240821.1. NM_001253892.1.
    NP_033233.2. NM_009207.3.
    XP_006535713.1. XM_006535650.1.
    XP_006535714.1. XM_006535651.1.
    XP_006535715.1. XM_006535652.1.
    XP_006535718.1. XM_006535655.1.
    XP_006535719.1. XM_006535656.1.
    UniGeneiMm.4580.

    Genome annotation databases

    EnsembliENSMUST00000080067; ENSMUSP00000078972; ENSMUSG00000028962.
    ENSMUST00000115047; ENSMUSP00000110699; ENSMUSG00000028962.
    ENSMUST00000115049; ENSMUSP00000110701; ENSMUSG00000028962.
    GeneIDi20535.
    KEGGimmu:20535.
    UCSCiuc008wrm.2. mouse. [P13808-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04036 mRNA. Translation: AAA65505.1 .
    AF255774 Genomic DNA. Translation: AAG23154.1 .
    AF255774 Genomic DNA. Translation: AAG23155.1 .
    AF255774 Genomic DNA. Translation: AAG23156.1 .
    AF255774 Genomic DNA. Translation: AAG23158.1 .
    AF255774 Genomic DNA. Translation: AAG23157.1 .
    CCDSi CCDS19119.1. [P13808-1 ]
    PIRi A31789.
    RefSeqi NP_001240821.1. NM_001253892.1.
    NP_033233.2. NM_009207.3.
    XP_006535713.1. XM_006535650.1.
    XP_006535714.1. XM_006535651.1.
    XP_006535715.1. XM_006535652.1.
    XP_006535718.1. XM_006535655.1.
    XP_006535719.1. XM_006535656.1.
    UniGenei Mm.4580.

    3D structure databases

    ProteinModelPortali P13808.
    SMRi P13808. Positions 318-641, 688-729.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P13808. 1 interaction.
    MINTi MINT-4088942.

    PTM databases

    PhosphoSitei P13808.

    Proteomic databases

    PaxDbi P13808.
    PRIDEi P13808.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000080067 ; ENSMUSP00000078972 ; ENSMUSG00000028962 .
    ENSMUST00000115047 ; ENSMUSP00000110699 ; ENSMUSG00000028962 .
    ENSMUST00000115049 ; ENSMUSP00000110701 ; ENSMUSG00000028962 .
    GeneIDi 20535.
    KEGGi mmu:20535.
    UCSCi uc008wrm.2. mouse. [P13808-1 ]

    Organism-specific databases

    CTDi 6522.
    MGIi MGI:109351. Slc4a2.

    Phylogenomic databases

    eggNOGi NOG268067.
    GeneTreei ENSGT00560000076933.
    HOGENOMi HOG000280683.
    HOVERGENi HBG004326.
    InParanoidi P13808.
    KOi K13855.
    OrthoDBi EOG7TMZR0.
    PhylomeDBi P13808.
    TreeFami TF313630.

    Miscellaneous databases

    ChiTaRSi SLC4A2. mouse.
    NextBioi 298803.
    PROi P13808.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13808.
    Bgeei P13808.
    Genevestigatori P13808.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR001717. Anion_exchange.
    IPR002978. Anion_exchange_2.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF14. PTHR11453:SF14. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR00165. ANIONEXCHNGR.
    PR01188. ANIONEXHNGR2.
    PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 2 hits.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line."
      Alper S.L., Kopito R.R., Libresco S.M., Lodish H.F.
      J. Biol. Chem. 263:17092-17099(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    2. "Molecular cloning and genomic organization of the mouse AE2 anion exchanger gene."
      Lecanda J., Urtasun R., Medina J.F.
      Biochem. Biophys. Res. Commun. 276:117-124(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144; SER-170; SER-172 AND THR-253, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiB3A2_MOUSE
    AccessioniPrimary (citable) accession number: P13808
    Secondary accession number(s): Q9ES09
    , Q9ES10, Q9ES11, Q9ES12, Q9ES13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3