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P13808

- B3A2_MOUSE

UniProt

P13808 - B3A2_MOUSE

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Protein

Anion exchange protein 2

Gene
Slc4a2, Ae2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functioni

  1. chloride transmembrane transporter activity Source: UniProtKB
  2. inorganic anion exchanger activity Source: InterPro

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. chloride transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Band 3-related protein
Short name:
B3RP
Non-erythroid band 3-like protein
Solute carrier family 4 member 2
Gene namesi
Name:Slc4a2
Synonyms:Ae2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:109351. Slc4a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 703703Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei704 – 72724Helical; Reviewed predictionAdd
BLAST
Transmembranei733 – 77038Helical; Reviewed predictionAdd
BLAST
Transmembranei790 – 81223Helical; Reviewed predictionAdd
BLAST
Transmembranei822 – 84322Helical; Reviewed predictionAdd
BLAST
Topological domaini844 – 89653Extracellular Reviewed predictionAdd
BLAST
Transmembranei897 – 91418Helical; Reviewed predictionAdd
BLAST
Topological domaini915 – 92915Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei930 – 95021Helical; Reviewed predictionAdd
BLAST
Transmembranei984 – 100623Helical; Reviewed predictionAdd
BLAST
Transmembranei1032 – 105322Helical; Reviewed predictionAdd
BLAST
Transmembranei1087 – 113246Helical; Reviewed predictionAdd
BLAST
Transmembranei1159 – 119537Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12371237Anion exchange protein 2PRO_0000079216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei112 – 1121Phosphoserine By similarity
Modified residuei131 – 1311Phosphoserine By similarity
Modified residuei144 – 1441Phosphoserine1 Publication
Modified residuei170 – 1701Phosphoserine1 Publication
Modified residuei172 – 1721Phosphoserine1 Publication
Modified residuei253 – 2531Phosphothreonine1 Publication
Modified residuei439 – 4391Phosphoserine By similarity
Glycosylationi855 – 8551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi866 – 8661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi878 – 8781N-linked (GlcNAc...) Reviewed prediction
Lipidationi1169 – 11691S-palmitoyl cysteine By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP13808.
PRIDEiP13808.

PTM databases

PhosphoSiteiP13808.

Expressioni

Tissue specificityi

Isoform a is widely expressed at similar levels in all tissues examined. Isoforms B1 and B2 are predominantly expressed in stomach although they are also detected at lower levels in other tissues. Isoform C1 is stomach-specific. Isoform C2 is expressed at slightly higher levels in lung and stomach than in other tissues.1 Publication

Gene expression databases

ArrayExpressiP13808.
BgeeiP13808.
GenevestigatoriP13808.

Interactioni

Protein-protein interaction databases

IntActiP13808. 1 interaction.
MINTiMINT-4088942.

Structurei

3D structure databases

ProteinModelPortaliP13808.
SMRiP13808. Positions 318-641, 688-729.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni704 – 1237534Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 316312Pro-richAdd
BLAST
Compositional biasi73 – 8715His-richAdd
BLAST
Compositional biasi861 – 8655Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
GeneTreeiENSGT00560000076933.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP13808.
KOiK13855.
OrthoDBiEOG7TMZR0.
PhylomeDBiP13808.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P13808-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEDELRT LGVERFEEIL     50
QEAGSRGGEE PGRSYGEEDF EYHRQSSHHI HHPLSTHLPP DARRRKTPQG 100
PGRKPRRRPG ASPTGETPTI EEGEEDEEEA SEAEGFRAPP QQPSPATTPS 150
AVQFFLQEDE GAERKPERTS PSPPTQTPHQ EAAPRASKGA QTGTLVEEMV 200
AVASATAGGD DGGAAGRPLT KAQPGHRSYN LQERRRIGSM TGVEQALLPR 250
VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSTQAAREGR 300
EPGPTPRARP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE 350
EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ 400
MVISDQIKAE DRANVLRALL LKHSHPSDEK EFSFPRNISA GSLGSLLGHH 450
HAQGTESDPH VTEPLIGGVP ETRLEVDRER ELPPPAPPAG ITRSKSKHEL 500
KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR 550
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE RDDLLTAINA 600
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGAGLEPKS 650
AQDKALLQMV EVAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL 700
DPQCLAAVIF IYFAALSPAI TFGGLLGEKT KDLIGVSELI MSTALQGVVF 750
CLLGAQPLLV IGFSGPLLVF EEAFFSFCSS NELEYLVGRV WIGFWLVFLA 800
LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI KIFQEHPLHG 850
CSGSNDSEAG SSSSSNMTWA TTILVPDNSS ASGQSGQEKP RGQPNTALLS 900
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI 950
EDTYTQKLSV PSGFSVTAPD KRGWVINPLG EKTPFPVWMM VASLLPAVLV 1000
FILIFMETQI TTLIISKKER MLQKGSGFHL DLLLIVAMGG ICALFGLPWL 1050
AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL LVALLVGLSM 1100
VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY 1150
VKKVRTMRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL 1200
TRIFTEREMK CLDANEAEPV FDECEGVDEY NEMPMPV 1237
Length:1,237
Mass (Da):136,814
Last modified:January 1, 1990 - v1
Checksum:i1A0782C0071782EE
GO
Isoform B1 (identifier: P13808-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPASGADSLHT → MTQ

Show »
Length:1,223
Mass (Da):135,452
Checksum:iE03B373EAAA48119
GO
Isoform B2 (identifier: P13808-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPASGADSLHT → MDFLLRPQ

Show »
Length:1,228
Mass (Da):136,092
Checksum:i8EC77B1EF4AF52A2
GO
Isoform C1 (identifier: P13808-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-198: Missing.

Show »
Length:1,039
Mass (Da):115,198
Checksum:i5F6C9A0FC1FECBC6
GO
Isoform C2 (identifier: P13808-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     167-193: ERTSPSPPTQTPHQEAAPRASKGAQTG → MPAFQEWKSGGLREEAVFGAHGCSVCR

Show »
Length:1,071
Mass (Da):118,705
Checksum:i9BED064CDDEAB4E4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 198198Missing in isoform C1. VSP_000460Add
BLAST
Alternative sequencei1 – 166166Missing in isoform C2. VSP_000459Add
BLAST
Alternative sequencei1 – 1717MSSAP…DSLHT → MTQ in isoform B1. VSP_000458Add
BLAST
Alternative sequencei1 – 1717MSSAP…DSLHT → MDFLLRPQ in isoform B2. VSP_000457Add
BLAST
Alternative sequencei167 – 19327ERTSP…GAQTG → MPAFQEWKSGGLREEAVFGA HGCSVCR in isoform C2. VSP_000461Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051A → G in AAG23154. 1 Publication
Sequence conflicti205 – 2051A → G in AAG23155. 1 Publication
Sequence conflicti205 – 2051A → G in AAG23156. 1 Publication
Sequence conflicti205 – 2051A → G in AAG23158. 1 Publication
Sequence conflicti205 – 2051A → G in AAG23157. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04036 mRNA. Translation: AAA65505.1.
AF255774 Genomic DNA. Translation: AAG23154.1.
AF255774 Genomic DNA. Translation: AAG23155.1.
AF255774 Genomic DNA. Translation: AAG23156.1.
AF255774 Genomic DNA. Translation: AAG23158.1.
AF255774 Genomic DNA. Translation: AAG23157.1.
CCDSiCCDS19119.1. [P13808-1]
PIRiA31789.
RefSeqiNP_001240821.1. NM_001253892.1.
NP_033233.2. NM_009207.3.
XP_006535713.1. XM_006535650.1.
XP_006535714.1. XM_006535651.1.
XP_006535715.1. XM_006535652.1.
XP_006535718.1. XM_006535655.1.
XP_006535719.1. XM_006535656.1.
UniGeneiMm.4580.

Genome annotation databases

EnsembliENSMUST00000080067; ENSMUSP00000078972; ENSMUSG00000028962.
ENSMUST00000115047; ENSMUSP00000110699; ENSMUSG00000028962.
ENSMUST00000115049; ENSMUSP00000110701; ENSMUSG00000028962.
GeneIDi20535.
KEGGimmu:20535.
UCSCiuc008wrm.2. mouse. [P13808-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04036 mRNA. Translation: AAA65505.1 .
AF255774 Genomic DNA. Translation: AAG23154.1 .
AF255774 Genomic DNA. Translation: AAG23155.1 .
AF255774 Genomic DNA. Translation: AAG23156.1 .
AF255774 Genomic DNA. Translation: AAG23158.1 .
AF255774 Genomic DNA. Translation: AAG23157.1 .
CCDSi CCDS19119.1. [P13808-1 ]
PIRi A31789.
RefSeqi NP_001240821.1. NM_001253892.1.
NP_033233.2. NM_009207.3.
XP_006535713.1. XM_006535650.1.
XP_006535714.1. XM_006535651.1.
XP_006535715.1. XM_006535652.1.
XP_006535718.1. XM_006535655.1.
XP_006535719.1. XM_006535656.1.
UniGenei Mm.4580.

3D structure databases

ProteinModelPortali P13808.
SMRi P13808. Positions 318-641, 688-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P13808. 1 interaction.
MINTi MINT-4088942.

PTM databases

PhosphoSitei P13808.

Proteomic databases

PaxDbi P13808.
PRIDEi P13808.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080067 ; ENSMUSP00000078972 ; ENSMUSG00000028962 .
ENSMUST00000115047 ; ENSMUSP00000110699 ; ENSMUSG00000028962 .
ENSMUST00000115049 ; ENSMUSP00000110701 ; ENSMUSG00000028962 .
GeneIDi 20535.
KEGGi mmu:20535.
UCSCi uc008wrm.2. mouse. [P13808-1 ]

Organism-specific databases

CTDi 6522.
MGIi MGI:109351. Slc4a2.

Phylogenomic databases

eggNOGi NOG268067.
GeneTreei ENSGT00560000076933.
HOGENOMi HOG000280683.
HOVERGENi HBG004326.
InParanoidi P13808.
KOi K13855.
OrthoDBi EOG7TMZR0.
PhylomeDBi P13808.
TreeFami TF313630.

Miscellaneous databases

ChiTaRSi SLC4A2. mouse.
NextBioi 298803.
PROi P13808.
SOURCEi Search...

Gene expression databases

ArrayExpressi P13808.
Bgeei P13808.
Genevestigatori P13808.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line."
    Alper S.L., Kopito R.R., Libresco S.M., Lodish H.F.
    J. Biol. Chem. 263:17092-17099(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "Molecular cloning and genomic organization of the mouse AE2 anion exchanger gene."
    Lecanda J., Urtasun R., Medina J.F.
    Biochem. Biophys. Res. Commun. 276:117-124(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144; SER-170; SER-172 AND THR-253, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiB3A2_MOUSE
AccessioniPrimary (citable) accession number: P13808
Secondary accession number(s): Q9ES09
, Q9ES10, Q9ES11, Q9ES12, Q9ES13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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