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Protein

Anion exchange protein 2

Gene

Slc4a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functioni

GO - Biological processi

  • chloride transport Source: UniProtKB
  • regulation of intracellular pH Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Band 3-related protein
Short name:
B3RP
Non-erythroid band 3-like protein
Solute carrier family 4 member 2
Gene namesi
Name:Slc4a2
Synonyms:Ae2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109351. Slc4a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 703CytoplasmicSequence analysisAdd BLAST703
Transmembranei704 – 727HelicalSequence analysisAdd BLAST24
Transmembranei733 – 770HelicalSequence analysisAdd BLAST38
Transmembranei790 – 812HelicalSequence analysisAdd BLAST23
Transmembranei822 – 843HelicalSequence analysisAdd BLAST22
Topological domaini844 – 896ExtracellularSequence analysisAdd BLAST53
Transmembranei897 – 914HelicalSequence analysisAdd BLAST18
Topological domaini915 – 929CytoplasmicSequence analysisAdd BLAST15
Transmembranei930 – 950HelicalSequence analysisAdd BLAST21
Transmembranei984 – 1006HelicalSequence analysisAdd BLAST23
Transmembranei1032 – 1053HelicalSequence analysisAdd BLAST22
Transmembranei1087 – 1132HelicalSequence analysisAdd BLAST46
Transmembranei1159 – 1195HelicalSequence analysisAdd BLAST37

GO - Cellular componenti

  • basolateral plasma membrane Source: MGI
  • focal adhesion Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792161 – 1237Anion exchange protein 2Add BLAST1237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphoserineBy similarity1
Modified residuei131PhosphoserineBy similarity1
Modified residuei144PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei239PhosphoserineBy similarity1
Modified residuei253PhosphothreonineCombined sources1
Modified residuei270N6-methyllysineBy similarity1
Modified residuei297Omega-N-methylarginineBy similarity1
Modified residuei439PhosphoserineBy similarity1
Glycosylationi855N-linked (GlcNAc...)Sequence analysis1
Glycosylationi866N-linked (GlcNAc...)Sequence analysis1
Glycosylationi878N-linked (GlcNAc...)Sequence analysis1
Lipidationi1169S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP13808.
PaxDbiP13808.
PeptideAtlasiP13808.
PRIDEiP13808.

PTM databases

iPTMnetiP13808.
PhosphoSitePlusiP13808.

Expressioni

Tissue specificityi

Isoform a is widely expressed at similar levels in all tissues examined. Isoforms B1 and B2 are predominantly expressed in stomach although they are also detected at lower levels in other tissues. Isoform C1 is stomach-specific. Isoform C2 is expressed at slightly higher levels in lung and stomach than in other tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000028962.

Interactioni

Protein-protein interaction databases

IntActiP13808. 1 interactor.
MINTiMINT-4088942.
STRINGi10090.ENSMUSP00000078972.

Structurei

3D structure databases

ProteinModelPortaliP13808.
SMRiP13808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni704 – 1237Membrane (anion exchange)Add BLAST534

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 316Pro-richAdd BLAST312
Compositional biasi73 – 87His-richAdd BLAST15
Compositional biasi861 – 865Poly-Ser5

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP13808.
KOiK13855.
PhylomeDBiP13808.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF14. PTHR11453:SF14. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P13808-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEDELRT LGVERFEEIL
60 70 80 90 100
QEAGSRGGEE PGRSYGEEDF EYHRQSSHHI HHPLSTHLPP DARRRKTPQG
110 120 130 140 150
PGRKPRRRPG ASPTGETPTI EEGEEDEEEA SEAEGFRAPP QQPSPATTPS
160 170 180 190 200
AVQFFLQEDE GAERKPERTS PSPPTQTPHQ EAAPRASKGA QTGTLVEEMV
210 220 230 240 250
AVASATAGGD DGGAAGRPLT KAQPGHRSYN LQERRRIGSM TGVEQALLPR
260 270 280 290 300
VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSTQAAREGR
310 320 330 340 350
EPGPTPRARP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE
360 370 380 390 400
EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ
410 420 430 440 450
MVISDQIKAE DRANVLRALL LKHSHPSDEK EFSFPRNISA GSLGSLLGHH
460 470 480 490 500
HAQGTESDPH VTEPLIGGVP ETRLEVDRER ELPPPAPPAG ITRSKSKHEL
510 520 530 540 550
KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR
560 570 580 590 600
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE RDDLLTAINA
610 620 630 640 650
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGAGLEPKS
660 670 680 690 700
AQDKALLQMV EVAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL
710 720 730 740 750
DPQCLAAVIF IYFAALSPAI TFGGLLGEKT KDLIGVSELI MSTALQGVVF
760 770 780 790 800
CLLGAQPLLV IGFSGPLLVF EEAFFSFCSS NELEYLVGRV WIGFWLVFLA
810 820 830 840 850
LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI KIFQEHPLHG
860 870 880 890 900
CSGSNDSEAG SSSSSNMTWA TTILVPDNSS ASGQSGQEKP RGQPNTALLS
910 920 930 940 950
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI
960 970 980 990 1000
EDTYTQKLSV PSGFSVTAPD KRGWVINPLG EKTPFPVWMM VASLLPAVLV
1010 1020 1030 1040 1050
FILIFMETQI TTLIISKKER MLQKGSGFHL DLLLIVAMGG ICALFGLPWL
1060 1070 1080 1090 1100
AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL LVALLVGLSM
1110 1120 1130 1140 1150
VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY
1160 1170 1180 1190 1200
VKKVRTMRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL
1210 1220 1230
TRIFTEREMK CLDANEAEPV FDECEGVDEY NEMPMPV
Length:1,237
Mass (Da):136,814
Last modified:January 1, 1990 - v1
Checksum:i1A0782C0071782EE
GO
Isoform B1 (identifier: P13808-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPASGADSLHT → MTQ

Show »
Length:1,223
Mass (Da):135,452
Checksum:iE03B373EAAA48119
GO
Isoform B2 (identifier: P13808-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPASGADSLHT → MDFLLRPQ

Show »
Length:1,228
Mass (Da):136,092
Checksum:i8EC77B1EF4AF52A2
GO
Isoform C1 (identifier: P13808-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-198: Missing.

Show »
Length:1,039
Mass (Da):115,198
Checksum:i5F6C9A0FC1FECBC6
GO
Isoform C2 (identifier: P13808-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     167-193: ERTSPSPPTQTPHQEAAPRASKGAQTG → MPAFQEWKSGGLREEAVFGAHGCSVCR

Show »
Length:1,071
Mass (Da):118,705
Checksum:i9BED064CDDEAB4E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205A → G in AAG23154 (PubMed:11006093).Curated1
Sequence conflicti205A → G in AAG23155 (PubMed:11006093).Curated1
Sequence conflicti205A → G in AAG23156 (PubMed:11006093).Curated1
Sequence conflicti205A → G in AAG23158 (PubMed:11006093).Curated1
Sequence conflicti205A → G in AAG23157 (PubMed:11006093).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0004601 – 198Missing in isoform C1. CuratedAdd BLAST198
Alternative sequenceiVSP_0004591 – 166Missing in isoform C2. CuratedAdd BLAST166
Alternative sequenceiVSP_0004581 – 17MSSAP…DSLHT → MTQ in isoform B1. CuratedAdd BLAST17
Alternative sequenceiVSP_0004571 – 17MSSAP…DSLHT → MDFLLRPQ in isoform B2. CuratedAdd BLAST17
Alternative sequenceiVSP_000461167 – 193ERTSP…GAQTG → MPAFQEWKSGGLREEAVFGA HGCSVCR in isoform C2. CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04036 mRNA. Translation: AAA65505.1.
AF255774 Genomic DNA. Translation: AAG23154.1.
AF255774 Genomic DNA. Translation: AAG23155.1.
AF255774 Genomic DNA. Translation: AAG23156.1.
AF255774 Genomic DNA. Translation: AAG23158.1.
AF255774 Genomic DNA. Translation: AAG23157.1.
CCDSiCCDS19119.1. [P13808-1]
PIRiA31789.
RefSeqiNP_001240821.1. NM_001253892.1.
NP_033233.2. NM_009207.3.
XP_006535713.1. XM_006535650.1.
XP_006535714.1. XM_006535651.3.
XP_006535718.1. XM_006535655.3.
XP_006535719.1. XM_006535656.3.
UniGeneiMm.4580.

Genome annotation databases

GeneIDi20535.
KEGGimmu:20535.
UCSCiuc008wrm.2. mouse. [P13808-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04036 mRNA. Translation: AAA65505.1.
AF255774 Genomic DNA. Translation: AAG23154.1.
AF255774 Genomic DNA. Translation: AAG23155.1.
AF255774 Genomic DNA. Translation: AAG23156.1.
AF255774 Genomic DNA. Translation: AAG23158.1.
AF255774 Genomic DNA. Translation: AAG23157.1.
CCDSiCCDS19119.1. [P13808-1]
PIRiA31789.
RefSeqiNP_001240821.1. NM_001253892.1.
NP_033233.2. NM_009207.3.
XP_006535713.1. XM_006535650.1.
XP_006535714.1. XM_006535651.3.
XP_006535718.1. XM_006535655.3.
XP_006535719.1. XM_006535656.3.
UniGeneiMm.4580.

3D structure databases

ProteinModelPortaliP13808.
SMRiP13808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP13808. 1 interactor.
MINTiMINT-4088942.
STRINGi10090.ENSMUSP00000078972.

PTM databases

iPTMnetiP13808.
PhosphoSitePlusiP13808.

Proteomic databases

MaxQBiP13808.
PaxDbiP13808.
PeptideAtlasiP13808.
PRIDEiP13808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20535.
KEGGimmu:20535.
UCSCiuc008wrm.2. mouse. [P13808-1]

Organism-specific databases

CTDi6522.
MGIiMGI:109351. Slc4a2.

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP13808.
KOiK13855.
PhylomeDBiP13808.
TreeFamiTF313630.

Miscellaneous databases

ChiTaRSiSlc4a2. mouse.
PROiP13808.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028962.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF14. PTHR11453:SF14. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3A2_MOUSE
AccessioniPrimary (citable) accession number: P13808
Secondary accession number(s): Q9ES09
, Q9ES10, Q9ES11, Q9ES12, Q9ES13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.