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P13808 (B3A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anion exchange protein 2

Short name=AE 2
Short name=Anion exchanger 2
Alternative name(s):
Band 3-related protein
Short name=B3RP
Non-erythroid band 3-like protein
Solute carrier family 4 member 2
Gene names
Name:Slc4a2
Synonyms:Ae2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1237 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plasma membrane anion exchange protein of wide distribution.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Isoform ais widely expressed at similar levels in all tissues examined. Isoforms B1 and B2 are predominantly expressed in stomach although they are also detected at lower levels in other tissues. Isoform C1 is stomach-specific. Isoform C2 is expressed at slightly higher levels in lung and stomach than in other tissues. Ref.2

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P13808-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B1 (identifier: P13808-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPASGADSLHT → MTQ
Isoform B2 (identifier: P13808-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPASGADSLHT → MDFLLRPQ
Isoform C1 (identifier: P13808-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-198: Missing.
Isoform C2 (identifier: P13808-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     167-193: ERTSPSPPTQTPHQEAAPRASKGAQTG → MPAFQEWKSGGLREEAVFGAHGCSVCR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12371237Anion exchange protein 2
PRO_0000079216

Regions

Topological domain1 – 703703Cytoplasmic Potential
Transmembrane704 – 72724Helical; Potential
Transmembrane733 – 77038Helical; Potential
Transmembrane790 – 81223Helical; Potential
Transmembrane822 – 84322Helical; Potential
Topological domain844 – 89653Extracellular Potential
Transmembrane897 – 91418Helical; Potential
Topological domain915 – 92915Cytoplasmic Potential
Transmembrane930 – 95021Helical; Potential
Transmembrane984 – 100623Helical; Potential
Transmembrane1032 – 105322Helical; Potential
Transmembrane1087 – 113246Helical; Potential
Transmembrane1159 – 119537Helical; Potential
Region704 – 1237534Membrane (anion exchange)
Compositional bias5 – 316312Pro-rich
Compositional bias73 – 8715His-rich
Compositional bias861 – 8655Poly-Ser

Amino acid modifications

Modified residue1121Phosphoserine By similarity
Modified residue1311Phosphoserine By similarity
Modified residue1441Phosphoserine Ref.3
Modified residue1701Phosphoserine Ref.3
Modified residue1721Phosphoserine Ref.3
Modified residue2531Phosphothreonine Ref.3
Modified residue4391Phosphoserine By similarity
Lipidation11691S-palmitoyl cysteine By similarity
Glycosylation8551N-linked (GlcNAc...) Potential
Glycosylation8661N-linked (GlcNAc...) Potential
Glycosylation8781N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 198198Missing in isoform C1.
VSP_000460
Alternative sequence1 – 166166Missing in isoform C2.
VSP_000459
Alternative sequence1 – 1717MSSAP…DSLHT → MTQ in isoform B1.
VSP_000458
Alternative sequence1 – 1717MSSAP…DSLHT → MDFLLRPQ in isoform B2.
VSP_000457
Alternative sequence167 – 19327ERTSP…GAQTG → MPAFQEWKSGGLREEAVFGA HGCSVCR in isoform C2.
VSP_000461

Experimental info

Sequence conflict2051A → G in AAG23154. Ref.2
Sequence conflict2051A → G in AAG23155. Ref.2
Sequence conflict2051A → G in AAG23156. Ref.2
Sequence conflict2051A → G in AAG23158. Ref.2
Sequence conflict2051A → G in AAG23157. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 1A0782C0071782EE

FASTA1,237136,814
        10         20         30         40         50         60 
MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEDELRT LGVERFEEIL QEAGSRGGEE 

        70         80         90        100        110        120 
PGRSYGEEDF EYHRQSSHHI HHPLSTHLPP DARRRKTPQG PGRKPRRRPG ASPTGETPTI 

       130        140        150        160        170        180 
EEGEEDEEEA SEAEGFRAPP QQPSPATTPS AVQFFLQEDE GAERKPERTS PSPPTQTPHQ 

       190        200        210        220        230        240 
EAAPRASKGA QTGTLVEEMV AVASATAGGD DGGAAGRPLT KAQPGHRSYN LQERRRIGSM 

       250        260        270        280        290        300 
TGVEQALLPR VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSTQAAREGR 

       310        320        330        340        350        360 
EPGPTPRARP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE EETERWGKPH 

       370        380        390        400        410        420 
VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ MVISDQIKAE DRANVLRALL 

       430        440        450        460        470        480 
LKHSHPSDEK EFSFPRNISA GSLGSLLGHH HAQGTESDPH VTEPLIGGVP ETRLEVDRER 

       490        500        510        520        530        540 
ELPPPAPPAG ITRSKSKHEL KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD 

       550        560        570        580        590        600 
AVLEVPVPVR FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE RDDLLTAINA 

       610        620        630        640        650        660 
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGAGLEPKS AQDKALLQMV 

       670        680        690        700        710        720 
EVAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL DPQCLAAVIF IYFAALSPAI 

       730        740        750        760        770        780 
TFGGLLGEKT KDLIGVSELI MSTALQGVVF CLLGAQPLLV IGFSGPLLVF EEAFFSFCSS 

       790        800        810        820        830        840 
NELEYLVGRV WIGFWLVFLA LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI 

       850        860        870        880        890        900 
KIFQEHPLHG CSGSNDSEAG SSSSSNMTWA TTILVPDNSS ASGQSGQEKP RGQPNTALLS 

       910        920        930        940        950        960 
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI EDTYTQKLSV 

       970        980        990       1000       1010       1020 
PSGFSVTAPD KRGWVINPLG EKTPFPVWMM VASLLPAVLV FILIFMETQI TTLIISKKER 

      1030       1040       1050       1060       1070       1080 
MLQKGSGFHL DLLLIVAMGG ICALFGLPWL AAATVRSVTH ANALTVMSKA VAPGDKPKIQ 

      1090       1100       1110       1120       1130       1140 
EVKEQRVTGL LVALLVGLSM VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM 

      1150       1160       1170       1180       1190       1200 
PPKHHPDVTY VKKVRTMRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL 

      1210       1220       1230 
TRIFTEREMK CLDANEAEPV FDECEGVDEY NEMPMPV 

« Hide

Isoform B1 [UniParc].

Checksum: E03B373EAAA48119
Show »

FASTA1,223135,452
Isoform B2 [UniParc].

Checksum: 8EC77B1EF4AF52A2
Show »

FASTA1,228136,092
Isoform C1 [UniParc].

Checksum: 5F6C9A0FC1FECBC6
Show »

FASTA1,039115,198
Isoform C2 [UniParc].

Checksum: 9BED064CDDEAB4E4
Show »

FASTA1,071118,705

References

« Hide 'large scale' references
[1]"Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line."
Alper S.L., Kopito R.R., Libresco S.M., Lodish H.F.
J. Biol. Chem. 263:17092-17099(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[2]"Molecular cloning and genomic organization of the mouse AE2 anion exchanger gene."
Lecanda J., Urtasun R., Medina J.F.
Biochem. Biophys. Res. Commun. 276:117-124(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144; SER-170; SER-172 AND THR-253, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04036 mRNA. Translation: AAA65505.1.
AF255774 Genomic DNA. Translation: AAG23154.1.
AF255774 Genomic DNA. Translation: AAG23155.1.
AF255774 Genomic DNA. Translation: AAG23156.1.
AF255774 Genomic DNA. Translation: AAG23158.1.
AF255774 Genomic DNA. Translation: AAG23157.1.
CCDSCCDS19119.1. [P13808-1]
PIRA31789.
RefSeqNP_001240821.1. NM_001253892.1.
NP_033233.2. NM_009207.3.
XP_006535713.1. XM_006535650.1.
XP_006535714.1. XM_006535651.1.
XP_006535715.1. XM_006535652.1.
XP_006535718.1. XM_006535655.1.
XP_006535719.1. XM_006535656.1.
UniGeneMm.4580.

3D structure databases

ProteinModelPortalP13808.
SMRP13808. Positions 318-641, 688-729.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP13808. 1 interaction.
MINTMINT-4088942.

PTM databases

PhosphoSiteP13808.

Proteomic databases

PaxDbP13808.
PRIDEP13808.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000080067; ENSMUSP00000078972; ENSMUSG00000028962.
ENSMUST00000115047; ENSMUSP00000110699; ENSMUSG00000028962.
ENSMUST00000115049; ENSMUSP00000110701; ENSMUSG00000028962.
GeneID20535.
KEGGmmu:20535.
UCSCuc008wrm.2. mouse. [P13808-1]

Organism-specific databases

CTD6522.
MGIMGI:109351. Slc4a2.

Phylogenomic databases

eggNOGNOG268067.
GeneTreeENSGT00560000076933.
HOGENOMHOG000280683.
HOVERGENHBG004326.
InParanoidP13808.
KOK13855.
OrthoDBEOG7TMZR0.
PhylomeDBP13808.
TreeFamTF313630.

Gene expression databases

ArrayExpressP13808.
BgeeP13808.
GenevestigatorP13808.

Family and domain databases

Gene3D3.40.1100.10. 1 hit.
InterProIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMSSF55804. SSF55804. 2 hits.
TIGRFAMsTIGR00834. ae. 1 hit.
PROSITEPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC4A2. mouse.
NextBio298803.
PROP13808.
SOURCESearch...

Entry information

Entry nameB3A2_MOUSE
AccessionPrimary (citable) accession number: P13808
Secondary accession number(s): Q9ES09 expand/collapse secondary AC list , Q9ES10, Q9ES11, Q9ES12, Q9ES13
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot