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P13807

- GYS1_HUMAN

UniProt

P13807 - GYS1_HUMAN

Protein

Glycogen [starch] synthase, muscle

Gene

GYS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

    Catalytic activityi

    UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

    Enzyme regulationi

    Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391UDP-glucoseBy similarity

    GO - Molecular functioni

    1. glucose binding Source: Ensembl
    2. glycogen (starch) synthase activity Source: UniProtKB
    3. glycogen synthase activity, transferring glucose-1-phosphate Source: Reactome
    4. protein binding Source: UniProtKB
    5. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. glucose metabolic process Source: Reactome
    3. glycogen biosynthetic process Source: UniProtKB
    4. heart development Source: Ensembl
    5. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Glycogen biosynthesis

    Enzyme and pathway databases

    BioCyciMetaCyc:HS02622-MONOMER.
    ReactomeiREACT_169208. Glycogen synthesis.
    REACT_200783. Myoclonic epilepsy of Lafora.
    UniPathwayiUPA00164.

    Protein family/group databases

    CAZyiGT3. Glycosyltransferase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycogen [starch] synthase, muscle (EC:2.4.1.11)
    Gene namesi
    Name:GYS1
    Synonyms:GYS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4706. GYS1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. inclusion body Source: Ensembl
    3. membrane Source: UniProtKB

    Pathology & Biotechi

    Involvement in diseasei

    Muscle glycogen storage disease 0 (GSD0b) [MIM:611556]: Metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi641 – 6411S → A: Abolishes PASK-mediated phosphorylation. 1 Publication
    Mutagenesisi645 – 6451S → A: Does not affect PASK-mediated phosphorylation. 1 Publication

    Keywords - Diseasei

    Diabetes mellitus, Disease mutation

    Organism-specific databases

    MIMi611556. phenotype.
    Orphaneti137625. Glycogen storage disease due to muscle and heart glycogen synthase deficiency.
    PharmGKBiPA29084.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 737736Glycogen [starch] synthase, musclePRO_0000194763Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81Phosphoserine; by AMPK and PKABy similarity
    Modified residuei11 – 111PhosphoserineBy similarity
    Modified residuei641 – 6411Phosphoserine2 Publications
    Modified residuei645 – 6451Phosphoserine1 Publication
    Modified residuei649 – 6491Phosphoserine1 Publication
    Modified residuei653 – 6531Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity
    Modified residuei657 – 6571Phosphoserine; by CK2By similarity
    Modified residuei698 – 6981PhosphoserineBy similarity
    Modified residuei727 – 7271Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B By similarity. Phosphorylated at Ser-641 by DYRK2, leading to inactivation By similarity. Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.By similarity3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP13807.
    PaxDbiP13807.
    PRIDEiP13807.

    PTM databases

    PhosphoSiteiP13807.

    Expressioni

    Gene expression databases

    ArrayExpressiP13807.
    BgeeiP13807.
    CleanExiHS_GYS1.
    GenevestigatoriP13807.

    Organism-specific databases

    HPAiCAB007793.
    HPA041598.

    Interactioni

    Subunit structurei

    Interacts with GYG1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GSK3BP498413EBI-740553,EBI-373586
    GYG1P469764EBI-740553,EBI-740533

    Protein-protein interaction databases

    BioGridi109252. 18 interactions.
    IntActiP13807. 17 interactions.
    MINTiMINT-1451793.
    STRINGi9606.ENSP00000317904.

    Structurei

    3D structure databases

    ProteinModelPortaliP13807.
    SMRiP13807. Positions 23-621.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0438.
    HOGENOMiHOG000160890.
    HOVERGENiHBG001960.
    InParanoidiP13807.
    KOiK00693.
    OMAiFAMKRHG.
    OrthoDBiEOG741Z1N.
    PhylomeDBiP13807.
    TreeFamiTF300306.

    Family and domain databases

    InterProiIPR008631. Glycogen_synth.
    [Graphical view]
    PANTHERiPTHR10176. PTHR10176. 1 hit.
    PfamiPF05693. Glycogen_syn. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P13807-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLNRTLSMS SLPGLEDWED EFDLENAVLF EVAWEVANKV GGIYTVLQTK    50
    AKVTGDEWGD NYFLVGPYTE QGVRTQVELL EAPTPALKRT LDSMNSKGCK 100
    VYFGRWLIEG GPLVVLLDVG ASAWALERWK GELWDTCNIG VPWYDREAND 150
    AVLFGFLTTW FLGEFLAQSE EKPHVVAHFH EWLAGVGLCL CRARRLPVAT 200
    IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH RYCMERAAAH 250
    CAHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS 300
    KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD VFLEALARLN 350
    YLLRVNGSEQ TVVAFFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF 400
    GRKLYESLLV GSLPDMNKML DKEDFTMMKR AIFATQRQSF PPVCTHNMLD 450
    DSSDPILTTI RRIGLFNSSA DRVKVIFHPE FLSSTSPLLP VDYEEFVRGC 500
    HLGVFPSYYE PWGYTPAECT VMGIPSISTN LSGFGCFMEE HIADPSAYGI 550
    YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY 600
    LGRYYMSARH MALSKAFPEH FTYEPNEADA AQGYRYPRPA SVPPSPSLSR 650
    HSSPHQSEDE EDPRNGPLEE DGERYDEDEE AAKDRRNIRA PEWPRRASCT 700
    SSTSGSKRNS VDTATSSSLS TPSEPLSPTS SLGEERN 737
    Length:737
    Mass (Da):83,786
    Last modified:February 1, 1996 - v2
    Checksum:i0E321BBFDEB0BD7F
    GO
    Isoform 2 (identifier: P13807-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         101-164: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:673
    Mass (Da):76,483
    Checksum:i8C059070E0D075FC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti136 – 1361T → I in AAA88046. (PubMed:2493642)Curated
    Sequence conflicti136 – 1361T → I in AAB60385. (PubMed:9010351)Curated
    Sequence conflicti462 – 4621Missing in AAB60385. (PubMed:9010351)Curated
    Sequence conflicti608 – 6081A → D in AAB60385. (PubMed:9010351)Curated
    Sequence conflicti706 – 7061S → R in AAA88046. (PubMed:2493642)Curated
    Sequence conflicti706 – 7061S → R in AAB60385. (PubMed:9010351)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081I → M.
    Corresponds to variant rs5455 [ dbSNP | Ensembl ].
    VAR_037958
    Natural varianti130 – 1301K → E.
    Corresponds to variant rs5456 [ dbSNP | Ensembl ].
    VAR_014727
    Natural varianti283 – 2831N → S.
    Corresponds to variant rs5461 [ dbSNP | Ensembl ].
    VAR_014728
    Natural varianti359 – 3591E → G.
    Corresponds to variant rs5465 [ dbSNP | Ensembl ].
    VAR_014729
    Natural varianti416 – 4161M → V.
    Corresponds to variant rs5447 [ dbSNP | Ensembl ].
    VAR_014730
    Natural varianti464 – 4641G → S in NIDDM. 1 Publication
    VAR_007859
    Natural varianti619 – 6191E → Q.
    Corresponds to variant rs5450 [ dbSNP | Ensembl ].
    VAR_014731
    Natural varianti691 – 6911P → A.
    Corresponds to variant rs5453 [ dbSNP | Ensembl ].
    VAR_014732

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei101 – 16464Missing in isoform 2. 1 PublicationVSP_042745Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04501 mRNA. Translation: AAA88046.1.
    Z33622
    , Z33623, Z33609, Z33624, Z33625, Z33626, Z33610, Z33627, Z33628, Z33629, Z33630, Z33631, Z33633 Genomic DNA. Translation: CAA83916.1.
    U32573 mRNA. Translation: AAB60385.1.
    AC008687 Genomic DNA. No translation available.
    AC026803 Genomic DNA. No translation available.
    AC098792 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52424.1.
    BC002617 mRNA. Translation: AAH02617.1.
    BC003182 mRNA. Translation: AAH03182.1.
    BC007688 mRNA. Translation: AAH07688.1.
    CCDSiCCDS12747.1. [P13807-1]
    CCDS54292.1. [P13807-2]
    PIRiA32156.
    RefSeqiNP_001155059.1. NM_001161587.1. [P13807-2]
    NP_002094.2. NM_002103.4. [P13807-1]
    UniGeneiHs.386225.

    Genome annotation databases

    EnsembliENST00000263276; ENSP00000263276; ENSG00000104812. [P13807-2]
    ENST00000323798; ENSP00000317904; ENSG00000104812. [P13807-1]
    GeneIDi2997.
    KEGGihsa:2997.
    UCSCiuc002plp.3. human. [P13807-1]
    uc010emm.3. human. [P13807-2]

    Polymorphism databases

    DMDMi1351366.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04501 mRNA. Translation: AAA88046.1 .
    Z33622
    , Z33623 , Z33609 , Z33624 , Z33625 , Z33626 , Z33610 , Z33627 , Z33628 , Z33629 , Z33630 , Z33631 , Z33633 Genomic DNA. Translation: CAA83916.1 .
    U32573 mRNA. Translation: AAB60385.1 .
    AC008687 Genomic DNA. No translation available.
    AC026803 Genomic DNA. No translation available.
    AC098792 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52424.1 .
    BC002617 mRNA. Translation: AAH02617.1 .
    BC003182 mRNA. Translation: AAH03182.1 .
    BC007688 mRNA. Translation: AAH07688.1 .
    CCDSi CCDS12747.1. [P13807-1 ]
    CCDS54292.1. [P13807-2 ]
    PIRi A32156.
    RefSeqi NP_001155059.1. NM_001161587.1. [P13807-2 ]
    NP_002094.2. NM_002103.4. [P13807-1 ]
    UniGenei Hs.386225.

    3D structure databases

    ProteinModelPortali P13807.
    SMRi P13807. Positions 23-621.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109252. 18 interactions.
    IntActi P13807. 17 interactions.
    MINTi MINT-1451793.
    STRINGi 9606.ENSP00000317904.

    Chemistry

    BindingDBi P13807.
    ChEMBLi CHEMBL4000.

    Protein family/group databases

    CAZyi GT3. Glycosyltransferase Family 3.

    PTM databases

    PhosphoSitei P13807.

    Polymorphism databases

    DMDMi 1351366.

    Proteomic databases

    MaxQBi P13807.
    PaxDbi P13807.
    PRIDEi P13807.

    Protocols and materials databases

    DNASUi 2997.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263276 ; ENSP00000263276 ; ENSG00000104812 . [P13807-2 ]
    ENST00000323798 ; ENSP00000317904 ; ENSG00000104812 . [P13807-1 ]
    GeneIDi 2997.
    KEGGi hsa:2997.
    UCSCi uc002plp.3. human. [P13807-1 ]
    uc010emm.3. human. [P13807-2 ]

    Organism-specific databases

    CTDi 2997.
    GeneCardsi GC19M049471.
    HGNCi HGNC:4706. GYS1.
    HPAi CAB007793.
    HPA041598.
    MIMi 138570. gene.
    611556. phenotype.
    neXtProti NX_P13807.
    Orphaneti 137625. Glycogen storage disease due to muscle and heart glycogen synthase deficiency.
    PharmGKBi PA29084.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0438.
    HOGENOMi HOG000160890.
    HOVERGENi HBG001960.
    InParanoidi P13807.
    KOi K00693.
    OMAi FAMKRHG.
    OrthoDBi EOG741Z1N.
    PhylomeDBi P13807.
    TreeFami TF300306.

    Enzyme and pathway databases

    UniPathwayi UPA00164 .
    BioCyci MetaCyc:HS02622-MONOMER.
    Reactomei REACT_169208. Glycogen synthesis.
    REACT_200783. Myoclonic epilepsy of Lafora.

    Miscellaneous databases

    ChiTaRSi GYS1. human.
    GenomeRNAii 2997.
    NextBioi 11884.
    PROi P13807.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13807.
    Bgeei P13807.
    CleanExi HS_GYS1.
    Genevestigatori P13807.

    Family and domain databases

    InterProi IPR008631. Glycogen_synth.
    [Graphical view ]
    PANTHERi PTHR10176. PTHR10176. 1 hit.
    Pfami PF05693. Glycogen_syn. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human muscle glycogen synthase cDNA sequence: a negatively charged protein with an asymmetric charge distribution."
      Browner M.F., Nakano K., Bang A.G., Fletterick R.J.
      Proc. Natl. Acad. Sci. U.S.A. 86:1443-1447(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Muscle.
    2. "Isolation and characterization of the human muscle glycogen synthase gene."
      Orho M., Nikula-Ijas P., Schalin-Jantti C., Permutt M.A., Groop L.C.
      Diabetes 44:1099-1105(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT NIDDM SER-464.
    3. "Cloning and characterization of a glycogen synthase cDNA from human endometrium."
      Su X., Schuler L., Shapiro S.S.
      J. Steroid Biochem. Mol. Biol. 59:459-465(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Endometrium.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney, Lymph and Skin.
    7. Cited for: PHOSPHORYLATION AT SER-641, MUTAGENESIS OF SER-641 AND SER-645.
    8. "Interaction between glycogenin and glycogen synthase."
      Skurat A.V., Dietrich A.D., Roach P.J.
      Arch. Biochem. Biophys. 456:93-97(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GYG1.
    9. "Cardiomyopathy and exercise intolerance in muscle glycogen storage disease 0."
      Kollberg G., Tulinius M., Gilljam T., Oestman-Smith I., Forsander G., Jotorp P., Oldfors A., Holme E.
      N. Engl. J. Med. 357:1507-1514(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN GSD0B.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641; SER-645 AND SER-649, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-727, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals."
      Kelsall I.R., Voss M., Munro S., Cuthbertson D.J., Cohen P.T.
      J. Neurochem. 118:596-610(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEPHOSPHORYLATION AT SER-641 AND SER-645 BY PP1.
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGYS1_HUMAN
    AccessioniPrimary (citable) accession number: P13807
    Secondary accession number(s): Q9BTT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 149 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3