##gff-version 3
P13805	UniProtKB	Chain	1	278	.	.	.	ID=PRO_0000186168;Note=Troponin T%2C slow skeletal muscle	
P13805	UniProtKB	Region	1	63	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P13805	UniProtKB	Region	105	153	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P13805	UniProtKB	Compositional bias	1	33	.	.	.	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P13805	UniProtKB	Modified residue	2	2	.	.	.	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P13805	UniProtKB	Alternative sequence	25	35	.	.	.	ID=VSP_006639;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4	
P13805	UniProtKB	Alternative sequence	205	220	.	.	.	ID=VSP_006640;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334	
P13805	UniProtKB	Natural variant	6	278	.	.	.	ID=VAR_088549;Note=In NEM5A%3B likely pathogenic. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32994279;Dbxref=PMID:32994279	
P13805	UniProtKB	Natural variant	65	65	.	.	.	ID=VAR_088550;Note=In NEM5C%3B uncertain significance%3B sligthly increased interaction with TPM3 both in the presence and absence of calcium. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35510366;Dbxref=PMID:35510366	
P13805	UniProtKB	Natural variant	96	96	.	.	.	ID=VAR_088551;Note=In NEM5B%3B likely pathogenic%3B loss-of-function variant unable to rescue the myopathic phenotype in zebrafish morphants%3B severely decreased interaction with TPM3 in absence of calcium%3B loss of interaction with TPM3 in the presence of calcium. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:31970803,ECO:0000269|PubMed:35510366;Dbxref=PMID:31970803,PMID:35510366	
P13805	UniProtKB	Natural variant	104	104	.	.	.	ID=VAR_088552;Note=In NEM5C%3B uncertain significance%3B does not affect levels of full-length protein in patient muscle%3B decreased interaction with TPM3 in the presence of calcium%3B no effect on interaction with TPM3 in the absence of calcium. E->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29178646,ECO:0000269|PubMed:35510366;Dbxref=PMID:29178646,PMID:35510366	
P13805	UniProtKB	Natural variant	112	278	.	.	.	ID=VAR_088553;Note=In NEM5A%3B likely pathogenic. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32994279;Dbxref=PMID:32994279	
P13805	UniProtKB	Natural variant	180	278	.	.	.	ID=VAR_088554;Note=In NEM5A%3B likely pathogenic. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10952871;Dbxref=PMID:10952871	
P13805	UniProtKB	Natural variant	242	242	.	.	.	ID=VAR_088555;Note=In NEM5B%3B likely pathogenic%3B loss-of-function variant unable to rescue the myopathic phenotype in zebrafish morphants. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35165004;Dbxref=PMID:35165004	
P13805	UniProtKB	Sequence conflict	20	20	.	.	.	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305