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Protein

Troponin T, slow skeletal muscle

Gene

TNNT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Molecular functioni

  • tropomyosin binding Source: UniProtKB
  • troponin T binding Source: Ensembl

GO - Biological processi

  • muscle filament sliding Source: Reactome
  • negative regulation of muscle contraction Source: UniProtKB
  • skeletal muscle contraction Source: UniProtKB
  • slow-twitch skeletal muscle fiber contraction Source: Ensembl
  • transition between fast and slow fiber Source: Ensembl

Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, slow skeletal muscle
Short name:
TnTs
Alternative name(s):
Slow skeletal muscle troponin T
Short name:
sTnT
Gene namesi
Name:TNNT1
Synonyms:TNT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105048.16
HGNCiHGNC:11948 TNNT1
MIMi191041 gene
neXtProtiNX_P13805

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Nemaline myopathy 5 (NEM5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 5 is a severe and progressive form common among Old Order Amish. Affected infants display tremors with hypotonia and mild contractures of the shoulders and hips. Proximal contractures progressively weaken and a pectus carinatum deformity develops before children die of respiratory insufficiency, usually in the second year.
See also OMIM:605355

Keywords - Diseasei

Nemaline myopathy

Organism-specific databases

DisGeNETi7138
GeneReviewsiTNNT1
MalaCardsiTNNT1
MIMi605355 phenotype
OpenTargetsiENSG00000105048
Orphaneti98902 Amish nemaline myopathy
PharmGKBiPA36637

Polymorphism and mutation databases

BioMutaiTNNT1
DMDMi1174800

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861681 – 278Troponin T, slow skeletal muscleAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Phosphoserine; by CK2By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP13805
PeptideAtlasiP13805
PRIDEiP13805
ProteomicsDBi52991
52992 [P13805-2]
52993 [P13805-3]

PTM databases

iPTMnetiP13805
PhosphoSitePlusiP13805

Expressioni

Gene expression databases

BgeeiENSG00000105048
CleanExiHS_TNNT1
ExpressionAtlasiP13805 baseline and differential
GenevisibleiP13805 HS

Organism-specific databases

HPAiCAB015168
HPA058448

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • tropomyosin binding Source: UniProtKB
  • troponin T binding Source: Ensembl

Protein-protein interaction databases

BioGridi112992, 61 interactors
IntActiP13805, 60 interactors
MINTiP13805
STRINGi9606.ENSP00000467176

Structurei

3D structure databases

ProteinModelPortaliP13805
SMRiP13805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00390000013611
HOGENOMiHOG000231049
HOVERGENiHBG052790
InParanoidiP13805
KOiK10372
OMAiDHMGEEQ
OrthoDBiEOG091G0U67
PhylomeDBiP13805

Family and domain databases

Gene3Di1.20.5.350, 2 hits
InterProiView protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13805-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDTEEQEYE EEQPEEEAAE EEEEAPEEPE PVAEPEEERP KPSRPVVPPL
60 70 80 90 100
IPPKIPEGER VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELVALK
110 120 130 140 150
ERIERRRSER AEQQRFRTEK ERERQAKLAE EKMRKEEEEA KKRAEDDAKK
160 170 180 190 200
KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE MKVRILSERK KPLDIDYMGE
210 220 230 240 250
EQLRARSAWL PPSQPSCPAR EKAQELSDWI HQLESEKFDL MAKLKQQKYE
260 270
INVLYNRISH AQKFRKGAGK GRVGGRWK
Length:278
Mass (Da):32,948
Last modified:January 23, 2007 - v4
Checksum:iD94DB18BC5804E04
GO
Isoform 2 (identifier: P13805-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-35: Missing.
     205-220: Missing.

Show »
Length:251
Mass (Da):30,096
Checksum:iDA9E80D5F8B5DE19
GO
Isoform 3 (identifier: P13805-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-220: Missing.

Show »
Length:262
Mass (Da):31,242
Checksum:i9CBA4A8DF3884CAF
GO

Sequence cautioni

The sequence AAH22086 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20E → D in AAA61204 (PubMed:2824479).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00663925 – 35Missing in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_006640205 – 220Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19308 mRNA Translation: AAA61205.1
M19309 mRNA Translation: AAA61204.1
S69208 mRNA Translation: AAB30272.1
S69209 mRNA Translation: AAB30273.1
AJ011712, AJ011713 Genomic DNA Translation: CAA09750.1
AJ011712, AJ011713 Genomic DNA Translation: CAA09751.1
AJ011712, AJ011713 Genomic DNA Translation: CAA09752.1
BT019630 mRNA Translation: AAV38436.1
BC010963 mRNA Translation: AAH10963.1
BC022086 mRNA Translation: AAH22086.2 Different initiation.
BC034143 mRNA Translation: AAH34143.1
S66057, S66170 Genomic DNA Translation: AAD13978.1 Sequence problems.
CCDSiCCDS12917.1 [P13805-1]
CCDS46185.1 [P13805-2]
CCDS59421.1 [P13805-3]
PIRiA29783 TPHUTW
RefSeqiNP_001119604.1, NM_001126132.2 [P13805-3]
NP_001119605.1, NM_001126133.2 [P13805-2]
NP_001278703.1, NM_001291774.1 [P13805-2]
NP_003274.3, NM_003283.5 [P13805-1]
XP_016882675.1, XM_017027186.1 [P13805-3]
UniGeneiHs.631558

Genome annotation databases

EnsembliENST00000291901; ENSP00000291901; ENSG00000105048 [P13805-3]
ENST00000356783; ENSP00000349233; ENSG00000105048 [P13805-2]
ENST00000587758; ENSP00000467789; ENSG00000105048 [P13805-2]
ENST00000588981; ENSP00000467176; ENSG00000105048 [P13805-1]
GeneIDi7138
KEGGihsa:7138
UCSCiuc002qjb.5 human [P13805-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTNNT1_HUMAN
AccessioniPrimary (citable) accession number: P13805
Secondary accession number(s): O95472, Q16061, Q5U0E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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