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P13799 (DEGS_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sensor protein degS
EC=2.7.13.3
Gene names
Name:degS
Synonyms:sacU
Ordered Locus Names:BSU35500
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU.

Catalytic activity

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Sequence similarities

Contains 1 histidine kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 385385Sensor protein degS
PRO_0000074756

Regions

Domain183 – 385203Histidine kinase
Coiled coil31 – 141111 Potential

Amino acid modifications

Modified residue761Phosphoserine Ref.6
Modified residue1891Phosphohistidine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P13799 [UniParc].

Last modified December 1, 1992. Version 2.
Checksum: 871109565A7E78F1

FASTA38544,958
        10         20         30         40         50         60 
MNKTKMDSKV LDSILMKMLK TVDGSKDEVF QIGEQSRQQY EQLVEELKQI KQQVYEVIEL 

        70         80         90        100        110        120 
GDKLEVQTRH ARNRLSEVSR NFHRFSEEEI RNAYEKAHKL QVELTMIQQR EKQLRERRDD 

       130        140        150        160        170        180 
LERRLLGLQE IIERSESLVS QITVVLNYLN QDLREVGLLL ADAQAKQDFG LRIIEAQEEE 

       190        200        210        220        230        240 
RKRVSREIHD GPAQMLANVM MRSELIERIF RDRGAEDGFQ EIKNLRQNVR NALYEVRRII 

       250        260        270        280        290        300 
YDLRPMALDD LGLIPTLRKY LYTTEEYNGK VKIHFQCIGE TEDQRLAPQF EVALFRLAQE 

       310        320        330        340        350        360 
AVSNALKHSE SEEITVKVEI TKDFVILMIK DNGKGFDLKE AKEKKNKSFG LLGMKERVDL 

       370        380 
LEGTMTIDSK IGLGTFIMIK VPLSL

« Hide

References

« Hide 'large scale' references
[1]"Localization of Bacillus subtilis sacU(Hy) mutations to two linked genes with similarities to the conserved procaryotic family of two-component signalling systems."
Henner D.J., Yang M., Ferrari E.
J. Bacteriol. 170:5102-5109(1988) [PubMed: 3141378] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Deduced polypeptides encoded by the Bacillus subtilis sacU locus share homology with two-component sensor-regulator systems."
Kunst F., Debarbouille M., Msadek T., Young M., Maueel C., Karamata D., Klier A., Rapoport G., Dedonder R.
J. Bacteriol. 170:5093-5101(1988) [PubMed: 3141377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sequence of the 305 degrees-307 degrees region of the Bacillus subtilis chromosome."
Soldo B., Lazarevic V., Mauel C., Karamata D.
Microbiology 142:3079-3088(1996) [PubMed: 8969505] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[4]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[5]"Cloning and characterization of Bacillus subtilis iep, which has positive and negative effects on production of extracellular proteases."
Tanaka T., Kawata M.
J. Bacteriol. 170:3593-3600(1988) [PubMed: 3136143] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 253-385.
Strain: 168.
[6]"The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis."
Macek B., Mijakovic I., Olsen J.V., Gnad F., Kumar C., Jensen P.R., Mann M.
Mol. Cell. Proteomics 6:697-707(2007) [PubMed: 17218307] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, MASS SPECTROMETRY.
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M23558 Genomic DNA. Translation: AAA22732.1.
M23649 Genomic DNA. Translation: AAA22734.1.
U56901 Genomic DNA. Translation: AAC44937.1.
AL009126 Genomic DNA. Translation: CAB15567.1.
M21658 Genomic DNA. Translation: AAA22544.1.
PIRRGBSDS. B30191.
RefSeqNP_391430.1. NC_000964.3.

3D structure databases

ProteinModelPortalP13799.
SMRP13799. Positions 177-384.
ModBaseSearch...

Protein-protein interaction databases

IntActP13799. 8 interactions.

PTM databases

PhosSiteP13799.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000001059; EBBACP00000001059; EBBACG00000001057.
GeneID936752.
GenomeReviewsGene locus BSU35500 in contig AL009126_GR.
KEGGbsu:BSU35500.
PATRIC18979108. VBIBacSub10457_3716.

Organism-specific databases

GenoListBSU35500. [Micado]

Phylogenomic databases

GeneTreeEBGT00070000031823.
HOGENOMHBG403296.
OMARIIYDLR.
PhylomeDBP13799.
ProtClustDBCLSK873661.

Enzyme and pathway databases

BioCycBSUB:BSU35500-MONOMER.
BRENDA2.7.13.3. 700.

Family and domain databases

InterProIPR003594. ATPase-like_ATP-bd.
IPR008595. DegS.
IPR011712. Sig_transdc_His_kin_sub3_dim/P.
IPR005467. Sig_transdc_His_kinase_core.
IPR016381. Sig_transdc_His_kinase_DegS.
[Graphical view]
Gene3DG3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
KOK07777.
PfamPF05384. DegS. 1 hit.
PF02518. HATPase_c. 1 hit.
PF07730. HisKA_3. 1 hit.
[Graphical view]
PIRSFPIRSF003169. STHK_DegS. 1 hit.
SMARTSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMSSF55874. ATP_bd_ATPase. 1 hit.
PROSITEPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDEGS_BACSU
AccessionPrimary (citable) accession number: P13799
Secondary accession number(s): P19590
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 1, 1992
Last modified: January 25, 2012
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents