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Protein

Plastin-3

Gene

PLS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi25 – 361PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi65 – 762PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • actin crosslink formation Source: GO_Central
  • actin filament bundle assembly Source: GO_Central
  • actin filament network formation Source: GO_Central
  • bone development Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102024-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-3
Alternative name(s):
T-plastin
Gene namesi
Name:PLS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:9091. PLS3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Osteoporosis (OSTEOP)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs.
See also OMIM:166710
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070278253A → AN in OSTEOP; associated with disease susceptibility. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi5358.
MalaCardsiPLS3.
MIMi166710. phenotype.
300910. phenotype.
OpenTargetsiENSG00000102024.
Orphaneti391330. X-linked osteoporosis with fractures.
PharmGKBiPA33418.

Polymorphism and mutation databases

BioMutaiPLS3.
DMDMi226694201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737471 – 630Plastin-3Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei127PhosphotyrosineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Modified residuei293PhosphoserineCombined sources1
Modified residuei297N6-acetyllysineBy similarity1
Modified residuei300N6-acetyllysineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei364N6-acetyllysineBy similarity1
Modified residuei391PhosphothreonineCombined sources1
Modified residuei409PhosphoserineBy similarity1
Modified residuei475N6-acetyllysineBy similarity1
Modified residuei477PhosphoserineBy similarity1
Modified residuei545N6-acetyllysineBy similarity1
Modified residuei582N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP13797.
MaxQBiP13797.
PaxDbiP13797.
PeptideAtlasiP13797.
PRIDEiP13797.

PTM databases

iPTMnetiP13797.
PhosphoSitePlusiP13797.
SwissPalmiP13797.

Expressioni

Tissue specificityi

Expressed in a variety of organs, including muscle, brain, uterus and esophagus.

Gene expression databases

BgeeiENSG00000102024.
CleanExiHS_PLS3.
ExpressionAtlasiP13797. baseline and differential.
GenevisibleiP13797. HS.

Organism-specific databases

HPAiHPA020433.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111372. 49 interactors.
IntActiP13797. 14 interactors.
MINTiMINT-3008106.
STRINGi9606.ENSP00000348163.

Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi123 – 136Combined sources14
Turni137 – 139Combined sources3
Turni144 – 146Combined sources3
Turni151 – 154Combined sources4
Helixi155 – 159Combined sources5
Helixi160 – 162Combined sources3
Helixi164 – 173Combined sources10
Helixi180 – 182Combined sources3
Helixi190 – 206Combined sources17
Helixi216 – 220Combined sources5
Helixi224 – 244Combined sources21
Helixi261 – 265Combined sources5
Helixi269 – 283Combined sources15
Turni294 – 298Combined sources5
Helixi300 – 309Combined sources10
Beta strandi315 – 317Combined sources3
Turni326 – 329Combined sources4
Helixi333 – 344Combined sources12
Turni345 – 348Combined sources4
Helixi355 – 359Combined sources5
Helixi363 – 374Combined sources12
Helixi522 – 535Combined sources14
Helixi549 – 551Combined sources3
Helixi553 – 562Combined sources10
Turni569 – 571Combined sources3
Helixi579 – 595Combined sources17
Helixi604 – 609Combined sources6
Turni612 – 616Combined sources5
Helixi617 – 625Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOAX-ray2.40A101-375[»]
1WJONMR-A520-630[»]
ProteinModelPortaliP13797.
SMRiP13797.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13797.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini52 – 87EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini109 – 382Actin-binding 1Add BLAST274
Domaini123 – 239CH 1PROSITE-ProRule annotationAdd BLAST117
Domaini267 – 378CH 2PROSITE-ProRule annotationAdd BLAST112
Domaini383 – 627Actin-binding 2Add BLAST245
Domaini397 – 506CH 3PROSITE-ProRule annotationAdd BLAST110
Domaini518 – 627CH 4PROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Contains 2 actin-binding domains.Curated
Contains 4 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiP13797.
KOiK17336.
OMAiRNFNDPA.
OrthoDBiEOG091G03YP.
PhylomeDBiP13797.
TreeFamiTF300680.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13797-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEMATTQIS KDELDELKEA FAKVDLNSNG FICDYELHEL FKEANMPLPG
60 70 80 90 100
YKVREIIQKL MLDGDRNKDG KISFDEFVYI FQEVKSSDIA KTFRKAINRK
110 120 130 140 150
EGICALGGTS ELSSEGTQHS YSEEEKYAFV NWINKALEND PDCRHVIPMN
160 170 180 190 200
PNTDDLFKAV GDGIVLCKMI NLSVPDTIDE RAINKKKLTP FIIQENLNLA
210 220 230 240 250
LNSASAIGCH VVNIGAEDLR AGKPHLVLGL LWQIIKIGLF ADIELSRNEA
260 270 280 290 300
LAALLRDGET LEELMKLSPE ELLLRWANFH LENSGWQKIN NFSADIKDSK
310 320 330 340 350
AYFHLLNQIA PKGQKEGEPR IDINMSGFNE TDDLKRAESM LQQADKLGCR
360 370 380 390 400
QFVTPADVVS GNPKLNLAFV ANLFNKYPAL TKPENQDIDW TLLEGETREE
410 420 430 440 450
RTFRNWMNSL GVNPHVNHLY ADLQDALVIL QLYERIKVPV DWSKVNKPPY
460 470 480 490 500
PKLGANMKKL ENCNYAVELG KHPAKFSLVG IGGQDLNDGN QTLTLALVWQ
510 520 530 540 550
LMRRYTLNVL EDLGDGQKAN DDIIVNWVNR TLSEAGKSTS IQSFKDKTIS
560 570 580 590 600
SSLAVVDLID AIQPGCINYD LVKSGNLTED DKHNNAKYAV SMARRIGARV
610 620 630
YALPEDLVEV KPKMVMTVFA CLMGRGMKRV
Length:630
Mass (Da):70,811
Last modified:April 14, 2009 - v4
Checksum:i631E6F803DC56A56
GO
Isoform 2 (identifier: P13797-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MDEMATTQISKDELDELKEAFAKV → ME
     296-296: I → IKLIDFSNSV

Note: No experimental confirmation available.
Show »
Length:617
Mass (Da):69,350
Checksum:i7DD45809B012DE95
GO
Isoform 3 (identifier: P13797-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):65,632
Checksum:i9291617EAC62FA5F
GO

Sequence cautioni

The sequence CAI39884 differs from that shown. Reason: Erroneous initiation.Curated

Polymorphismi

Genetic variations in PLS3 define the bone mineral density quantitative trait locus 18 (BMND18) [MIMi:300910]. Variance in bone mineral density influences bone mass, contributes to size determination in the general population, and is a susceptibility factor for osteoporotic fractures.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070278253A → AN in OSTEOP; associated with disease susceptibility. 1 Publication1
Natural variantiVAR_035462488D → A in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562351 – 45Missing in isoform 3. CuratedAdd BLAST45
Alternative sequenceiVSP_0562361 – 24MDEMA…AFAKV → ME in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_056237296I → IKLIDFSNSV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22299 mRNA. Translation: AAB02844.1.
M34427 mRNA. Translation: AAA36759.1.
AK291194 mRNA. Translation: BAF83883.1.
AK294509 mRNA. Translation: BAG57725.1.
AK300575 mRNA. Translation: BAH13307.1.
AK312391 mRNA. Translation: BAG35308.1.
AC003983 Genomic DNA. No translation available.
AL589842, AC005000 Genomic DNA. Translation: CAI39884.1. Different initiation.
CH471120 Genomic DNA. Translation: EAX02614.1.
BC039049 mRNA. Translation: AAH39049.1.
BC056898 mRNA. Translation: AAH56898.1.
L05491 Genomic DNA. Translation: AAA61214.1.
CCDSiCCDS14568.1. [P13797-1]
CCDS78499.1. [P13797-2]
PIRiA34789.
RefSeqiNP_001129497.1. NM_001136025.4. [P13797-1]
NP_001165806.1. NM_001172335.2.
NP_001269266.1. NM_001282337.1. [P13797-2]
NP_001269267.1. NM_001282338.1. [P13797-3]
NP_005023.2. NM_005032.6. [P13797-1]
XP_011535836.1. XM_011537534.1. [P13797-1]
UniGeneiHs.496622.

Genome annotation databases

EnsembliENST00000289290; ENSP00000289290; ENSG00000102024. [P13797-2]
ENST00000355899; ENSP00000348163; ENSG00000102024. [P13797-1]
ENST00000539310; ENSP00000445339; ENSG00000102024. [P13797-1]
GeneIDi5358.
KEGGihsa:5358.
UCSCiuc004eqd.4. human. [P13797-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22299 mRNA. Translation: AAB02844.1.
M34427 mRNA. Translation: AAA36759.1.
AK291194 mRNA. Translation: BAF83883.1.
AK294509 mRNA. Translation: BAG57725.1.
AK300575 mRNA. Translation: BAH13307.1.
AK312391 mRNA. Translation: BAG35308.1.
AC003983 Genomic DNA. No translation available.
AL589842, AC005000 Genomic DNA. Translation: CAI39884.1. Different initiation.
CH471120 Genomic DNA. Translation: EAX02614.1.
BC039049 mRNA. Translation: AAH39049.1.
BC056898 mRNA. Translation: AAH56898.1.
L05491 Genomic DNA. Translation: AAA61214.1.
CCDSiCCDS14568.1. [P13797-1]
CCDS78499.1. [P13797-2]
PIRiA34789.
RefSeqiNP_001129497.1. NM_001136025.4. [P13797-1]
NP_001165806.1. NM_001172335.2.
NP_001269266.1. NM_001282337.1. [P13797-2]
NP_001269267.1. NM_001282338.1. [P13797-3]
NP_005023.2. NM_005032.6. [P13797-1]
XP_011535836.1. XM_011537534.1. [P13797-1]
UniGeneiHs.496622.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOAX-ray2.40A101-375[»]
1WJONMR-A520-630[»]
ProteinModelPortaliP13797.
SMRiP13797.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111372. 49 interactors.
IntActiP13797. 14 interactors.
MINTiMINT-3008106.
STRINGi9606.ENSP00000348163.

PTM databases

iPTMnetiP13797.
PhosphoSitePlusiP13797.
SwissPalmiP13797.

Polymorphism and mutation databases

BioMutaiPLS3.
DMDMi226694201.

Proteomic databases

EPDiP13797.
MaxQBiP13797.
PaxDbiP13797.
PeptideAtlasiP13797.
PRIDEiP13797.

Protocols and materials databases

DNASUi5358.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289290; ENSP00000289290; ENSG00000102024. [P13797-2]
ENST00000355899; ENSP00000348163; ENSG00000102024. [P13797-1]
ENST00000539310; ENSP00000445339; ENSG00000102024. [P13797-1]
GeneIDi5358.
KEGGihsa:5358.
UCSCiuc004eqd.4. human. [P13797-1]

Organism-specific databases

CTDi5358.
DisGeNETi5358.
GeneCardsiPLS3.
HGNCiHGNC:9091. PLS3.
HPAiHPA020433.
MalaCardsiPLS3.
MIMi166710. phenotype.
300131. gene.
300910. phenotype.
neXtProtiNX_P13797.
OpenTargetsiENSG00000102024.
Orphaneti391330. X-linked osteoporosis with fractures.
PharmGKBiPA33418.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiP13797.
KOiK17336.
OMAiRNFNDPA.
OrthoDBiEOG091G03YP.
PhylomeDBiP13797.
TreeFamiTF300680.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102024-MONOMER.

Miscellaneous databases

ChiTaRSiPLS3. human.
EvolutionaryTraceiP13797.
GeneWikiiPLS3.
GenomeRNAii5358.
PROiP13797.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102024.
CleanExiHS_PLS3.
ExpressionAtlasiP13797. baseline and differential.
GenevisibleiP13797. HS.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLST_HUMAN
AccessioniPrimary (citable) accession number: P13797
Secondary accession number(s): A8K579
, B1AQ09, B4DGB4, B7Z6M1, Q86YI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 187 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.