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Protein

Plastin-2

Gene

LCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi22 – 331PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi62 – 732PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • GTPase binding Source: UniProtKB

GO - Biological processi

  • actin crosslink formation Source: GO_Central
  • actin filament bundle assembly Source: UniProtKB
  • actin filament network formation Source: GO_Central
  • animal organ regeneration Source: Ensembl
  • cell migration Source: UniProtKB
  • extracellular matrix disassembly Source: UniProtKB
  • positive regulation of podosome assembly Source: UniProtKB
  • protein kinase A signaling Source: UniProtKB
  • regulation of intracellular protein transport Source: UniProtKB
  • T cell activation involved in immune response Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136167-MONOMER.
SIGNORiP13796.

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-2
Alternative name(s):
L-plastin
LC64P
Lymphocyte cytosolic protein 1
Short name:
LCP-1
Gene namesi
Name:LCP1
Synonyms:PLS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:6528. LCP1.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • actin filament Source: UniProtKB
  • actin filament bundle Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • filopodium Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • phagocytic cup Source: Ensembl
  • plasma membrane Source: HPA
  • podosome Source: UniProtKB
  • ruffle Source: UniProtKB
  • ruffle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving LCP1 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;13)(q27;q14), with BCL6.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5S → A: Abolishes phosphorylation and reduces the cell surface expression of CD69 and IL2RA. Reduces association with the actin cytoskeleton. 2 Publications1
Mutagenesisi5S → E: Promotes association with the actin cytoskeleton. 2 Publications1

Organism-specific databases

DisGeNETi3936.
OpenTargetsiENSG00000136167.
PharmGKBiPA30312.

Polymorphism and mutation databases

BioMutaiLCP1.
DMDMi308153685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000737432 – 627Plastin-2Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei5PhosphoserineCombined sources2 Publications1
Modified residuei7PhosphoserineCombined sources1
Modified residuei28PhosphotyrosineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei76N6-acetyllysineCombined sources1
Modified residuei88N6-acetyllysineCombined sources1
Modified residuei124PhosphotyrosineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei291PhosphothreonineCombined sources1
Modified residuei294N6-acetyllysineCombined sources1
Modified residuei297N6-acetyllysineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei353PhosphothreonineCombined sources1
Modified residuei361N6-acetyllysineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei472N6-acetyllysineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei542N6-acetyllysineCombined sources1
Modified residuei579N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP13796.
MaxQBiP13796.
PaxDbiP13796.
PeptideAtlasiP13796.
PRIDEiP13796.

PTM databases

iPTMnetiP13796.
PhosphoSitePlusiP13796.
SwissPalmiP13796.

Expressioni

Tissue specificityi

Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.1 Publication

Gene expression databases

BgeeiENSG00000136167.
CleanExiHS_LCP1.
ExpressionAtlasiP13796. baseline and differential.
GenevisibleiP13796. HS.

Organism-specific databases

HPAiCAB020673.
HPA019493.

Interactioni

Subunit structurei

Monomer. Interacts with AIF1 (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110128. 19 interactors.
DIPiDIP-34767N.
IntActiP13796. 7 interactors.
MINTiMINT-3008082.
STRINGi9606.ENSP00000315757.

Structurei

Secondary structure

1627
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi520 – 532Combined sources13
Helixi545 – 548Combined sources4
Helixi550 – 559Combined sources10
Turni566 – 568Combined sources3
Helixi576 – 593Combined sources18
Helixi601 – 604Combined sources4
Turni605 – 607Combined sources3
Helixi609 – 612Combined sources4
Helixi615 – 620Combined sources6
Turni621 – 623Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D85NMR-A517-627[»]
ProteinModelPortaliP13796.
SMRiP13796.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13796.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 44EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini49 – 84EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini106 – 379Actin-binding 1Add BLAST274
Domaini120 – 236CH 1PROSITE-ProRule annotationAdd BLAST117
Domaini264 – 375CH 2PROSITE-ProRule annotationAdd BLAST112
Domaini380 – 624Actin-binding 2Add BLAST245
Domaini394 – 503CH 3PROSITE-ProRule annotationAdd BLAST110
Domaini515 – 624CH 4PROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Contains 2 actin-binding domains.Curated
Contains 4 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiP13796.
KOiK17276.
OMAiQPGSIKY.
OrthoDBiEOG091G03YP.
PhylomeDBiP13796.
TreeFamiTF300680.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13796-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGSVSDEE MMELREAFAK VDTDGNGYIS FNELNDLFKA ACLPLPGYRV
60 70 80 90 100
REITENLMAT GDLDQDGRIS FDEFIKIFHG LKSTDVAKTF RKAINKKEGI
110 120 130 140 150
CAIGGTSEQS SVGTQHSYSE EEKYAFVNWI NKALENDPDC RHVIPMNPNT
160 170 180 190 200
NDLFNAVGDG IVLCKMINLS VPDTIDERTI NKKKLTPFTI QENLNLALNS
210 220 230 240 250
ASAIGCHVVN IGAEDLKEGK PYLVLGLLWQ VIKIGLFADI ELSRNEALIA
260 270 280 290 300
LLREGESLED LMKLSPEELL LRWANYHLEN AGCNKIGNFS TDIKDSKAYY
310 320 330 340 350
HLLEQVAPKG DEEGVPAVVI DMSGLREKDD IQRAECMLQQ AERLGCRQFV
360 370 380 390 400
TATDVVRGNP KLNLAFIANL FNRYPALHKP ENQDIDWGAL EGETREERTF
410 420 430 440 450
RNWMNSLGVN PRVNHLYSDL SDALVIFQLY EKIKVPVDWN RVNKPPYPKL
460 470 480 490 500
GGNMKKLENC NYAVELGKNQ AKFSLVGIGG QDLNEGNRTL TLALIWQLMR
510 520 530 540 550
RYTLNILEEI GGGQKVNDDI IVNWVNETLR EAKKSSSISS FKDPKISTSL
560 570 580 590 600
PVLDLIDAIQ PGSINYDLLK TENLNDDEKL NNAKYAISMA RKIGARVYAL
610 620
PEDLVEVNPK MVMTVFACLM GKGMKRV
Length:627
Mass (Da):70,288
Last modified:October 5, 2010 - v6
Checksum:i668E4AA6A3FC7B58
GO
Isoform 2 (identifier: P13796-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MARGSVSDEEMMELREAFAKVDTDG → MCAEDGDSKFSMSISMNSPFLEILH
     26-456: Missing.

Note: No experimental confirmation available.
Show »
Length:196
Mass (Da):21,792
Checksum:i06D5580FBCC9F5E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti611M → T AA sequence (PubMed:3261603).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00137124D → E.1
Natural variantiVAR_024398533K → E.5 PublicationsCorresponds to variant rs4941543dbSNPEnsembl.1
Natural variantiVAR_030826544P → A.Corresponds to variant rs17067725dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564501 – 25MARGS…VDTDG → MCAEDGDSKFSMSISMNSPF LEILH in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_05645126 – 456Missing in isoform 2. 1 PublicationAdd BLAST431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02923 mRNA. Translation: AAA63236.1.
AK300556 mRNA. Translation: BAG62262.1.
AK312393 mRNA. Translation: BAG35310.1.
AL137141 Genomic DNA. Translation: CAI12168.2.
CH471075 Genomic DNA. Translation: EAX08757.1.
BC007673 mRNA. Translation: AAH07673.1.
BC010271 mRNA. Translation: AAH10271.1.
M22300 mRNA. Translation: AAB02845.1.
AH002870 Genomic DNA. Translation: AAA59529.1.
M34426 mRNA. Translation: AAA36184.1.
CCDSiCCDS9403.1. [P13796-1]
PIRiA35836.
RefSeqiNP_002289.2. NM_002298.4. [P13796-1]
XP_005266431.1. XM_005266374.1. [P13796-1]
UniGeneiHs.381099.
Hs.658408.

Genome annotation databases

EnsembliENST00000323076; ENSP00000315757; ENSG00000136167. [P13796-1]
ENST00000398576; ENSP00000381581; ENSG00000136167. [P13796-1]
GeneIDi3936.
KEGGihsa:3936.
UCSCiuc001vba.5. human. [P13796-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02923 mRNA. Translation: AAA63236.1.
AK300556 mRNA. Translation: BAG62262.1.
AK312393 mRNA. Translation: BAG35310.1.
AL137141 Genomic DNA. Translation: CAI12168.2.
CH471075 Genomic DNA. Translation: EAX08757.1.
BC007673 mRNA. Translation: AAH07673.1.
BC010271 mRNA. Translation: AAH10271.1.
M22300 mRNA. Translation: AAB02845.1.
AH002870 Genomic DNA. Translation: AAA59529.1.
M34426 mRNA. Translation: AAA36184.1.
CCDSiCCDS9403.1. [P13796-1]
PIRiA35836.
RefSeqiNP_002289.2. NM_002298.4. [P13796-1]
XP_005266431.1. XM_005266374.1. [P13796-1]
UniGeneiHs.381099.
Hs.658408.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D85NMR-A517-627[»]
ProteinModelPortaliP13796.
SMRiP13796.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110128. 19 interactors.
DIPiDIP-34767N.
IntActiP13796. 7 interactors.
MINTiMINT-3008082.
STRINGi9606.ENSP00000315757.

PTM databases

iPTMnetiP13796.
PhosphoSitePlusiP13796.
SwissPalmiP13796.

Polymorphism and mutation databases

BioMutaiLCP1.
DMDMi308153685.

Proteomic databases

EPDiP13796.
MaxQBiP13796.
PaxDbiP13796.
PeptideAtlasiP13796.
PRIDEiP13796.

Protocols and materials databases

DNASUi3936.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323076; ENSP00000315757; ENSG00000136167. [P13796-1]
ENST00000398576; ENSP00000381581; ENSG00000136167. [P13796-1]
GeneIDi3936.
KEGGihsa:3936.
UCSCiuc001vba.5. human. [P13796-1]

Organism-specific databases

CTDi3936.
DisGeNETi3936.
GeneCardsiLCP1.
H-InvDBHIX0130592.
HGNCiHGNC:6528. LCP1.
HPAiCAB020673.
HPA019493.
MIMi153430. gene.
neXtProtiNX_P13796.
OpenTargetsiENSG00000136167.
PharmGKBiPA30312.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiP13796.
KOiK17276.
OMAiQPGSIKY.
OrthoDBiEOG091G03YP.
PhylomeDBiP13796.
TreeFamiTF300680.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136167-MONOMER.
SIGNORiP13796.

Miscellaneous databases

ChiTaRSiLCP1. human.
EvolutionaryTraceiP13796.
GeneWikiiLCP1.
GenomeRNAii3936.
PROiP13796.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136167.
CleanExiHS_LCP1.
ExpressionAtlasiP13796. baseline and differential.
GenevisibleiP13796. HS.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLSL_HUMAN
AccessioniPrimary (citable) accession number: P13796
Secondary accession number(s): B2R613, B4DUA0, Q5TBN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 194 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.