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Protein

Alkaline phosphatase synthesis transcriptional regulatory protein PhoP

Gene

phoP

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi136 – 235OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST100

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processPhosphate transport, Transcription, Transcription regulation, Transport, Two-component regulatory system

Enzyme and pathway databases

BioCyciBSUB:BSU29110-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
Gene namesi
Name:phoP
Ordered Locus Names:BSU29110
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000811941 – 240Alkaline phosphatase synthesis transcriptional regulatory protein PhoPAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by PhoR.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP13792.
PRIDEiP13792.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100015886.

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi12 – 24Combined sources13
Beta strandi28 – 34Combined sources7
Helixi35 – 45Combined sources11
Beta strandi48 – 55Combined sources8
Beta strandi57 – 59Combined sources3
Helixi61 – 70Combined sources10
Beta strandi77 – 81Combined sources5
Helixi89 – 94Combined sources6
Beta strandi99 – 104Combined sources6
Helixi107 – 119Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVOX-ray1.60A1-135[»]
ProteinModelPortaliP13792.
SMRiP13792.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13792.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 118Response regulatoryPROSITE-ProRule annotationAdd BLAST115

Phylogenomic databases

eggNOGiENOG4105DPZ. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034819.
InParanoidiP13792.
KOiK07658.
OMAiSYPRRVW.
PhylomeDBiP13792.

Family and domain databases

CDDicd00156. REC. 1 hit.
cd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

P13792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKILVVDD EESIVTLLQY NLERSGYDVI TASDGEEALK KAETEKPDLI
60 70 80 90 100
VLDVMLPKLD GIEVCKQLRQ QKLMFPILML TAKDEEFDKV LGLELGADDY
110 120 130 140 150
MTKPFSPREV NARVKAILRR SEIAAPSSEM KNDEMEGQIV IGDLKILPDH
160 170 180 190 200
YEAYFKESQL ELTPKEFELL LYLGRHKGRV LTRDLLLSAV WNYDFAGDTR
210 220 230 240
IVDVHISHLR DKIENNTKKP IYIKTIRGLG YKLEEPKMNE
Length:240
Mass (Da):27,598
Last modified:July 7, 2009 - v4
Checksum:iE61A6FADBE513D97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124A → R in AAA22661 (PubMed:3036763).Curated1
Sequence conflicti124A → R in AAC00348 (PubMed:9387221).Curated1
Sequence conflicti154Y → I in AAA22661 (PubMed:3036763).Curated1
Sequence conflicti211D → PT in AAA22661 (PubMed:3036763).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67676 Genomic DNA. Translation: CAA47908.1.
M16775 Genomic DNA. Translation: AAA22661.1.
AF008220 Genomic DNA. Translation: AAC00348.1.
AL009126 Genomic DNA. Translation: CAB14871.2.
U05257 Genomic DNA. Translation: AAA96344.1.
M23549 Genomic DNA. Translation: AAA22662.1.
PIRiF69676. RGBSAP.
RefSeqiNP_390789.2. NC_000964.3.
WP_003229442.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14871; CAB14871; BSU29110.
GeneIDi936644.
KEGGibsu:BSU29110.
PATRICifig|224308.179.peg.3160.

Similar proteinsi

Entry informationi

Entry nameiPHOP_BACSU
AccessioniPrimary (citable) accession number: P13792
Secondary accession number(s): O34804
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 7, 2009
Last modified: August 30, 2017
This is version 148 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references