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Protein

Alkaline phosphatase synthesis transcriptional regulatory protein PhoP

Gene

phoP

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Phosphate transport, Transcription, Transcription regulation, Transport, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU29110-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
Gene namesi
Name:phoP
Ordered Locus Names:BSU29110
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570 Componenti: Chromosome

Organism-specific databases

GenoListiBSU29110. [Micado]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Alkaline phosphatase synthesis transcriptional regulatory protein PhoPPRO_0000081194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 5314-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by PhoR.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP13792.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU29110.

Structurei

Secondary structure

1
240
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85Combined sources
Helixi12 – 2413Combined sources
Beta strandi28 – 347Combined sources
Helixi35 – 4511Combined sources
Beta strandi48 – 558Combined sources
Beta strandi57 – 593Combined sources
Helixi61 – 7010Combined sources
Beta strandi77 – 815Combined sources
Helixi89 – 946Combined sources
Beta strandi99 – 1046Combined sources
Helixi107 – 11913Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MVOX-ray1.60A1-135[»]
ProteinModelPortaliP13792.
SMRiP13792. Positions 1-237.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13792.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 118115Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
InParanoidiP13792.
KOiK07658.
OMAiYNLERSG.
OrthoDBiEOG6G4VQG.
PhylomeDBiP13792.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKILVVDD EESIVTLLQY NLERSGYDVI TASDGEEALK KAETEKPDLI
60 70 80 90 100
VLDVMLPKLD GIEVCKQLRQ QKLMFPILML TAKDEEFDKV LGLELGADDY
110 120 130 140 150
MTKPFSPREV NARVKAILRR SEIAAPSSEM KNDEMEGQIV IGDLKILPDH
160 170 180 190 200
YEAYFKESQL ELTPKEFELL LYLGRHKGRV LTRDLLLSAV WNYDFAGDTR
210 220 230 240
IVDVHISHLR DKIENNTKKP IYIKTIRGLG YKLEEPKMNE
Length:240
Mass (Da):27,598
Last modified:July 7, 2009 - v4
Checksum:iE61A6FADBE513D97
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241A → R in AAA22661 (PubMed:3036763).Curated
Sequence conflicti124 – 1241A → R in AAC00348 (PubMed:9387221).Curated
Sequence conflicti154 – 1541Y → I in AAA22661 (PubMed:3036763).Curated
Sequence conflicti211 – 2111D → PT in AAA22661 (PubMed:3036763).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67676 Genomic DNA. Translation: CAA47908.1.
M16775 Genomic DNA. Translation: AAA22661.1.
AF008220 Genomic DNA. Translation: AAC00348.1.
AL009126 Genomic DNA. Translation: CAB14871.2.
U05257 Genomic DNA. Translation: AAA96344.1.
M23549 Genomic DNA. Translation: AAA22662.1.
PIRiF69676. RGBSAP.
RefSeqiNP_390789.2. NC_000964.3.
WP_003229442.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14871; CAB14871; BSU29110.
GeneIDi936644.
KEGGibsu:BSU29110.
PATRICi18977714. VBIBacSub10457_3045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67676 Genomic DNA. Translation: CAA47908.1.
M16775 Genomic DNA. Translation: AAA22661.1.
AF008220 Genomic DNA. Translation: AAC00348.1.
AL009126 Genomic DNA. Translation: CAB14871.2.
U05257 Genomic DNA. Translation: AAA96344.1.
M23549 Genomic DNA. Translation: AAA22662.1.
PIRiF69676. RGBSAP.
RefSeqiNP_390789.2. NC_000964.3.
WP_003229442.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MVOX-ray1.60A1-135[»]
ProteinModelPortaliP13792.
SMRiP13792. Positions 1-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU29110.

Proteomic databases

PaxDbiP13792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14871; CAB14871; BSU29110.
GeneIDi936644.
KEGGibsu:BSU29110.
PATRICi18977714. VBIBacSub10457_3045.

Organism-specific databases

GenoListiBSU29110. [Micado]

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
InParanoidiP13792.
KOiK07658.
OMAiYNLERSG.
OrthoDBiEOG6G4VQG.
PhylomeDBiP13792.

Enzyme and pathway databases

BioCyciBSUB:BSU29110-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP13792.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the phoP gene encoding PhoP, the response regulator of the phosphate regulon of Bacillus subtilis."
    Lee J.W., Hulett F.M.
    Nucleic Acids Res. 20:5848-5848(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / JH642.
  2. "Cloning and nucleotide sequence of phoP, the regulatory gene for alkaline phosphatase and phosphodiesterase in Bacillus subtilis."
    Seki T., Yoshikawa H., Takahashi H., Saito H.
    J. Bacteriol. 169:2913-2916(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region."
    Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.
    Microbiology 143:3431-3441(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  4. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  5. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 124.
  6. "Identification of two distinct Bacillus subtilis citrate synthase genes."
    Jin S., Sonenshein A.L.
    J. Bacteriol. 176:4669-4679(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6.
    Strain: 168 / SMY.
  7. "Nucleotide sequence of the Bacillus subtilis phoR gene."
    Seki T., Yoshikawa H., Takahashi H., Saito H.
    J. Bacteriol. 170:5935-5938(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 212-240.

Entry informationi

Entry nameiPHOP_BACSU
AccessioniPrimary (citable) accession number: P13792
Secondary accession number(s): O34804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 7, 2009
Last modified: April 29, 2015
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.