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P13792

- PHOP_BACSU

UniProt

P13792 - PHOP_BACSU

Protein

Alkaline phosphatase synthesis transcriptional regulatory protein PhoP

Gene

phoP

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 4 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro

    GO - Biological processi

    1. phosphate ion transport Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Phosphate transport, Transcription, Transcription regulation, Transport, Two-component regulatory system

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciBSUB:BSU29110-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
    Gene namesi
    Name:phoP
    Ordered Locus Names:BSU29110
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    Organism-specific databases

    GenoListiBSU29110. [Micado]

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Alkaline phosphatase synthesis transcriptional regulatory protein PhoPPRO_0000081194Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 5314-aspartylphosphatePROSITE-ProRule annotations

    Post-translational modificationi

    Phosphorylated by PhoR.Curated

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP13792.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU29110.

    Structurei

    Secondary structure

    1
    240
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 85
    Helixi12 – 2413
    Beta strandi28 – 347
    Helixi35 – 4511
    Beta strandi48 – 558
    Beta strandi57 – 593
    Helixi61 – 7010
    Beta strandi77 – 815
    Helixi89 – 946
    Beta strandi99 – 1046
    Helixi107 – 11913

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MVOX-ray1.60A1-135[»]
    ProteinModelPortaliP13792.
    SMRiP13792. Positions 1-237.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP13792.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 118115Response regulatoryPROSITE-ProRule annotationsAdd
    BLAST

    Sequence similaritiesi

    Contains 1 response regulatory domain.PROSITE-ProRule annotations

    Phylogenomic databases

    eggNOGiCOG0745.
    HOGENOMiHOG000034819.
    KOiK07658.
    OrthoDBiEOG6G4VQG.
    PhylomeDBiP13792.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR016032. Sig_transdc_resp-reg_C-effctor.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46894. SSF46894. 1 hit.
    SSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    P13792-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKKILVVDD EESIVTLLQY NLERSGYDVI TASDGEEALK KAETEKPDLI    50
    VLDVMLPKLD GIEVCKQLRQ QKLMFPILML TAKDEEFDKV LGLELGADDY 100
    MTKPFSPREV NARVKAILRR SEIAAPSSEM KNDEMEGQIV IGDLKILPDH 150
    YEAYFKESQL ELTPKEFELL LYLGRHKGRV LTRDLLLSAV WNYDFAGDTR 200
    IVDVHISHLR DKIENNTKKP IYIKTIRGLG YKLEEPKMNE 240
    Length:240
    Mass (Da):27,598
    Last modified:July 7, 2009 - v4
    Checksum:iE61A6FADBE513D97
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241A → R in AAA22661. (PubMed:3036763)Curated
    Sequence conflicti124 – 1241A → R in AAC00348. (PubMed:9387221)Curated
    Sequence conflicti154 – 1541Y → I in AAA22661. (PubMed:3036763)Curated
    Sequence conflicti211 – 2111D → PT in AAA22661. (PubMed:3036763)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67676 Genomic DNA. Translation: CAA47908.1.
    M16775 Genomic DNA. Translation: AAA22661.1.
    AF008220 Genomic DNA. Translation: AAC00348.1.
    AL009126 Genomic DNA. Translation: CAB14871.2.
    U05257 Genomic DNA. Translation: AAA96344.1.
    M23549 Genomic DNA. Translation: AAA22662.1.
    PIRiF69676. RGBSAP.
    RefSeqiNP_390789.2. NC_000964.3.
    WP_003229442.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB14871; CAB14871; BSU29110.
    GeneIDi936644.
    KEGGibsu:BSU29110.
    PATRICi18977714. VBIBacSub10457_3045.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67676 Genomic DNA. Translation: CAA47908.1 .
    M16775 Genomic DNA. Translation: AAA22661.1 .
    AF008220 Genomic DNA. Translation: AAC00348.1 .
    AL009126 Genomic DNA. Translation: CAB14871.2 .
    U05257 Genomic DNA. Translation: AAA96344.1 .
    M23549 Genomic DNA. Translation: AAA22662.1 .
    PIRi F69676. RGBSAP.
    RefSeqi NP_390789.2. NC_000964.3.
    WP_003229442.1. NZ_CM000487.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MVO X-ray 1.60 A 1-135 [» ]
    ProteinModelPortali P13792.
    SMRi P13792. Positions 1-237.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU29110.

    Proteomic databases

    PaxDbi P13792.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB14871 ; CAB14871 ; BSU29110 .
    GeneIDi 936644.
    KEGGi bsu:BSU29110.
    PATRICi 18977714. VBIBacSub10457_3045.

    Organism-specific databases

    GenoListi BSU29110. [Micado ]

    Phylogenomic databases

    eggNOGi COG0745.
    HOGENOMi HOG000034819.
    KOi K07658.
    OrthoDBi EOG6G4VQG.
    PhylomeDBi P13792.

    Enzyme and pathway databases

    BioCyci BSUB:BSU29110-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P13792.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR016032. Sig_transdc_resp-reg_C-effctor.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46894. SSF46894. 1 hit.
    SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the phoP gene encoding PhoP, the response regulator of the phosphate regulon of Bacillus subtilis."
      Lee J.W., Hulett F.M.
      Nucleic Acids Res. 20:5848-5848(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168 / JH642.
    2. "Cloning and nucleotide sequence of phoP, the regulatory gene for alkaline phosphatase and phosphodiesterase in Bacillus subtilis."
      Seki T., Yoshikawa H., Takahashi H., Saito H.
      J. Bacteriol. 169:2913-2916(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region."
      Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.
      Microbiology 143:3431-3441(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    4. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    5. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
      Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
      Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 124.
    6. "Identification of two distinct Bacillus subtilis citrate synthase genes."
      Jin S., Sonenshein A.L.
      J. Bacteriol. 176:4669-4679(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6.
      Strain: 168 / SMY.
    7. "Nucleotide sequence of the Bacillus subtilis phoR gene."
      Seki T., Yoshikawa H., Takahashi H., Saito H.
      J. Bacteriol. 170:5935-5938(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 212-240.

    Entry informationi

    Entry nameiPHOP_BACSU
    AccessioniPrimary (citable) accession number: P13792
    Secondary accession number(s): O34804
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 130 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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