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P13792 (PHOP_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
Gene names
Name:phoP
Ordered Locus Names:BSU29110
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase.

Subcellular location

Cytoplasm Probable.

Post-translational modification

Phosphorylated by PhoR Probable.

Sequence similarities

Contains 1 response regulatory domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
PRO_0000081194

Regions

Domain4 – 118115Response regulatory

Amino acid modifications

Modified residue5314-aspartylphosphate By similarity

Experimental info

Sequence conflict1241A → R in AAA22661. Ref.2
Sequence conflict1241A → R in AAC00348. Ref.3
Sequence conflict1541Y → I in AAA22661. Ref.2
Sequence conflict2111D → PT in AAA22661. Ref.2

Secondary structure

...................... 240
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P13792 [UniParc].

Last modified July 7, 2009. Version 4.
Checksum: E61A6FADBE513D97

FASTA24027,598
        10         20         30         40         50         60 
MNKKILVVDD EESIVTLLQY NLERSGYDVI TASDGEEALK KAETEKPDLI VLDVMLPKLD 

        70         80         90        100        110        120 
GIEVCKQLRQ QKLMFPILML TAKDEEFDKV LGLELGADDY MTKPFSPREV NARVKAILRR 

       130        140        150        160        170        180 
SEIAAPSSEM KNDEMEGQIV IGDLKILPDH YEAYFKESQL ELTPKEFELL LYLGRHKGRV 

       190        200        210        220        230        240 
LTRDLLLSAV WNYDFAGDTR IVDVHISHLR DKIENNTKKP IYIKTIRGLG YKLEEPKMNE 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the phoP gene encoding PhoP, the response regulator of the phosphate regulon of Bacillus subtilis."
Lee J.W., Hulett F.M.
Nucleic Acids Res. 20:5848-5848(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[2]"Cloning and nucleotide sequence of phoP, the regulatory gene for alkaline phosphatase and phosphodiesterase in Bacillus subtilis."
Seki T., Yoshikawa H., Takahashi H., Saito H.
J. Bacteriol. 169:2913-2916(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region."
Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.
Microbiology 143:3431-3441(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[4]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[5]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 124.
[6]"Identification of two distinct Bacillus subtilis citrate synthase genes."
Jin S., Sonenshein A.L.
J. Bacteriol. 176:4669-4679(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6.
Strain: 168 / SMY.
[7]"Nucleotide sequence of the Bacillus subtilis phoR gene."
Seki T., Yoshikawa H., Takahashi H., Saito H.
J. Bacteriol. 170:5935-5938(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 212-240.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X67676 Genomic DNA. Translation: CAA47908.1.
M16775 Genomic DNA. Translation: AAA22661.1.
AF008220 Genomic DNA. Translation: AAC00348.1.
AL009126 Genomic DNA. Translation: CAB14871.2.
U05257 Genomic DNA. Translation: AAA96344.1.
M23549 Genomic DNA. Translation: AAA22662.1.
PIRRGBSAP. F69676.
RefSeqNP_390789.2. NC_000964.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1MVOX-ray1.60A1-135[»]
ProteinModelPortalP13792.
SMRP13792. Positions 1-237.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU29110.

Proteomic databases

PaxDbP13792.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB14871; CAB14871; BSU29110.
GeneID936644.
KEGGbsu:BSU29110.
PATRIC18977714. VBIBacSub10457_3045.

Organism-specific databases

GenoListBSU29110. [Micado]

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034819.
KOK07658.
OrthoDBEOG6G4VQG.
ProtClustDBCLSK2393393.

Enzyme and pathway databases

BioCycBSUB:BSU29110-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP13792.

Entry information

Entry namePHOP_BACSU
AccessionPrimary (citable) accession number: P13792
Secondary accession number(s): O34804
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 7, 2009
Last modified: April 16, 2014
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList