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Protein

Troponin T, cardiac muscle

Gene

TNNT2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, cardiac muscle
Short name:
TnTc
Alternative name(s):
Cardiac muscle troponin T
Short name:
cTnT
Gene namesi
Name:TNNT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 285284Troponin T, cardiac musclePRO_0000186172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCurated
Modified residuei2 – 21Phosphoserine; by CK21 Publication
Modified residuei177 – 1771PhosphoserineBy similarity
Modified residuei191 – 1911Phosphothreonine; by PKC/PRKCA1 Publication
Modified residuei195 – 1951Phosphoserine; by PKC/PRKCABy similarity
Modified residuei200 – 2001Phosphothreonine; by PKC/PRKCA and RAF11 Publication
Modified residuei281 – 2811Phosphothreonine; by PKC/PRKCA1 Publication

Post-translational modificationi

The N-terminus is blocked.
Phosphorylation at Thr-200 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP13789.
PRIDEiP13789.

PTM databases

iPTMnetiP13789.

Interactioni

Protein-protein interaction databases

IntActiP13789. 1 interaction.
MINTiMINT-8189921.
STRINGi9913.ENSBTAP00000054984.

Structurei

3D structure databases

ProteinModelPortaliP13789.
SMRiP13789. Positions 88-121, 199-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGiKOG3634. Eukaryota.
ENOG410XS6A. LUCA.
HOVERGENiHBG052790.
InParanoidiP13789.

Family and domain databases

InterProiIPR027707. TNNT.
IPR001978. Troponin.
[Graphical view]
PANTHERiPTHR11521. PTHR11521. 1 hit.
PfamiPF00992. Troponin. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13789-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDVEEAVEE YEEQEEAAEE EHEEAVEEEA GGEAEAGEPC TAEDGEEEEG
60 70 80 90 100
REAEDGPVEE FKPKPRPFMP NLVPPKIPDG ERVDFDDIHR KRMEKDLNEL
110 120 130 140 150
QTLIEAHFEN RKKEEEELVS LKDRIEKRRA ERAEQQRIRA EREKERQTRL
160 170 180 190 200
AEERARREEE ESRRKAEDEA RKKKALSNMM HFGGYIQKAQ TERKSGKRQT
210 220 230 240 250
EREKKKKILA ERRKVLAIDH LNEDQLREKA KELWQMIYDL EAEKFDLQEK
260 270 280
FKQQKYEINV LRNRINDNQK VSKTRGKAKV TGRWK
Length:285
Mass (Da):33,914
Last modified:January 23, 2007 - v3
Checksum:i31290F00B6082499
GO
Isoform 2 (identifier: P13789-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-22: AAEEEH → N

Show »
Length:280
Mass (Da):33,361
Checksum:i00E181B564AAA76E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei17 – 226AAEEEH → N in isoform 2. CuratedVSP_006631

Sequence databases

PIRiA28008.
UniGeneiBt.3879.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

PIRiA28008.
UniGeneiBt.3879.

3D structure databases

ProteinModelPortaliP13789.
SMRiP13789. Positions 88-121, 199-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP13789. 1 interaction.
MINTiMINT-8189921.
STRINGi9913.ENSBTAP00000054984.

PTM databases

iPTMnetiP13789.

Proteomic databases

PaxDbiP13789.
PRIDEiP13789.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3634. Eukaryota.
ENOG410XS6A. LUCA.
HOVERGENiHBG052790.
InParanoidiP13789.

Family and domain databases

InterProiIPR027707. TNNT.
IPR001978. Troponin.
[Graphical view]
PANTHERiPTHR11521. PTHR11521. 1 hit.
PfamiPF00992. Troponin. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNT2_BOVIN
AccessioniPrimary (citable) accession number: P13789
Secondary accession number(s): P13790
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.