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Protein

Hemoglobin subunit zeta

Gene

HBZ1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit zeta
Alternative name(s):
Hemoglobin zeta chain
Zeta-globin
Gene namesi
Name:HBZ1
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 142141Hemoglobin subunit zetaPRO_0000052850Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei53 – 531PhosphoserineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiP13787.
PRIDEiP13787.

Interactioni

Subunit structurei

Heterotetramer of two zeta chains and beta-type chains.By similarity

Structurei

3D structure databases

ProteinModelPortaliP13787.
SMRiP13787. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP13787.
KOiK13826.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002340. Haemoglobin_zeta.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00816. ZETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTKAERTM VVSIWGKISM QADAVGTEAL QRLFSSYPQT KTYFPHFDLH
60 70 80 90 100
EGSPQLRAHG SKVAAAVGDA VKSIDNVAGA LAKLSELHAY ILRVDPVNFK
110 120 130 140
FLSHCLLVTL ASRLPADFTA DAHAAWDKFL SIVSSVLTEK YR
Length:142
Mass (Da):15,563
Last modified:January 23, 2007 - v2
Checksum:i20217A19AE85A07E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07051 Genomic DNA. Translation: CAA30095.1.
X07052 Genomic DNA. Translation: CAA30096.1.
PIRiS01714.
RefSeqiNP_001108014.1. NM_001114542.1.
UniGeneiEca.11477.

Genome annotation databases

GeneIDi100065056.
KEGGiecb:100065056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07051 Genomic DNA. Translation: CAA30095.1.
X07052 Genomic DNA. Translation: CAA30096.1.
PIRiS01714.
RefSeqiNP_001108014.1. NM_001114542.1.
UniGeneiEca.11477.

3D structure databases

ProteinModelPortaliP13787.
SMRiP13787. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiP13787.
PRIDEiP13787.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100065056.
KEGGiecb:100065056.

Organism-specific databases

CTDi100065056.

Phylogenomic databases

HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP13787.
KOiK13826.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002340. Haemoglobin_zeta.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00816. ZETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBAZ_HORSE
AccessioniPrimary (citable) accession number: P13787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.