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Protein

HLA class II histocompatibility antigen, DO beta chain

Gene

HLA-DOB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB
  • MHC class II receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:G66-32195-MONOMER.
ReactomeiR-HSA-2132295. MHC class II antigen presentation.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DO beta chain
Alternative name(s):
MHC class II antigen DOB
Gene namesi
Name:HLA-DOB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4937. HLA-DOB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 224ExtracellularSequence analysisAdd BLAST198
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 273CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

  • endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: Reactome
  • lysosome Source: MGI
  • MHC class II protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

DisGeNETi3112.
OpenTargetsiENSG00000239457.
ENSG00000241106.
ENSG00000241386.
ENSG00000241910.
ENSG00000243612.
PharmGKBiPA35061.

Polymorphism and mutation databases

BioMutaiHLA-DOB.
DMDMi122261.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001896327 – 273HLA class II histocompatibility antigen, DO beta chainAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 105PROSITE-ProRule annotation
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi143 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP13765.
PeptideAtlasiP13765.
PRIDEiP13765.

PTM databases

iPTMnetiP13765.
PhosphoSitePlusiP13765.

Expressioni

Gene expression databases

BgeeiENSG00000239457.
CleanExiHS_HLA-DOB.
ExpressionAtlasiP13765. baseline and differential.
GenevisibleiP13765. HS.

Organism-specific databases

HPAiHPA013846.

Interactioni

Subunit structurei

Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109357. 2 interactors.
DIPiDIP-60117N.
MINTiMINT-6630170.
STRINGi9606.ENSP00000390020.

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 44Combined sources11
Turni45 – 48Combined sources4
Beta strandi49 – 58Combined sources10
Beta strandi61 – 67Combined sources7
Turni68 – 70Combined sources3
Beta strandi72 – 75Combined sources4
Helixi78 – 80Combined sources3
Helixi81 – 89Combined sources9
Helixi91 – 103Combined sources13
Helixi105 – 112Combined sources8
Helixi113 – 115Combined sources3
Turni116 – 118Combined sources3
Beta strandi124 – 131Combined sources8
Beta strandi139 – 151Combined sources13
Beta strandi154 – 159Combined sources6
Beta strandi166 – 169Combined sources4
Beta strandi177 – 179Combined sources3
Beta strandi181 – 189Combined sources9
Beta strandi197 – 202Combined sources6
Beta strandi210 – 214Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I0PX-ray3.20D/H30-218[»]
ProteinModelPortaliP13765.
SMRiP13765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 213Ig-like C1-typeAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 120Beta-1Add BLAST94
Regioni121 – 214Beta-2Add BLAST94
Regioni215 – 224Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
GeneTreeiENSGT00760000118970.
HOGENOMiHOG000100909.
HOVERGENiHBG012730.
InParanoidiP13765.
KOiK06752.
OMAiFNLEEYA.
OrthoDBiEOG091G0SXL.
PhylomeDBiP13765.
TreeFamiTF336626.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGWVPWVV ALLVNLTRLD SSMTQGTDSP EDFVIQAKAD CYFTNGTEKV
60 70 80 90 100
QFVVRFIFNL EEYVRFDSDV GMFVALTKLG QPDAEQWNSR LDLLERSRQA
110 120 130 140 150
VDGVCRHNYR LGAPFTVGRK VQPEVTVYPE RTPLLHQHNL LHCSVTGFYP
160 170 180 190 200
GDIKIKWFLN GQEERAGVMS TGPIRNGDWT FQTVVMLEMT PELGHVYTCL
210 220 230 240 250
VDHSSLLSPV SVEWRAQSEY SWRKMLSGIA AFLLGLIFLL VGIVIQLRAQ
260 270
KGYVRTQMSG NEVSRAVLLP QSC
Length:273
Mass (Da):30,822
Last modified:January 1, 1990 - v1
Checksum:iC06A1360DCC4AD26
GO

Polymorphismi

The following alleles of DOB are known: DOB*01:01, DOB*01:02, DOB*01:03 and DOB*01:04. The sequence shown is that of DOB*01:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01674318R → Q in allele DOB*01:02. Corresponds to variant rs2071554dbSNPEnsembl.1
Natural variantiVAR_050363210V → I.2 PublicationsCorresponds to variant rs11575907dbSNPEnsembl.1
Natural variantiVAR_016745234L → F in allele DOB*01:04. Corresponds to variant rs2070121dbSNPEnsembl.1
Natural variantiVAR_016744244V → I in allele DOB*01:03. Corresponds to variant rs2621330dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03066 mRNA. Translation: CAA26870.1.
M26040 mRNA. Translation: AAA59718.1.
X66401 Genomic DNA. Translation: CAA47028.1.
CR541832 mRNA. Translation: CAG46631.1.
CR788227 Genomic DNA. Translation: CAQ08588.1.
BC006097 mRNA. Translation: AAH06097.1.
L29472 Genomic DNA. Translation: AAA59717.1.
X87344 Genomic DNA. Translation: CAA60789.1.
AB035252 Genomic DNA. No translation available.
CCDSiCCDS4754.1.
PIRiS27335. A24669.
RefSeqiNP_002111.1. NM_002120.3.
UniGeneiHs.1802.

Genome annotation databases

EnsembliENST00000426644; ENSP00000395780; ENSG00000243612.
ENST00000438763; ENSP00000390020; ENSG00000241106.
ENST00000447178; ENSP00000405108; ENSG00000241386.
ENST00000454286; ENSP00000397268; ENSG00000243496.
ENST00000454969; ENSP00000410390; ENSG00000241910.
ENST00000456406; ENSP00000394783; ENSG00000239457.
GeneIDi3112.
KEGGihsa:3112.
UCSCiuc011gkh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03066 mRNA. Translation: CAA26870.1.
M26040 mRNA. Translation: AAA59718.1.
X66401 Genomic DNA. Translation: CAA47028.1.
CR541832 mRNA. Translation: CAG46631.1.
CR788227 Genomic DNA. Translation: CAQ08588.1.
BC006097 mRNA. Translation: AAH06097.1.
L29472 Genomic DNA. Translation: AAA59717.1.
X87344 Genomic DNA. Translation: CAA60789.1.
AB035252 Genomic DNA. No translation available.
CCDSiCCDS4754.1.
PIRiS27335. A24669.
RefSeqiNP_002111.1. NM_002120.3.
UniGeneiHs.1802.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I0PX-ray3.20D/H30-218[»]
ProteinModelPortaliP13765.
SMRiP13765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109357. 2 interactors.
DIPiDIP-60117N.
MINTiMINT-6630170.
STRINGi9606.ENSP00000390020.

PTM databases

iPTMnetiP13765.
PhosphoSitePlusiP13765.

Polymorphism and mutation databases

BioMutaiHLA-DOB.
DMDMi122261.

Proteomic databases

PaxDbiP13765.
PeptideAtlasiP13765.
PRIDEiP13765.

Protocols and materials databases

DNASUi3112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426644; ENSP00000395780; ENSG00000243612.
ENST00000438763; ENSP00000390020; ENSG00000241106.
ENST00000447178; ENSP00000405108; ENSG00000241386.
ENST00000454286; ENSP00000397268; ENSG00000243496.
ENST00000454969; ENSP00000410390; ENSG00000241910.
ENST00000456406; ENSP00000394783; ENSG00000239457.
GeneIDi3112.
KEGGihsa:3112.
UCSCiuc011gkh.2. human.

Organism-specific databases

CTDi3112.
DisGeNETi3112.
GeneCardsiHLA-DOB.
H-InvDBHIX0207728.
HIX0207758.
HGNCiHGNC:4937. HLA-DOB.
HPAiHPA013846.
MIMi142920. gene.
600629. gene.
neXtProtiNX_P13765.
OpenTargetsiENSG00000239457.
ENSG00000241106.
ENSG00000241386.
ENSG00000241910.
ENSG00000243612.
PharmGKBiPA35061.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
GeneTreeiENSGT00760000118970.
HOGENOMiHOG000100909.
HOVERGENiHBG012730.
InParanoidiP13765.
KOiK06752.
OMAiFNLEEYA.
OrthoDBiEOG091G0SXL.
PhylomeDBiP13765.
TreeFamiTF336626.

Enzyme and pathway databases

BioCyciZFISH:G66-32195-MONOMER.
ReactomeiR-HSA-2132295. MHC class II antigen presentation.

Miscellaneous databases

ChiTaRSiHLA-DOB. human.
GeneWikiiHLA-DOB.
GenomeRNAii3112.
PROiP13765.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000239457.
CleanExiHS_HLA-DOB.
ExpressionAtlasiP13765. baseline and differential.
GenevisibleiP13765. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOB_HUMAN
AccessioniPrimary (citable) accession number: P13765
Secondary accession number(s): B0V0Y0
, Q29746, Q29825, Q6FHC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.