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P13760

- 2B14_HUMAN

UniProt

P13760 - 2B14_HUMAN

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Protein

HLA class II histocompatibility antigen, DRB1-4 beta chain

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functioni

  1. MHC class II receptor activity Source: UniProtKB
  2. peptide antigen binding Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. cytokine-mediated signaling pathway Source: Reactome
  3. detection of bacterium Source: UniProtKB
  4. humoral immune response mediated by circulating immunoglobulin Source: UniProtKB
  5. immune response Source: UniProtKB
  6. immunoglobulin production involved in immunoglobulin mediated immune response Source: UniProtKB
  7. inflammatory response to antigenic stimulus Source: UniProtKB
  8. interferon-gamma-mediated signaling pathway Source: Reactome
  9. negative regulation of inflammatory response to antigenic stimulus Source: UniProtKB
  10. negative regulation of interferon-gamma production Source: UniProtKB
  11. negative regulation of T cell proliferation Source: UniProtKB
  12. peptide antigen assembly with MHC class II protein complex Source: UniProt
  13. positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  14. protein tetramerization Source: UniProtKB
  15. regulation of interleukin-10 secretion Source: UniProtKB
  16. regulation of interleukin-4 production Source: UniProtKB
  17. signal transduction Source: ProtInc
  18. T cell costimulation Source: Reactome
  19. T cell receptor signaling pathway Source: Reactome
  20. T-helper 1 type immune response Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DRB1-4 beta chain
Alternative name(s):
MHC class II antigen DRB1*4
Short name:
DR-4
Short name:
DR4
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4948. HLA-DRB1.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Lysosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Late endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

GO - Cellular componenti

  1. clathrin-coated endocytic vesicle membrane Source: Reactome
  2. endocytic vesicle membrane Source: Reactome
  3. ER to Golgi transport vesicle membrane Source: Reactome
  4. external side of plasma membrane Source: UniProtKB
  5. Golgi membrane Source: Reactome
  6. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  7. integral component of plasma membrane Source: UniProtKB
  8. late endosome membrane Source: UniProtKB
  9. lysosomal membrane Source: UniProtKB
  10. MHC class II protein complex Source: UniProt
  11. plasma membrane Source: Reactome
  12. trans-Golgi network membrane Source: Reactome
  13. transport vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Add
BLAST
Chaini30 – 266237HLA class II histocompatibility antigen, DRB1-4 beta chainPRO_0000018950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 108PROSITE-ProRule annotation
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi146 ↔ 202PROSITE-ProRule annotation
Cross-linki254 – 254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP13760.
PaxDbiP13760.
PRIDEiP13760.

PTM databases

PhosphoSiteiP13760.

Expressioni

Gene expression databases

CleanExiHS_HLA-DRB1.
GenevestigatoriP13760.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Protein-protein interaction databases

IntActiP13760. 6 interactions.

Structurei

Secondary structure

1
266
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 4712
Turni48 – 514
Beta strandi52 – 6110
Beta strandi64 – 707
Turni71 – 733
Beta strandi74 – 807
Helixi81 – 833
Helixi84 – 918
Helixi94 – 10613
Helixi108 – 1158
Helixi116 – 1183
Turni119 – 1213
Beta strandi127 – 1337
Beta strandi143 – 15412
Beta strandi157 – 1626
Beta strandi165 – 1673
Beta strandi171 – 1733
Beta strandi180 – 1823
Beta strandi184 – 1918
Beta strandi199 – 2057
Beta strandi213 – 2186

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D5MX-ray2.00B30-221[»]
1D5XX-ray2.45B30-221[»]
1D5ZX-ray2.00B30-221[»]
1D6EX-ray2.45B30-221[»]
1J8HX-ray2.40B30-221[»]
2SEBX-ray2.50B30-221[»]
3O6FX-ray2.80B/F31-221[»]
3T0EX-ray4.00B30-221[»]
4IS6X-ray2.50B30-221[»]
4MCYX-ray2.30B30-219[»]
4MCZX-ray2.41B30-219[»]
4MD0X-ray2.19B30-219[»]
4MD4X-ray1.95B30-219[»]
4MD5X-ray1.65B30-219[»]
4MDIX-ray2.00B30-219[»]
4MDJX-ray1.70B30-219[»]
ProteinModelPortaliP13760.
SMRiP13760. Positions 30-219.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13760.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 227198ExtracellularSequence AnalysisAdd
BLAST
Topological domaini251 – 26616CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei228 – 25023HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 21489Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 12495Beta-1Add
BLAST
Regioni125 – 227103Beta-2Add
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG68200.
HOVERGENiHBG012730.
PhylomeDBiP13760.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13760-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCLKFPGGS CMAALTVTLM VLSSPLALAG DTRPRFLEQV KHECHFFNGT
60 70 80 90 100
ERVRFLDRYF YHQEEYVRFD SDVGEYRAVT ELGRPDAEYW NSQKDLLEQK
110 120 130 140 150
RAAVDTYCRH NYGVGESFTV QRRVYPEVTV YPAKTQPLQH HNLLVCSVNG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKTG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSLT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PTGFLS
Length:266
Mass (Da):30,112
Last modified:January 1, 1990 - v1
Checksum:i8116E91DA38294E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541G → A in AAA59805. (PubMed:3476943)Curated

Polymorphismi

The following alleles of DRB1-4 are known: DRB1*04:01, DRB1*04:02, DRB1*04:03, DRB1*04:04, DRB1*04:05, DRB1*04:06, DRB1*04:07, DRB1*04:08, DRB1*04:09, DRB1*04:10, DRB1*04:11, DRB1*04:12, DRB1*04:13, DRB1*04:14, DRB1*04:15, DRB1*04:16, DRB1*04:17, DRB1*04:18, DRB1*04:19, DRB1*04:20, DRB1*04:21, DRB1*04:22, DRB1*04:23, DRB1*04:24, DRB1*04:25, DRB1*04:26, DRB1*04:27, DRB1*04:28, DRB1*04:29, DRB1*04:30, DRB1*04:31, DRB1*04:32, DRB1*04:33, DRB1*04:34, DRB1*04:35, DRB1*04:36, DRB1*04:37, DRB1*04:38, DRB1*04:39, DRB1*04:40, DRB1*04:41, DRB1*04:42, DRB1*04:43, DRB1*04:44, DRB1*04:45, DRB1*04:46, DRB1*04:47, DRB1*04:48, DRB1*04:49, DRB1*04:50, DRB1*04:51, DRB1*04:52, DRB1*04:53, DRB1*04:54, DRB1*04:55, DRB1*04:56, DRB1*04:57, DRB1*04:58, DRB1*04:59, DRB1*04:60, DRB1*04:61, DRB1*04:62, DRB1*04:63, DRB1*04:64, DRB1*04:65, DRB1*04:66, DRB1*04:67, DRB1*04:68, DRB1*04:69, DRB1*04:70, DRB1*04:71, DRB1*04:72, DRB1*04:73, DRB1*04:74, DRB1*04:75, DRB1*04:76, DRB1*04:77 and DRB1*04:78. The sequence shown is that of DRB1*04:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51K → R.
Corresponds to variant rs9270305 [ dbSNP | Ensembl ].
VAR_056529
Natural varianti86 – 861D → S in allele DRB1*04:11; requires 2 nucleotide substitutions.
VAR_016673
Natural varianti96 – 961L → I in allele DRB1*04:02.
VAR_016674
Natural varianti99 – 991Q → D in allele DRB1*04:02; requires 2 nucleotide substitutions.
VAR_016675
Natural varianti100 – 1001K → E in allele DRB1*04:02.
VAR_016676
Natural varianti100 – 1001K → R in allele DRB1*04:03, allele DRB1*04:04 and allele DRB1*04:11.
VAR_016677
Natural varianti103 – 1031A → E in allele DRB1*04:03 and allele DRB1*04:11.
VAR_016678
Natural varianti115 – 1151G → V in allele DRB1*04:02, allele DRB1*04:03, allele DRB1*04:04 and allele DRB1*04:11.
VAR_016679
Natural varianti236 – 2361V → M.
Corresponds to variant rs2230816 [ dbSNP | Ensembl ].
VAR_056530
Natural varianti262 – 2621T → R.
Corresponds to variant rs9269744 [ dbSNP | Ensembl ].
VAR_056531

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20548 Genomic DNA. No translation available.
M20549 Genomic DNA. No translation available.
M20550 Genomic DNA. No translation available.
AL137064 Genomic DNA. Translation: CAC19360.1.
M17381 mRNA. Translation: AAA59805.1.
K02776 Genomic DNA. Translation: AAA59808.1.
X96851 Genomic DNA. No translation available.
AJ297586 mRNA. Translation: CAC08826.2.
AF029269 Genomic DNA. Translation: AAF65479.1.
AF112876 Genomic DNA. Translation: AAD29581.1.
AJ295845 Genomic DNA. Translation: CAC08181.1.
X02902 mRNA. Translation: CAA26660.1.
M15069 mRNA. Translation: AAA59809.1.
L42143 mRNA. Translation: AAA67104.1.
PIRiA94681. A29310.
I79419.
UniGeneiHs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

Genome annotation databases

EnsembliENST00000419393; ENSP00000403458; ENSG00000228080.

Polymorphism databases

DMDMi122253.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20548 Genomic DNA. No translation available.
M20549 Genomic DNA. No translation available.
M20550 Genomic DNA. No translation available.
AL137064 Genomic DNA. Translation: CAC19360.1 .
M17381 mRNA. Translation: AAA59805.1 .
K02776 Genomic DNA. Translation: AAA59808.1 .
X96851 Genomic DNA. No translation available.
AJ297586 mRNA. Translation: CAC08826.2 .
AF029269 Genomic DNA. Translation: AAF65479.1 .
AF112876 Genomic DNA. Translation: AAD29581.1 .
AJ295845 Genomic DNA. Translation: CAC08181.1 .
X02902 mRNA. Translation: CAA26660.1 .
M15069 mRNA. Translation: AAA59809.1 .
L42143 mRNA. Translation: AAA67104.1 .
PIRi A94681. A29310.
I79419.
UniGenei Hs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1D5M X-ray 2.00 B 30-221 [» ]
1D5X X-ray 2.45 B 30-221 [» ]
1D5Z X-ray 2.00 B 30-221 [» ]
1D6E X-ray 2.45 B 30-221 [» ]
1J8H X-ray 2.40 B 30-221 [» ]
2SEB X-ray 2.50 B 30-221 [» ]
3O6F X-ray 2.80 B/F 31-221 [» ]
3T0E X-ray 4.00 B 30-221 [» ]
4IS6 X-ray 2.50 B 30-221 [» ]
4MCY X-ray 2.30 B 30-219 [» ]
4MCZ X-ray 2.41 B 30-219 [» ]
4MD0 X-ray 2.19 B 30-219 [» ]
4MD4 X-ray 1.95 B 30-219 [» ]
4MD5 X-ray 1.65 B 30-219 [» ]
4MDI X-ray 2.00 B 30-219 [» ]
4MDJ X-ray 1.70 B 30-219 [» ]
ProteinModelPortali P13760.
SMRi P13760. Positions 30-219.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P13760. 6 interactions.

PTM databases

PhosphoSitei P13760.

Polymorphism databases

DMDMi 122253.

Proteomic databases

MaxQBi P13760.
PaxDbi P13760.
PRIDEi P13760.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000419393 ; ENSP00000403458 ; ENSG00000228080 .

Organism-specific databases

GeneCardsi GC06M032546.
GC06Mo32637.
H-InvDB HIX0207659.
HGNCi HGNC:4948. HLA-DRB1.
MIMi 142857. gene.
neXtProti NX_P13760.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68200.
HOVERGENi HBG012730.
PhylomeDBi P13760.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSi HLA-DRB1. human.
EvolutionaryTracei P13760.
PROi P13760.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-DRB1.
Genevestigatori P13760.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view ]
ProDomi PD000328. MHC_II_b_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Class II genes of the human major histocompatibility complex. Organization and evolutionary relationship of the DR beta genes."
    Andersson G., Larhammar D., Widmark E., Servenius B., Peterson P.A., Rask L.
    J. Biol. Chem. 262:8748-8758(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DRB1*04:01).
  2. Erratum
    Andersson G., Larhammar D., Widmark E., Servenius B., Peterson P.A., Rask L.
    J. Biol. Chem. 263:8551-8551(1988)
    Cited for: SEQUENCE REVISION.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DRB1*04:01).
  4. "Allelic variation in the DR subregion of the human major histocompatibility complex."
    Bell J.I., Denney D. Jr., Foster L., Belt T.K., Todd J.A., McDevitt H.O.
    Proc. Natl. Acad. Sci. U.S.A. 84:6234-6238(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB1*04:01).
  5. "Structural organization of the DR subregion of the human major histocompatibility complex."
    Spies T., Sorrentino R., Boss J.M., Okada K., Strominger J.L.
    Proc. Natl. Acad. Sci. U.S.A. 82:5165-5169(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*04:01).
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*04:01).
  7. "Complete cDNA sequences of the HLA-DRB1*0402 and DRB1*11041 alleles."
    Ramon D., Corell A., Cox S.T., Soteriou B., Madrigal J.A., Marsh S.G.E.
    Eur. J. Immunogenet. 29:453-455(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*04:02).
  8. "HLA class II polymorphism."
    Arnaiz-Villena A.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-115 (ALLELE DRB1*04:03).
    Tissue: Blood.
  9. "New HLA class II (DRB1) alleles detected by sequencing-based typing."
    Greville W.D., van Eijck A., Dunckley H.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-122 (ALLELE DRB1*04:03).
  10. "Confirmatory sequence of HLA-DRB1*04032."
    Guttridge M.G., Hammond L.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*04:03).
  11. "Sequence polymorphism of HLA DR beta 1 alleles relating to T-cell-recognized determinants."
    Cairns J.S., Curtsinger J.M., Dahl C.A., Freeman S., Alter B.J., Bach F.H.
    Nature 317:166-168(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*04:04).
  12. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-123 (ALLELE DRB1*04:04).
  13. "Full cDNA sequence of HLA-DRB1*0411."
    Zhao W., Fernandez-Vina M.A., Stastny P.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*04:11).
  14. "Invariant chain structure and MHC class II function."
    Cresswell P.
    Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  15. "Presentation of antigens by MHC class II molecules: getting the most out of them."
    Villadangos J.A.
    Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  16. "Autophagy in MHC class II presentation: sampling from within."
    Menendez-Benito V., Neefjes J.
    Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  17. "MHC class II molecules on the move for successful antigen presentation."
    Rocha N., Neefjes J.
    EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  18. "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."
    De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E.
    Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
  19. "MHC class II transport at a glance."
    Berger A.C., Roche P.A.
    J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  20. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
    Beswick E.J., Reyes V.E.
    World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II."
    Dessen A., Lawrence C.M., Cupo S., Zaller D.M., Wiley D.C.
    Immunity 7:473-481(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF COMPLEX WITH A COLLAGEN PEPTIDE.

Entry informationi

Entry namei2B14_HUMAN
AccessioniPrimary (citable) accession number: P13760
Secondary accession number(s): O19717
, O19739, P13759, Q29875, Q30145, Q9GIX9, Q9GIY4, Q9MY13, Q9XRY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3