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P13747

- HLAE_HUMAN

UniProt

P13747 - HLAE_HUMAN

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Protein

HLA class I histocompatibility antigen, alpha chain E

Gene

HLA-E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.

GO - Molecular functioni

  1. MHC class I protein binding Source: UniProt
  2. peptide antigen binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: UniProt
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  4. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  5. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  6. cytokine-mediated signaling pathway Source: Reactome
  7. innate immune response Source: Reactome
  8. interferon-gamma-mediated signaling pathway Source: Reactome
  9. positive regulation of natural killer cell mediated immunity Source: UniProt
  10. positive regulation of T cell mediated cytotoxicity Source: InterPro
  11. protection from natural killer cell mediated cytotoxicity Source: UniProt
  12. regulation of immune response Source: Reactome
  13. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_147814. DAP12 signaling.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, alpha chain E
Alternative name(s):
MHC class I antigen E
Gene namesi
Name:HLA-E
Synonyms:HLA-6.2, HLAE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4962. HLA-E.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 305284ExtracellularSequence AnalysisAdd
BLAST
Transmembranei306 – 32924HelicalSequence AnalysisAdd
BLAST
Topological domaini330 – 35829CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. ER to Golgi transport vesicle membrane Source: Reactome
  4. extracellular vesicular exosome Source: UniProt
  5. Golgi membrane Source: Reactome
  6. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  7. MHC class I protein complex Source: UniProtKB-KW
  8. phagocytic vesicle membrane Source: Reactome
  9. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 358337HLA class I histocompatibility antigen, alpha chain EPRO_0000018882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...)1 Publication
Disulfide bondi122 ↔ 185
Disulfide bondi224 ↔ 280

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP13747.
PaxDbiP13747.
PRIDEiP13747.

PTM databases

PhosphoSiteiP13747.

Expressioni

Gene expression databases

CleanExiHS_HLA-E.
GenevestigatoriP13747.

Organism-specific databases

HPAiCAB024589.
HPA031454.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Protein-protein interaction databases

BioGridi109378. 47 interactions.
DIPiDIP-32N.
IntActiP13747. 18 interactions.
STRINGi9606.ENSP00000373091.

Structurei

Secondary structure

1
358
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 3310Combined sources
Beta strandi36 – 405Combined sources
Beta strandi42 – 498Combined sources
Beta strandi52 – 587Combined sources
Beta strandi61 – 633Combined sources
Beta strandi65 – 684Combined sources
Helixi71 – 733Combined sources
Helixi78 – 10528Combined sources
Beta strandi110 – 1123Combined sources
Beta strandi115 – 12410Combined sources
Beta strandi128 – 13912Combined sources
Beta strandi142 – 1476Combined sources
Beta strandi151 – 1588Combined sources
Helixi159 – 1613Combined sources
Helixi162 – 1709Combined sources
Turni171 – 1733Combined sources
Helixi174 – 1829Combined sources
Helixi184 – 19512Combined sources
Helixi197 – 2004Combined sources
Beta strandi207 – 2148Combined sources
Beta strandi216 – 23217Combined sources
Beta strandi235 – 2395Combined sources
Turni241 – 2433Combined sources
Beta strandi249 – 2513Combined sources
Beta strandi258 – 2603Combined sources
Beta strandi262 – 27110Combined sources
Helixi275 – 2773Combined sources
Beta strandi279 – 2835Combined sources
Beta strandi287 – 2893Combined sources
Beta strandi291 – 2933Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KPRX-ray2.80A/C22-295[»]
1KTLX-ray3.10A/C22-295[»]
1MHEX-ray2.85A/C22-295[»]
2ESVX-ray2.60A23-297[»]
3AM8X-ray2.80A/B22-297[»]
3BZEX-ray2.50A/C/E/G23-295[»]
3BZFX-ray2.50A/C22-297[»]
3CDGX-ray3.40A/C23-295[»]
3CIIX-ray4.41A/D23-295[»]
ProteinModelPortaliP13747.
SMRiP13747. Positions 22-297.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13747.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini206 – 29489Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 11190Alpha-1Add
BLAST
Regioni112 – 20392Alpha-2Add
BLAST
Regioni204 – 29592Alpha-3Add
BLAST
Regioni296 – 30510Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG329718.
HOVERGENiHBG016709.
InParanoidiP13747.
KOiK06751.
OMAiGPRYSHA.
PhylomeDBiP13747.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13747-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD
60 70 80 90 100
DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR
110 120 130 140 150
TLRGYYNQSE AGSHTLQWMH GCELGPDRRF LRGYEQFAYD GKDYLTLNED
160 170 180 190 200
LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL
210 220 230 240 250
LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE
260 270 280 290 300
LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ
310 320 330 340 350
PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA

QGSESHSL
Length:358
Mass (Da):40,157
Last modified:August 29, 2003 - v3
Checksum:i2A211B603591D248
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101L → S in AAA52655. (PubMed:3131426)Curated

Polymorphismi

The following alleles of E-1 are known: E*01:01, E*0102, E*01:03 and E*01:04. The sequence shown is that of E*01:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981N → K.
Corresponds to variant rs1059510 [ dbSNP | Ensembl ].
VAR_059510
Natural varianti104 – 1041G → R in allele E*0102.
VAR_004395
Natural varianti128 – 1281R → G in allele E*01:03 and allele E*01:04.
Corresponds to variant rs1264457 [ dbSNP | Ensembl ].
VAR_016651
Natural varianti178 – 1781R → G in allele E*01:04.
Corresponds to variant rs41562314 [ dbSNP | Ensembl ].
VAR_016652

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20022 mRNA. Translation: AAA52655.1.
AJ293263 mRNA. Translation: CAC07212.1.
AJ293264 mRNA. Translation: CAC07213.1.
AF523274 Genomic DNA. Translation: AAM74969.1.
AF523275 Genomic DNA. Translation: AAM74970.1.
AF523276 Genomic DNA. Translation: AAM74971.1.
AF523277 Genomic DNA. Translation: AAM74972.1.
AF523278 Genomic DNA. Translation: AAM74973.1.
AF523279 Genomic DNA. Translation: AAM74974.1.
AF523280 Genomic DNA. Translation: AAM74975.1.
AF523281 Genomic DNA. Translation: AAM74976.1.
AF523282 Genomic DNA. Translation: AAM74977.1.
AF523283 Genomic DNA. Translation: AAM74978.1.
BA000025 Genomic DNA. Translation: BAB63328.1.
BC002578 mRNA. Translation: AAH02578.1.
BC004297 mRNA. Translation: AAH04297.1.
M21533 Genomic DNA. Translation: AAA59835.1.
AY221103 mRNA. Translation: AAO34408.1.
AY216681 mRNA. Translation: AAO37688.1.
M32508 Genomic DNA. Translation: AAA63225.1.
CCDSiCCDS34379.1.
PIRiA28834.
RefSeqiNP_005507.3. NM_005516.5.
UniGeneiHs.650174.

Genome annotation databases

EnsembliENST00000383597; ENSP00000373091; ENSG00000206493.
ENST00000415289; ENSP00000409910; ENSG00000229252.
ENST00000415649; ENSP00000390707; ENSG00000233904.
ENST00000427936; ENSP00000397420; ENSG00000230254.
GeneIDi3133.
KEGGihsa:3133.

Polymorphism databases

DMDMi34395942.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20022 mRNA. Translation: AAA52655.1 .
AJ293263 mRNA. Translation: CAC07212.1 .
AJ293264 mRNA. Translation: CAC07213.1 .
AF523274 Genomic DNA. Translation: AAM74969.1 .
AF523275 Genomic DNA. Translation: AAM74970.1 .
AF523276 Genomic DNA. Translation: AAM74971.1 .
AF523277 Genomic DNA. Translation: AAM74972.1 .
AF523278 Genomic DNA. Translation: AAM74973.1 .
AF523279 Genomic DNA. Translation: AAM74974.1 .
AF523280 Genomic DNA. Translation: AAM74975.1 .
AF523281 Genomic DNA. Translation: AAM74976.1 .
AF523282 Genomic DNA. Translation: AAM74977.1 .
AF523283 Genomic DNA. Translation: AAM74978.1 .
BA000025 Genomic DNA. Translation: BAB63328.1 .
BC002578 mRNA. Translation: AAH02578.1 .
BC004297 mRNA. Translation: AAH04297.1 .
M21533 Genomic DNA. Translation: AAA59835.1 .
AY221103 mRNA. Translation: AAO34408.1 .
AY216681 mRNA. Translation: AAO37688.1 .
M32508 Genomic DNA. Translation: AAA63225.1 .
CCDSi CCDS34379.1.
PIRi A28834.
RefSeqi NP_005507.3. NM_005516.5.
UniGenei Hs.650174.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KPR X-ray 2.80 A/C 22-295 [» ]
1KTL X-ray 3.10 A/C 22-295 [» ]
1MHE X-ray 2.85 A/C 22-295 [» ]
2ESV X-ray 2.60 A 23-297 [» ]
3AM8 X-ray 2.80 A/B 22-297 [» ]
3BZE X-ray 2.50 A/C/E/G 23-295 [» ]
3BZF X-ray 2.50 A/C 22-297 [» ]
3CDG X-ray 3.40 A/C 23-295 [» ]
3CII X-ray 4.41 A/D 23-295 [» ]
ProteinModelPortali P13747.
SMRi P13747. Positions 22-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109378. 47 interactions.
DIPi DIP-32N.
IntActi P13747. 18 interactions.
STRINGi 9606.ENSP00000373091.

PTM databases

PhosphoSitei P13747.

Polymorphism databases

DMDMi 34395942.

Proteomic databases

MaxQBi P13747.
PaxDbi P13747.
PRIDEi P13747.

Protocols and materials databases

DNASUi 3133.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000383597 ; ENSP00000373091 ; ENSG00000206493 .
ENST00000415289 ; ENSP00000409910 ; ENSG00000229252 .
ENST00000415649 ; ENSP00000390707 ; ENSG00000233904 .
ENST00000427936 ; ENSP00000397420 ; ENSG00000230254 .
GeneIDi 3133.
KEGGi hsa:3133.

Organism-specific databases

CTDi 3133.
GeneCardsi GC06P030457.
GC06Pj30447.
GC06Pk30447.
GC06Pn30446.
GC06Po30448.
HGNCi HGNC:4962. HLA-E.
HPAi CAB024589.
HPA031454.
MIMi 143010. gene.
neXtProti NX_P13747.
PharmGKBi PA35081.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG329718.
HOVERGENi HBG016709.
InParanoidi P13747.
KOi K06751.
OMAi GPRYSHA.
PhylomeDBi P13747.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_147814. DAP12 signaling.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-E. human.
EvolutionaryTracei P13747.
GeneWikii HLA-E.
GenomeRNAii 3133.
NextBioi 12427.
PROi P13747.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-E.
Genevestigatori P13747.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene."
    Mizuno S., Trapani J.A., Koller B.H., Dupont B., Yang S.Y.
    J. Immunol. 140:4024-4030(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE E*01:01).
  2. "Cell surface expression of HLA-E: interaction with human beta-2 microglobulin and allelic differences."
    Ulbrecht M., Courturier A., Martinozzi S., Pla M., Srivastava R., Peterson P.A., Weiss E.H.
    Eur. J. Immunol. 29:537-547(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELES E*01:01 AND E*01:03).
  3. "HLA-E, F, and G polymorphism: genomic sequence defines new variation spanning the nonclassical class I genes."
    Ishitani A., Miki A., Williams L.M., Moore Y., Geraghty D.E.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELES E*01:01 AND E*01:03).
  4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE E*01:01).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE E*01:01).
    Tissue: Ovarian adenocarcinoma and Pancreas.
  6. "HLA-E. A novel HLA class I gene expressed in resting T lymphocytes."
    Koller B.H., Geraghty D.E., Shimizu Y., Demars R., Orr H.T.
    J. Immunol. 141:897-904(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE E*0102).
  7. Ulbrecht M.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE E*01:03).
  8. "A new variant of HLA-E*010303 with three synonymous mutations."
    He X., Xu L., Liu Y., Zeng Y.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE E*01:03).
  9. "Cloning of HLA-E cDNA from activated peripheral leukocytes."
    He X., Xu L., Liu Y., Zeng Y.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE E*01:03).
  10. "Polymorphism in the human class I MHC locus HLA-E in Japanese."
    Ohya K., Kondo K., Mizuno S.
    Immunogenetics 32:205-209(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 112-203 (ALLELE E*01:04).
    Tissue: Peripheral blood.
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-107.
    Tissue: Leukemic T-cell.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E."
    O'Callaghan C.A., Tormo J., Willcox B.E., Braud V.M., Jakobsen B.K., Stuart D.I., McMichael A.J., Bell J.I., Jones E.Y.
    Mol. Cell 1:531-541(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 22-295.
  14. "Definitive high resolution typing of HLA-E allelic polymorphisms: identifying potential errors in existing allele data."
    Grimsley C., Kawasaki A., Gassner C., Sageshima N., Nose Y., Hatake K., Geraghty D.E., Ishitani A.
    Tissue Antigens 60:206-212(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM, QUESTIONING ON ALLELES E*0102 AND E*01:04.

Entry informationi

Entry nameiHLAE_HUMAN
AccessioniPrimary (citable) accession number: P13747
Secondary accession number(s): Q30169
, Q9BT83, Q9GIY7, Q9GIY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 29, 2003
Last modified: November 26, 2014
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The existence of allele E*0102 (PubMed:3260916) and allele E*0104 (PubMed:1977695) is uncertain. The alleles could not be confirmed in further studies (PubMed:12445303).3 Publications

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3