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Protein

HLA class I histocompatibility antigen, alpha chain E

Gene

HLA-E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • MHC class I protein binding Source: UniProtKB
  • natural killer cell lectin-like receptor binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137361-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.
R-HSA-2424491. DAP12 signaling.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, alpha chain E
Alternative name(s):
MHC class I antigen E
Gene namesi
Name:HLA-E
Synonyms:HLA-6.2, HLAE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4962. HLA-E.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 305ExtracellularSequence analysisAdd BLAST284
Transmembranei306 – 329HelicalSequence analysisAdd BLAST24
Topological domaini330 – 358CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • early endosome membrane Source: Reactome
  • ER to Golgi transport vesicle membrane Source: Reactome
  • extracellular exosome Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  • MHC class Ib protein complex Source: UniProtKB
  • MHC class I protein complex Source: UniProtKB
  • phagocytic vesicle membrane Source: Reactome
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3133.
OpenTargetsiENSG00000206493.
ENSG00000229252.
ENSG00000230254.
ENSG00000233904.
PharmGKBiPA35081.

Polymorphism and mutation databases

BioMutaiHLA-E.
DMDMi34395942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001888222 – 358HLA class I histocompatibility antigen, alpha chain EAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...)1 Publication1
Disulfide bondi122 ↔ 185
Disulfide bondi224 ↔ 280

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP13747.
PaxDbiP13747.
PeptideAtlasiP13747.
PRIDEiP13747.
TopDownProteomicsiP13747.

PTM databases

iPTMnetiP13747.
PhosphoSitePlusiP13747.
SwissPalmiP13747.

Expressioni

Gene expression databases

BgeeiENSG00000206493.
CleanExiHS_HLA-E.

Organism-specific databases

HPAiHPA031454.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • MHC class I protein binding Source: UniProtKB
  • natural killer cell lectin-like receptor binding Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109378. 49 interactors.
DIPiDIP-32N.
IntActiP13747. 18 interactors.
STRINGi9606.ENSP00000365817.

Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 33Combined sources10
Beta strandi36 – 40Combined sources5
Beta strandi42 – 49Combined sources8
Beta strandi52 – 58Combined sources7
Beta strandi61 – 63Combined sources3
Beta strandi65 – 68Combined sources4
Helixi71 – 73Combined sources3
Helixi78 – 105Combined sources28
Beta strandi110 – 112Combined sources3
Beta strandi115 – 124Combined sources10
Beta strandi128 – 139Combined sources12
Beta strandi142 – 147Combined sources6
Beta strandi151 – 158Combined sources8
Helixi159 – 161Combined sources3
Helixi162 – 170Combined sources9
Turni171 – 173Combined sources3
Helixi174 – 182Combined sources9
Helixi184 – 195Combined sources12
Helixi197 – 200Combined sources4
Beta strandi207 – 214Combined sources8
Beta strandi216 – 232Combined sources17
Beta strandi235 – 239Combined sources5
Turni241 – 243Combined sources3
Beta strandi249 – 251Combined sources3
Beta strandi258 – 260Combined sources3
Beta strandi262 – 271Combined sources10
Helixi275 – 277Combined sources3
Beta strandi279 – 283Combined sources5
Beta strandi287 – 289Combined sources3
Beta strandi291 – 293Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KPRX-ray2.80A/C22-295[»]
1KTLX-ray3.10A/C22-295[»]
1MHEX-ray2.85A/C22-295[»]
2ESVX-ray2.60A23-297[»]
3AM8X-ray2.80A/B22-297[»]
3BZEX-ray2.50A/C/E/G23-295[»]
3BZFX-ray2.50A/C22-297[»]
3CDGX-ray3.40A/C23-295[»]
3CIIX-ray4.41A/D23-295[»]
ProteinModelPortaliP13747.
SMRiP13747.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13747.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 294Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 111Alpha-1Add BLAST90
Regioni112 – 203Alpha-2Add BLAST92
Regioni204 – 295Alpha-3Add BLAST92
Regioni296 – 305Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JD1V. Eukaryota.
ENOG410YKQA. LUCA.
HOVERGENiHBG016709.
InParanoidiP13747.
KOiK06751.
OMAiRSHISHH.
OrthoDBiEOG091G09OH.
PhylomeDBiP13747.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD
60 70 80 90 100
DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR
110 120 130 140 150
TLRGYYNQSE AGSHTLQWMH GCELGPDRRF LRGYEQFAYD GKDYLTLNED
160 170 180 190 200
LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL
210 220 230 240 250
LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE
260 270 280 290 300
LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ
310 320 330 340 350
PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA

QGSESHSL
Length:358
Mass (Da):40,157
Last modified:August 29, 2003 - v3
Checksum:i2A211B603591D248
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10L → S in AAA52655 (PubMed:3131426).Curated1

Polymorphismi

The following alleles of E-1 are known: E*01:01, E*01:02, E*01:03 and E*01:04. The sequence shown is that of E*01:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05951098N → K.Corresponds to variant rs1059510dbSNPEnsembl.1
Natural variantiVAR_004395104G → R in allele E*01:02. 1
Natural variantiVAR_016651128R → G in allele E*01:03 and allele E*01:04. Corresponds to variant rs1264457dbSNPEnsembl.1
Natural variantiVAR_016652178R → G in allele E*01:04. Corresponds to variant rs41562314dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20022 mRNA. Translation: AAA52655.1.
AJ293263 mRNA. Translation: CAC07212.1.
AJ293264 mRNA. Translation: CAC07213.1.
AF523274 Genomic DNA. Translation: AAM74969.1.
AF523275 Genomic DNA. Translation: AAM74970.1.
AF523276 Genomic DNA. Translation: AAM74971.1.
AF523277 Genomic DNA. Translation: AAM74972.1.
AF523278 Genomic DNA. Translation: AAM74973.1.
AF523279 Genomic DNA. Translation: AAM74974.1.
AF523280 Genomic DNA. Translation: AAM74975.1.
AF523281 Genomic DNA. Translation: AAM74976.1.
AF523282 Genomic DNA. Translation: AAM74977.1.
AF523283 Genomic DNA. Translation: AAM74978.1.
BA000025 Genomic DNA. Translation: BAB63328.1.
BC002578 mRNA. Translation: AAH02578.1.
BC004297 mRNA. Translation: AAH04297.1.
M21533 Genomic DNA. Translation: AAA59835.1.
AY221103 mRNA. Translation: AAO34408.1.
AY216681 mRNA. Translation: AAO37688.1.
M32508 Genomic DNA. Translation: AAA63225.1.
CCDSiCCDS34379.1.
PIRiA28834.
RefSeqiNP_005507.3. NM_005516.5.
UniGeneiHs.650174.

Genome annotation databases

EnsembliENST00000383597; ENSP00000373091; ENSG00000206493.
ENST00000415289; ENSP00000409910; ENSG00000229252.
ENST00000415649; ENSP00000390707; ENSG00000233904.
ENST00000427936; ENSP00000397420; ENSG00000230254.
GeneIDi3133.
KEGGihsa:3133.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20022 mRNA. Translation: AAA52655.1.
AJ293263 mRNA. Translation: CAC07212.1.
AJ293264 mRNA. Translation: CAC07213.1.
AF523274 Genomic DNA. Translation: AAM74969.1.
AF523275 Genomic DNA. Translation: AAM74970.1.
AF523276 Genomic DNA. Translation: AAM74971.1.
AF523277 Genomic DNA. Translation: AAM74972.1.
AF523278 Genomic DNA. Translation: AAM74973.1.
AF523279 Genomic DNA. Translation: AAM74974.1.
AF523280 Genomic DNA. Translation: AAM74975.1.
AF523281 Genomic DNA. Translation: AAM74976.1.
AF523282 Genomic DNA. Translation: AAM74977.1.
AF523283 Genomic DNA. Translation: AAM74978.1.
BA000025 Genomic DNA. Translation: BAB63328.1.
BC002578 mRNA. Translation: AAH02578.1.
BC004297 mRNA. Translation: AAH04297.1.
M21533 Genomic DNA. Translation: AAA59835.1.
AY221103 mRNA. Translation: AAO34408.1.
AY216681 mRNA. Translation: AAO37688.1.
M32508 Genomic DNA. Translation: AAA63225.1.
CCDSiCCDS34379.1.
PIRiA28834.
RefSeqiNP_005507.3. NM_005516.5.
UniGeneiHs.650174.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KPRX-ray2.80A/C22-295[»]
1KTLX-ray3.10A/C22-295[»]
1MHEX-ray2.85A/C22-295[»]
2ESVX-ray2.60A23-297[»]
3AM8X-ray2.80A/B22-297[»]
3BZEX-ray2.50A/C/E/G23-295[»]
3BZFX-ray2.50A/C22-297[»]
3CDGX-ray3.40A/C23-295[»]
3CIIX-ray4.41A/D23-295[»]
ProteinModelPortaliP13747.
SMRiP13747.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109378. 49 interactors.
DIPiDIP-32N.
IntActiP13747. 18 interactors.
STRINGi9606.ENSP00000365817.

PTM databases

iPTMnetiP13747.
PhosphoSitePlusiP13747.
SwissPalmiP13747.

Polymorphism and mutation databases

BioMutaiHLA-E.
DMDMi34395942.

Proteomic databases

EPDiP13747.
PaxDbiP13747.
PeptideAtlasiP13747.
PRIDEiP13747.
TopDownProteomicsiP13747.

Protocols and materials databases

DNASUi3133.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383597; ENSP00000373091; ENSG00000206493.
ENST00000415289; ENSP00000409910; ENSG00000229252.
ENST00000415649; ENSP00000390707; ENSG00000233904.
ENST00000427936; ENSP00000397420; ENSG00000230254.
GeneIDi3133.
KEGGihsa:3133.

Organism-specific databases

CTDi3133.
DisGeNETi3133.
GeneCardsiHLA-E.
HGNCiHGNC:4962. HLA-E.
HPAiHPA031454.
MIMi143010. gene.
neXtProtiNX_P13747.
OpenTargetsiENSG00000206493.
ENSG00000229252.
ENSG00000230254.
ENSG00000233904.
PharmGKBiPA35081.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JD1V. Eukaryota.
ENOG410YKQA. LUCA.
HOVERGENiHBG016709.
InParanoidiP13747.
KOiK06751.
OMAiRSHISHH.
OrthoDBiEOG091G09OH.
PhylomeDBiP13747.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137361-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.
R-HSA-2424491. DAP12 signaling.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-E. human.
EvolutionaryTraceiP13747.
GeneWikiiHLA-E.
GenomeRNAii3133.
PROiP13747.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000206493.
CleanExiHS_HLA-E.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHLAE_HUMAN
AccessioniPrimary (citable) accession number: P13747
Secondary accession number(s): Q30169
, Q9BT83, Q9GIY7, Q9GIY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 29, 2003
Last modified: November 2, 2016
This is version 173 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The existence of allele E*01:02 (PubMed:3260916) and allele E*01:04 (PubMed:1977695) is uncertain. The alleles could not be confirmed in further studies (PubMed:12445303).3 Publications

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.