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P13747

- HLAE_HUMAN

UniProt

P13747 - HLAE_HUMAN

Protein

HLA class I histocompatibility antigen, alpha chain E

Gene

HLA-E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 153 (01 Oct 2014)
      Sequence version 3 (29 Aug 2003)
      Previous versions | rss
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    Functioni

    Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.

    GO - Molecular functioni

    1. MHC class I protein binding Source: UniProt
    2. peptide antigen binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: UniProt
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    4. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    5. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    6. cytokine-mediated signaling pathway Source: Reactome
    7. innate immune response Source: Reactome
    8. interferon-gamma-mediated signaling pathway Source: Reactome
    9. positive regulation of natural killer cell mediated immunity Source: UniProt
    10. positive regulation of T cell mediated cytotoxicity Source: InterPro
    11. protection from natural killer cell mediated cytotoxicity Source: UniProt
    12. regulation of immune response Source: Reactome
    13. type I interferon signaling pathway Source: Reactome

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_147694. DAP12 interactions.
    REACT_147814. DAP12 signaling.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, alpha chain E
    Alternative name(s):
    MHC class I antigen E
    Gene namesi
    Name:HLA-E
    Synonyms:HLA-6.2, HLAE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4962. HLA-E.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. early endosome membrane Source: Reactome
    3. ER to Golgi transport vesicle membrane Source: Reactome
    4. extracellular vesicular exosome Source: UniProt
    5. Golgi membrane Source: Reactome
    6. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    7. MHC class I protein complex Source: UniProtKB-KW
    8. phagocytic vesicle membrane Source: Reactome
    9. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35081.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 358337HLA class I histocompatibility antigen, alpha chain EPRO_0000018882Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi107 – 1071N-linked (GlcNAc...)1 Publication
    Disulfide bondi122 ↔ 185
    Disulfide bondi224 ↔ 280

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP13747.
    PaxDbiP13747.
    PRIDEiP13747.

    PTM databases

    PhosphoSiteiP13747.

    Expressioni

    Gene expression databases

    CleanExiHS_HLA-E.
    GenevestigatoriP13747.

    Organism-specific databases

    HPAiCAB024589.
    HPA031454.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

    Protein-protein interaction databases

    BioGridi109378. 6 interactions.
    DIPiDIP-32N.
    IntActiP13747. 18 interactions.
    STRINGi9606.ENSP00000373091.

    Structurei

    Secondary structure

    1
    358
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi24 – 3310
    Beta strandi36 – 405
    Beta strandi42 – 498
    Beta strandi52 – 587
    Beta strandi61 – 633
    Beta strandi65 – 684
    Helixi71 – 733
    Helixi78 – 10528
    Beta strandi110 – 1123
    Beta strandi115 – 12410
    Beta strandi128 – 13912
    Beta strandi142 – 1476
    Beta strandi151 – 1588
    Helixi159 – 1613
    Helixi162 – 1709
    Turni171 – 1733
    Helixi174 – 1829
    Helixi184 – 19512
    Helixi197 – 2004
    Beta strandi207 – 2148
    Beta strandi216 – 23217
    Beta strandi235 – 2395
    Turni241 – 2433
    Beta strandi249 – 2513
    Beta strandi258 – 2603
    Beta strandi262 – 27110
    Helixi275 – 2773
    Beta strandi279 – 2835
    Beta strandi287 – 2893
    Beta strandi291 – 2933

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KPRX-ray2.80A/C22-295[»]
    1KTLX-ray3.10A/C22-295[»]
    1MHEX-ray2.85A/C22-295[»]
    2ESVX-ray2.60A23-297[»]
    3AM8X-ray2.80A/B22-297[»]
    3BZEX-ray2.50A/C/E/G23-295[»]
    3BZFX-ray2.50A/C22-297[»]
    3CDGX-ray3.40A/C23-295[»]
    3CIIX-ray4.41A/D23-295[»]
    ProteinModelPortaliP13747.
    SMRiP13747. Positions 22-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP13747.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 305284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini330 – 35829CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei306 – 32924HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini206 – 29489Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 11190Alpha-1Add
    BLAST
    Regioni112 – 20392Alpha-2Add
    BLAST
    Regioni204 – 29592Alpha-3Add
    BLAST
    Regioni296 – 30510Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG329718.
    HOVERGENiHBG016709.
    InParanoidiP13747.
    KOiK06751.
    OMAiGPRYSHA.
    PhylomeDBiP13747.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13747-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD    50
    DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR 100
    TLRGYYNQSE AGSHTLQWMH GCELGPDRRF LRGYEQFAYD GKDYLTLNED 150
    LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL 200
    LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE 250
    LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ 300
    PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA 350
    QGSESHSL 358
    Length:358
    Mass (Da):40,157
    Last modified:August 29, 2003 - v3
    Checksum:i2A211B603591D248
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101L → S in AAA52655. (PubMed:3131426)Curated

    Polymorphismi

    The following alleles of E-1 are known: E*01:01, E*0102, E*01:03 and E*01:04. The sequence shown is that of E*01:01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti98 – 981N → K.
    Corresponds to variant rs1059510 [ dbSNP | Ensembl ].
    VAR_059510
    Natural varianti104 – 1041G → R in allele E*0102.
    VAR_004395
    Natural varianti128 – 1281R → G in allele E*01:03 and allele E*01:04.
    Corresponds to variant rs1264457 [ dbSNP | Ensembl ].
    VAR_016651
    Natural varianti178 – 1781R → G in allele E*01:04.
    Corresponds to variant rs41562314 [ dbSNP | Ensembl ].
    VAR_016652

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20022 mRNA. Translation: AAA52655.1.
    AJ293263 mRNA. Translation: CAC07212.1.
    AJ293264 mRNA. Translation: CAC07213.1.
    AF523274 Genomic DNA. Translation: AAM74969.1.
    AF523275 Genomic DNA. Translation: AAM74970.1.
    AF523276 Genomic DNA. Translation: AAM74971.1.
    AF523277 Genomic DNA. Translation: AAM74972.1.
    AF523278 Genomic DNA. Translation: AAM74973.1.
    AF523279 Genomic DNA. Translation: AAM74974.1.
    AF523280 Genomic DNA. Translation: AAM74975.1.
    AF523281 Genomic DNA. Translation: AAM74976.1.
    AF523282 Genomic DNA. Translation: AAM74977.1.
    AF523283 Genomic DNA. Translation: AAM74978.1.
    BA000025 Genomic DNA. Translation: BAB63328.1.
    BC002578 mRNA. Translation: AAH02578.1.
    BC004297 mRNA. Translation: AAH04297.1.
    M21533 Genomic DNA. Translation: AAA59835.1.
    AY221103 mRNA. Translation: AAO34408.1.
    AY216681 mRNA. Translation: AAO37688.1.
    M32508 Genomic DNA. Translation: AAA63225.1.
    CCDSiCCDS34379.1.
    PIRiA28834.
    RefSeqiNP_005507.3. NM_005516.5.
    UniGeneiHs.650174.

    Genome annotation databases

    EnsembliENST00000383597; ENSP00000373091; ENSG00000206493.
    ENST00000415289; ENSP00000409910; ENSG00000229252.
    ENST00000415649; ENSP00000390707; ENSG00000233904.
    ENST00000427936; ENSP00000397420; ENSG00000230254.
    GeneIDi3133.
    KEGGihsa:3133.

    Polymorphism databases

    DMDMi34395942.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20022 mRNA. Translation: AAA52655.1 .
    AJ293263 mRNA. Translation: CAC07212.1 .
    AJ293264 mRNA. Translation: CAC07213.1 .
    AF523274 Genomic DNA. Translation: AAM74969.1 .
    AF523275 Genomic DNA. Translation: AAM74970.1 .
    AF523276 Genomic DNA. Translation: AAM74971.1 .
    AF523277 Genomic DNA. Translation: AAM74972.1 .
    AF523278 Genomic DNA. Translation: AAM74973.1 .
    AF523279 Genomic DNA. Translation: AAM74974.1 .
    AF523280 Genomic DNA. Translation: AAM74975.1 .
    AF523281 Genomic DNA. Translation: AAM74976.1 .
    AF523282 Genomic DNA. Translation: AAM74977.1 .
    AF523283 Genomic DNA. Translation: AAM74978.1 .
    BA000025 Genomic DNA. Translation: BAB63328.1 .
    BC002578 mRNA. Translation: AAH02578.1 .
    BC004297 mRNA. Translation: AAH04297.1 .
    M21533 Genomic DNA. Translation: AAA59835.1 .
    AY221103 mRNA. Translation: AAO34408.1 .
    AY216681 mRNA. Translation: AAO37688.1 .
    M32508 Genomic DNA. Translation: AAA63225.1 .
    CCDSi CCDS34379.1.
    PIRi A28834.
    RefSeqi NP_005507.3. NM_005516.5.
    UniGenei Hs.650174.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KPR X-ray 2.80 A/C 22-295 [» ]
    1KTL X-ray 3.10 A/C 22-295 [» ]
    1MHE X-ray 2.85 A/C 22-295 [» ]
    2ESV X-ray 2.60 A 23-297 [» ]
    3AM8 X-ray 2.80 A/B 22-297 [» ]
    3BZE X-ray 2.50 A/C/E/G 23-295 [» ]
    3BZF X-ray 2.50 A/C 22-297 [» ]
    3CDG X-ray 3.40 A/C 23-295 [» ]
    3CII X-ray 4.41 A/D 23-295 [» ]
    ProteinModelPortali P13747.
    SMRi P13747. Positions 22-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109378. 6 interactions.
    DIPi DIP-32N.
    IntActi P13747. 18 interactions.
    STRINGi 9606.ENSP00000373091.

    PTM databases

    PhosphoSitei P13747.

    Polymorphism databases

    DMDMi 34395942.

    Proteomic databases

    MaxQBi P13747.
    PaxDbi P13747.
    PRIDEi P13747.

    Protocols and materials databases

    DNASUi 3133.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383597 ; ENSP00000373091 ; ENSG00000206493 .
    ENST00000415289 ; ENSP00000409910 ; ENSG00000229252 .
    ENST00000415649 ; ENSP00000390707 ; ENSG00000233904 .
    ENST00000427936 ; ENSP00000397420 ; ENSG00000230254 .
    GeneIDi 3133.
    KEGGi hsa:3133.

    Organism-specific databases

    CTDi 3133.
    GeneCardsi GC06P030457.
    GC06Pj30447.
    GC06Pk30447.
    GC06Pn30446.
    GC06Po30448.
    HGNCi HGNC:4962. HLA-E.
    HPAi CAB024589.
    HPA031454.
    MIMi 143010. gene.
    neXtProti NX_P13747.
    PharmGKBi PA35081.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329718.
    HOVERGENi HBG016709.
    InParanoidi P13747.
    KOi K06751.
    OMAi GPRYSHA.
    PhylomeDBi P13747.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_147694. DAP12 interactions.
    REACT_147814. DAP12 signaling.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-E. human.
    EvolutionaryTracei P13747.
    GeneWikii HLA-E.
    GenomeRNAii 3133.
    NextBioi 12427.
    PROi P13747.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_HLA-E.
    Genevestigatori P13747.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene."
      Mizuno S., Trapani J.A., Koller B.H., Dupont B., Yang S.Y.
      J. Immunol. 140:4024-4030(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE E*01:01).
    2. "Cell surface expression of HLA-E: interaction with human beta-2 microglobulin and allelic differences."
      Ulbrecht M., Courturier A., Martinozzi S., Pla M., Srivastava R., Peterson P.A., Weiss E.H.
      Eur. J. Immunol. 29:537-547(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ALLELES E*01:01 AND E*01:03).
    3. "HLA-E, F, and G polymorphism: genomic sequence defines new variation spanning the nonclassical class I genes."
      Ishitani A., Miki A., Williams L.M., Moore Y., Geraghty D.E.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELES E*01:01 AND E*01:03).
    4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE E*01:01).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE E*01:01).
      Tissue: Ovarian adenocarcinoma and Pancreas.
    6. "HLA-E. A novel HLA class I gene expressed in resting T lymphocytes."
      Koller B.H., Geraghty D.E., Shimizu Y., Demars R., Orr H.T.
      J. Immunol. 141:897-904(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE E*0102).
    7. Ulbrecht M.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE E*01:03).
    8. "A new variant of HLA-E*010303 with three synonymous mutations."
      He X., Xu L., Liu Y., Zeng Y.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE E*01:03).
    9. "Cloning of HLA-E cDNA from activated peripheral leukocytes."
      He X., Xu L., Liu Y., Zeng Y.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE E*01:03).
    10. "Polymorphism in the human class I MHC locus HLA-E in Japanese."
      Ohya K., Kondo K., Mizuno S.
      Immunogenetics 32:205-209(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 112-203 (ALLELE E*01:04).
      Tissue: Peripheral blood.
    11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-107.
      Tissue: Leukemic T-cell.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E."
      O'Callaghan C.A., Tormo J., Willcox B.E., Braud V.M., Jakobsen B.K., Stuart D.I., McMichael A.J., Bell J.I., Jones E.Y.
      Mol. Cell 1:531-541(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 22-295.
    14. "Definitive high resolution typing of HLA-E allelic polymorphisms: identifying potential errors in existing allele data."
      Grimsley C., Kawasaki A., Gassner C., Sageshima N., Nose Y., Hatake K., Geraghty D.E., Ishitani A.
      Tissue Antigens 60:206-212(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM, QUESTIONING ON ALLELES E*0102 AND E*01:04.

    Entry informationi

    Entry nameiHLAE_HUMAN
    AccessioniPrimary (citable) accession number: P13747
    Secondary accession number(s): Q30169
    , Q9BT83, Q9GIY7, Q9GIY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: August 29, 2003
    Last modified: October 1, 2014
    This is version 153 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The existence of allele E*0102 (PubMed:3260916) and allele E*0104 (PubMed:1977695) is uncertain. The alleles could not be confirmed in further studies (PubMed:12445303).3 Publications

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3