P13746 (1A11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, A-11 alpha chain

Alternative name(s):
MHC class I antigen A*11

Gene names

Name:	HLA-A
Synonyms:	HLAA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of A-11 are known: A*11:01 (A-11E), A*11:02 (A-11K), A*11:03, A*11:04, A*11:05 and A*11:07. The sequence shown is that of A*11:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Non-traceable author statement Ref.11. Source: UniProtKB virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Non-traceable author statement Ref.11. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P13746-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P13746-2)

Also known as: Long;

The sequence of this isoform differs from the canonical sequence as follows:
     337-337: S → SGGEGVK

Note: Only produced by allele A*1103.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Chain

25 – 365

341

HLA class I histocompatibility antigen, A-11 alpha chain

PRO_0000018816

Regions

Topological domain

25 – 308

284

Extracellular Potential

Transmembrane

309 – 332

24

Helical; Potential

Topological domain

333 – 365

33

Cytoplasmic Potential

Domain

209 – 295

87

Ig-like C1-type

Region

25 – 114

90

Alpha-1

Region

115 – 206

92

Alpha-2

Region

207 – 298

92

Alpha-3

Region

299 – 308

10

Connecting peptide

Amino acid modifications

Glycosylation

110

1

N-linked (GlcNAc...) By similarity

Disulfide bond

125 ↔ 188

Ref.13

Disulfide bond

227 ↔ 283

Ref.13

Natural variations

Alternative sequence

337

1

S → SGGEGVK in isoform 2.

VSP_008099

Natural variant

43

1

E → K in allele A*11:02.

VAR_004353

Natural variant

89

1

R → G.
Corresponds to variant rs1059459 [ dbSNP | Ensembl ].

VAR_056254

Natural variant

94

1

Q → H.
Corresponds to variant rs1059463 [ dbSNP | Ensembl ].

VAR_056255

Natural variant

101

1

D → N.
Corresponds to variant rs1136688 [ dbSNP | Ensembl ].

VAR_056256

Natural variant

131

1

G → W.
Corresponds to variant rs1136702 [ dbSNP | Ensembl ].

VAR_056257

Natural variant

133

1

F → L in allele A*11:07.
Corresponds to variant rs1059488 [ dbSNP | Ensembl ].

VAR_016731

Natural variant

151

1

N → K.
Corresponds to variant rs1059509 [ dbSNP | Ensembl ].

VAR_056258

Natural variant

166

1

I → T.
Corresponds to variant rs1059516 [ dbSNP | Ensembl ].

VAR_056259

Natural variant

168

1

K → E in allele A*11:05.

VAR_016732

Natural variant

169

1

R → H.
Corresponds to variant rs1059520 [ dbSNP | Ensembl ].

VAR_056260

Natural variant

175

1

H → R in allele A*11:03.

VAR_016733

Natural variant

176

1

A → E in allele A*11:03.

VAR_016734

Natural variant

187

1

R → T in allele A*11:04.

VAR_016735

Natural variant

205

1

R → H.
Corresponds to variant rs17185861 [ dbSNP | Ensembl ].

VAR_056261

Natural variant

345

1

T → S in allele A*11:05.

VAR_016736

Secondary structure

1

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365

Helix Strand Turn

Details...

Beta strand

27 – 36

10

Beta strand

41 – 43

3

Beta strand

45 – 52

8

Beta strand

55 – 61

7

Beta strand

64 – 66

3

Helix

74 – 76

3

Helix

81 – 108

28

Beta strand

113 – 115

3

Beta strand

118 – 127

10

Beta strand

133 – 142

10

Beta strand

145 – 150

6

Beta strand

157 – 159

3

Helix

162 – 173

12

Helix

176 – 185

10

Helix

187 – 198

12

Helix

200 – 203

4

Beta strand

210 – 217

8

Beta strand

219 – 235

17

Beta strand

238 – 243

6

Beta strand

246 – 248

3

Beta strand

252 – 254

3

Beta strand

261 – 263

3

Beta strand

265 – 274

10

Helix

278 – 280

3

Beta strand

281 – 286

6

Beta strand

288 – 292

5

Beta strand

294 – 297

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: FE449CE2D4BF6CC5	FASTA	365	40,937
	10 20 30 40 50 60 MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEDGSHTIQ 130 140 150 160 170 180 IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHAAEQQ 190 200 210 220 230 240 RAYLEGRCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL 310 320 330 340 350 360 SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV
	Isoform 2 (Long) [UniParc]. Checksum: 062B8A9EEA8C7C4E	FASTA	371	41,464
	10 20 30 40 50 60 MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEDGSHTIQ 130 140 150 160 170 180 IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHAAEQQ 190 200 210 220 230 240 RAYLEGRCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL 310 320 330 340 350 360 SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSGGE GVKDRKGGSY TQAASSDSAQ 370 GSDVSLTACK V

References

[1]	"Nucleotide sequences of chimpanzee MHC class I alleles: evidence for trans-species mode of evolution." Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J. EMBO J. 7:2765-2774(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*11:01 AND A*11:02).
[2]	"Sequence analysis of serological HLA-A11 split antigens, A11.1 and A11.2." Lin L., Tokunaga K., Ishikawa Y., Bannai M., Kashiwase K., Kuwata S., Akaza T., Tadokoro K., Shibata Y., Juji T. Tissue Antigens 43:78-82(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*11:01 AND A*11:02).
[3]	"Identification of an HLA-A11 serological variant and its characterization by sequencing based typing." Morrell G., Whalley J., Stewart A., Day S., Lewis L., Makar Y., Ross J., Dunn P.P. Tissue Antigens 53:591-594(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*11:05).
[4]	"Complete sequence analysis of the A*1103 allele." Tijssen H.J., Sistermans E.A., van den Beucken M.J.G., Krausa P., Joosten I. Tissue Antigens 55:68-70(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:03). Tissue: Blood.
[5]	"A unique second donor splice site in the intron 5 sequence of the HLA-A*11 alleles results in a class I transcript encoding a molecule with an elongated cytoplasmic domain." Tijssen H.J., Sistermans E.A., Joosten I. Tissue Antigens 55:422-428(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:03). Tissue: Blood.
[6]	"Seventeen more novel HLA-A locus alleles." Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 55:369-373(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*11:05).
[7]	"Identification of HLA-A*11 variant (A*1107) in the Korean population." Pyo C.W., Choi H.B., Han H., Hong Y.S., Kim T.G. Tissue Antigens 58:190-192(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:07).
[8]	"Identification and frequency of a novel HLA-A allele, A*110104." Sun Y., Liu S., Luo Y., Liang F., Xi Y. Tissue Antigens 68:453-454(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:04) (ISOFORM 2).
[9]	"Cloning of high frequency HLA-B alleles from Chinese population." Xu L.-H., Chi X.-Y., Jia Q.-T., Li F.-Y., Zha Q.-B., He X.-H. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:04) (ISOFORM 2).
[10]	Bettinotti M.P. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*11:04).
[11]	"DNA sequence of HLA-A11: remarkable homology with HLA-A3 allows identification of residues involved in epitopes recognized by antibodies and T cells." Cowan E.P., Jelachich M.L., Biddison W.E., Coligan J.E. Immunogenetics 25:241-250(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-365 (ALLELE A*11:01).
[12]	"A11 alleles (A*11O4)." Chandanayingyong D., Sirikong M., Luangtrakool K., Srinak D., Rungroung E., Bejchandra S. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*11:04).
[13]	"High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide." Blicher T., Kastrup J.S., Buus S., Gajhede M. Acta Crystallogr. D 61:1031-1040(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 25-299 (ALLELE A*11:01) IN COMPLEX WITH SARS NUCLEOCAPSID PEPTIDE, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X13111 mRNA. Translation: CAA31503.1.
X13112 mRNA. Translation: CAA31504.1.
D16841 mRNA. Translation: BAA04117.1.
D16842 mRNA. Translation: BAA04118.1.
AJ306733 Genomic DNA. Translation: CAC37336.1.
X91399 mRNA. Translation: CAA62745.1.
Y17224 mRNA. Translation: CAB38056.1.
Y17224 mRNA. Translation: CAB38057.1.
AH007763 Genomic DNA. Translation: AAD33991.1.
AF165065 mRNA. Translation: AAF25781.1.
DQ336694 mRNA. Translation: ABC59611.1.
AY786586 mRNA. Translation: AAV53344.1.
AY786587 mRNA. Translation: AAV53345.1.
U50574 mRNA. Translation: AAB60406.1.
AH003070 Genomic DNA. Translation: AAA65449.1.
AH005647 Genomic DNA. Translation: AAB87052.1.
AH005646 Genomic DNA. Translation: AAB87051.1.

IPI

IPI00472112.
IPI00472448.

PIR

I83063.
A47636. S03536.

UniGene

Hs.181244.
Hs.713441.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Q94	X-ray	2.40	A/D	25-299	[»]
1QVO	X-ray	2.22	A/D	25-299	[»]
1X7Q	X-ray	1.45	A	25-299	[»]
2HN7	X-ray	1.60	A	25-299	[»]

ProteinModelPortal

P13746.

ModBase

Search...

Polymorphism databases

DMDM

122157.

Proteomic databases

PRIDE

P13746.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000376809; ENSP00000366005; ENSG00000206503.
ENST00000396634; ENSP00000379873; ENSG00000206503.

Organism-specific databases

GeneCards

GC06P029933.

HGNC

HGNC:4931. HLA-A.

MIM

142800. gene.

neXtProt

NX_P13746.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

HBG016709.

Gene expression databases

ArrayExpress

P13746.

Bgee

P13746.

CleanEx

HS_HLA-A.

Genevestigator

P13746.

GermOnline

ENSG00000204632. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.30.500.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]

PRINTS

PR01638. MHCCLASSI.

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

HLA-A. human.

EvolutionaryTrace

P13746.

SOURCE

Search...

Entry information

Entry name

1A11_HUMAN

Accession

Primary (citable) accession number: P13746
Secondary accession number(s): O19605 , O19606, Q29747, Q29835, Q5S3G1, Q9BCN0, Q9MYI5, Q9TQE9, Q9TQP6, Q9TQP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.