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Protein

HLA class I histocompatibility antigen, A-11 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • TAP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-11 alpha chain
Alternative name(s):
MHC class I antigen A*11
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000206503.11
HGNCiHGNC:4931 HLA-A
MIMi142800 gene
neXtProtiNX_P13746

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 365CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3105
MalaCardsiHLA-A

Polymorphism and mutation databases

DMDMi122157

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001881625 – 365HLA class I histocompatibility antigen, A-11 alpha chainAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication
Modified residuei343PhosphoserineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP13746
MaxQBiP13746
PeptideAtlasiP13746
PRIDEiP13746

PTM databases

iPTMnetiP13746
PhosphoSitePlusiP13746
SwissPalmiP13746

Expressioni

Gene expression databases

BgeeiENSG00000206503
CleanExiHS_HLA-A
ExpressionAtlasiP13746 baseline and differential
GenevisibleiP13746 HS

Organism-specific databases

HPAiCAB078470

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • TAP binding Source: UniProtKB

Protein-protein interaction databases

IntActiP13746, 9 interactors

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 159Combined sources3
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Beta strandi246 – 248Combined sources3
Helixi249 – 251Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi288 – 292Combined sources5
Beta strandi294 – 297Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q94X-ray2.40A/D25-299[»]
1QVOX-ray2.22A/D25-299[»]
1X7QX-ray1.45A25-299[»]
2HN7X-ray1.60A25-299[»]
4MJ5X-ray2.40A25-298[»]
4MJ6X-ray2.57A25-298[»]
4N8VX-ray2.50A/D25-298[»]
4UQ2X-ray2.43A/C25-299[»]
5GRDX-ray1.80A25-299[»]
5GRGX-ray1.94A25-299[»]
5GSDX-ray2.30A25-299[»]
5WJLX-ray3.15A/D/G25-298[»]
5WJNX-ray2.85A/D/G25-298[»]
5WKFX-ray2.95A/F25-298[»]
5WKHX-ray3.20A/F25-298[»]
ProteinModelPortaliP13746
SMRiP13746
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13746

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13746-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAAHAAEQQ RAYLEGRCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,937
Last modified:January 1, 1990 - v1
Checksum:iFE449CE2D4BF6CC5
GO
Isoform 2 (identifier: P13746-2) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     337-337: S → SGGEGVK

Note: Only produced by allele A*1103.
Show »
Length:371
Mass (Da):41,464
Checksum:i062B8A9EEA8C7C4E
GO

Polymorphismi

The following alleles of A-11 are known: A*11:01 (A-11E), A*11:02 (A-11K), A*11:03, A*11:04, A*11:05 and A*11:07. The sequence shown is that of A*11:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00435343E → K in allele A*11:02. 1
Natural variantiVAR_05625489R → G. Corresponds to variant dbSNP:rs199474430Ensembl.1
Natural variantiVAR_05625594Q → H. Corresponds to variant dbSNP:rs78306866Ensembl.1
Natural variantiVAR_056256101D → N. Corresponds to variant dbSNP:rs1136688Ensembl.1
Natural variantiVAR_056257131G → W. Corresponds to variant dbSNP:rs1136702Ensembl.1
Natural variantiVAR_016731133F → L in allele A*11:07. Corresponds to variant dbSNP:rs1059488Ensembl.1
Natural variantiVAR_056258151N → K. Corresponds to variant dbSNP:rs1059509Ensembl.1
Natural variantiVAR_056259166I → TCombined sourcesCorresponds to variant dbSNP:rs1059516Ensembl.1
Natural variantiVAR_016732168K → E in allele A*11:05. 1
Natural variantiVAR_056260169R → H. Corresponds to variant dbSNP:rs1059520Ensembl.1
Natural variantiVAR_016733175H → R in allele A*11:03. 1
Natural variantiVAR_016734176A → E in allele A*11:03. 1
Natural variantiVAR_016735187R → T in allele A*11:04. 1
Natural variantiVAR_056261205R → H. Corresponds to variant dbSNP:rs17185861Ensembl.1
Natural variantiVAR_016736345T → S in allele A*11:05. Combined sources1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008099337S → SGGEGVK in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13111 mRNA Translation: CAA31503.1
X13112 mRNA Translation: CAA31504.1
D16841 mRNA Translation: BAA04117.1
D16842 mRNA Translation: BAA04118.1
AJ306733 Genomic DNA Translation: CAC37336.1
X91399 mRNA Translation: CAA62745.1
Y17224 mRNA Translation: CAB38056.1
Y17224 mRNA Translation: CAB38057.1
AH007763 Genomic DNA Translation: AAD33991.1
AF165065 mRNA Translation: AAF25781.1
DQ336694 mRNA Translation: ABC59611.1
AY786586 mRNA Translation: AAV53344.1
AY786587 mRNA Translation: AAV53345.1
U50574 mRNA Translation: AAB60406.1
AH003070 Genomic DNA Translation: AAA65449.1
AH005647 Genomic DNA Translation: AAB87052.1
AH005646 Genomic DNA Translation: AAB87051.1
PIRiI83063
S03536 A47636
UniGeneiHs.181244
Hs.713441

Genome annotation databases

EnsembliENST00000376809; ENSP00000366005; ENSG00000206503
ENST00000396634; ENSP00000379873; ENSG00000206503

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry namei1A11_HUMAN
AccessioniPrimary (citable) accession number: P13746
Secondary accession number(s): O19605
, O19606, Q29747, Q29835, Q5S3G1, Q9BCN0, Q9MYI5, Q9TQE9, Q9TQP6, Q9TQP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 23, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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