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P13745

- GSTA1_MOUSE

UniProt

P13745 - GSTA1_MOUSE

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Protein

Glutathione S-transferase A1

Gene

Gsta1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione
Binding sitei45 – 451Glutathione
Binding sitei55 – 551Glutathione; via amide nitrogen and carbonyl oxygen

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
  2. response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A1 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 1
Glutathione S-transferase Ya
Glutathione S-transferase Ya1
Cleaved into the following chain:
Gene namesi
Name:Gsta1
Synonyms:Gsta, Gstya
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1095417. Gsta1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Glutathione S-transferase A1PRO_0000185788Add
BLAST
Initiator methioninei1 – 11Removed; alternateBy similarity
Chaini2 – 223222Glutathione S-transferase A1, N-terminally processedPRO_0000423204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP13745.
PaxDbiP13745.
PRIDEiP13745.

PTM databases

PhosphoSiteiP13745.

Expressioni

Inductioni

Induced in the liver by beta-naphthoflavone (BNF) and 23-t-butyl-4-hydroxyanisole (BHA).1 Publication

Gene expression databases

BgeeiP13745.
CleanExiMM_GSTA1.
GenevestigatoriP13745.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiP13745. 3 interactions.
MINTiMINT-4096961.

Structurei

Secondary structure

1
223
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 127Combined sources
Turni14 – 163Combined sources
Helixi17 – 259Combined sources
Beta strandi31 – 355Combined sources
Helixi38 – 469Combined sources
Beta strandi57 – 604Combined sources
Beta strandi63 – 675Combined sources
Helixi68 – 7811Combined sources
Helixi86 – 10823Combined sources
Helixi109 – 1113Combined sources
Turni114 – 1163Combined sources
Helixi117 – 13014Combined sources
Helixi132 – 14312Combined sources
Beta strandi146 – 1494Combined sources
Helixi155 – 17117Combined sources
Helixi172 – 1754Combined sources
Helixi179 – 18911Combined sources
Helixi192 – 1987Combined sources
Helixi210 – 2178Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F3AX-ray1.90A/B2-223[»]
1F3BX-ray2.00A/B2-223[»]
ProteinModelPortaliP13745.
SMRiP13745. Positions 2-222.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13745.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminalAdd
BLAST
Domaini85 – 208124GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 682Glutathione binding

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiP13745.
KOiK00799.
OMAiILHYSND.
OrthoDBiEOG79CZ0K.
PhylomeDBiP13745.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13745-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGKPVLHYF NARGRMECIR WLLAAAGVEF EEKFIQSPED LEKLKKDGNL
60 70 80 90 100
MFDQVPMVEI DGMKLAQTRA ILNYIATKYD LYGKDMKERA LIDMYSEGIL
110 120 130 140 150
DLTEMIGQLV LCPPDQREAK TALAKDRTKN RYLPAFEKVL KSHGQDYLVG
160 170 180 190 200
NRLTRVDIHL LEVLLYVEEF DASLLTPFPL LKAFKSRISS LPNVKKFLQP
210 220
GSQRKPPMDA KQIQEARKAF KIQ
Length:223
Mass (Da):25,608
Last modified:January 23, 2007 - v2
Checksum:iA348A07133FBEC1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19256
, M19251, M19252, M19253, M19254, M19255 Genomic DNA. Translation: AAA37750.1. Sequence problems.
BC132572 mRNA. Translation: AAI32573.1.
BC132576 mRNA. Translation: AAI32577.1.
CCDSiCCDS23358.1.
PIRiA27848.
RefSeqiNP_032207.3. NM_008181.3.
UniGeneiMm.467426.

Genome annotation databases

EnsembliENSMUST00000098537; ENSMUSP00000096139; ENSMUSG00000074183.
GeneIDi14857.
KEGGimmu:14857.
UCSCiuc009qtz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19256
, M19251 , M19252 , M19253 , M19254 , M19255 Genomic DNA. Translation: AAA37750.1 . Sequence problems.
BC132572 mRNA. Translation: AAI32573.1 .
BC132576 mRNA. Translation: AAI32577.1 .
CCDSi CCDS23358.1.
PIRi A27848.
RefSeqi NP_032207.3. NM_008181.3.
UniGenei Mm.467426.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1F3A X-ray 1.90 A/B 2-223 [» ]
1F3B X-ray 2.00 A/B 2-223 [» ]
ProteinModelPortali P13745.
SMRi P13745. Positions 2-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P13745. 3 interactions.
MINTi MINT-4096961.

PTM databases

PhosphoSitei P13745.

Proteomic databases

MaxQBi P13745.
PaxDbi P13745.
PRIDEi P13745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098537 ; ENSMUSP00000096139 ; ENSMUSG00000074183 .
GeneIDi 14857.
KEGGi mmu:14857.
UCSCi uc009qtz.1. mouse.

Organism-specific databases

CTDi 2938.
MGIi MGI:1095417. Gsta1.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.
InParanoidi P13745.
KOi K00799.
OMAi ILHYSND.
OrthoDBi EOG79CZ0K.
PhylomeDBi P13745.
TreeFami TF105321.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

EvolutionaryTracei P13745.
NextBioi 287087.
PROi P13745.
SOURCEi Search...

Gene expression databases

Bgeei P13745.
CleanExi MM_GSTA1.
Genevestigatori P13745.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse glutathione S-transferase Ya subunit: gene structure and sequence."
    Daniel V., Sharon R., Tichauer Y., Sarid S.
    DNA 6:317-324(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver."
    McLellan L.I., Kerr L.A., Cronshaw A.D., Hayes J.D.
    Biochem. J. 276:461-469(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-36; 51-59; 63-165 AND 208-223, INDUCTION.
    Tissue: Liver.
  4. "Residue R216 and catalytic efficiency of a murine class alpha glutathione S-transferase toward benzo[a]pyrene 7(R),8(S)-diol 9(S), 10(R)-epoxide."
    Gu Y., Singh S.V., Ji X.
    Biochemistry 39:12552-12557(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEXES WITH GLUTATHIONE AND SUBSTRATE, SUBUNIT.

Entry informationi

Entry nameiGSTA1_MOUSE
AccessioniPrimary (citable) accession number: P13745
Secondary accession number(s): A2RTN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3