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P13745

- GSTA1_MOUSE

UniProt

P13745 - GSTA1_MOUSE

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Protein
Glutathione S-transferase A1
Gene
Gsta1, Gsta, Gstya
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione
Binding sitei45 – 451Glutathione
Binding sitei55 – 551Glutathione; via amide nitrogen and carbonyl oxygen

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
  2. response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A1 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 1
Glutathione S-transferase Ya
Glutathione S-transferase Ya1
Cleaved into the following chain:
Gene namesi
Name:Gsta1
Synonyms:Gsta, Gstya
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1095417. Gsta1.

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Glutathione S-transferase A1
PRO_0000185788Add
BLAST
Initiator methioninei1 – 11Removed; alternate By similarity
Chaini2 – 223222Glutathione S-transferase A1, N-terminally processed
PRO_0000423204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP13745.
PaxDbiP13745.
PRIDEiP13745.

PTM databases

PhosphoSiteiP13745.

Expressioni

Inductioni

Induced in the liver by beta-naphthoflavone (BNF) and 23-t-butyl-4-hydroxyanisole (BHA).1 Publication

Gene expression databases

BgeeiP13745.
CleanExiMM_GSTA1.
GenevestigatoriP13745.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiP13745. 3 interactions.
MINTiMINT-4096961.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 127
Turni14 – 163
Helixi17 – 259
Beta strandi31 – 355
Helixi38 – 469
Beta strandi57 – 604
Beta strandi63 – 675
Helixi68 – 7811
Helixi86 – 10823
Helixi109 – 1113
Turni114 – 1163
Helixi117 – 13014
Helixi132 – 14312
Beta strandi146 – 1494
Helixi155 – 17117
Helixi172 – 1754
Helixi179 – 18911
Helixi192 – 1987
Helixi210 – 2178

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F3AX-ray1.90A/B2-223[»]
1F3BX-ray2.00A/B2-223[»]
ProteinModelPortaliP13745.
SMRiP13745. Positions 2-222.

Miscellaneous databases

EvolutionaryTraceiP13745.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminal
Add
BLAST
Domaini85 – 208124GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 682Glutathione binding

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiA2RTN4.
KOiK00799.
OMAiILHYSND.
OrthoDBiEOG79CZ0K.
PhylomeDBiP13745.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13745-1 [UniParc]FASTAAdd to Basket

« Hide

MAGKPVLHYF NARGRMECIR WLLAAAGVEF EEKFIQSPED LEKLKKDGNL    50
MFDQVPMVEI DGMKLAQTRA ILNYIATKYD LYGKDMKERA LIDMYSEGIL 100
DLTEMIGQLV LCPPDQREAK TALAKDRTKN RYLPAFEKVL KSHGQDYLVG 150
NRLTRVDIHL LEVLLYVEEF DASLLTPFPL LKAFKSRISS LPNVKKFLQP 200
GSQRKPPMDA KQIQEARKAF KIQ 223
Length:223
Mass (Da):25,608
Last modified:January 23, 2007 - v2
Checksum:iA348A07133FBEC1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19256
, M19251, M19252, M19253, M19254, M19255 Genomic DNA. Translation: AAA37750.1. Sequence problems.
BC132572 mRNA. Translation: AAI32573.1.
BC132576 mRNA. Translation: AAI32577.1.
CCDSiCCDS23358.1.
PIRiA27848.
RefSeqiNP_032207.3. NM_008181.3.
UniGeneiMm.467426.

Genome annotation databases

EnsembliENSMUST00000098537; ENSMUSP00000096139; ENSMUSG00000074183.
GeneIDi14857.
KEGGimmu:14857.
UCSCiuc009qtz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19256
, M19251 , M19252 , M19253 , M19254 , M19255 Genomic DNA. Translation: AAA37750.1 . Sequence problems.
BC132572 mRNA. Translation: AAI32573.1 .
BC132576 mRNA. Translation: AAI32577.1 .
CCDSi CCDS23358.1.
PIRi A27848.
RefSeqi NP_032207.3. NM_008181.3.
UniGenei Mm.467426.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1F3A X-ray 1.90 A/B 2-223 [» ]
1F3B X-ray 2.00 A/B 2-223 [» ]
ProteinModelPortali P13745.
SMRi P13745. Positions 2-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P13745. 3 interactions.
MINTi MINT-4096961.

Chemistry

DrugBanki DB00143. Glutathione.

PTM databases

PhosphoSitei P13745.

Proteomic databases

MaxQBi P13745.
PaxDbi P13745.
PRIDEi P13745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098537 ; ENSMUSP00000096139 ; ENSMUSG00000074183 .
GeneIDi 14857.
KEGGi mmu:14857.
UCSCi uc009qtz.1. mouse.

Organism-specific databases

CTDi 2938.
MGIi MGI:1095417. Gsta1.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.
InParanoidi A2RTN4.
KOi K00799.
OMAi ILHYSND.
OrthoDBi EOG79CZ0K.
PhylomeDBi P13745.
TreeFami TF105321.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

EvolutionaryTracei P13745.
NextBioi 287087.
PROi P13745.
SOURCEi Search...

Gene expression databases

Bgeei P13745.
CleanExi MM_GSTA1.
Genevestigatori P13745.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse glutathione S-transferase Ya subunit: gene structure and sequence."
    Daniel V., Sharon R., Tichauer Y., Sarid S.
    DNA 6:317-324(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver."
    McLellan L.I., Kerr L.A., Cronshaw A.D., Hayes J.D.
    Biochem. J. 276:461-469(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-36; 51-59; 63-165 AND 208-223, INDUCTION.
    Tissue: Liver.
  4. "Residue R216 and catalytic efficiency of a murine class alpha glutathione S-transferase toward benzo[a]pyrene 7(R),8(S)-diol 9(S), 10(R)-epoxide."
    Gu Y., Singh S.V., Ji X.
    Biochemistry 39:12552-12557(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEXES WITH GLUTATHIONE AND SUBSTRATE, SUBUNIT.

Entry informationi

Entry nameiGSTA1_MOUSE
AccessioniPrimary (citable) accession number: P13745
Secondary accession number(s): A2RTN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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