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Protein

Serpin H1

Gene

SERPINH1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei364 – 3652Reactive bond homologBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiREACT_311308. Collagen biosynthesis and modifying enzymes.

Protein family/group databases

MEROPSiI04.036.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
47 kDa heat shock protein
Collagen-binding protein
Short name:
Colligin
Gene namesi
Name:SERPINH1
Synonyms:HSP47
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 15152 PublicationsAdd
BLAST
Chaini16 – 405390Serpin H1PRO_0000032519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP13731.
PRIDEiP13731.

Expressioni

Inductioni

By heat shock.

Interactioni

Protein-protein interaction databases

BioGridi676488. 1 interaction.
IntActiP13731. 1 interaction.
STRINGi9031.ENSGALP00000018265.

Structurei

3D structure databases

ProteinModelPortaliP13731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi402 – 4054Prevents secretion from ERCurated

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG104930.
InParanoidiP13731.
KOiK09501.
OMAiNYEHSKI.
OrthoDBiEOG7GBFX4.
PhylomeDBiP13731.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIFLVLALC GLAAAVPSED RKLSDKATTL ADRSTTLAFN LYHAMAKDKN
60 70 80 90 100
MENILLSPVV VASSLGLVSL GGKATTASQA KAVLSADKLN DDYVHSGLSE
110 120 130 140 150
LLNEVSNSTA RNVTWKIGNR LYGPASINFA DDFVKNSKKH YNYEHSKINF
160 170 180 190 200
RDKRSALKSI NEWAAQTTDG KLPEVTKDVE KTDGALIVNA MFFKPHWDEK
210 220 230 240 250
FHHKMVDNRG FMVTRSYTVG VPMMHRTGLY NYYDDEAEKL QVVEMPLAHK
260 270 280 290 300
LSSMIFIMPN HVEPLERVEK LLNREQLKTW ASKMKKRSVA ISLPKVVLEV
310 320 330 340 350
SHDLQKHLAD LGLTEAIDKT KADLSKISGK KDLYLSNVFH AAALEWDTDG
360 370 380 390 400
NPYDADIYGR EEMRNPKLFY ADHPFIFMIK DSKTNSILFI GRLVRPKGDK

MRDEL
Length:405
Mass (Da):45,682
Last modified:December 1, 1992 - v2
Checksum:i768318F3E9B59EFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57157 mRNA. Translation: CAA40444.1.
PIRiA41252.
RefSeqiNP_990622.1. NM_205291.1.
UniGeneiGga.4168.

Genome annotation databases

EnsembliENSGALT00000018287; ENSGALP00000018265; ENSGALG00000011214.
GeneIDi396228.
KEGGigga:396228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57157 mRNA. Translation: CAA40444.1.
PIRiA41252.
RefSeqiNP_990622.1. NM_205291.1.
UniGeneiGga.4168.

3D structure databases

ProteinModelPortaliP13731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676488. 1 interaction.
IntActiP13731. 1 interaction.
STRINGi9031.ENSGALP00000018265.

Protein family/group databases

MEROPSiI04.036.

Proteomic databases

PaxDbiP13731.
PRIDEiP13731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000018287; ENSGALP00000018265; ENSGALG00000011214.
GeneIDi396228.
KEGGigga:396228.

Organism-specific databases

CTDi871.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG104930.
InParanoidiP13731.
KOiK09501.
OMAiNYEHSKI.
OrthoDBiEOG7GBFX4.
PhylomeDBiP13731.
TreeFamiTF343094.

Enzyme and pathway databases

ReactomeiREACT_311308. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

NextBioi20816280.
PROiP13731.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts."
    Hirayoshi K., Kudo H., Takeuchi H., Nakai A., Iwamatsu A., Yamada K.M., Nagata K.
    Mol. Cell. Biol. 11:4036-4044(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 16-51; 117-134 AND 159-177.
    Tissue: Fibroblast.
  2. "Characterization of a novel transformation-sensitive heat-shock protein (HSP47) that binds to collagen."
    Nagata K., Saga S., Yamada K.M.
    Biochem. Biophys. Res. Commun. 153:428-434(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-51.

Entry informationi

Entry nameiSERPH_CHICK
AccessioniPrimary (citable) accession number: P13731
Secondary accession number(s): P29042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 1, 1992
Last modified: May 27, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.