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P13731 (SERPH_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serpin H1
Alternative name(s):
47 kDa heat shock protein
Collagen-binding protein
Short name=Colligin
Gene names
Name:SERPINH1
Synonyms:HSP47
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Subcellular location

Endoplasmic reticulum lumen.

Induction

By heat shock.

Sequence similarities

Belongs to the serpin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Ref.1 Ref.2
Chain16 – 405390Serpin H1
PRO_0000032519

Regions

Motif402 – 4054Prevents secretion from ER Probable

Sites

Site364 – 3652Reactive bond homolog By similarity

Amino acid modifications

Glycosylation1071N-linked (GlcNAc...) Potential
Glycosylation1121N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P13731 [UniParc].

Last modified December 1, 1992. Version 2.
Checksum: 768318F3E9B59EFA

FASTA40545,682
        10         20         30         40         50         60 
MQIFLVLALC GLAAAVPSED RKLSDKATTL ADRSTTLAFN LYHAMAKDKN MENILLSPVV 

        70         80         90        100        110        120 
VASSLGLVSL GGKATTASQA KAVLSADKLN DDYVHSGLSE LLNEVSNSTA RNVTWKIGNR 

       130        140        150        160        170        180 
LYGPASINFA DDFVKNSKKH YNYEHSKINF RDKRSALKSI NEWAAQTTDG KLPEVTKDVE 

       190        200        210        220        230        240 
KTDGALIVNA MFFKPHWDEK FHHKMVDNRG FMVTRSYTVG VPMMHRTGLY NYYDDEAEKL 

       250        260        270        280        290        300 
QVVEMPLAHK LSSMIFIMPN HVEPLERVEK LLNREQLKTW ASKMKKRSVA ISLPKVVLEV 

       310        320        330        340        350        360 
SHDLQKHLAD LGLTEAIDKT KADLSKISGK KDLYLSNVFH AAALEWDTDG NPYDADIYGR 

       370        380        390        400 
EEMRNPKLFY ADHPFIFMIK DSKTNSILFI GRLVRPKGDK MRDEL

« Hide

References

[1]"HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts."
Hirayoshi K., Kudo H., Takeuchi H., Nakai A., Iwamatsu A., Yamada K.M., Nagata K.
Mol. Cell. Biol. 11:4036-4044(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 16-51; 117-134 AND 159-177.
Tissue: Fibroblast.
[2]"Characterization of a novel transformation-sensitive heat-shock protein (HSP47) that binds to collagen."
Nagata K., Saga S., Yamada K.M.
Biochem. Biophys. Res. Commun. 153:428-434(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 16-51.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X57157 mRNA. Translation: CAA40444.1.
IPIIPI00600018.
PIRA41252.
RefSeqNP_990622.1. NM_205291.1.
UniGeneGga.4168.

3D structure databases

ProteinModelPortalP13731.
ModBaseSearch...

Protein-protein interaction databases

IntActP13731. 1 interaction.
STRING9031.ENSGALP00000018265.

Protein family/group databases

MEROPSI04.035.

Proteomic databases

PaxDbP13731.
PRIDEP13731.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000018287; ENSGALP00000018265; ENSGALG00000011214.
GeneID396228.
KEGGgga:396228.

Organism-specific databases

CTD871.

Phylogenomic databases

eggNOGCOG4826.
GeneTreeENSGT00560000076649.
HOGENOMHOG000238519.
HOVERGENHBG104930.
InParanoidP13731.
KOK09501.
OMAINEWASQ.
OrthoDBEOG43FGX2.

Family and domain databases

InterProIPR023795. Protease_inhib_I4_serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. Prot_inh_serpin. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816280.

Entry information

Entry nameSERPH_CHICK
AccessionPrimary (citable) accession number: P13731
Secondary accession number(s): P29042
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 1, 1992
Last modified: April 3, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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