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Protein

Serpin H1

Gene

SERPINH1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei364 – 365Reactive bond homologBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

ReactomeiR-GGA-1650814 Collagen biosynthesis and modifying enzymes

Protein family/group databases

MEROPSiI04.035

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
47 kDa heat shock protein
Collagen-binding protein
Short name:
Colligin
Gene namesi
Name:SERPINH1
Synonyms:HSP47
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 152 PublicationsAdd BLAST15
ChainiPRO_000003251916 – 405Serpin H1Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP13731
PRIDEiP13731

Expressioni

Inductioni

By heat shock.

Gene expression databases

BgeeiENSGALG00000011214

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi676488, 1 interactor
IntActiP13731, 1 interactor
STRINGi9031.ENSGALP00000018265

Structurei

3D structure databases

ProteinModelPortaliP13731
SMRiP13731
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi402 – 405Prevents secretion from ERCurated4

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00900000140788
HOGENOMiHOG000238519
HOVERGENiHBG104930
InParanoidiP13731
KOiK09501
OMAiGVPMMHR
OrthoDBiEOG091G08O0
PhylomeDBiP13731
TreeFamiTF343094

Family and domain databases

CDDicd02046 hsp47, 1 hit
InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR033830 Serpin_H1_domain
IPR036186 Serpin_sf
IPR033547 SERPINH1
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF27 PTHR11461:SF27, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIFLVLALC GLAAAVPSED RKLSDKATTL ADRSTTLAFN LYHAMAKDKN
60 70 80 90 100
MENILLSPVV VASSLGLVSL GGKATTASQA KAVLSADKLN DDYVHSGLSE
110 120 130 140 150
LLNEVSNSTA RNVTWKIGNR LYGPASINFA DDFVKNSKKH YNYEHSKINF
160 170 180 190 200
RDKRSALKSI NEWAAQTTDG KLPEVTKDVE KTDGALIVNA MFFKPHWDEK
210 220 230 240 250
FHHKMVDNRG FMVTRSYTVG VPMMHRTGLY NYYDDEAEKL QVVEMPLAHK
260 270 280 290 300
LSSMIFIMPN HVEPLERVEK LLNREQLKTW ASKMKKRSVA ISLPKVVLEV
310 320 330 340 350
SHDLQKHLAD LGLTEAIDKT KADLSKISGK KDLYLSNVFH AAALEWDTDG
360 370 380 390 400
NPYDADIYGR EEMRNPKLFY ADHPFIFMIK DSKTNSILFI GRLVRPKGDK

MRDEL
Length:405
Mass (Da):45,682
Last modified:December 1, 1992 - v2
Checksum:i768318F3E9B59EFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57157 mRNA Translation: CAA40444.1
PIRiA41252
RefSeqiNP_990622.1, NM_205291.1
XP_015136452.1, XM_015280966.1
XP_015136453.1, XM_015280967.1
UniGeneiGga.4168

Genome annotation databases

EnsembliENSGALT00000018287; ENSGALP00000018265; ENSGALG00000011214
GeneIDi396228
KEGGigga:396228

Similar proteinsi

Entry informationi

Entry nameiSERPH_CHICK
AccessioniPrimary (citable) accession number: P13731
Secondary accession number(s): P29042
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 1, 1992
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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