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P13731

- SERPH_CHICK

UniProt

P13731 - SERPH_CHICK

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Protein

Serpin H1

Gene

SERPINH1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei364 – 3652Reactive bond homologBy similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. chondrocyte development involved in endochondral bone morphogenesis Source: Ensembl
  2. collagen biosynthetic process Source: Ensembl
  3. collagen fibril organization Source: Ensembl
  4. negative regulation of endopeptidase activity Source: RefGenome
  5. protein maturation Source: Ensembl
  6. regulation of proteolysis Source: RefGenome
  7. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiREACT_198187. Collagen biosynthesis and modifying enzymes.

Protein family/group databases

MEROPSiI04.036.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
47 kDa heat shock protein
Collagen-binding protein
Short name:
Colligin
Gene namesi
Name:SERPINH1
Synonyms:HSP47
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
  4. extracellular space Source: InterPro
  5. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 15152 PublicationsAdd
BLAST
Chaini16 – 405390Serpin H1PRO_0000032519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP13731.
PRIDEiP13731.

Expressioni

Inductioni

By heat shock.

Interactioni

Protein-protein interaction databases

BioGridi676488. 1 interaction.
IntActiP13731. 1 interaction.
STRINGi9031.ENSGALP00000018265.

Structurei

3D structure databases

ProteinModelPortaliP13731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi402 – 4054Prevents secretion from ERCurated

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG104930.
InParanoidiP13731.
KOiK09501.
OMAiGVPMMHR.
OrthoDBiEOG7GBFX4.
PhylomeDBiP13731.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13731-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQIFLVLALC GLAAAVPSED RKLSDKATTL ADRSTTLAFN LYHAMAKDKN
60 70 80 90 100
MENILLSPVV VASSLGLVSL GGKATTASQA KAVLSADKLN DDYVHSGLSE
110 120 130 140 150
LLNEVSNSTA RNVTWKIGNR LYGPASINFA DDFVKNSKKH YNYEHSKINF
160 170 180 190 200
RDKRSALKSI NEWAAQTTDG KLPEVTKDVE KTDGALIVNA MFFKPHWDEK
210 220 230 240 250
FHHKMVDNRG FMVTRSYTVG VPMMHRTGLY NYYDDEAEKL QVVEMPLAHK
260 270 280 290 300
LSSMIFIMPN HVEPLERVEK LLNREQLKTW ASKMKKRSVA ISLPKVVLEV
310 320 330 340 350
SHDLQKHLAD LGLTEAIDKT KADLSKISGK KDLYLSNVFH AAALEWDTDG
360 370 380 390 400
NPYDADIYGR EEMRNPKLFY ADHPFIFMIK DSKTNSILFI GRLVRPKGDK

MRDEL
Length:405
Mass (Da):45,682
Last modified:December 1, 1992 - v2
Checksum:i768318F3E9B59EFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57157 mRNA. Translation: CAA40444.1.
PIRiA41252.
RefSeqiNP_990622.1. NM_205291.1.
UniGeneiGga.4168.

Genome annotation databases

EnsembliENSGALT00000018287; ENSGALP00000018265; ENSGALG00000011214.
GeneIDi396228.
KEGGigga:396228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57157 mRNA. Translation: CAA40444.1 .
PIRi A41252.
RefSeqi NP_990622.1. NM_205291.1.
UniGenei Gga.4168.

3D structure databases

ProteinModelPortali P13731.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 676488. 1 interaction.
IntActi P13731. 1 interaction.
STRINGi 9031.ENSGALP00000018265.

Protein family/group databases

MEROPSi I04.036.

Proteomic databases

PaxDbi P13731.
PRIDEi P13731.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000018287 ; ENSGALP00000018265 ; ENSGALG00000011214 .
GeneIDi 396228.
KEGGi gga:396228.

Organism-specific databases

CTDi 871.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118839.
HOGENOMi HOG000238519.
HOVERGENi HBG104930.
InParanoidi P13731.
KOi K09501.
OMAi GVPMMHR.
OrthoDBi EOG7GBFX4.
PhylomeDBi P13731.
TreeFami TF343094.

Enzyme and pathway databases

Reactomei REACT_198187. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

NextBioi 20816280.
PROi P13731.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts."
    Hirayoshi K., Kudo H., Takeuchi H., Nakai A., Iwamatsu A., Yamada K.M., Nagata K.
    Mol. Cell. Biol. 11:4036-4044(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 16-51; 117-134 AND 159-177.
    Tissue: Fibroblast.
  2. "Characterization of a novel transformation-sensitive heat-shock protein (HSP47) that binds to collagen."
    Nagata K., Saga S., Yamada K.M.
    Biochem. Biophys. Res. Commun. 153:428-434(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-51.

Entry informationi

Entry nameiSERPH_CHICK
AccessioniPrimary (citable) accession number: P13731
Secondary accession number(s): P29042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 1, 1992
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3