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P13731

- SERPH_CHICK

UniProt

P13731 - SERPH_CHICK

Protein

Serpin H1

Gene

SERPINH1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei364 – 3652Reactive bond homologBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. collagen biosynthetic process Source: Ensembl
    2. collagen fibril organization Source: Ensembl
    3. negative regulation of endopeptidase activity Source: RefGenome
    4. protein maturation Source: Ensembl
    5. regulation of proteolysis Source: RefGenome
    6. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Enzyme and pathway databases

    ReactomeiREACT_198187. Collagen biosynthesis and modifying enzymes.

    Protein family/group databases

    MEROPSiI04.035.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin H1
    Alternative name(s):
    47 kDa heat shock protein
    Collagen-binding protein
    Short name:
    Colligin
    Gene namesi
    Name:SERPINH1
    Synonyms:HSP47
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
    3. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    4. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 15152 PublicationsAdd
    BLAST
    Chaini16 – 405390Serpin H1PRO_0000032519Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP13731.
    PRIDEiP13731.

    Expressioni

    Inductioni

    By heat shock.

    Interactioni

    Protein-protein interaction databases

    BioGridi676488. 1 interaction.
    IntActiP13731. 1 interaction.
    STRINGi9031.ENSGALP00000018265.

    Structurei

    3D structure databases

    ProteinModelPortaliP13731.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi402 – 4054Prevents secretion from ERCurated

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00750000117718.
    HOGENOMiHOG000238519.
    HOVERGENiHBG104930.
    InParanoidiP13731.
    KOiK09501.
    OMAiGVPMMHR.
    OrthoDBiEOG7GBFX4.
    PhylomeDBiP13731.
    TreeFamiTF343094.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13731-1 [UniParc]FASTAAdd to Basket

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    MQIFLVLALC GLAAAVPSED RKLSDKATTL ADRSTTLAFN LYHAMAKDKN    50
    MENILLSPVV VASSLGLVSL GGKATTASQA KAVLSADKLN DDYVHSGLSE 100
    LLNEVSNSTA RNVTWKIGNR LYGPASINFA DDFVKNSKKH YNYEHSKINF 150
    RDKRSALKSI NEWAAQTTDG KLPEVTKDVE KTDGALIVNA MFFKPHWDEK 200
    FHHKMVDNRG FMVTRSYTVG VPMMHRTGLY NYYDDEAEKL QVVEMPLAHK 250
    LSSMIFIMPN HVEPLERVEK LLNREQLKTW ASKMKKRSVA ISLPKVVLEV 300
    SHDLQKHLAD LGLTEAIDKT KADLSKISGK KDLYLSNVFH AAALEWDTDG 350
    NPYDADIYGR EEMRNPKLFY ADHPFIFMIK DSKTNSILFI GRLVRPKGDK 400
    MRDEL 405
    Length:405
    Mass (Da):45,682
    Last modified:December 1, 1992 - v2
    Checksum:i768318F3E9B59EFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57157 mRNA. Translation: CAA40444.1.
    PIRiA41252.
    RefSeqiNP_990622.1. NM_205291.1.
    UniGeneiGga.4168.

    Genome annotation databases

    EnsembliENSGALT00000018287; ENSGALP00000018265; ENSGALG00000011214.
    GeneIDi396228.
    KEGGigga:396228.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57157 mRNA. Translation: CAA40444.1 .
    PIRi A41252.
    RefSeqi NP_990622.1. NM_205291.1.
    UniGenei Gga.4168.

    3D structure databases

    ProteinModelPortali P13731.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 676488. 1 interaction.
    IntActi P13731. 1 interaction.
    STRINGi 9031.ENSGALP00000018265.

    Protein family/group databases

    MEROPSi I04.035.

    Proteomic databases

    PaxDbi P13731.
    PRIDEi P13731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000018287 ; ENSGALP00000018265 ; ENSGALG00000011214 .
    GeneIDi 396228.
    KEGGi gga:396228.

    Organism-specific databases

    CTDi 871.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00750000117718.
    HOGENOMi HOG000238519.
    HOVERGENi HBG104930.
    InParanoidi P13731.
    KOi K09501.
    OMAi GVPMMHR.
    OrthoDBi EOG7GBFX4.
    PhylomeDBi P13731.
    TreeFami TF343094.

    Enzyme and pathway databases

    Reactomei REACT_198187. Collagen biosynthesis and modifying enzymes.

    Miscellaneous databases

    NextBioi 20816280.
    PROi P13731.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts."
      Hirayoshi K., Kudo H., Takeuchi H., Nakai A., Iwamatsu A., Yamada K.M., Nagata K.
      Mol. Cell. Biol. 11:4036-4044(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 16-51; 117-134 AND 159-177.
      Tissue: Fibroblast.
    2. "Characterization of a novel transformation-sensitive heat-shock protein (HSP47) that binds to collagen."
      Nagata K., Saga S., Yamada K.M.
      Biochem. Biophys. Res. Commun. 153:428-434(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 16-51.

    Entry informationi

    Entry nameiSERPH_CHICK
    AccessioniPrimary (citable) accession number: P13731
    Secondary accession number(s): P29042
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3