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Protein

Serpin H1

Gene

SERPINH1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei364 – 365Reactive bond homologBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

ReactomeiR-GGA-1650814. Collagen biosynthesis and modifying enzymes.

Protein family/group databases

MEROPSiI04.035.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
47 kDa heat shock protein
Collagen-binding protein
Short name:
Colligin
Gene namesi
Name:SERPINH1
Synonyms:HSP47
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 152 PublicationsAdd BLAST15
ChainiPRO_000003251916 – 405Serpin H1Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP13731.
PRIDEiP13731.

Expressioni

Inductioni

By heat shock.

Gene expression databases

BgeeiENSGALG00000011214.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi676488. 1 interactor.
IntActiP13731. 1 interactor.
STRINGi9031.ENSGALP00000018265.

Structurei

3D structure databases

ProteinModelPortaliP13731.
SMRiP13731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi402 – 405Prevents secretion from ERCurated4

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00890000139355.
HOGENOMiHOG000238519.
HOVERGENiHBG104930.
InParanoidiP13731.
KOiK09501.
OMAiNYEHSKI.
OrthoDBiEOG091G08O0.
PhylomeDBiP13731.
TreeFamiTF343094.

Family and domain databases

CDDicd02046. hsp47. 1 hit.
InterProiView protein in InterPro
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
IPR033830. Serpin_H1_domain.
IPR033547. SERPINH1.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF220. PTHR11461:SF220. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIFLVLALC GLAAAVPSED RKLSDKATTL ADRSTTLAFN LYHAMAKDKN
60 70 80 90 100
MENILLSPVV VASSLGLVSL GGKATTASQA KAVLSADKLN DDYVHSGLSE
110 120 130 140 150
LLNEVSNSTA RNVTWKIGNR LYGPASINFA DDFVKNSKKH YNYEHSKINF
160 170 180 190 200
RDKRSALKSI NEWAAQTTDG KLPEVTKDVE KTDGALIVNA MFFKPHWDEK
210 220 230 240 250
FHHKMVDNRG FMVTRSYTVG VPMMHRTGLY NYYDDEAEKL QVVEMPLAHK
260 270 280 290 300
LSSMIFIMPN HVEPLERVEK LLNREQLKTW ASKMKKRSVA ISLPKVVLEV
310 320 330 340 350
SHDLQKHLAD LGLTEAIDKT KADLSKISGK KDLYLSNVFH AAALEWDTDG
360 370 380 390 400
NPYDADIYGR EEMRNPKLFY ADHPFIFMIK DSKTNSILFI GRLVRPKGDK

MRDEL
Length:405
Mass (Da):45,682
Last modified:December 1, 1992 - v2
Checksum:i768318F3E9B59EFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57157 mRNA. Translation: CAA40444.1.
PIRiA41252.
RefSeqiNP_990622.1. NM_205291.1.
XP_015136452.1. XM_015280966.1.
XP_015136453.1. XM_015280967.1.
UniGeneiGga.4168.

Genome annotation databases

EnsembliENSGALT00000018287; ENSGALP00000018265; ENSGALG00000011214.
GeneIDi396228.
KEGGigga:396228.

Similar proteinsi

Entry informationi

Entry nameiSERPH_CHICK
AccessioniPrimary (citable) accession number: P13731
Secondary accession number(s): P29042
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 1, 1992
Last modified: August 30, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families