Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bone marrow proteoglycan

Gene

PRG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity

Keywords - Ligandi

Heparin-binding, Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134802-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiI63.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone marrow proteoglycan
Short name:
BMPG
Alternative name(s):
Proteoglycan 2
Cleaved into the following chain:
Eosinophil granule major basic protein
Short name:
EMBP
Short name:
MBP
Alternative name(s):
Pregnancy-associated major basic protein
Gene namesi
Name:PRG2
Synonyms:MBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:9362. PRG2.

Subcellular locationi

Bone marrow proteoglycan :
Eosinophil granule major basic protein :

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: ProtInc
  • transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5553.
MalaCardsiPRG2.
OpenTargetsiENSG00000186652.
PharmGKBiPA33734.

Chemistry databases

DrugBankiDB00020. Sargramostim.

Polymorphism and mutation databases

BioMutaiPRG2.
DMDMi281185479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 163 PublicationsAdd BLAST16
ChainiPRO_000025992317 – 222Bone marrow proteoglycanAdd BLAST206
PropeptideiPRO_000001738517 – 105Acidic2 PublicationsAdd BLAST89
ChainiPRO_0000017386106 – 222Eosinophil granule major basic proteinAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23O-linked (GalNAc...); partial1 Publication1
Glycosylationi24O-linked (GalNAc...)2 Publications1
Glycosylationi25O-linked (GalNAc...)2 Publications1
Glycosylationi34O-linked (GalNAc...); partial1 Publication1
Disulfide bondi51Interchain (with C-461 in PAPPA)PROSITE-ProRule annotation1 Publication
Glycosylationi62O-linked (Xyl...) (chondroitin sulfate)2 Publications1
Glycosylationi86N-linked (GlcNAc...)2 Publications1
Disulfide bondi125 ↔ 220PROSITE-ProRule annotation1 Publication
Disulfide bondi169Interchain (with C-732 in PAPPA)PROSITE-ProRule annotation1 Publication
Disulfide bondi197 ↔ 212PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Nitrated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration, Proteoglycan

Proteomic databases

EPDiP13727.
PaxDbiP13727.
PeptideAtlasiP13727.
PRIDEiP13727.
TopDownProteomicsiP13727-1. [P13727-1]

PTM databases

iPTMnetiP13727.
PhosphoSitePlusiP13727.

Expressioni

Tissue specificityi

High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.2 Publications

Developmental stagei

Levels of the proform increase in serum and placenta during pregnancy.2 Publications

Gene expression databases

BgeeiENSG00000186652.
CleanExiHS_MBP.
HS_PRG2.
GenevisibleiP13727. HS.

Organism-specific databases

HPAiHPA038515.

Interactioni

Subunit structurei

In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.5 Publications

Protein-protein interaction databases

BioGridi111544. 62 interactors.
IntActiP13727. 2 interactors.
MINTiMINT-1375191.
STRINGi9606.ENSP00000312134.

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi109 – 116Combined sources8
Helixi118 – 129Combined sources12
Beta strandi130 – 133Combined sources4
Helixi139 – 149Combined sources11
Beta strandi153 – 164Combined sources12
Beta strandi166 – 168Combined sources3
Beta strandi171 – 174Combined sources4
Beta strandi187 – 189Combined sources3
Beta strandi196 – 201Combined sources6
Turni202 – 205Combined sources4
Beta strandi207 – 210Combined sources4
Beta strandi216 – 221Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H8UX-ray1.80A/B106-222[»]
2BRSX-ray2.20A/B106-222[»]
4QXXX-ray1.45Z131-135[»]
ProteinModelPortaliP13727.
SMRiP13727.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13727.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 222C-type lectinPROSITE-ProRule annotationAdd BLAST119

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00440000039859.
HOGENOMiHOG000261603.
HOVERGENiHBG005583.
InParanoidiP13727.
KOiK10786.
OMAiGHWRRAH.
OrthoDBiEOG091G0LK4.
PhylomeDBiP13727.
TreeFamiTF336281.

Family and domain databases

CDDicd03598. CLECT_EMBP_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR033816. EMBP_CTLD.
IPR002352. Eosinophil_major_basic.
[Graphical view]
PANTHERiPTHR10068. PTHR10068. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00770. EMAJORBASICP.
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13727-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLPLLLALL FGAVSALHLR SETSTFETPL GAKTLPEDEE TPEQEMEETP
60 70 80 90 100
CRELEEEEEW GSGSEDASKK DGAVESISVP DMVDKNLTCP EEEDTVKVVG
110 120 130 140 150
IPGCQTCRYL LVRSLQTFSQ AWFTCRRCYR GNLVSIHNFN INYRIQCSVS
160 170 180 190 200
ALNQGQVWIG GRITGSGRCR RFQWVDGSRW NFAYWAAHQP WSRGGHCVAL
210 220
CTRGGHWRRA HCLRRLPFIC SY
Length:222
Mass (Da):25,206
Last modified:December 15, 2009 - v2
Checksum:iCDD545642555E2D0
GO
Isoform 2 (identifier: P13727-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-122: Missing.

Show »
Length:211
Mass (Da):23,901
Checksum:i56CDF739284A3DE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84D → H in AAA36203 (PubMed:3171483).Curated1
Sequence conflicti190P → L in BAG35128 (PubMed:14702039).Curated1
Sequence conflicti192S → T in CAA81207 (PubMed:7531438).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036401179R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs142359007dbSNPEnsembl.1
Natural variantiVAR_060729206H → Y.8 PublicationsCorresponds to variant rs536455dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056735112 – 122Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00809 mRNA. Translation: CAA68751.1.
M36805 mRNA. Translation: AAA36203.1.
M34462 Genomic DNA. Translation: AAA35796.1.
M35670 mRNA. Translation: AAA35965.1.
X14088 mRNA. Translation: CAA32250.1.
X65787 mRNA. Translation: CAA46670.1.
Z26248 mRNA. Translation: CAA81207.1.
AK312195 mRNA. Translation: BAG35128.1.
CR450311 mRNA. Translation: CAG29307.1.
DQ846874 mRNA. Translation: ABI63361.1.
AP000781 Genomic DNA. No translation available.
BC005929 mRNA. Translation: AAH05929.1.
CCDSiCCDS58133.1. [P13727-2]
CCDS7955.1. [P13727-1]
PIRiI54055. JL0085.
RefSeqiNP_001230174.1. NM_001243245.2. [P13727-2]
NP_001289855.1. NM_001302926.1. [P13727-1]
NP_001289856.1. NM_001302927.1. [P13727-1]
NP_002719.3. NM_002728.5. [P13727-1]
UniGeneiHs.512633.

Genome annotation databases

EnsembliENST00000311862; ENSP00000312134; ENSG00000186652. [P13727-1]
ENST00000525955; ENSP00000433016; ENSG00000186652. [P13727-1]
ENST00000533605; ENSP00000433231; ENSG00000186652. [P13727-2]
GeneIDi5553.
KEGGihsa:5553.
UCSCiuc001nkc.4. human. [P13727-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Major basic protein entry

Functional Glycomics Gateway - Glycan Binding

Eosinophil major basic protein

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00809 mRNA. Translation: CAA68751.1.
M36805 mRNA. Translation: AAA36203.1.
M34462 Genomic DNA. Translation: AAA35796.1.
M35670 mRNA. Translation: AAA35965.1.
X14088 mRNA. Translation: CAA32250.1.
X65787 mRNA. Translation: CAA46670.1.
Z26248 mRNA. Translation: CAA81207.1.
AK312195 mRNA. Translation: BAG35128.1.
CR450311 mRNA. Translation: CAG29307.1.
DQ846874 mRNA. Translation: ABI63361.1.
AP000781 Genomic DNA. No translation available.
BC005929 mRNA. Translation: AAH05929.1.
CCDSiCCDS58133.1. [P13727-2]
CCDS7955.1. [P13727-1]
PIRiI54055. JL0085.
RefSeqiNP_001230174.1. NM_001243245.2. [P13727-2]
NP_001289855.1. NM_001302926.1. [P13727-1]
NP_001289856.1. NM_001302927.1. [P13727-1]
NP_002719.3. NM_002728.5. [P13727-1]
UniGeneiHs.512633.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H8UX-ray1.80A/B106-222[»]
2BRSX-ray2.20A/B106-222[»]
4QXXX-ray1.45Z131-135[»]
ProteinModelPortaliP13727.
SMRiP13727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111544. 62 interactors.
IntActiP13727. 2 interactors.
MINTiMINT-1375191.
STRINGi9606.ENSP00000312134.

Chemistry databases

DrugBankiDB00020. Sargramostim.

Protein family/group databases

MEROPSiI63.001.

PTM databases

iPTMnetiP13727.
PhosphoSitePlusiP13727.

Polymorphism and mutation databases

BioMutaiPRG2.
DMDMi281185479.

Proteomic databases

EPDiP13727.
PaxDbiP13727.
PeptideAtlasiP13727.
PRIDEiP13727.
TopDownProteomicsiP13727-1. [P13727-1]

Protocols and materials databases

DNASUi5553.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311862; ENSP00000312134; ENSG00000186652. [P13727-1]
ENST00000525955; ENSP00000433016; ENSG00000186652. [P13727-1]
ENST00000533605; ENSP00000433231; ENSG00000186652. [P13727-2]
GeneIDi5553.
KEGGihsa:5553.
UCSCiuc001nkc.4. human. [P13727-1]

Organism-specific databases

CTDi5553.
DisGeNETi5553.
GeneCardsiPRG2.
H-InvDBHIX0009634.
HGNCiHGNC:9362. PRG2.
HPAiHPA038515.
MalaCardsiPRG2.
MIMi605601. gene.
neXtProtiNX_P13727.
OpenTargetsiENSG00000186652.
PharmGKBiPA33734.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00440000039859.
HOGENOMiHOG000261603.
HOVERGENiHBG005583.
InParanoidiP13727.
KOiK10786.
OMAiGHWRRAH.
OrthoDBiEOG091G0LK4.
PhylomeDBiP13727.
TreeFamiTF336281.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134802-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiPRG2. human.
EvolutionaryTraceiP13727.
GeneWikiiMajor_basic_protein.
GenomeRNAii5553.
PROiP13727.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186652.
CleanExiHS_MBP.
HS_PRG2.
GenevisibleiP13727. HS.

Family and domain databases

CDDicd03598. CLECT_EMBP_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR033816. EMBP_CTLD.
IPR002352. Eosinophil_major_basic.
[Graphical view]
PANTHERiPTHR10068. PTHR10068. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00770. EMAJORBASICP.
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRG2_HUMAN
AccessioniPrimary (citable) accession number: P13727
Secondary accession number(s): A6XMW0
, B2R5I1, P81448, Q14227, Q6ICT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 15, 2009
Last modified: November 30, 2016
This is version 178 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds heparin. Does not bind calcium.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.