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Protein

Tissue factor

Gene

F3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.1 Publication

GO - Molecular functioni

  • cytokine receptor activity Source: GO_Central
  • phospholipid binding Source: BHF-UCL
  • protease binding Source: BHF-UCL

GO - Biological processi

  • activation of blood coagulation via clotting cascade Source: BHF-UCL
  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
  • activation of plasma proteins involved in acute inflammatory response Source: BHF-UCL
  • blood coagulation Source: BHF-UCL
  • blood coagulation, extrinsic pathway Source: Reactome
  • cytokine-mediated signaling pathway Source: GO_Central
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: BHF-UCL
  • positive regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
  • positive regulation of positive chemotaxis Source: BHF-UCL
  • positive regulation of protein kinase B signaling Source: BHF-UCL
  • protein processing Source: BHF-UCL

Keywordsi

Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation
SIGNORiP13726

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor
Short name:
TF
Alternative name(s):
Coagulation factor III
Thromboplastin
CD_antigen: CD142
Gene namesi
Name:F3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117525.13
HGNCiHGNC:3541 F3
MIMi134390 gene
neXtProtiNX_P13726

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 251ExtracellularSequence analysisAdd BLAST219
Transmembranei252 – 274HelicalSequence analysisAdd BLAST23
Topological domaini275 – 295CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2152
OpenTargetsiENSG00000117525
PharmGKBiPA158

Chemistry databases

ChEMBLiCHEMBL4081
DrugBankiDB07207 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
DB13150 Coagulation factor VII human
DB00036 Coagulation factor VIIa Recombinant Human

Polymorphism and mutation databases

BioMutaiF3
DMDMi135666

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Add BLAST32
ChainiPRO_000003363833 – 295Tissue factorAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 891 Publication
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi218 ↔ 2411 Publication
Lipidationi277S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

EPDiP13726
MaxQBiP13726
PaxDbiP13726
PeptideAtlasiP13726
PRIDEiP13726

PTM databases

iPTMnetiP13726
PhosphoSitePlusiP13726
SwissPalmiP13726

Expressioni

Tissue specificityi

Lung, placenta and pancreas.1 Publication

Inductioni

TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.1 Publication

Gene expression databases

BgeeiENSG00000117525
CleanExiHS_F3
GenevisibleiP13726 HS

Organism-specific databases

HPAiCAB009438
HPA049292
HPA069132

Interactioni

Subunit structurei

Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protease binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi108451, 13 interactors
CORUMiP13726
DIPiDIP-6136N
IntActiP13726, 3 interactors
STRINGi9606.ENSP00000334145

Chemistry databases

BindingDBiP13726

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 49Combined sources8
Beta strandi52 – 58Combined sources7
Beta strandi62 – 72Combined sources11
Beta strandi73 – 75Combined sources3
Beta strandi78 – 85Combined sources8
Beta strandi87 – 90Combined sources4
Helixi92 – 95Combined sources4
Helixi96 – 98Combined sources3
Beta strandi103 – 111Combined sources9
Helixi113 – 115Combined sources3
Turni119 – 122Combined sources4
Beta strandi126 – 128Combined sources3
Helixi134 – 137Combined sources4
Beta strandi145 – 151Combined sources7
Beta strandi154 – 159Combined sources6
Beta strandi163 – 168Combined sources6
Beta strandi171 – 174Combined sources4
Helixi175 – 179Combined sources5
Helixi180 – 182Combined sources3
Beta strandi184 – 191Combined sources8
Beta strandi194 – 196Combined sources3
Beta strandi198 – 210Combined sources13
Beta strandi213 – 215Combined sources3
Beta strandi217 – 224Combined sources8
Beta strandi229 – 231Combined sources3
Beta strandi240 – 243Combined sources4
Beta strandi279 – 284Combined sources6
Beta strandi289 – 293Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHWX-ray3.00C/F33-251[»]
1BOYX-ray2.20A33-251[»]
1DANX-ray2.00T37-116[»]
U122-242[»]
1FAKX-ray2.10T37-242[»]
1J9CX-ray2.90T33-242[»]
1JPSX-ray1.85T33-251[»]
1NL8model-T33-242[»]
1O5DX-ray2.05T34-251[»]
1TFHX-ray2.40A/B33-251[»]
1UJ3X-ray2.10C38-242[»]
1W0YX-ray2.50T33-242[»]
1W2KX-ray3.00T33-242[»]
1WQVX-ray2.50T33-250[»]
1WSSX-ray2.60T33-250[»]
1WTGX-ray2.20T33-250[»]
1WUNX-ray2.40T33-250[»]
1WV7X-ray2.70T33-250[»]
1Z6JX-ray2.00T33-243[»]
2A2QX-ray1.80T38-242[»]
2AEIX-ray2.52T33-243[»]
2AERX-ray1.87T38-242[»]
2B7DX-ray2.24T34-251[»]
2B8OX-ray2.80T38-242[»]
2C4FX-ray1.72T38-112[»]
U123-242[»]
2CEFNMR-A277-295[»]
2CEHNMR-A277-295[»]
2CEZNMR-A277-295[»]
2CFJNMR-A277-295[»]
2EC9X-ray2.00T38-112[»]
U123-242[»]
2F9BX-ray2.54T34-251[»]
2FIRX-ray2.00T38-242[»]
2FLBX-ray1.95T34-251[»]
2FLRX-ray2.35T34-251[»]
2HFTX-ray1.69A33-243[»]
2PUQX-ray2.05T38-241[»]
2ZP0X-ray2.70T33-250[»]
2ZWLX-ray2.20T33-250[»]
2ZZUX-ray2.50T33-250[»]
3ELAX-ray2.20T33-241[»]
3TH2X-ray1.72T38-242[»]
3TH3X-ray2.70T38-242[»]
3TH4X-ray1.80T38-242[»]
4IBLX-ray1.80T33-251[»]
4M7LX-ray3.40T37-245[»]
4YLQX-ray1.40T33-251[»]
4Z6AX-ray2.25T36-242[»]
4ZMAX-ray2.30T33-251[»]
5W06X-ray2.60T37-245[»]
ProteinModelPortaliP13726
SMRiP13726
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13726

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 48WKS motif3
Motifi77 – 79WKS motif3
Motifi190 – 192WKS motif3

Sequence similaritiesi

Belongs to the tissue factor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYA1 Eukaryota
ENOG4111MW4 LUCA
GeneTreeiENSGT00390000012668
HOGENOMiHOG000043076
HOVERGENiHBG005051
InParanoidiP13726
KOiK03901
OMAiNTNEFLI
OrthoDBiEOG091G0MKF
PhylomeDBiP13726
TreeFamiTF352627

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
IPR001187 Tissue_factor
IPR030472 Tissue_Factor_CS
PANTHERiPTHR20859:SF22 PTHR20859:SF22, 1 hit
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
PIRSFiPIRSF002498 Tissue_factor_3, 1 hit
PRINTSiPR00346 TISSUEFACTOR
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS00621 TISSUE_FACTOR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms may exist.
Isoform 1 (identifier: P13726-1) [UniParc]FASTAAdd to basket
Also known as: flTF

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METPAWPRVP RPETAVARTL LLGWVFAQVA GASGTTNTVA AYNLTWKSTN
60 70 80 90 100
FKTILEWEPK PVNQVYTVQI STKSGDWKSK CFYTTDTECD LTDEIVKDVK
110 120 130 140 150
QTYLARVFSY PAGNVESTGS AGEPLYENSP EFTPYLETNL GQPTIQSFEQ
160 170 180 190 200
VGTKVNVTVE DERTLVRRNN TFLSLRDVFG KDLIYTLYYW KSSSSGKKTA
210 220 230 240 250
KTNTNEFLID VDKGENYCFS VQAVIPSRTV NRKSTDSPVE CMGQEKGEFR
260 270 280 290
EIFYIIGAVV FVVIILVIIL AISLHKCRKA GVGQSWKENS PLNVS
Length:295
Mass (Da):33,068
Last modified:January 1, 1990 - v1
Checksum:iD3486C713ED8EAD0
GO
Isoform 2 (identifier: P13726-2) [UniParc]FASTAAdd to basket
Also known as: asHTF

The sequence of this isoform differs from the canonical sequence as follows:
     199-238: TAKTNTNEFL...TVNRKSTDSP → YSTSLELWYL...WGRAGRRTPH
     239-295: Missing.

Show »
Length:238
Mass (Da):27,145
Checksum:i5021EDB85C12B48C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti260V → A in AAA61151 (PubMed:2823875).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01429836T → A1 PublicationCorresponds to variant dbSNP:rs3917604Ensembl.1
Natural variantiVAR_014299145I → V1 PublicationCorresponds to variant dbSNP:rs3917627Ensembl.1
Natural variantiVAR_012008163R → W. Corresponds to variant dbSNP:rs5901Ensembl.1
Natural variantiVAR_052280281G → E. Corresponds to variant dbSNP:rs3789683Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041896199 – 238TAKTN…STDSP → YSTSLELWYLWSSSLSSSWL YLYTSVERQEWGRAGRRTPH in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_041897239 – 295Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16553 mRNA Translation: AAA61151.1
J02931 mRNA Translation: AAA61150.1
M27436 mRNA Translation: AAA36734.1
J02846 Genomic DNA Translation: AAA61152.1
BT019808 mRNA Translation: AAV38611.1
CR541792 mRNA Translation: CAG46591.1
AF487337 mRNA Translation: AAO61150.1
AF540377 Genomic DNA Translation: AAN01236.1
AC093117 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73044.1
CH471097 Genomic DNA Translation: EAW73045.1
BC011029 mRNA Translation: AAH11029.1
CCDSiCCDS53345.1 [P13726-2]
CCDS750.1 [P13726-1]
PIRiA43645 KFHU3
RefSeqiNP_001171567.1, NM_001178096.1 [P13726-2]
NP_001984.1, NM_001993.4 [P13726-1]
UniGeneiHs.62192

Genome annotation databases

EnsembliENST00000334047; ENSP00000334145; ENSG00000117525 [P13726-1]
ENST00000370207; ENSP00000359226; ENSG00000117525 [P13726-2]
GeneIDi2152
KEGGihsa:2152
UCSCiuc001dqr.4 human [P13726-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTF_HUMAN
AccessioniPrimary (citable) accession number: P13726
Secondary accession number(s): D3DT47, Q6FHG2, Q86WH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 23, 2018
This is version 198 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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