Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acyl-coenzyme A oxidase

Gene

POX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:YGL205W-MONOMER.
YEAST:YGL205W-MONOMER.
ReactomeiR-SCE-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-SCE-2046106. alpha-linolenic acid (ALA) metabolism.
R-SCE-389887. Beta-oxidation of pristanoyl-CoA.
R-SCE-390247. Beta-oxidation of very long chain fatty acids.
UniPathwayiUPA00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidase (EC:1.3.3.6)
Short name:
Acyl-CoA oxidase
Gene namesi
Name:POX1
Synonyms:FOX1
Ordered Locus Names:YGL205W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL205W.
SGDiS000003173. POX1.

Subcellular locationi

GO - Cellular componenti

  • peroxisomal matrix Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Acyl-coenzyme A oxidasePRO_0000204704Add
BLAST

Interactioni

Subunit structurei

Homooctamer.

Protein-protein interaction databases

BioGridi33051. 57 interactions.
DIPiDIP-6592N.
IntActiP13711. 5 interactions.
MINTiMINT-707840.

Structurei

3D structure databases

ProteinModelPortaliP13711.
SMRiP13711. Positions 14-720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000062919.
HOGENOMiHOG000181256.
InParanoidiP13711.
KOiK00232.
OMAiPILKTDT.
OrthoDBiEOG092C0VH7.

Family and domain databases

Gene3Di1.10.540.10. 2 hits.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

P13711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRTTINPD SVVLNPQKFI QKERADSKIK VDQVNTFLES SPERRTLTHA
60 70 80 90 100
LIDQIVNDPI LKTDTDYYDA KKMQEREITA KKIARLASYM EHDIKTVRKH
110 120 130 140 150
FRDTDLMKEL QANDPDKASP LTNKDLFIFD KRLSLVANID PQLGTRVGVH
160 170 180 190 200
LGLFGNCIKG NGTDEQIRYW LQERGATLMK GIYGCFAMTE LGHGSNVAQL
210 220 230 240 250
QTRAVYDKQN DTFVIDTPDL TATKWWIGGA AHSATHAAVY ARLIVEGKDY
260 270 280 290 300
GVKTFVVPLR DPSTFQLLAG VSIGDIGAKM GRDGIDNGWI QFRNVVIPRE
310 320 330 340 350
FMLSRFTKVV RSPDGSVTVK TEPQLDQISG YSALLSGRVN MVMDSFRFGS
360 370 380 390 400
KFATIAVRYA VGRQQFAPRK GLSETQLIDY PLHQYRVLPQ LCVPYLVSPV
410 420 430 440 450
AFKLMDNYYS TLDELYNASS SAYKAALVTV SKKLKNLFID SASLKATNTW
460 470 480 490 500
LIATLIDELR QTCGGHGYSQ YNGFGKGYDD WVVQCTWEGD NNVLSLTSAK
510 520 530 540 550
SILKKFIDSA TKGRFDNTLD VDSFSYLKPQ YIGSVVSGEI KSGLKELGDY
560 570 580 590 600
TEIWSITLIK LLAHIGTLVE KSRSIDSVSK LLVLVSKFHA LRCMLKTYYD
610 620 630 640 650
KLNSRDSHIS DEITKESMWN VYKLFSLYFI DKHSGEFQQF KIFTPDQISK
660 670 680 690 700
VVQPQLLALL PIVRKDCIGL TDSFELPDAM LNSPIGYFDG DIYHNYFNEV
710 720 730 740
CRNNPVEADG AGKPSYHALL SSMLGRGFEF DQKLGGAANA EILSKINK
Length:748
Mass (Da):84,042
Last modified:October 1, 1996 - v2
Checksum:i5C0664455A050BDA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti443 – 4431S → T in AAA34891 (PubMed:2189786).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27515 Genomic DNA. Translation: AAA34891.1.
Z72727 Genomic DNA. Translation: CAA96918.1.
Z72726 Genomic DNA. Translation: CAA96917.1.
BK006941 Genomic DNA. Translation: DAA07911.1.
PIRiS64224.
RefSeqiNP_011310.1. NM_001181070.1.

Genome annotation databases

EnsemblFungiiYGL205W; YGL205W; YGL205W.
GeneIDi852667.
KEGGisce:YGL205W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27515 Genomic DNA. Translation: AAA34891.1.
Z72727 Genomic DNA. Translation: CAA96918.1.
Z72726 Genomic DNA. Translation: CAA96917.1.
BK006941 Genomic DNA. Translation: DAA07911.1.
PIRiS64224.
RefSeqiNP_011310.1. NM_001181070.1.

3D structure databases

ProteinModelPortaliP13711.
SMRiP13711. Positions 14-720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33051. 57 interactions.
DIPiDIP-6592N.
IntActiP13711. 5 interactions.
MINTiMINT-707840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL205W; YGL205W; YGL205W.
GeneIDi852667.
KEGGisce:YGL205W.

Organism-specific databases

EuPathDBiFungiDB:YGL205W.
SGDiS000003173. POX1.

Phylogenomic databases

GeneTreeiENSGT00530000062919.
HOGENOMiHOG000181256.
InParanoidiP13711.
KOiK00232.
OMAiPILKTDT.
OrthoDBiEOG092C0VH7.

Enzyme and pathway databases

UniPathwayiUPA00661.
BioCyciMetaCyc:YGL205W-MONOMER.
YEAST:YGL205W-MONOMER.
ReactomeiR-SCE-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-SCE-2046106. alpha-linolenic acid (ALA) metabolism.
R-SCE-389887. Beta-oxidation of pristanoyl-CoA.
R-SCE-390247. Beta-oxidation of very long chain fatty acids.

Miscellaneous databases

PROiP13711.

Family and domain databases

Gene3Di1.10.540.10. 2 hits.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACOX_YEAST
AccessioniPrimary (citable) accession number: P13711
Secondary accession number(s): D6VTV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.