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Protein

Acyl-coenzyme A oxidase

Gene

POX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:YGL205W-MONOMER
YEAST:YGL205W-MONOMER
ReactomeiR-SCE-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-SCE-2046106 alpha-linolenic acid (ALA) metabolism
R-SCE-389887 Beta-oxidation of pristanoyl-CoA
R-SCE-390247 Beta-oxidation of very long chain fatty acids
R-SCE-9033241 Peroxisomal protein import
UniPathwayiUPA00661

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidase (EC:1.3.3.6)
Short name:
Acyl-CoA oxidase
Gene namesi
Name:POX1
Synonyms:FOX1
Ordered Locus Names:YGL205W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL205W
SGDiS000003173 POX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047041 – 748Acyl-coenzyme A oxidaseAdd BLAST748

Proteomic databases

PaxDbiP13711
PRIDEiP13711

Interactioni

Subunit structurei

Homooctamer.

Protein-protein interaction databases

BioGridi33051, 121 interactors
DIPiDIP-6592N
IntActiP13711, 6 interactors
MINTiP13711
STRINGi4932.YGL205W

Structurei

3D structure databases

ProteinModelPortaliP13711
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000062919
HOGENOMiHOG000181256
InParanoidiP13711
KOiK00232
OMAiQKACVIA
OrthoDBiEOG092C0VH7

Family and domain databases

CDDicd01150 AXO, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

Sequencei

Sequence statusi: Complete.

P13711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRTTINPD SVVLNPQKFI QKERADSKIK VDQVNTFLES SPERRTLTHA
60 70 80 90 100
LIDQIVNDPI LKTDTDYYDA KKMQEREITA KKIARLASYM EHDIKTVRKH
110 120 130 140 150
FRDTDLMKEL QANDPDKASP LTNKDLFIFD KRLSLVANID PQLGTRVGVH
160 170 180 190 200
LGLFGNCIKG NGTDEQIRYW LQERGATLMK GIYGCFAMTE LGHGSNVAQL
210 220 230 240 250
QTRAVYDKQN DTFVIDTPDL TATKWWIGGA AHSATHAAVY ARLIVEGKDY
260 270 280 290 300
GVKTFVVPLR DPSTFQLLAG VSIGDIGAKM GRDGIDNGWI QFRNVVIPRE
310 320 330 340 350
FMLSRFTKVV RSPDGSVTVK TEPQLDQISG YSALLSGRVN MVMDSFRFGS
360 370 380 390 400
KFATIAVRYA VGRQQFAPRK GLSETQLIDY PLHQYRVLPQ LCVPYLVSPV
410 420 430 440 450
AFKLMDNYYS TLDELYNASS SAYKAALVTV SKKLKNLFID SASLKATNTW
460 470 480 490 500
LIATLIDELR QTCGGHGYSQ YNGFGKGYDD WVVQCTWEGD NNVLSLTSAK
510 520 530 540 550
SILKKFIDSA TKGRFDNTLD VDSFSYLKPQ YIGSVVSGEI KSGLKELGDY
560 570 580 590 600
TEIWSITLIK LLAHIGTLVE KSRSIDSVSK LLVLVSKFHA LRCMLKTYYD
610 620 630 640 650
KLNSRDSHIS DEITKESMWN VYKLFSLYFI DKHSGEFQQF KIFTPDQISK
660 670 680 690 700
VVQPQLLALL PIVRKDCIGL TDSFELPDAM LNSPIGYFDG DIYHNYFNEV
710 720 730 740
CRNNPVEADG AGKPSYHALL SSMLGRGFEF DQKLGGAANA EILSKINK
Length:748
Mass (Da):84,042
Last modified:October 1, 1996 - v2
Checksum:i5C0664455A050BDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti443S → T in AAA34891 (PubMed:2189786).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27515 Genomic DNA Translation: AAA34891.1
Z72727 Genomic DNA Translation: CAA96918.1
Z72726 Genomic DNA Translation: CAA96917.1
BK006941 Genomic DNA Translation: DAA07911.1
PIRiS64224
RefSeqiNP_011310.1, NM_001181070.1

Genome annotation databases

EnsemblFungiiYGL205W; YGL205W; YGL205W
GeneIDi852667
KEGGisce:YGL205W

Similar proteinsi

Entry informationi

Entry nameiACOX_YEAST
AccessioniPrimary (citable) accession number: P13711
Secondary accession number(s): D6VTV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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