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Protein

Homeotic protein female sterile

Gene

fs(1)h

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required maternally for proper expression of other homeotic genes involved in pattern formation, such as Ubx.1 Publication

GO - Molecular functioni

GO - Biological processi

  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • positive regulation of transcription elongation from RNA polymerase II promoter Source: FlyBase
  • protein phosphorylation Source: GOC
  • regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • terminal region determination Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein female sterile
Alternative name(s):
Fragile-chorion membrane protein
Gene namesi
Name:fs(1)h
Synonyms:fsh
ORF Names:CG2252
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004656. fs(1)h.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence analysisAdd
BLAST
Transmembranei750 – 77021HelicalSequence analysisAdd
BLAST
Transmembranei790 – 81021HelicalSequence analysisAdd
BLAST
Transmembranei816 – 83015HelicalSequence analysisAdd
BLAST
Transmembranei874 – 89421HelicalSequence analysisAdd
BLAST
Transmembranei1731 – 175121HelicalSequence analysisAdd
BLAST
Transmembranei1939 – 195921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20382038Homeotic protein female sterilePRO_0000211194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei452 – 4521Phosphoserine1 Publication
Modified residuei943 – 9431Phosphoserine1 Publication
Modified residuei1653 – 16531Phosphoserine1 Publication
Modified residuei1980 – 19801Phosphoserine1 Publication
Modified residuei1988 – 19881Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP13709.
PRIDEiP13709.

PTM databases

iPTMnetiP13709.

Expressioni

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiP13709.
ExpressionAtlasiP13709. differential.
GenevisibleiP13709. DM.

Interactioni

Protein-protein interaction databases

BioGridi58193. 8 interactions.
DIPiDIP-19376N.
IntActiP13709. 29 interactions.
MINTiMINT-925900.
STRINGi7227.FBpp0305499.

Structurei

3D structure databases

ProteinModelPortaliP13709.
SMRiP13709. Positions 1-141, 477-586, 947-1025.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 12373Bromo 1PROSITE-ProRule annotationAdd
BLAST
Domaini495 – 56773Bromo 2PROSITE-ProRule annotationAdd
BLAST
Domaini942 – 102483NETPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 bromo domains.PROSITE-ProRule annotation
Contains 1 NET domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1474. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
HOGENOMiHOG000264002.
InParanoidiP13709.
OrthoDBiEOG7TTQ86.
PhylomeDBiP13709.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR031354. BRD4_CDT.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]
PfamiPF17035. BET. 1 hit.
PF17105. BRD4_CDT. 1 hit.
PF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P13709-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSEPPPRY EPPVEPVNGI VQPPVIPPAE RPGRNTNQLQ YLIKTVMKVI
60 70 80 90 100
WKHHFSWPFQ QPVDAKKLNL PDYHKIIKQP MDMGTIKKRL ENNYYWSAKE
110 120 130 140 150
TIQDFNTMFN NCYVYNKPGE DVVVMAQTLE KVFLQKIESM PKEELELEPV
160 170 180 190 200
TAKGGKKKQR APATPKSSSG GAGASTGSGT SSAAVTSGPG SGSTKVSVAA
210 220 230 240 250
SSAQQSGLQG ATGAGGGSSS TPGTQPGSGA GGAIAARPVS AMGGTVSSTA
260 270 280 290 300
GGAPSIPPIS TMPPHTVPGS TNTTTTAMAG GVGGPGAAGA NPNAAALMAS
310 320 330 340 350
LLNAGQTGAY PGAPGQTAVN SSSLLDGSTA AVAAAAAAAA AAAAAAGGAA
360 370 380 390 400
GAAGGAGTIP AVAVNAANAV QAYVNAGVSV GVDAVIPPQQ PAKIKKGVKR
410 420 430 440 450
KADTTTPTAN AFESPYTQMD SKSAKIATRR ESNRQDLTFQ GSGYNMSPLG
460 470 480 490 500
VSGVPGLGGL VAGGVAGVAV AKNKEKLSDA LKSCNEILKE LFSKKHSGYA
510 520 530 540 550
WPFYKPVDAE MLGLHDYHDI IKKPMDLGTV KRKMDNREYK SAPEFAADVR
560 570 580 590 600
LIFTNCYKYN PPDHDVVAMG RKLQDVFEMR YANIPDEPVA NAAHHHGHGH
610 620 630 640 650
GHGHGHGHGH GHGHGHGHGH GYGGSSSLKH DASDSSSEDS SDTENESNSD
660 670 680 690 700
EERSARLKML ESKLLGLQEE IRKLSEEASA KKKAKKKLKE KKKSIGGGSG
710 720 730 740 750
SGSASHHCHA TGGGANAGGA GGPGSGGHGS VSVPGGVGSL GPGGAGGANL
760 770 780 790 800
NALLGGSLVG HGGAAVAGGV PNVGALHSQV HDVAMAFSQM AGGGAAAGAG
810 820 830 840 850
FGAGVTAAGA SSGGKAGTLA GALAAGAAAG AGGTTAGSGS SKGAKSKGGR
860 870 880 890 900
GAKGSGAGGV GASNNAAAGN AAGGAAGAAA GAGSVGGVGG AGAAGGGNAS
910 920 930 940 950
KRAKGSSSAG AGGGVGGANA SAGGAGARGS SKKKPSQVMN FDSEEEDTAK
960 970 980 990 1000
PMSYDEKRQL SLDINKLPGD KLGRVVHIIQ NREPSLRDSN PDEIEIDFET
1010 1020 1030 1040 1050
LKPSTLRELE SYVASCLRKK THKKPSGKSK DEQMAEKKQE LEKRLQDVTG
1060 1070 1080 1090 1100
QLGASKKTAK KDESASSKVE AVQPANPVSS SSSSSDSSSS SSSDSSSSDS
1110 1120 1130 1140 1150
SDSEAGDGDE RPPRKKKSRD SNGSNVNNPS INVVMGGNLP SGALSPTTML
1160 1170 1180 1190 1200
MGLDHVVNSN TPTSQMSNML GNANPLTAAA MLNNNNKTSL PGSNFGGAPA
1210 1220 1230 1240 1250
PGNMMHAGAG VPVAGAAVSA STGQQHNKNG PNDLSKVQPG GPINAALPPH
1260 1270 1280 1290 1300
SFAGGTATVA TSQSSGGIRI ASNLHKPSGL GGGDLGEHHA ALAAALTSGI
1310 1320 1330 1340 1350
NSTGTAGGGI NNNGGSNNNA NPLGGSHGDA MVNASLASLA SGLKQIPQFD
1360 1370 1380 1390 1400
DPVEQSLASL EFSAGSTGKS GLTDNFLMQQ HLMQPAGPQQ QQQQQQQQPF
1410 1420 1430 1440 1450
GHQQQQQQQQ QQQQQQQQHM DYVTELLSKG AENVGGMNGN HLLNFNLDMA
1460 1470 1480 1490 1500
AAYQQKHPQQ QQQQAHNNGF NVADFGMAGF DGLNMTAASF LDLEPSLQQQ
1510 1520 1530 1540 1550
QMQQMQLQQQ HHQQQQQQTH QQQQQHQQQH HQQQQQQQLT QQQLQQQQQQ
1560 1570 1580 1590 1600
QQQQQHLQQQ QHQQQHHQAA NKLLIIPKPI ESMMPSPPDK QQLQQHQKVL
1610 1620 1630 1640 1650
PPQQSPSDMK LHPNAAAAAA VASAQAKLVQ TFKANEQNLK NASSWSSLAS
1660 1670 1680 1690 1700
ANSPQSHTSS SSSSSKAKPA MDSFQQFRNK AKERDRLKLL EAAEKEKKNQ
1710 1720 1730 1740 1750
KEAAEKEQQR KHHKSSSSSL TSAAVAQAAA IAAATAAAAV TLGAAAAAAL
1760 1770 1780 1790 1800
ASSASNPSGG SSSGGAGSTS QQAITGDRDR DRDRERERER SGSGGGQSGN
1810 1820 1830 1840 1850
GNNSSNSANS NGPGSAGSGG SGGGGGSGPA SAGGPNSGGG GTANSNSGGG
1860 1870 1880 1890 1900
GGGGGPALLN AGSNSNSGVG SGGAASSNSN SSVGGIVGSG GPGSNSQGSS
1910 1920 1930 1940 1950
GGGGGGPASG GGMGSGAIDY GQQVAVLTQV AANAQAQHVA AAVAAQAILA
1960 1970 1980 1990 2000
ASPLGAMESG RKSVHDAQPQ ISRVEDIKAS PGGQGQSSPA QQSPQDRAAA
2010 2020 2030
KRAEQRRAEQ ERRRREALAG QIDMNMQSDL MAAFEETL
Length:2,038
Mass (Da):205,345
Last modified:June 21, 2005 - v2
Checksum:iDC4A1A7B1266191E
GO
Isoform A (identifier: P13709-2) [UniParc]FASTAAdd to basket

Also known as: C, D, E

The sequence of this isoform differs from the canonical sequence as follows:
     1022-1022: H → RKPYY
     1107-2038: Missing.

Show »
Length:1,110
Mass (Da):110,620
Checksum:i9E60DC63BB2DC524
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti909 – 9091A → G in AAA28540 (PubMed:2567251).Curated
Sequence conflicti1403 – 14031Q → QQ in AAA28540 (PubMed:2567251).Curated
Sequence conflicti1532 – 15321Missing in AAA28540 (PubMed:2567251).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1022 – 10221H → RKPYY in isoform A. 2 PublicationsVSP_014148
Alternative sequencei1107 – 2038932Missing in isoform A. 2 PublicationsVSP_014149Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23221 mRNA. Translation: AAA28540.1.
M23222 mRNA. Translation: AAA28541.1.
AE014298 Genomic DNA. Translation: AAF46312.3.
AE014298 Genomic DNA. Translation: AAN09226.1.
AE014298 Genomic DNA. Translation: AAS65277.1.
AE014298 Genomic DNA. Translation: AAS65278.1.
AE014298 Genomic DNA. Translation: AAS65279.1.
BT015270 mRNA. Translation: AAT94499.1.
M15762 Genomic DNA. Translation: AAA70424.1.
M15763 mRNA. Translation: AAA70423.1.
M15764 mRNA. Translation: AAA70422.1.
PIRiA43742.
RefSeqiNP_001162699.1. NM_001169228.2. [P13709-2]
NP_511078.2. NM_078523.3. [P13709-1]
NP_727228.1. NM_167144.4. [P13709-2]
NP_996368.1. NM_206645.4. [P13709-2]
NP_996369.1. NM_206646.4. [P13709-2]
NP_996370.1. NM_206647.3. [P13709-2]
UniGeneiDm.7909.

Genome annotation databases

EnsemblMetazoaiFBtr0071119; FBpp0071074; FBgn0004656. [P13709-1]
GeneIDi31722.
KEGGidme:Dmel_CG2252.
UCSCiCG2252-RC. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23221 mRNA. Translation: AAA28540.1.
M23222 mRNA. Translation: AAA28541.1.
AE014298 Genomic DNA. Translation: AAF46312.3.
AE014298 Genomic DNA. Translation: AAN09226.1.
AE014298 Genomic DNA. Translation: AAS65277.1.
AE014298 Genomic DNA. Translation: AAS65278.1.
AE014298 Genomic DNA. Translation: AAS65279.1.
BT015270 mRNA. Translation: AAT94499.1.
M15762 Genomic DNA. Translation: AAA70424.1.
M15763 mRNA. Translation: AAA70423.1.
M15764 mRNA. Translation: AAA70422.1.
PIRiA43742.
RefSeqiNP_001162699.1. NM_001169228.2. [P13709-2]
NP_511078.2. NM_078523.3. [P13709-1]
NP_727228.1. NM_167144.4. [P13709-2]
NP_996368.1. NM_206645.4. [P13709-2]
NP_996369.1. NM_206646.4. [P13709-2]
NP_996370.1. NM_206647.3. [P13709-2]
UniGeneiDm.7909.

3D structure databases

ProteinModelPortaliP13709.
SMRiP13709. Positions 1-141, 477-586, 947-1025.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58193. 8 interactions.
DIPiDIP-19376N.
IntActiP13709. 29 interactions.
MINTiMINT-925900.
STRINGi7227.FBpp0305499.

PTM databases

iPTMnetiP13709.

Proteomic databases

PaxDbiP13709.
PRIDEiP13709.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071119; FBpp0071074; FBgn0004656. [P13709-1]
GeneIDi31722.
KEGGidme:Dmel_CG2252.
UCSCiCG2252-RC. d. melanogaster.

Organism-specific databases

CTDi31722.
FlyBaseiFBgn0004656. fs(1)h.

Phylogenomic databases

eggNOGiKOG1474. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
HOGENOMiHOG000264002.
InParanoidiP13709.
OrthoDBiEOG7TTQ86.
PhylomeDBiP13709.

Miscellaneous databases

GenomeRNAii31722.
PROiP13709.

Gene expression databases

BgeeiP13709.
ExpressionAtlasiP13709. differential.
GenevisibleiP13709. DM.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR031354. BRD4_CDT.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]
PfamiPF17035. BET. 1 hit.
PF17105. BRD4_CDT. 1 hit.
PF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila fsh locus, a maternal effect homeotic gene, encodes apparent membrane proteins."
    Haynes S.R., Mozer B.A., Bhatia-Dey N., Dawid I.B.
    Dev. Biol. 134:246-257(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A AND B), FUNCTION, DEVELOPMENTAL STAGE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Pen repeat sequences are GGN clusters and encode a glycine-rich domain in a Drosophila cDNA homologous to the rat helix destabilizing protein."
    Haynes S.R., Rebbert M.L., Mozer B.A., Forquignon F., Dawid I.B.
    Proc. Natl. Acad. Sci. U.S.A. 84:1819-1823(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 308-357 AND 848-897, NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1812-1861.
    Strain: Canton-S.
    Tissue: Embryo.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452; SER-943; SER-1653; SER-1980 AND SER-1988, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiFSH_DROME
AccessioniPrimary (citable) accession number: P13709
Secondary accession number(s): A4V442
, P13710, Q8IRN6, Q9W3L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 21, 2005
Last modified: June 8, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.