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P13707

- GPDA_MOUSE

UniProt

P13707 - GPDA_MOUSE

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Protein
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Gene
Gpd1, Gdc-1, Gdc1, Kiaa4010
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411NAD By similarity
Binding sitei97 – 971NAD By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei153 – 1531NAD; via amide nitrogen By similarity
Active sitei204 – 2041Proton acceptor Reviewed prediction
Binding sitei269 – 2691NAD By similarity
Binding sitei296 – 2961NAD; via amide nitrogen By similarity
Binding sitei298 – 2981NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: Ensembl
  2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: MGI
  3. glycerol-3-phosphate dehydrogenase activity Source: Ensembl

GO - Biological processi

  1. NADH oxidation Source: Ensembl
  2. cellular response to cAMP Source: MGI
  3. cellular response to tumor necrosis factor Source: MGI
  4. gluconeogenesis Source: MGI
  5. glycerol-3-phosphate catabolic process Source: InterPro
  6. glycerol-3-phosphate metabolic process Source: MGI
  7. glycerolipid metabolic process Source: Ensembl
  8. glycerophosphate shuttle Source: MGI
  9. positive regulation of glycolytic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_188640. Synthesis of PA.
SABIO-RKP13707.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (EC:1.1.1.8)
Short name:
GPD-C
Short name:
GPDH-C
Gene namesi
Name:Gpd1
Synonyms:Gdc-1, Gdc1, Kiaa4010
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:95679. Gpd1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. glycerol-3-phosphate dehydrogenase complex Source: MGI
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
PRO_0000138080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891N6-succinyllysine1 Publication

Proteomic databases

MaxQBiP13707.
PaxDbiP13707.
PRIDEiP13707.

2D gel databases

REPRODUCTION-2DPAGEIPI00230185.
P13707.
SWISS-2DPAGEP13707.

PTM databases

PhosphoSiteiP13707.

Expressioni

Gene expression databases

ArrayExpressiP13707.
BgeeiP13707.
CleanExiMM_GPD1.
GenevestigatoriP13707.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP13707. 7 interactions.
MINTiMINT-1855802.

Structurei

3D structure databases

ProteinModelPortaliP13707.
SMRiP13707. Positions 1-349.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 2702Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiP13707.
KOiK00006.
OMAiPVGEFIH.
OrthoDBiEOG7ZKSBS.
PhylomeDBiP13707.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13707-1 [UniParc]FASTAAdd to Basket

« Hide

MAGKKVCIVG SGNWGSAIAK IVGSNAGRLA HFDPRVTMWV FEEDIGGRKL    50
TEIINTQHEN VKYLPGHKLP PNVVAIPDVV QAATGADILV FVVPHQFIGK 100
ICDQLKGHLK ANTIGISLIK GVDEGPNGLK LISEVIGERL GIPMSVLMGA 150
NIASEVAEEK FCETTIGCKD PAQGQLLKDL MQTPNFRITV VQEVDTVEIC 200
GALKNIVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFCSGTVSSA 250
TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE MLNGQKLQGP 300
QTARELHSIL QHKGLVDKFP LFTAVYKVCY EGQPVGEFIR CLQNHPEHM 349
Length:349
Mass (Da):37,573
Last modified:January 23, 2007 - v3
Checksum:iF2C572DADFEA1B99
GO

Sequence cautioni

The sequence BAD90479.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181G → R AA sequence 1 Publication
Sequence conflicti246 – 2461T → I in AAA37726. 1 Publication
Sequence conflicti246 – 2461T → I in AAA37727. 1 Publication
Sequence conflicti246 – 2461T → I in BAD90479. 1 Publication
Sequence conflicti318 – 3181K → R in BAE23246. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02655 mRNA. Translation: AAA37728.1.
M25558 Genomic DNA. Translation: AAA37726.1.
M13366 Genomic DNA. Translation: AAA37727.1.
AK220445 mRNA. Translation: BAD90479.1. Different initiation.
AK137134 mRNA. Translation: BAE23246.1.
AK004565 mRNA. Translation: BAB23376.1.
AK018733 mRNA. Translation: BAB31376.1.
BC005756 mRNA. Translation: AAH05756.1.
BC019391 mRNA. Translation: AAH19391.1.
CCDSiCCDS27828.1.
PIRiA25952.
RefSeqiNP_034401.1. NM_010271.2.
UniGeneiMm.252391.

Genome annotation databases

EnsembliENSMUST00000023760; ENSMUSP00000023760; ENSMUSG00000023019.
GeneIDi14555.
KEGGimmu:14555.
UCSCiuc007xqd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02655 mRNA. Translation: AAA37728.1 .
M25558 Genomic DNA. Translation: AAA37726.1 .
M13366 Genomic DNA. Translation: AAA37727.1 .
AK220445 mRNA. Translation: BAD90479.1 . Different initiation.
AK137134 mRNA. Translation: BAE23246.1 .
AK004565 mRNA. Translation: BAB23376.1 .
AK018733 mRNA. Translation: BAB31376.1 .
BC005756 mRNA. Translation: AAH05756.1 .
BC019391 mRNA. Translation: AAH19391.1 .
CCDSi CCDS27828.1.
PIRi A25952.
RefSeqi NP_034401.1. NM_010271.2.
UniGenei Mm.252391.

3D structure databases

ProteinModelPortali P13707.
SMRi P13707. Positions 1-349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P13707. 7 interactions.
MINTi MINT-1855802.

Chemistry

ChEMBLi CHEMBL1075171.

PTM databases

PhosphoSitei P13707.

2D gel databases

REPRODUCTION-2DPAGE IPI00230185.
P13707.
SWISS-2DPAGE P13707.

Proteomic databases

MaxQBi P13707.
PaxDbi P13707.
PRIDEi P13707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023760 ; ENSMUSP00000023760 ; ENSMUSG00000023019 .
GeneIDi 14555.
KEGGi mmu:14555.
UCSCi uc007xqd.1. mouse.

Organism-specific databases

CTDi 2819.
MGIi MGI:95679. Gpd1.
Rougei Search...

Phylogenomic databases

eggNOGi COG0240.
GeneTreei ENSGT00390000003114.
HOGENOMi HOG000246855.
HOVERGENi HBG003669.
InParanoidi P13707.
KOi K00006.
OMAi PVGEFIH.
OrthoDBi EOG7ZKSBS.
PhylomeDBi P13707.
TreeFami TF300836.

Enzyme and pathway databases

Reactomei REACT_188640. Synthesis of PA.
SABIO-RK P13707.

Miscellaneous databases

ChiTaRSi GPD1. mouse.
NextBioi 286250.
PROi P13707.
SOURCEi Search...

Gene expression databases

ArrayExpressi P13707.
Bgeei P13707.
CleanExi MM_GPD1.
Genevestigatori P13707.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and hormonal regulation of mouse glycerophosphate dehydrogenase mRNA during adipocyte and muscle cell differentiation."
    Dobson D.E., Groves D.L., Spiegelman B.M.
    J. Biol. Chem. 262:1804-1809(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Primary structure of the mouse glycerol-3-phosphate dehydrogenase gene."
    Ireland R.C., Kotarski M.A., Johnston L.A., Stadler U., Birkenmeier E., Kozak L.P.
    J. Biol. Chem. 261:11779-11785(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of three genes participating in the adipose differentiation of 3T3 cells."
    Phillips M., Djian P., Green H.
    J. Biol. Chem. 261:10821-10827(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney, Lung and Urinary bladder.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  7. Lubec G., Klug S., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 50-62; 111-130; 205-218; 230-240; 297-304 AND 319-340, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain and Hippocampus.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-289, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGPDA_MOUSE
AccessioniPrimary (citable) accession number: P13707
Secondary accession number(s): Q3UVM3, Q5DTS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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