Reviewed, UniProtKB/Swiss-Prot P13701 (SYB_TORCA)

Names and origin

Protein names	Recommended name:     Synaptobrevin Alternative name(s):     Synaptic vesicle-associated integral membrane protein     VAMP-1
Organism	Torpedo californica (Pacific electric ray)
Taxonomic identifier	7787 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Squalea › Hypnosqualea › Pristiorajea › Batoidea › Torpediniformes › Torpedinoidei › Torpedinidae › Torpedo

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This protein may play a role in packaging, transport or release of neurotransmitters.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction › synapse › synaptosome. Note: Neuronal synaptic vesicles.
Tissue specificity	Nervous system specific.
Sequence similarities	Belongs to the synaptobrevin family. Contains 1 v-SNARE coiled-coil homology domain.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse Synaptosome
Domain	Coiled coil Transmembrane
Gene Ontology (GO)
Biological process	vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-KW synaptosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	Synaptobrevin		PRO_0000206743
Regions
	Topological domain	1 – 98	98	Cytoplasmic Potential
	Transmembrane	99 – 118	20	Anchor for type IV membrane protein Potential
	Topological domain	119 – 120	2	Vesicular Potential
	Domain	35 – 95	61	v-SNARE coiled-coil homology
	Compositional bias	1 – 28	28	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	P13701-1 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: D430AEE0A6F4A1AB	FASTA	120	12,979
	10 20 30 40 50 60 MSAPPSGPAP DAQGGAPGQP TGPPGAPPNT TSNRRLQQTQ AQVEEVVDII RVNVDKVLER 70 80 90 100 110 120 DQKLSELDDR ADALQAGASQ FESSAAKLKR KYWWKNCKMM IMLGGIGAII VIVIIIYFFT

References

[1]	"VAMP-1: a synaptic vesicle-associated integral membrane protein." Trimble W.S., Cowen D.M., Scheller R.H. Proc. Natl. Acad. Sci. U.S.A. 85:4538-4542(1988) [PubMed: 3380805] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	J03777 mRNA. Translation: AAA49286.1.
PIR	A32146.
3D structure databases
SMR	P13701. Positions 32-100.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P13701.
Family and domain databases
InterPro	IPR001388. Synaptobrevin. IPR016444. Synaptobrevin_met/fun. [Graphical view]
Pfam	PF00957. Synaptobrevin. 1 hit. [Graphical view]
PIRSF	PIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTS	PR00219. SYNAPTOBREVN.
PROSITE	PS00417. SYNAPTOBREVIN. 1 hit. PS50892. V_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYB_TORCA

Accession

Primary (citable) accession number: P13701

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)