P13701 (SYB_TORCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Synaptobrevin Alternative name(s): Synaptic vesicle-associated integral membrane protein VAMP-1
Organism	Torpedo californica (Pacific electric ray)
Taxonomic identifier	7787 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Squalea › Hypnosqualea › Pristiorajea › Batoidea › Torpediniformes › Torpedinoidei › Torpedinidae › Torpedo

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein may play a role in packaging, transport or release of neurotransmitters.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction › synapse › synaptosome. Note: Neuronal synaptic vesicles.
Tissue specificity	Nervous system specific.
Sequence similarities	Belongs to the synaptobrevin family. Contains 1 v-SNARE coiled-coil homology domain.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse Synaptosome
Domain	Coiled coil Transmembrane Transmembrane helix
Gene Ontology (GO)
Biological process	vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synaptosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	Synaptobrevin		PRO_0000206743
Regions
	Topological domain	1 – 98	98	Cytoplasmic Potential
	Transmembrane	99 – 118	20	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	119 – 120	2	Vesicular Potential
	Domain	35 – 95	61	v-SNARE coiled-coil homology
	Compositional bias	1 – 28	28	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	P13701 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: D430AEE0A6F4A1AB	FASTA	120	12,979
	10 20 30 40 50 60 MSAPPSGPAP DAQGGAPGQP TGPPGAPPNT TSNRRLQQTQ AQVEEVVDII RVNVDKVLER 70 80 90 100 110 120 DQKLSELDDR ADALQAGASQ FESSAAKLKR KYWWKNCKMM IMLGGIGAII VIVIIIYFFT

References

[1]	"VAMP-1: a synaptic vesicle-associated integral membrane protein." Trimble W.S., Cowen D.M., Scheller R.H. Proc. Natl. Acad. Sci. U.S.A. 85:4538-4542(1988) [PubMed: 3380805] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J03777 mRNA. Translation: AAA49286.1.
PIR	A32146.
3D structure databases
ProteinModelPortal	P13701.
SMR	P13701. Positions 32-100.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006675.
Family and domain databases
InterPro	IPR001388. Synaptobrevin. IPR016444. Synaptobrevin_met/fun. [Graphical view]
Pfam	PF00957. Synaptobrevin. 1 hit. [Graphical view]
PIRSF	PIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTS	PR00219. SYNAPTOBREVN.
PROSITE	PS00417. SYNAPTOBREVIN. 1 hit. PS50892. V_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYB_TORCA

Accession

Primary (citable) accession number: P13701

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	August 10, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program