P13693 (TCTP_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 132.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Translationally-controlled tumor protein Short name=TCTP Alternative name(s): Fortilin Histamine-releasing factor Short name=HRF p23 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 172 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in calcium binding and microtubule stabilization. |
| Subunit structure | Interacts with STEAP3. Ref.17 |
| Subcellular location | |
| Tissue specificity | Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate. Ref.15 |
| Induction | Down-regulated in response to enterovirus 71 (EV71) infection. Ref.20 |
| Sequence similarities | Belongs to the TCTP family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Ligand | Calcium |
| PTM | Acetylation Phosphoprotein |
| Technical term | 3D-structure Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological process | anti-apoptosis Traceable author statement. Source: UniProtKB calcium ion transportInferred by curator Ref.19. Source: UniProtKB cellular calcium ion homeostasisInferred by curator Ref.19. Source: UniProtKB response to virusInferred from expression pattern Ref.20. Source: UniProtKB |
| Cellular component | extracellular space Inferred from direct assay Ref.17. Source: MGI multivesicular bodyInferred from direct assay Ref.17. Source: MGI |
| Molecular function | calcium ion binding Inferred from direct assay Ref.18Ref.19. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 172 | 172 | Translationally-controlled tumor protein | PRO_0000211268 | ||||||||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||||||||
| Modified residue | 46 | 1 | Phosphoserine; by PLK1 Ref.16 Ref.21 Ref.22 | |||||||||||||||||||||||||||||||||||
| Modified residue | 53 | 1 | Phosphoserine Ref.22 | |||||||||||||||||||||||||||||||||||
| Modified residue | 64 | 1 | Phosphoserine; by PLK1 Ref.16 | |||||||||||||||||||||||||||||||||||
| Modified residue | 93 | 1 | N6-acetyllysine Ref.23 | |||||||||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||||||||
| Natural variant | 146 | 1 | V → F. Corresponds to variant rs3087989 [ dbSNP | Ensembl ]. | VAR_052273 | ||||||||||||||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 53 – 54 | 2 | SA → YG in AAH12431. Ref.9 | |||||||||||||||||||||||||||||||||||
| Sequence conflict | 168 | 1 | E → K in AAQ01550. Ref.3 | |||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 2 – 6 | 5 | ||||||||||||||||||||||||||||||||||||
| Turn | 7 – 9 | 3 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 12 – 15 | 4 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 18 – 23 | 6 | ||||||||||||||||||||||||||||||||||||
| Helix | 24 – 26 | 3 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 28 – 32 | 5 | ||||||||||||||||||||||||||||||||||||
| Helix | 71 – 75 | 5 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 79 – 81 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 85 – 106 | 22 | ||||||||||||||||||||||||||||||||||||
| Helix | 108 – 110 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 111 – 127 | 17 | ||||||||||||||||||||||||||||||||||||
| Helix | 129 – 131 | 3 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 133 – 136 | 4 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 146 – 151 | 6 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 158 – 163 | 6 | ||||||||||||||||||||||||||||||||||||
| Helix | 164 – 166 | 3 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 167 – 171 | 5 | ||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "cDNA sequence coding for a translationally controlled human tumor protein." Gross B., Gaestel M., Boehm H., Bielka H. Nucleic Acids Res. 17:8367-8367(1989) [PubMed: 2813067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | Thiele H. Thesis (2000), Humboldt-University Berlin, Germany Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Cloning and characterization of TCTP from human eosinophils." Gnanasekar M., Ramaswamy K. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | Gao T.H., Duan F.L., Zhu W.L. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [5] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea. |
| [7] | "The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. Ross M.T.Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [8] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [9] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Placenta. |
| [10] | "Human liver protein map: a reference database established by microsequencing and gel comparison." Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J. Electrophoresis 13:992-1001(1992) [PubMed: 1286669] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-10. Tissue: Liver. |
| [11] | "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes." Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J. Electrophoresis 13:960-969(1992) [PubMed: 1286667] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-4; 22-31; 39-45 AND 103-109. Tissue: Keratinocyte. |
| [12] | "Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2." Rasmussen R.K., Ji H., Eddes J.S., Moritz R.L., Reid G.E., Simpson R.J., Dorow D.S. Electrophoresis 18:588-598(1997) [PubMed: 9150946] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-19. Tissue: Mammary carcinoma. |
| [13] | "Molecular identification of an IgE-dependent histamine-releasing factor." MacDonald S.M., Rafnar T., Langdon J., Lichtenstein L.M. Science 269:688-690(1995) [PubMed: 7542803] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-18. |
| [14] | Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 6-34; 111-123 AND 131-164, MASS SPECTROMETRY. Tissue: Fetal brain cortex. |
| [15] | "Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes." Sanchez J.-C., Schaller D., Ravier F., Golaz O., Jaccoud S., Belet M., Wilkins M.R., James R., Deshusses J., Hochstrasser D.F. Electrophoresis 18:150-155(1997) [PubMed: 9059837] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION. |
| [16] | "Plk phosphorylation regulates the microtubule-stabilizing protein TCTP." Yarm F.R. Mol. Cell. Biol. 22:6209-6221(2002) [PubMed: 12167714] [Abstract] Cited for: PHOSPHORYLATION AT SER-46 AND SER-64. |
| [17] | "TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway." Amzallag N., Passer B.J., Allanic D., Segura E., Thery C., Goud B., Amson R., Telerman A. J. Biol. Chem. 279:46104-46112(2004) [PubMed: 15319436] [Abstract] Cited for: INTERACTION WITH STEAP3. |
| [18] | "Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity." Arcuri F., Papa S., Carducci A., Romagnoli R., Liberatori S., Riparbelli M.G., Sanchez J.-C., Tosi P., del Vecchio M.T. Prostate 60:130-140(2004) [PubMed: 15162379] [Abstract] Cited for: CALCIUM-BINDING. |
| [19] | "The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells." Arcuri F., Papa S., Meini A., Carducci A., Romagnoli R., Bianchi L., Riparbelli M.G., Sanchez J.-C., Palmi M., Tosi P., Cintorino M. Biol. Reprod. 73:745-751(2005) [PubMed: 15958728] [Abstract] Cited for: CALCIUM-BINDING. Tissue: Placenta. |
| [20] | "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection." Leong W.F., Chow V.T. Cell. Microbiol. 8:565-580(2006) [PubMed: 16548883] [Abstract] Cited for: INDUCTION, MASS SPECTROMETRY. |
| [21] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [22] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46 AND SER-53, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [23] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-93, MASS SPECTROMETRY. |
| [24] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [25] | "Solution structure of human translationally controlled tumor protein." Liu D.S., Feng Y.G., Wang J.F. Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | X16064 mRNA. Translation: CAA34200.1. AJ400717 Genomic DNA. Translation: CAB87812.1. AY334563 mRNA. Translation: AAQ01550.1. AY117678 mRNA. Translation: AAM51565.1. CR457036 mRNA. Translation: CAG33317.1. AK312951 mRNA. Translation: BAG35792.1. AL138963 Genomic DNA. Translation: CAH72034.1. CH471075 Genomic DNA. Translation: EAX08732.1. BC003352 mRNA. Translation: AAH03352.1. BC012431 mRNA. Translation: AAH12431.1. BC052333 mRNA. Translation: AAH52333.1. | ||||||||||||||||||||||||
| IPI | IPI00550900. | ||||||||||||||||||||||||
| PIR | S06590. | ||||||||||||||||||||||||
| RefSeq | NP_003286.1. NM_003295.2. | ||||||||||||||||||||||||
| UniGene | Hs.374596. | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||||||||
| ProteinModelPortal | P13693. | ||||||||||||||||||||||||
| SMR | P13693. Positions 1-172. | ||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| IntAct | P13693. 23 interactions. | ||||||||||||||||||||||||
| MINT | MINT-2634453. | ||||||||||||||||||||||||
| STRING | P13693. | ||||||||||||||||||||||||
Protein family/group databases | |||||||||||||||||||||||||
| Allergome | 3816. Hom s TCTP. | ||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||
| PhosphoSite | P13693. | ||||||||||||||||||||||||
Polymorphism databases | |||||||||||||||||||||||||
| DMDM | 136479. | ||||||||||||||||||||||||
2D gel databases | |||||||||||||||||||||||||
| SWISS-2DPAGE | P13693. | ||||||||||||||||||||||||
| Aarhus/Ghent-2DPAGE | 8114. IEF. 9119. IEF. | ||||||||||||||||||||||||
| DOSAC-COBS-2DPAGE | P13693. | ||||||||||||||||||||||||
| OGP | P13693. | ||||||||||||||||||||||||
| REPRODUCTION-2DPAGE | IPI00550900. | ||||||||||||||||||||||||
| Siena-2DPAGE | P13693. | ||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||
| PRIDE | P13693. | ||||||||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENST00000309246; ENSP00000339051; ENSG00000133112. ENST00000379060; ENSP00000368350; ENSG00000133112. | ||||||||||||||||||||||||
| GeneID | 7178. | ||||||||||||||||||||||||
| KEGG | hsa:7178. | ||||||||||||||||||||||||
| UCSC | uc001uzy.1. human. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| CTD | 7178. | ||||||||||||||||||||||||
| GeneCards | GC13M045921. | ||||||||||||||||||||||||
| H-InvDB | HIX0011286. HIX0028410. HIX0034276. | ||||||||||||||||||||||||
| HGNC | HGNC:12022. TPT1. | ||||||||||||||||||||||||
| HPA | CAB008364. | ||||||||||||||||||||||||
| MIM | 600763. gene. | ||||||||||||||||||||||||
| neXtProt | NX_P13693. | ||||||||||||||||||||||||
| PharmGKB | PA36701. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| eggNOG | prNOG17188. | ||||||||||||||||||||||||
| HOVERGEN | HBG002282. | ||||||||||||||||||||||||
| InParanoid | P13693. | ||||||||||||||||||||||||
| OrthoDB | EOG4FJ89Z. | ||||||||||||||||||||||||
| PhylomeDB | P13693. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | P13693. | ||||||||||||||||||||||||
| Bgee | P13693. | ||||||||||||||||||||||||
| CleanEx | HS_TPT1. | ||||||||||||||||||||||||
| Genevestigator | P13693. | ||||||||||||||||||||||||
| GermOnline | ENSG00000133112. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR011057. Mss4-like. IPR011323. Mss4/transl-control_tumor. IPR018103. Translation_control_tumour_CS. IPR018105. Translational_control_tumour_p. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:2.170.150.10. Mss4/transl-control_tumor. 1 hit. | ||||||||||||||||||||||||
| PANTHER | PTHR11991. TCTP. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF00838. TCTP. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PRINTS | PR01653. TCTPROTEIN. | ||||||||||||||||||||||||
| SUPFAM | SSF51316. Mss4_like. 1 hit. | ||||||||||||||||||||||||
| PROSITE | PS01002. TCTP_1. 1 hit. PS01003. TCTP_2. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other | |||||||||||||||||||||||||
| NextBio | 28136. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | TCTP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P13693 Secondary accession number(s): B2R7E5 Q9UC70 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 13 Human chromosome 13: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with