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Protein

Translationally-controlled tumor protein

Gene

TPT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in calcium binding and microtubule stabilization.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • microtubule binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • calcium ion transport Source: UniProtKB
  • cell differentiation Source: GO_Central
  • cellular calcium ion homeostasis Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • regulation of apoptotic process Source: UniProtKB
  • response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133112-MONOMER.
SIGNORiP13693.

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein
Short name:
TCTP
Alternative name(s):
Fortilin
Histamine-releasing factor
Short name:
HRF
p23
Gene namesi
Name:TPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:12022. TPT1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: MGI
  • multivesicular body Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi7178.
OpenTargetsiENSG00000133112.
PharmGKBiPA36701.

Protein family/group databases

Allergomei3816. Hom s TCTP.

Polymorphism and mutation databases

DMDMi136479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112681 – 172Translationally-controlled tumor proteinAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46Phosphoserine; by PLK1Combined sources1 Publication1
Modified residuei53PhosphoserineCombined sources1
Modified residuei64Phosphoserine; by PLK11 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP13693.
MaxQBiP13693.
PaxDbiP13693.
PeptideAtlasiP13693.
PRIDEiP13693.
TopDownProteomicsiP13693-1. [P13693-1]

2D gel databases

DOSAC-COBS-2DPAGEP13693.
OGPiP13693.
REPRODUCTION-2DPAGEIPI00550900.
SWISS-2DPAGEP13693.

PTM databases

iPTMnetiP13693.
PhosphoSitePlusiP13693.
SwissPalmiP13693.

Expressioni

Tissue specificityi

Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.1 Publication

Inductioni

Down-regulated in response to enterovirus 71 (EV71) infection.1 Publication

Gene expression databases

BgeeiENSG00000133112.
CleanExiHS_TPT1.
ExpressionAtlasiP13693. baseline and differential.
GenevisibleiP13693. HS.

Organism-specific databases

HPAiCAB008364.
HPA039437.

Interactioni

Subunit structurei

Interacts with STEAP3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATP1A1P050235EBI-1783169,EBI-358778
EEF1DP296923EBI-1783169,EBI-358607
EEF1DP29692-23EBI-1783169,EBI-5280572
HSPB1P047922EBI-1783169,EBI-352682
TP53P046375EBI-1783169,EBI-366083
TRIP13Q156453EBI-1783169,EBI-358993
TSC22D1Q157145EBI-1783169,EBI-712609

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113030. 32 interactors.
DIPiDIP-40097N.
IntActiP13693. 32 interactors.
MINTiMINT-2634453.
STRINGi9606.ENSP00000431872.

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Turni7 – 9Combined sources3
Beta strandi12 – 15Combined sources4
Beta strandi18 – 23Combined sources6
Helixi24 – 26Combined sources3
Beta strandi28 – 32Combined sources5
Turni46 – 48Combined sources3
Helixi71 – 75Combined sources5
Beta strandi79 – 81Combined sources3
Helixi85 – 106Combined sources22
Helixi108 – 110Combined sources3
Helixi111 – 127Combined sources17
Helixi129 – 131Combined sources3
Beta strandi133 – 136Combined sources4
Beta strandi146 – 151Combined sources6
Beta strandi158 – 163Combined sources6
Helixi164 – 166Combined sources3
Beta strandi167 – 171Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZ1X-ray2.00A/B/C/D1-172[»]
2HR9NMR-A1-172[»]
3EBMX-ray2.60A/B/C/D1-172[»]
4Z9VX-ray2.10C/D/E/F/G/H11-31[»]
ProteinModelPortaliP13693.
SMRiP13693.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13693.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 172TCTPPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation
Contains 1 TCTP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
HOVERGENiHBG002282.
InParanoidiP13693.
PhylomeDBiP13693.
TreeFamiTF300238.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13693-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG
60 70 80 90 100
NASAEGPEGE GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK
110 120 130 140 150
GKLEEQRPER VKPFMTGAAE QIKHILANFK NYQFFIGENM NPDGMVALLD
160 170
YREDGVTPYM IFFKDGLEME KC
Length:172
Mass (Da):19,595
Last modified:January 1, 1990 - v1
Checksum:iBD31399B71CA62F9
GO
Isoform 2 (identifier: P13693-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:138
Mass (Da):15,597
Checksum:iFD4A670AEFAC61FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53 – 54SA → YG in AAH12431 (PubMed:15489334).Curated2
Sequence conflicti168E → K in AAQ01550 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052273146V → F.Corresponds to variant rs3087989dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0548381 – 34Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16064 mRNA. Translation: CAA34200.1.
AJ400717 Genomic DNA. Translation: CAB87812.1.
AY334563 mRNA. Translation: AAQ01550.1.
AY117678 mRNA. Translation: AAM51565.1.
CR457036 mRNA. Translation: CAG33317.1.
AK312951 mRNA. Translation: BAG35792.1.
AL138963 Genomic DNA. Translation: CAH72034.1.
CH471075 Genomic DNA. Translation: EAX08731.1.
CH471075 Genomic DNA. Translation: EAX08732.1.
BC003352 mRNA. Translation: AAH03352.1.
BC012431 mRNA. Translation: AAH12431.1.
BC022436 mRNA. Translation: AAH22436.1.
BC052333 mRNA. Translation: AAH52333.1.
CCDSiCCDS66538.1. [P13693-2]
CCDS9397.1. [P13693-1]
PIRiS06590.
RefSeqiNP_001273202.1. NM_001286273.1. [P13693-2]
NP_003286.1. NM_003295.3. [P13693-1]
UniGeneiHs.374596.
Hs.717316.

Genome annotation databases

EnsembliENST00000379055; ENSP00000368344; ENSG00000133112. [P13693-2]
ENST00000379056; ENSP00000368345; ENSG00000133112. [P13693-2]
ENST00000530705; ENSP00000431872; ENSG00000133112. [P13693-1]
GeneIDi7178.
KEGGihsa:7178.
UCSCiuc001uzy.3. human. [P13693-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16064 mRNA. Translation: CAA34200.1.
AJ400717 Genomic DNA. Translation: CAB87812.1.
AY334563 mRNA. Translation: AAQ01550.1.
AY117678 mRNA. Translation: AAM51565.1.
CR457036 mRNA. Translation: CAG33317.1.
AK312951 mRNA. Translation: BAG35792.1.
AL138963 Genomic DNA. Translation: CAH72034.1.
CH471075 Genomic DNA. Translation: EAX08731.1.
CH471075 Genomic DNA. Translation: EAX08732.1.
BC003352 mRNA. Translation: AAH03352.1.
BC012431 mRNA. Translation: AAH12431.1.
BC022436 mRNA. Translation: AAH22436.1.
BC052333 mRNA. Translation: AAH52333.1.
CCDSiCCDS66538.1. [P13693-2]
CCDS9397.1. [P13693-1]
PIRiS06590.
RefSeqiNP_001273202.1. NM_001286273.1. [P13693-2]
NP_003286.1. NM_003295.3. [P13693-1]
UniGeneiHs.374596.
Hs.717316.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZ1X-ray2.00A/B/C/D1-172[»]
2HR9NMR-A1-172[»]
3EBMX-ray2.60A/B/C/D1-172[»]
4Z9VX-ray2.10C/D/E/F/G/H11-31[»]
ProteinModelPortaliP13693.
SMRiP13693.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113030. 32 interactors.
DIPiDIP-40097N.
IntActiP13693. 32 interactors.
MINTiMINT-2634453.
STRINGi9606.ENSP00000431872.

Protein family/group databases

Allergomei3816. Hom s TCTP.

PTM databases

iPTMnetiP13693.
PhosphoSitePlusiP13693.
SwissPalmiP13693.

Polymorphism and mutation databases

DMDMi136479.

2D gel databases

DOSAC-COBS-2DPAGEP13693.
OGPiP13693.
REPRODUCTION-2DPAGEIPI00550900.
SWISS-2DPAGEP13693.

Proteomic databases

EPDiP13693.
MaxQBiP13693.
PaxDbiP13693.
PeptideAtlasiP13693.
PRIDEiP13693.
TopDownProteomicsiP13693-1. [P13693-1]

Protocols and materials databases

DNASUi7178.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379055; ENSP00000368344; ENSG00000133112. [P13693-2]
ENST00000379056; ENSP00000368345; ENSG00000133112. [P13693-2]
ENST00000530705; ENSP00000431872; ENSG00000133112. [P13693-1]
GeneIDi7178.
KEGGihsa:7178.
UCSCiuc001uzy.3. human. [P13693-1]

Organism-specific databases

CTDi7178.
DisGeNETi7178.
GeneCardsiTPT1.
HGNCiHGNC:12022. TPT1.
HPAiCAB008364.
HPA039437.
MIMi600763. gene.
neXtProtiNX_P13693.
OpenTargetsiENSG00000133112.
PharmGKBiPA36701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
HOVERGENiHBG002282.
InParanoidiP13693.
PhylomeDBiP13693.
TreeFamiTF300238.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133112-MONOMER.
SIGNORiP13693.

Miscellaneous databases

ChiTaRSiTPT1. human.
EvolutionaryTraceiP13693.
GeneWikiiTPT1.
Translationally-controlled_tumor_protein.
GenomeRNAii7178.
PROiP13693.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133112.
CleanExiHS_TPT1.
ExpressionAtlasiP13693. baseline and differential.
GenevisibleiP13693. HS.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCTP_HUMAN
AccessioniPrimary (citable) accession number: P13693
Secondary accession number(s): B2R7E5
, Q6YLS2, Q7Z4J4, Q8TBK7, Q96EE2, Q9UC70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 183 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.