P13688 (CEAM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 1

Alternative name(s):
Biliary glycoprotein 1
Short name=BGP-1
CD_antigen=CD66a

Gene names

Name:	CEACAM1
Synonyms:	BGP, BGP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein Ref.4 Ref.6. Isoform 2: Secreted Ref.4 Ref.6. Isoform 3: Secreted Ref.4 Ref.6. Isoform 4: Secreted Ref.4 Ref.6. Isoform 5: Cell membrane; Single-pass type I membrane protein Ref.4 Ref.6. Isoform 6: Cell membrane; Single-pass type I membrane protein Ref.4 Ref.6. Isoform 7: Cell membrane; Single-pass type I membrane protein Ref.4 Ref.6. Isoform 8: Cell membrane; Single-pass type I membrane protein. Note: Localizes to sites of cell-cell contact. Ref.4 Ref.6
Sequence similarities	Belongs to the immunoglobulin superfamily. CEA family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Sequence caution	The sequence AAA57141.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Pyrrolidone carboxylic acid
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	angiogenesis Non-traceable author statement. Source: UniProtKB cell migration Non-traceable author statement. Source: UniProtKB homophilic cell adhesion Non-traceable author statement. Source: UniProtKB integrin-mediated signaling pathway Non-traceable author statement. Source: UniProtKB
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Non-traceable author statement. Source: UniProtKB membrane fraction Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CARTPT	Q16568	3	EBI-4314481,EBI-4314526
CEACAM6	P40199	2	EBI-4314481,EBI-4314501

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P13688-1) Also known as: BGPa; CEACAM1-4L; TM1-CEA; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P13688-2) Also known as: BGPg; CEACAM1-4C1; The sequence of this isoform differs from the canonical sequence as follows:      416-417: YN → CK      418-526: Missing.
Isoform 3 (identifier: P13688-3) Also known as: BGPh; CEACAM1-3; The sequence of this isoform differs from the canonical sequence as follows:      320-321: EL → GK      322-526: Missing.
Isoform 4 (identifier: P13688-4) Also known as: BGPi; CEACAM1-3C2; The sequence of this isoform differs from the canonical sequence as follows:      321-351: LSPVVAKPQIKASKTTVTGDKDSVNLTCSTN → SPVLGEDEAVPGQHHPQHKPCQEGGCWDVLV      352-526: Missing.
Isoform 5 (identifier: P13688-5) Also known as: BGPy; CEACAM1-3AL; The sequence of this isoform differs from the canonical sequence as follows:      321-416: LSPVVAKPQI...SDPIMLNVNY → RQNLTMLPRLDSNSWAQAILPSVSQSAEITD
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	246	1	D → Y in BAA02063. Ref.5
	Sequence conflict	329	1	R → G in BAA02063. Ref.5
	Sequence conflict	323	1	N → L in AAA57143. Ref.6
	Sequence conflict	337	1	Q → E in AAA57143. Ref.6
Isoform 6 (identifier: P13688-6) Also known as: BGPb; CEACAM1-3L; TM2-CEA; The sequence of this isoform differs from the canonical sequence as follows:      320-416: ELSPVVAKPQ...SDPIMLNVNY → D
Isoform 7 (identifier: P13688-7) Also known as: BGPx; CEACAM1-1L; The sequence of this isoform differs from the canonical sequence as follows:      143-416: Missing.
Isoform 8 (identifier: P13688-8) Also known as: BGPc; CEACAM1-4S; TM3-CEA; The sequence of this isoform differs from the canonical sequence as follows:      459-464: RASDQR → SSGPLQ      465-526: Missing.
Isoform 9 (identifier: P13688-9) Also known as: BGPz; CEACAM1-3AS; The sequence of this isoform differs from the canonical sequence as follows:      321-416: LSPVVAKPQI...SDPIMLNVNY → MAFHHVAKAGLKLLSSSNPPASTSQSAKITD      459-464: RASDQR → SSGPLQ      465-526: Missing.
Isoform 10 (identifier: P13688-10) The sequence of this isoform differs from the canonical sequence as follows:      460-468: ASDQRDLTE → TTPMTHLTR      469-526: Missing.
Note: No experimental confirmation available.
Isoform 11 (identifier: P13688-11) Also known as: BGPd; CEACAM1-3S; The sequence of this isoform differs from the canonical sequence as follows:      320-416: ELSPVVAKPQ...SDPIMLNVNY → D      459-464: RASDQR → SSGPLQ      465-526: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 34

34

Chain

35 – 526

492

Carcinoembryonic antigen-related cell adhesion molecule 1

PRO_0000014562

Regions

Topological domain

35 – 428

394

Extracellular Potential

Transmembrane

429 – 452

24

Helical; Potential

Topological domain

453 – 526

74

Cytoplasmic Potential

Domain

35 – 142

108

Ig-like V-type

Domain

145 – 232

88

Ig-like C2-type 1

Domain

237 – 317

81

Ig-like C2-type 2

Domain

323 – 413

91

Ig-like C2-type 3

Amino acid modifications

Modified residue

35

1

Pyrrolidone carboxylic acid

Glycosylation

104

1

N-linked (GlcNAc...) Ref.16

Glycosylation

111

1

N-linked (GlcNAc...) Ref.16

Glycosylation

115

1

N-linked (GlcNAc...)

Glycosylation

152

1

N-linked (GlcNAc...) Ref.17

Glycosylation

182

1

N-linked (GlcNAc...) Potential

Glycosylation

197

1

N-linked (GlcNAc...) Potential

Glycosylation

208

1

N-linked (GlcNAc...) Ref.17

Glycosylation

224

1

N-linked (GlcNAc...) Ref.17

Glycosylation

232

1

N-linked (GlcNAc...) Potential

Glycosylation

254

1

N-linked (GlcNAc...)

Glycosylation

274

1

N-linked (GlcNAc...) Potential

Glycosylation

288

1

N-linked (GlcNAc...) Potential

Glycosylation

292

1

N-linked (GlcNAc...) Potential

Glycosylation

302

1

N-linked (GlcNAc...) Potential

Glycosylation

309

1

N-linked (GlcNAc...) Potential

Glycosylation

345

1

N-linked (GlcNAc...) Potential

Glycosylation

351

1

N-linked (GlcNAc...) Potential

Glycosylation

363

1

N-linked (GlcNAc...) Ref.17

Glycosylation

378

1

N-linked (GlcNAc...) Ref.17

Glycosylation

405

1

N-linked (GlcNAc...) Ref.17

Disulfide bond

167 ↔ 215

Probable

Disulfide bond

259 ↔ 299

Probable

Disulfide bond

348 ↔ 396

Probable

Natural variations

Alternative sequence

143 – 416

274

Missing in isoform 7.

VSP_012222

Alternative sequence

320 – 416

97

ELSPV…LNVNY → D in isoform 6 and isoform 11.

VSP_010938

Alternative sequence

320 – 321

2

EL → GK in isoform 3.

VSP_002478

Alternative sequence

321 – 416

96

LSPVV…LNVNY → RQNLTMLPRLDSNSWAQAIL PSVSQSAEITD in isoform 5.

VSP_009227

Alternative sequence

321 – 416

96

LSPVV…LNVNY → MAFHHVAKAGLKLLSSSNPP ASTSQSAKITD in isoform 9.

VSP_040571

Alternative sequence

321 – 351

31

LSPVV…TCSTN → SPVLGEDEAVPGQHHPQHKP CQEGGCWDVLV in isoform 4.

VSP_002480

Alternative sequence

322 – 526

205

Missing in isoform 3.

VSP_002479

Alternative sequence

352 – 526

175

Missing in isoform 4.

VSP_002481

Alternative sequence

416 – 417

2

YN → CK in isoform 2.

VSP_002482

Alternative sequence

418 – 526

109

Missing in isoform 2.

VSP_002483

Alternative sequence

459 – 464

6

RASDQR → SSGPLQ in isoform 8, isoform 9 and isoform 11.

VSP_040572

Alternative sequence

460 – 468

9

ASDQRDLTE → TTPMTHLTR in isoform 10.

VSP_040573

Alternative sequence

465 – 526

62

Missing in isoform 8, isoform 9 and isoform 11.

VSP_040574

Alternative sequence

469 – 526

58

Missing in isoform 10.

VSP_040575

Natural variant

35

1

Q → K. Ref.9
Corresponds to variant rs8111171 [ dbSNP | Ensembl ].

VAR_049844

Natural variant

83

1

A → V. Ref.9
Corresponds to variant rs8110904 [ dbSNP | Ensembl ].

VAR_049845

Natural variant

123

1

Q → H. Ref.9
Corresponds to variant rs8111468 [ dbSNP | Ensembl ].

VAR_049846

Natural variant

376

1

Q → R. Ref.9
Corresponds to variant rs41355544 [ dbSNP | Ensembl ].

VAR_049847

Experimental info

Sequence conflict

142

1

P → H in AAA57142. Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

526

Helix Strand Turn

Details...

Beta strand

37 – 45

9

Beta strand

51 – 56

6

Beta strand

60 – 72

13

Helix

75 – 77

3

Beta strand

78 – 83

6

Turn

84 – 87

4

Beta strand

88 – 91

4

Beta strand

99 – 101

3

Beta strand

107 – 109

3

Helix

114 – 116

3

Beta strand

118 – 126

9

Beta strand

132 – 140

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (BGPa) (CEACAM1-4L) (TM1-CEA) [UniParc]. Last modified July 1, 1993. Version 2. Checksum: CAD1B2328D069AF8	FASTA	526	57,560
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 330 340 350 360 ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST NDTGISIRWF 370 380 390 400 410 420 FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN PISKNQSDPI MLNVNYNALP 430 440 450 460 470 480 QENGLSPGAI AGIVIGVVAL VALIAVALAC FLHFGKTGRA SDQRDLTEHK PSVSNHTQDH 490 500 510 520 SNDPPNKMNE VTYSTLNFEA QQPTQPTSAS PSLTATEIIY SEVKKQ
	Isoform 2 (BGPg) (CEACAM1-4C1) [UniParc]. Checksum: 5D4B9F86184AA4B4	FASTA	417	45,950
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 330 340 350 360 ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST NDTGISIRWF 370 380 390 400 410 FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN PISKNQSDPI MLNVNCK
	Isoform 3 (BGPh) (CEACAM1-3) [UniParc]. Checksum: 81DE2F4E62AD42A7	FASTA	321	35,302
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 ANNSVTGCNR TTVKTIIVTG K
	Isoform 4 (BGPi) (CEACAM1-3C2) [UniParc]. Checksum: 33CEF445429E8DD4	FASTA	351	38,578
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 330 340 350 ANNSVTGCNR TTVKTIIVTE SPVLGEDEAV PGQHHPQHKP CQEGGCWDVL V
	Isoform 5 (BGPy) (CEACAM1-3AL) [UniParc]. Checksum: E7810D2559DF7A8F	FASTA	461	50,349
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 330 340 350 360 ANNSVTGCNR TTVKTIIVTE RQNLTMLPRL DSNSWAQAIL PSVSQSAEIT DNALPQENGL 370 380 390 400 410 420 SPGAIAGIVI GVVALVALIA VALACFLHFG KTGRASDQRD LTEHKPSVSN HTQDHSNDPP 430 440 450 460 NKMNEVTYST LNFEAQQPTQ PTSASPSLTA TEIIYSEVKK Q
	Isoform 6 (BGPb) (CEACAM1-3L) (TM2-CEA) [UniParc]. Checksum: 195DE9F171D1414F	FASTA	430	46,910
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 330 340 350 360 ANNSVTGCNR TTVKTIIVTD NALPQENGLS PGAIAGIVIG VVALVALIAV ALACFLHFGK 370 380 390 400 410 420 TGRASDQRDL TEHKPSVSNH TQDHSNDPPN KMNEVTYSTL NFEAQQPTQP TSASPSLTAT 430 EIIYSEVKKQ
	Isoform 7 (BGPx) (CEACAM1-1L) [UniParc]. Checksum: 6C85A702292B6367	FASTA	252	27,431
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPNALPQENG LSPGAIAGIV IGVVALVALI AVALACFLHF 190 200 210 220 230 240 GKTGRASDQR DLTEHKPSVS NHTQDHSNDP PNKMNEVTYS TLNFEAQQPT QPTSASPSLT 250 ATEIIYSEVK KQ
	Isoform 8 (BGPc) (CEACAM1-4S) (TM3-CEA) [UniParc]. Checksum: 598E4D71BF05EDA9	FASTA	464	50,521
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 330 340 350 360 ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST NDTGISIRWF 370 380 390 400 410 420 FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN PISKNQSDPI MLNVNYNALP 430 440 450 460 QENGLSPGAI AGIVIGVVAL VALIAVALAC FLHFGKTGSS GPLQ
	Isoform 9 (BGPz) (CEACAM1-3AS) [UniParc]. Checksum: 0BC49C50F3525841	FASTA	399	43,062
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 330 340 350 360 ANNSVTGCNR TTVKTIIVTE MAFHHVAKAG LKLLSSSNPP ASTSQSAKIT DNALPQENGL 370 380 390 SPGAIAGIVI GVVALVALIA VALACFLHFG KTGSSGPLQ
	Isoform 10 [UniParc]. Checksum: 215C1A33EEFFFD68	FASTA	468	51,147
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 330 340 350 360 ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST NDTGISIRWF 370 380 390 400 410 420 FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN PISKNQSDPI MLNVNYNALP 430 440 450 460 QENGLSPGAI AGIVIGVVAL VALIAVALAC FLHFGKTGRT TPMTHLTR
	Isoform 11 (BGPd) (CEACAM1-3S) [UniParc]. Checksum: 23D7E54B4DC54318	FASTA	368	39,871
	10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 330 340 350 360 ANNSVTGCNR TTVKTIIVTD NALPQENGLS PGAIAGIVIG VVALVALIAV ALACFLHFGK TGSSGPLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen." Hinoda Y., Neumaier M., Hefta S.A., Drzeniek Z., Wagener C., Shively L., Hefta L.J.F., Shively J.E., Paxton R.J. Proc. Natl. Acad. Sci. U.S.A. 85:6959-6963(1988) [PubMed: 2457922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
[2]	Erratum Hinoda Y., Neumaier M., Hefta S.A., Drzeniek Z., Wagener C., Shively L., Hefta L.J.F., Shively J.E., Paxton R.J. Proc. Natl. Acad. Sci. U.S.A. 86:1668-1668(1989) Cited for: SEQUENCE REVISION.
[3]	"Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family." Barnett T.R., Kretschmer A., Austen D.A., Goebel S.J., Hart J.T., Elting J.J., Kamarck M.E. J. Cell Biol. 108:267-276(1989) [PubMed: 2537311] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6 AND 8).
[4]	"Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library." Kuroki M., Arakawa F., Matsuo Y., Oikawa S., Nakazato H., Matsuoka Y. Biochem. Biophys. Res. Commun. 176:578-585(1991) [PubMed: 2025273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), SUBCELLULAR LOCATION, GLYCOSYLATION. Tissue: Leukocyte.
[5]	"Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins." Barnett T.R., Drake L., Pickle W. II Mol. Cell. Biol. 13:1273-1282(1993) [PubMed: 8423792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), NUCLEOTIDE SEQUENCE [MRNA] OF 293-494 (ISOFORM 5), NUCLEOTIDE SEQUENCE [MRNA] OF 293-458 (ISOFORM 9), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 293-458, GLYCOSYLATION.
[6]	"CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant." Watt S.M., Fawcett J., Murdoch S.J., Teixeira A.M., Gschmeissner S.E., Hajibagheri N.M., Simmons D.L. Blood 84:200-210(1994) [PubMed: 8018919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), SUBCELLULAR LOCATION. Tissue: Colon adenocarcinoma.
[7]	"A new isoform of human biliary glycoprotein (BGP) containing a domain encoded by an Alu-like sequence." Kuroki M., Matsuo Y., Misumi Y., Oikawa S., Matsuoka Y. Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). Tissue: Monocyte.
[8]	"Isolation of the cDNA encoding a putative carcinoembryonic antigen-related cell adhesion molecule 1 short form 3 (CEACAM1-3S)." Long S., Phillips A., Ma H., Paoni N.F., Wong-Staal F., Fan W. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11).
[9]	SeattleSNPs variation discovery resource Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-35; VAL-83; HIS-123 AND ARG-376.
[10]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10). Tissue: Skin.
[13]	"Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas." Hauck W., Nedellec P., Turbide C., Stanners C.P., Barnett T.R., Beauchemin N. Eur. J. Biochem. 223:529-541(1994) [PubMed: 8055923] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21, DISEASE.
[14]	"Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene." Nedellec P., Turbide C., Beauchemin N. Eur. J. Biochem. 231:104-114(1995) [PubMed: 7628460] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
[15]	"Redefined nomenclature for members of the carcinoembryonic antigen family." Beauchemin N., Draber P., Dveksler G., Gold P., Gray-Owen S., Grunert F., Hammarstrom S., Holmes K.V., Karlsson A., Kuroki M., Lin S.H., Lucka L., Najjar S.M., Neumaier M., Obrink B., Shively J.E., Skubitz K.M., Stanners C.P. , Thomas P., Thompson J.A., Virji M., von Kleist S., Wagener C., Watt S., Zimmermann W. Exp. Cell Res. 252:243-249(1999) [PubMed: 11501563] [Abstract] Cited for: NOMENCLATURE OF ALTERNATIVE SPLICING ISOFORMS.
[16]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-104 AND ASN-111, MASS SPECTROMETRY. Tissue: Plasma.
[17]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-152; ASN-208; ASN-224; ASN-363; ASN-378 AND ASN-405, MASS SPECTROMETRY. Tissue: Liver.
[18]	"Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae." Fedarovich A., Tomberg J., Nicholas R.A., Davies C. Acta Crystallogr. D 62:971-979(2006) [PubMed: 16929097] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 34-141.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J03858 mRNA. Translation: AAA51826.1.
X14831 mRNA. Translation: CAA32940.1.
X16354 mRNA. Translation: CAA34404.1.
X16356 mRNA. Translation: CAA34405.1.
D90311 mRNA. Translation: BAA14341.1.
D90312 mRNA. Translation: BAA14342.1.
D90313 mRNA. Translation: BAA14343.1.
M69176 mRNA. Translation: AAA51825.1.
M72238 mRNA. Translation: AAA58393.1.
M72238 mRNA. Translation: AAA58394.1.
M76741 Genomic DNA. Translation: AAA57141.1. Sequence problems.
M76742 mRNA. Translation: AAA57142.1.
M76743 mRNA. Translation: AAA57143.1.
M76744 mRNA. Translation: AAA57144.1.
S71326 mRNA. Translation: AAB31183.1.
D12502 mRNA. Translation: BAA02063.1.
AY766113 mRNA. Translation: AAV34600.1.
DQ989182 Genomic DNA. Translation: ABI75349.1.
AC004785 Genomic DNA. Translation: AAC18433.1.
AC004785 Genomic DNA. Translation: AAC18434.1.
AC004785 Genomic DNA. Translation: AAC18435.1.
AC004785 Genomic DNA. Translation: AAC18436.1.
AC004785 Genomic DNA. Translation: AAC18437.1.
AC004785 Genomic DNA. Translation: AAC18438.1.
AC004785 Genomic DNA. Translation: AAC18439.1.
CH471126 Genomic DNA. Translation: EAW57137.1.
CH471126 Genomic DNA. Translation: EAW57140.1.
CH471126 Genomic DNA. Translation: EAW57141.1.
CH471126 Genomic DNA. Translation: EAW57143.1.
BC014473 mRNA. Translation: AAH14473.1.
X67277 Genomic DNA. Translation: CAA47694.1.

IPI

IPI00009938.
IPI00012676.
IPI00018920.
IPI00018936.
IPI00216039.
IPI00328130.
IPI00437847.
IPI00641900.
IPI00644390.
IPI00879975.
IPI00935840.

PIR

A32164.
B48078.
JH0394.
JH0395.
JH0396.

RefSeq

NP_001020083.1. NM_001024912.2.
NP_001171742.1. NM_001184813.1.
NP_001171744.1. NM_001184815.1.
NP_001171745.1. NM_001184816.1.
NP_001192273.1. NM_001205344.1.
NP_001703.2. NM_001712.4.

UniGene

Hs.512682.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2GK2	X-ray	2.20	A/B	34-141	[»]

ProteinModelPortal

P13688.

SMR

P13688. Positions 34-419.

ModBase

Search...

Protein-protein interaction databases

IntAct

P13688. 7 interactions.

MINT

MINT-5002435.

STRING

P13688.

PTM databases

PhosphoSite

P13688.

Polymorphism databases

DMDM

399116.

Proteomic databases

PRIDE

P13688.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000161559; ENSP00000161559; ENSG00000079385.

GeneID

634.

KEGG

hsa:634.

UCSC

uc002otv.1. human.
uc002otx.1. human.
uc002oty.1. human.
uc002oua.1. human.
uc002oub.1. human.
uc002ouc.1. human.
uc010eik.1. human.

Organism-specific databases

CTD

634.

GeneCards

GC19M043009.

H-InvDB

HIX0015179.

HGNC

HGNC:1814. CEACAM1.

HPA

CAB002146.
HPA011041.

MIM

109770. gene.

neXtProt

NX_P13688.

PharmGKB

PA26358.

GenAtlas

Search...

Phylogenomic databases

eggNOG

maNOG13157.

GeneTree

ENSGT00550000074209.

HOVERGEN

HBG007922.

PhylomeDB

P13688.

Gene expression databases

ArrayExpress

P13688.

Bgee

P13688.

CleanEx

HS_CEACAM1.

Genevestigator

P13688.

GermOnline

ENSG00000079385. Homo sapiens.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 4 hits.

KO

K06499.

Pfam

PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

DrugBank

DB00113. Arcitumomab.

NextBio

2562.

SOURCE

Search...

Entry information

Entry name

CEAM1_HUMAN

Accession

Primary (citable) accession number: P13688
Secondary accession number(s): A6NE38 , A8MY49, O60430, Q069I7, Q13854, Q13857, Q13858, Q13859, Q13860, Q15600, Q15601, Q16170, Q5UB49, Q7KYP5, Q96CA7, Q9UQV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	July 1, 1993
Last modified:	January 25, 2012
This is version 134 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.