P13684 (LEVI_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Prolevitide Cleaved into the following 2 chains: Amphipathic peptide Levitide
Organism	Xenopus laevis (African clawed frog)
Taxonomic identifier	8355 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	88 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Tissue specificity	Expressed by the skin glands.
Sequence similarities	Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Amphibian defense peptide Hormone Neuropeptide
PTM	Amidation Pyrrolidone carboxylic acid
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: UniProtKB-KW neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 88	68	Prolevitide		PRO_0000010674
	Peptide	39 – 63	25	Amphipathic peptide		PRO_0000010675
	Peptide	74 – 87	14	Levitide Ref.1		PRO_0000010676
Amino acid modifications
	Modified residue	74	1	Pyrrolidone carboxylic acid
	Modified residue	87	1	Glutamine amide

Sequences

	Sequence		Length	Mass (Da)
	P13684 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 36A1E2B40D9B593E	FASTA	88	9,590
	10 20 30 40 50 60 MYKGIFLCVL FAVICANSLA KPSSDADEDN DEVERYVRGW ASKIGQTLGK IAKVGLQGLM 70 80 QPKREAMLRS AEAQGMIGTL TSKRIKQG

References

[1]

"Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences." Poulter L., Terry A.S., Williams D.H., Giovannini M.G., Moore C.H., Gibson B.W. J. Biol. Chem. 263:3279-3283(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 74-87. Tissue: Skin and Skin secretion.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M18681 mRNA. Translation: AAA49899.1.
PIR	A28056.
RefSeq	NP_001079112.1. NM_001085643.1.
UniGene	Xl.822.
3D structure databases
ModBase	Search...
Protein family/group databases
TCDB	1.C.16.1.4. magainin family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	373645.
KEGG	xla:373645.
Organism-specific databases
CTD	373645.
Xenbase	XB-GENE-6252880. levi.
Phylogenomic databases
HOVERGEN	HBG008341.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

LEVI_XENLA

Accession

Primary (citable) accession number: P13684

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program