P13682 (ZNF35_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 35

Alternative name(s):
Zinc finger protein HF.10

Gene names

Name:

ZNF35

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 11 C2H2-type zinc fingers.
Sequence caution	The sequence AAA85451.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAG37343.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAA30268.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to retinoic acid Inferred from sequence or structural similarity PubMed 20186958. Source: UniProtKB spermatogenesis Inferred from sequence or structural similarity PubMed 20186958. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 20186958. Source: UniProtKB perinuclear region of cytoplasm Inferred from direct assay PubMed 20186958. Source: UniProtKB
Molecular_function	sequence-specific DNA binding Inferred from direct assay PubMed 8477855. Source: UniProtKB sequence-specific DNA binding transcription factor activity Inferred from direct assay Ref.2. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 527	527	Zinc finger protein 35		PRO_0000047366
Regions
	Zinc finger	222 – 244	23	C2H2-type 1
	Zinc finger	250 – 272	23	C2H2-type 2
	Zinc finger	278 – 300	23	C2H2-type 3
	Zinc finger	306 – 328	23	C2H2-type 4
	Zinc finger	334 – 356	23	C2H2-type 5
	Zinc finger	362 – 384	23	C2H2-type 6
	Zinc finger	390 – 412	23	C2H2-type 7
	Zinc finger	418 – 440	23	C2H2-type 8
	Zinc finger	446 – 468	23	C2H2-type 9
	Zinc finger	474 – 496	23	C2H2-type 10
	Zinc finger	502 – 524	23	C2H2-type 11
	Region	9 – 221	213	Globular domain
	Compositional bias	22 – 27	6	Poly-Glu
Experimental info
	Sequence conflict	413 – 440	28	Missing in CAA30268. Ref.1
	Sequence conflict	432	1	C → S in AAA85451. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P13682 [UniParc]. Last modified July 13, 2010. Version 4. Checksum: 9E7099A290ED938B	FASTA	527	59,089
	10 20 30 40 50 60 MTAELREAMA LAPWGPVKVK KEEEEEENFP GQASSQQVHS ENIKVWAPVQ GLQTGLDGSE 70 80 90 100 110 120 EEEKGQNISW DMAVVLKATQ EAPAASTLGS YSLPGTLAKS EILETHGTMN FLGAETKNLQ 130 140 150 160 170 180 LLVPKTEICE EAEKPLIISE RIQKADPQGP ELGEACEKGN MLKRQRIKRE KKDFRQVIVN 190 200 210 220 230 240 DCHLPESFKE EENQKCKKSG GKYSLNSGAV KNPKTQLGQK PFTCSVCGKG FSQSANLVVH 250 260 270 280 290 300 QRIHTGEKPF ECHECGKAFI QSANLVVHQR IHTGQKPYVC SKCGKAFTQS SNLTVHQKIH 310 320 330 340 350 360 SLEKTFKCNE CEKAFSYSSQ LARHQKVHIT EKCYECNECG KTFTRSSNLI VHQRIHTGEK 370 380 390 400 410 420 PFACNDCGKA FTQSANLIVH QRSHTGEKPY ECKECGKAFS CFSHLIVHQR IHTAEKPYDC 430 440 450 460 470 480 SECGKAFSQL SCLIVHQRIH SGDLPYVCNE CGKAFTCSSY LLIHQRIHNG EKPYTCNECG 490 500 510 520 KAFRQRSSLT VHQRTHTGEK PYECEKCGAA FISNSHLMRH HRTHLVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation." Pannuti A., Lanfrancone L., Pascucci A., Pelicci P.-G., la Mantia G., Lania L. Nucleic Acids Res. 16:4227-4237(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22." Lanfrancone L., Pengue G., Pandolfi P.P., Salcini A.E., Giacomucci A., Longo L., Donti E., de Luca P., la Mantia G., Pelicci P.-G., Lania L. Genomics 12:720-728(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-527.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X07289 mRNA. Translation: CAA30268.1. Different initiation. L35269, M76702, M76703 Genomic DNA. Translation: AAA85451.1. Different initiation. AK314821 mRNA. Translation: BAG37343.1. Different initiation. AC099669 Genomic DNA. No translation available. BC013597 mRNA. Translation: AAH13597.2. BT006962 mRNA. Translation: AAP35608.1.
IPI	IPI00761023.
PIR	A38073.
RefSeq	NP_003411.3. NM_003420.3.
UniGene	Hs.288658.
3D structure databases
ProteinModelPortal	P13682.
SMR	P13682. Positions 183-501.
ModBase	Search...
PTM databases
PhosphoSite	P13682.
Polymorphism databases
DMDM	300669709.
Proteomic databases
PaxDb	P13682.
PRIDE	P13682.
Protocols and materials databases
DNASU	7584.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000396056; ENSP00000379368; ENSG00000169981.
GeneID	7584.
KEGG	hsa:7584.
UCSC	uc003cnq.3. human.
Organism-specific databases
CTD	7584.
GeneCards	GC03P044690.
HGNC	HGNC:13099. ZNF35.
HPA	HPA051859. HPA054738.
MIM	194533. gene.
neXtProt	NX_P13682.
PharmGKB	PA37674.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	P13682.
OMA	VPKTEIC.
OrthoDB	EOG43R3MB.
Gene expression databases
ArrayExpress	P13682.
Bgee	P13682.
CleanEx	HS_ZNF35.
Genevestigator	P13682.
GermOnline	ENSG00000169981. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 11 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 11 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 11 hits. PS50157. ZINC_FINGER_C2H2_2. 11 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF35. human.
GenomeRNAi	7584.
NextBio	29649.
SOURCE	Search...

Entry information

Entry name

ZNF35_HUMAN

Accession

Primary (citable) accession number: P13682
Secondary accession number(s): B2RBU6, Q53Y54, Q96D01

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 128 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.