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P13682

- ZNF35_HUMAN

UniProt

P13682 - ZNF35_HUMAN

Protein

Zinc finger protein 35

Gene

ZNF35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 4 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri222 – 24423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri250 – 27223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri418 – 44023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri446 – 46823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri474 – 49623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri502 – 52423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to retinoic acid Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: ProtInc
    3. spermatogenesis Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 35
    Alternative name(s):
    Zinc finger protein HF.10
    Gene namesi
    Name:ZNF35
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:13099. ZNF35.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cell Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37674.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Zinc finger protein 35PRO_0000047366Add
    BLAST

    Proteomic databases

    MaxQBiP13682.
    PaxDbiP13682.
    PRIDEiP13682.

    PTM databases

    PhosphoSiteiP13682.

    Expressioni

    Gene expression databases

    ArrayExpressiP13682.
    BgeeiP13682.
    CleanExiHS_ZNF35.
    GenevestigatoriP13682.

    Organism-specific databases

    HPAiHPA051859.
    HPA054738.

    Interactioni

    Protein-protein interaction databases

    BioGridi113412. 3 interactions.
    MINTiMINT-4720812.

    Structurei

    3D structure databases

    ProteinModelPortaliP13682.
    SMRiP13682. Positions 183-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni9 – 221213Globular domainAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi22 – 276Poly-Glu

    Sequence similaritiesi

    Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri222 – 24423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri250 – 27223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri418 – 44023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri446 – 46823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri474 – 49623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri502 – 52423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiP13682.
    OMAiVPKTEIC.
    PhylomeDBiP13682.
    TreeFamiTF350849.

    Family and domain databases

    Gene3Di3.30.160.60. 11 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 11 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13682-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAELREAMA LAPWGPVKVK KEEEEEENFP GQASSQQVHS ENIKVWAPVQ    50
    GLQTGLDGSE EEEKGQNISW DMAVVLKATQ EAPAASTLGS YSLPGTLAKS 100
    EILETHGTMN FLGAETKNLQ LLVPKTEICE EAEKPLIISE RIQKADPQGP 150
    ELGEACEKGN MLKRQRIKRE KKDFRQVIVN DCHLPESFKE EENQKCKKSG 200
    GKYSLNSGAV KNPKTQLGQK PFTCSVCGKG FSQSANLVVH QRIHTGEKPF 250
    ECHECGKAFI QSANLVVHQR IHTGQKPYVC SKCGKAFTQS SNLTVHQKIH 300
    SLEKTFKCNE CEKAFSYSSQ LARHQKVHIT EKCYECNECG KTFTRSSNLI 350
    VHQRIHTGEK PFACNDCGKA FTQSANLIVH QRSHTGEKPY ECKECGKAFS 400
    CFSHLIVHQR IHTAEKPYDC SECGKAFSQL SCLIVHQRIH SGDLPYVCNE 450
    CGKAFTCSSY LLIHQRIHNG EKPYTCNECG KAFRQRSSLT VHQRTHTGEK 500
    PYECEKCGAA FISNSHLMRH HRTHLVE 527
    Length:527
    Mass (Da):59,089
    Last modified:July 13, 2010 - v4
    Checksum:i9E7099A290ED938B
    GO

    Sequence cautioni

    The sequence AAA85451.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG37343.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAA30268.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti413 – 44028Missing in CAA30268. (PubMed:3380682)CuratedAdd
    BLAST
    Sequence conflicti432 – 4321C → S in AAA85451. (PubMed:1572646)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07289 mRNA. Translation: CAA30268.1. Different initiation.
    L35269, M76702, M76703 Genomic DNA. Translation: AAA85451.1. Different initiation.
    AK314821 mRNA. Translation: BAG37343.1. Different initiation.
    AC099669 Genomic DNA. No translation available.
    BC013597 mRNA. Translation: AAH13597.2.
    BT006962 mRNA. Translation: AAP35608.1.
    CCDSiCCDS2718.2.
    PIRiA38073.
    RefSeqiNP_003411.3. NM_003420.3.
    XP_005265499.1. XM_005265442.1.
    XP_005265500.1. XM_005265443.1.
    XP_005265501.1. XM_005265444.1.
    UniGeneiHs.288658.

    Genome annotation databases

    EnsembliENST00000396056; ENSP00000379368; ENSG00000169981.
    GeneIDi7584.
    KEGGihsa:7584.
    UCSCiuc003cnq.3. human.

    Polymorphism databases

    DMDMi300669709.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07289 mRNA. Translation: CAA30268.1 . Different initiation.
    L35269 , M76702 , M76703 Genomic DNA. Translation: AAA85451.1 . Different initiation.
    AK314821 mRNA. Translation: BAG37343.1 . Different initiation.
    AC099669 Genomic DNA. No translation available.
    BC013597 mRNA. Translation: AAH13597.2 .
    BT006962 mRNA. Translation: AAP35608.1 .
    CCDSi CCDS2718.2.
    PIRi A38073.
    RefSeqi NP_003411.3. NM_003420.3.
    XP_005265499.1. XM_005265442.1.
    XP_005265500.1. XM_005265443.1.
    XP_005265501.1. XM_005265444.1.
    UniGenei Hs.288658.

    3D structure databases

    ProteinModelPortali P13682.
    SMRi P13682. Positions 183-524.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113412. 3 interactions.
    MINTi MINT-4720812.

    PTM databases

    PhosphoSitei P13682.

    Polymorphism databases

    DMDMi 300669709.

    Proteomic databases

    MaxQBi P13682.
    PaxDbi P13682.
    PRIDEi P13682.

    Protocols and materials databases

    DNASUi 7584.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396056 ; ENSP00000379368 ; ENSG00000169981 .
    GeneIDi 7584.
    KEGGi hsa:7584.
    UCSCi uc003cnq.3. human.

    Organism-specific databases

    CTDi 7584.
    GeneCardsi GC03P044690.
    HGNCi HGNC:13099. ZNF35.
    HPAi HPA051859.
    HPA054738.
    MIMi 194533. gene.
    neXtProti NX_P13682.
    PharmGKBi PA37674.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi P13682.
    OMAi VPKTEIC.
    PhylomeDBi P13682.
    TreeFami TF350849.

    Miscellaneous databases

    ChiTaRSi ZNF35. human.
    GeneWikii ZNF35.
    GenomeRNAii 7584.
    NextBioi 29649.
    PROi P13682.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13682.
    Bgeei P13682.
    CleanExi HS_ZNF35.
    Genevestigatori P13682.

    Family and domain databases

    Gene3Di 3.30.160.60. 11 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 11 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 11 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation."
      Pannuti A., Lanfrancone L., Pascucci A., Pelicci P.-G., la Mantia G., Lania L.
      Nucleic Acids Res. 16:4227-4237(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22."
      Lanfrancone L., Pengue G., Pandolfi P.P., Salcini A.E., Giacomucci A., Longo L., Donti E., de Luca P., la Mantia G., Pelicci P.-G., Lania L.
      Genomics 12:720-728(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-527.

    Entry informationi

    Entry nameiZNF35_HUMAN
    AccessioniPrimary (citable) accession number: P13682
    Secondary accession number(s): B2RBU6, Q53Y54, Q96D01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 141 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3