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Protein

Zinc finger protein 35

Gene

ZNF35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • cellular response to retinoic acid Source: UniProtKB
  • regulation of transcription, DNA-templated Source: ProtInc
  • spermatogenesis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169981-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 35
Alternative name(s):
Zinc finger protein HF.10
Gene namesi
Name:ZNF35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13099. ZNF35.

Subcellular locationi

GO - Cellular componenti

  • cell Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7584.
OpenTargetsiENSG00000169981.
ENSG00000281306.
PharmGKBiPA37674.

Polymorphism and mutation databases

BioMutaiZNF35.
DMDMi300669709.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473661 – 527Zinc finger protein 35Add BLAST527

Proteomic databases

EPDiP13682.
MaxQBiP13682.
PaxDbiP13682.
PeptideAtlasiP13682.
PRIDEiP13682.

PTM databases

iPTMnetiP13682.
PhosphoSitePlusiP13682.

Expressioni

Gene expression databases

BgeeiENSG00000169981.
CleanExiHS_ZNF35.
ExpressionAtlasiP13682. baseline and differential.
GenevisibleiP13682. HS.

Organism-specific databases

HPAiHPA051859.
HPA054738.

Interactioni

Protein-protein interaction databases

BioGridi113412. 8 interactors.
IntActiP13682. 26 interactors.
MINTiMINT-4720812.
STRINGi9606.ENSP00000379368.

Structurei

3D structure databases

ProteinModelPortaliP13682.
SMRiP13682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 221Globular domainAdd BLAST213

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 27Poly-Glu6

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133839.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP13682.
OMAiVPKTEIC.
OrthoDBiEOG091G02KC.
PhylomeDBiP13682.
TreeFamiTF350849.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAELREAMA LAPWGPVKVK KEEEEEENFP GQASSQQVHS ENIKVWAPVQ
60 70 80 90 100
GLQTGLDGSE EEEKGQNISW DMAVVLKATQ EAPAASTLGS YSLPGTLAKS
110 120 130 140 150
EILETHGTMN FLGAETKNLQ LLVPKTEICE EAEKPLIISE RIQKADPQGP
160 170 180 190 200
ELGEACEKGN MLKRQRIKRE KKDFRQVIVN DCHLPESFKE EENQKCKKSG
210 220 230 240 250
GKYSLNSGAV KNPKTQLGQK PFTCSVCGKG FSQSANLVVH QRIHTGEKPF
260 270 280 290 300
ECHECGKAFI QSANLVVHQR IHTGQKPYVC SKCGKAFTQS SNLTVHQKIH
310 320 330 340 350
SLEKTFKCNE CEKAFSYSSQ LARHQKVHIT EKCYECNECG KTFTRSSNLI
360 370 380 390 400
VHQRIHTGEK PFACNDCGKA FTQSANLIVH QRSHTGEKPY ECKECGKAFS
410 420 430 440 450
CFSHLIVHQR IHTAEKPYDC SECGKAFSQL SCLIVHQRIH SGDLPYVCNE
460 470 480 490 500
CGKAFTCSSY LLIHQRIHNG EKPYTCNECG KAFRQRSSLT VHQRTHTGEK
510 520
PYECEKCGAA FISNSHLMRH HRTHLVE
Length:527
Mass (Da):59,089
Last modified:July 13, 2010 - v4
Checksum:i9E7099A290ED938B
GO

Sequence cautioni

The sequence AAA85451 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG37343 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA30268 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti413 – 440Missing in CAA30268 (PubMed:3380682).CuratedAdd BLAST28
Sequence conflicti432C → S in AAA85451 (PubMed:1572646).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07289 mRNA. Translation: CAA30268.1. Different initiation.
L35269, M76702, M76703 Genomic DNA. Translation: AAA85451.1. Different initiation.
AK314821 mRNA. Translation: BAG37343.1. Different initiation.
AC099669 Genomic DNA. No translation available.
BC013597 mRNA. Translation: AAH13597.2.
BT006962 mRNA. Translation: AAP35608.1.
CCDSiCCDS2718.2.
PIRiA38073.
RefSeqiNP_003411.3. NM_003420.3.
XP_016862618.1. XM_017007129.1.
XP_016862619.1. XM_017007130.1.
XP_016862620.1. XM_017007131.1.
UniGeneiHs.288658.

Genome annotation databases

EnsembliENST00000396056; ENSP00000379368; ENSG00000169981.
ENST00000625394; ENSP00000486354; ENSG00000281306.
GeneIDi7584.
KEGGihsa:7584.
UCSCiuc003cnq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07289 mRNA. Translation: CAA30268.1. Different initiation.
L35269, M76702, M76703 Genomic DNA. Translation: AAA85451.1. Different initiation.
AK314821 mRNA. Translation: BAG37343.1. Different initiation.
AC099669 Genomic DNA. No translation available.
BC013597 mRNA. Translation: AAH13597.2.
BT006962 mRNA. Translation: AAP35608.1.
CCDSiCCDS2718.2.
PIRiA38073.
RefSeqiNP_003411.3. NM_003420.3.
XP_016862618.1. XM_017007129.1.
XP_016862619.1. XM_017007130.1.
XP_016862620.1. XM_017007131.1.
UniGeneiHs.288658.

3D structure databases

ProteinModelPortaliP13682.
SMRiP13682.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113412. 8 interactors.
IntActiP13682. 26 interactors.
MINTiMINT-4720812.
STRINGi9606.ENSP00000379368.

PTM databases

iPTMnetiP13682.
PhosphoSitePlusiP13682.

Polymorphism and mutation databases

BioMutaiZNF35.
DMDMi300669709.

Proteomic databases

EPDiP13682.
MaxQBiP13682.
PaxDbiP13682.
PeptideAtlasiP13682.
PRIDEiP13682.

Protocols and materials databases

DNASUi7584.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396056; ENSP00000379368; ENSG00000169981.
ENST00000625394; ENSP00000486354; ENSG00000281306.
GeneIDi7584.
KEGGihsa:7584.
UCSCiuc003cnq.4. human.

Organism-specific databases

CTDi7584.
DisGeNETi7584.
GeneCardsiZNF35.
HGNCiHGNC:13099. ZNF35.
HPAiHPA051859.
HPA054738.
MIMi194533. gene.
neXtProtiNX_P13682.
OpenTargetsiENSG00000169981.
ENSG00000281306.
PharmGKBiPA37674.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133839.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP13682.
OMAiVPKTEIC.
OrthoDBiEOG091G02KC.
PhylomeDBiP13682.
TreeFamiTF350849.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169981-MONOMER.

Miscellaneous databases

ChiTaRSiZNF35. human.
GeneWikiiZNF35.
GenomeRNAii7584.
PROiP13682.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169981.
CleanExiHS_ZNF35.
ExpressionAtlasiP13682. baseline and differential.
GenevisibleiP13682. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF35_HUMAN
AccessioniPrimary (citable) accession number: P13682
Secondary accession number(s): B2RBU6, Q53Y54, Q96D01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 161 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.