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Protein

Zinc finger protein 35

Gene

ZNF35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • DNA binding transcription factor activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • cellular response to retinoic acid Source: UniProtKB
  • regulation of transcription, DNA-templated Source: ProtInc
  • spermatogenesis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 35
Alternative name(s):
Zinc finger protein HF.10
Gene namesi
Name:ZNF35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000169981.10
HGNCiHGNC:13099 ZNF35
MIMi194533 gene
neXtProtiNX_P13682

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7584
OpenTargetsiENSG00000169981
PharmGKBiPA37674

Polymorphism and mutation databases

BioMutaiZNF35
DMDMi300669709

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473661 – 527Zinc finger protein 35Add BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki158Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki189Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki276Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP13682
MaxQBiP13682
PaxDbiP13682
PeptideAtlasiP13682
PRIDEiP13682

PTM databases

iPTMnetiP13682
PhosphoSitePlusiP13682

Expressioni

Gene expression databases

BgeeiENSG00000169981
CleanExiHS_ZNF35
ExpressionAtlasiP13682 baseline and differential
GenevisibleiP13682 HS

Organism-specific databases

HPAiHPA051859
HPA054738

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113412, 8 interactors
IntActiP13682, 28 interactors
STRINGi9606.ENSP00000379368

Structurei

3D structure databases

ProteinModelPortaliP13682
SMRiP13682
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 221Globular domainAdd BLAST213

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 27Poly-Glu6

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00860000133839
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP13682
OMAiFSHLIVH
OrthoDBiEOG091G02KC
PhylomeDBiP13682
TreeFamiTF350849

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

P13682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAELREAMA LAPWGPVKVK KEEEEEENFP GQASSQQVHS ENIKVWAPVQ
60 70 80 90 100
GLQTGLDGSE EEEKGQNISW DMAVVLKATQ EAPAASTLGS YSLPGTLAKS
110 120 130 140 150
EILETHGTMN FLGAETKNLQ LLVPKTEICE EAEKPLIISE RIQKADPQGP
160 170 180 190 200
ELGEACEKGN MLKRQRIKRE KKDFRQVIVN DCHLPESFKE EENQKCKKSG
210 220 230 240 250
GKYSLNSGAV KNPKTQLGQK PFTCSVCGKG FSQSANLVVH QRIHTGEKPF
260 270 280 290 300
ECHECGKAFI QSANLVVHQR IHTGQKPYVC SKCGKAFTQS SNLTVHQKIH
310 320 330 340 350
SLEKTFKCNE CEKAFSYSSQ LARHQKVHIT EKCYECNECG KTFTRSSNLI
360 370 380 390 400
VHQRIHTGEK PFACNDCGKA FTQSANLIVH QRSHTGEKPY ECKECGKAFS
410 420 430 440 450
CFSHLIVHQR IHTAEKPYDC SECGKAFSQL SCLIVHQRIH SGDLPYVCNE
460 470 480 490 500
CGKAFTCSSY LLIHQRIHNG EKPYTCNECG KAFRQRSSLT VHQRTHTGEK
510 520
PYECEKCGAA FISNSHLMRH HRTHLVE
Length:527
Mass (Da):59,089
Last modified:July 13, 2010 - v4
Checksum:i9E7099A290ED938B
GO

Sequence cautioni

The sequence AAA85451 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG37343 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA30268 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti413 – 440Missing in CAA30268 (PubMed:3380682).CuratedAdd BLAST28
Sequence conflicti432C → S in AAA85451 (PubMed:1572646).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07289 mRNA Translation: CAA30268.1 Different initiation.
L35269, M76702, M76703 Genomic DNA Translation: AAA85451.1 Different initiation.
AK314821 mRNA Translation: BAG37343.1 Different initiation.
AC099669 Genomic DNA No translation available.
BC013597 mRNA Translation: AAH13597.2
BT006962 mRNA Translation: AAP35608.1
CCDSiCCDS2718.2
PIRiA38073
RefSeqiNP_003411.3, NM_003420.3
XP_016862618.1, XM_017007129.1
XP_016862619.1, XM_017007130.1
XP_016862620.1, XM_017007131.1
UniGeneiHs.288658

Genome annotation databases

EnsembliENST00000396056; ENSP00000379368; ENSG00000169981
ENST00000625394; ENSP00000486354; ENSG00000281306
GeneIDi7584
KEGGihsa:7584
UCSCiuc003cnq.4 human

Similar proteinsi

Entry informationi

Entry nameiZNF35_HUMAN
AccessioniPrimary (citable) accession number: P13682
Secondary accession number(s): B2RBU6, Q53Y54, Q96D01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 13, 2010
Last modified: May 23, 2018
This is version 174 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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