Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P13682 (ZNF35_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 35
Alternative name(s):
Zinc finger protein HF.10
Gene names
Name:ZNF35
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 11 C2H2-type zinc fingers.

Sequence caution

The sequence AAA85451.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAG37343.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAA30268.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Zinc finger protein 35
PRO_0000047366

Regions

Zinc finger222 – 24423C2H2-type 1
Zinc finger250 – 27223C2H2-type 2
Zinc finger278 – 30023C2H2-type 3
Zinc finger306 – 32823C2H2-type 4
Zinc finger334 – 35623C2H2-type 5
Zinc finger362 – 38423C2H2-type 6
Zinc finger390 – 41223C2H2-type 7
Zinc finger418 – 44023C2H2-type 8
Zinc finger446 – 46823C2H2-type 9
Zinc finger474 – 49623C2H2-type 10
Zinc finger502 – 52423C2H2-type 11
Region9 – 221213Globular domain
Compositional bias22 – 276Poly-Glu

Experimental info

Sequence conflict413 – 44028Missing in CAA30268. Ref.1
Sequence conflict4321C → S in AAA85451. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P13682 [UniParc].

Last modified July 13, 2010. Version 4.
Checksum: 9E7099A290ED938B

FASTA52759,089
        10         20         30         40         50         60 
MTAELREAMA LAPWGPVKVK KEEEEEENFP GQASSQQVHS ENIKVWAPVQ GLQTGLDGSE 

        70         80         90        100        110        120 
EEEKGQNISW DMAVVLKATQ EAPAASTLGS YSLPGTLAKS EILETHGTMN FLGAETKNLQ 

       130        140        150        160        170        180 
LLVPKTEICE EAEKPLIISE RIQKADPQGP ELGEACEKGN MLKRQRIKRE KKDFRQVIVN 

       190        200        210        220        230        240 
DCHLPESFKE EENQKCKKSG GKYSLNSGAV KNPKTQLGQK PFTCSVCGKG FSQSANLVVH 

       250        260        270        280        290        300 
QRIHTGEKPF ECHECGKAFI QSANLVVHQR IHTGQKPYVC SKCGKAFTQS SNLTVHQKIH 

       310        320        330        340        350        360 
SLEKTFKCNE CEKAFSYSSQ LARHQKVHIT EKCYECNECG KTFTRSSNLI VHQRIHTGEK 

       370        380        390        400        410        420 
PFACNDCGKA FTQSANLIVH QRSHTGEKPY ECKECGKAFS CFSHLIVHQR IHTAEKPYDC 

       430        440        450        460        470        480 
SECGKAFSQL SCLIVHQRIH SGDLPYVCNE CGKAFTCSSY LLIHQRIHNG EKPYTCNECG 

       490        500        510        520 
KAFRQRSSLT VHQRTHTGEK PYECEKCGAA FISNSHLMRH HRTHLVE 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation."
Pannuti A., Lanfrancone L., Pascucci A., Pelicci P.-G., la Mantia G., Lania L.
Nucleic Acids Res. 16:4227-4237(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22."
Lanfrancone L., Pengue G., Pandolfi P.P., Salcini A.E., Giacomucci A., Longo L., Donti E., de Luca P., la Mantia G., Pelicci P.-G., Lania L.
Genomics 12:720-728(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-527.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07289 mRNA. Translation: CAA30268.1. Different initiation.
L35269, M76702, M76703 Genomic DNA. Translation: AAA85451.1. Different initiation.
AK314821 mRNA. Translation: BAG37343.1. Different initiation.
AC099669 Genomic DNA. No translation available.
BC013597 mRNA. Translation: AAH13597.2.
BT006962 mRNA. Translation: AAP35608.1.
CCDSCCDS2718.2.
PIRA38073.
RefSeqNP_003411.3. NM_003420.3.
XP_005265499.1. XM_005265442.1.
XP_005265500.1. XM_005265443.1.
XP_005265501.1. XM_005265444.1.
UniGeneHs.288658.

3D structure databases

ProteinModelPortalP13682.
SMRP13682. Positions 183-524.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113412. 3 interactions.
MINTMINT-4720812.

PTM databases

PhosphoSiteP13682.

Polymorphism databases

DMDM300669709.

Proteomic databases

MaxQBP13682.
PaxDbP13682.
PRIDEP13682.

Protocols and materials databases

DNASU7584.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000396056; ENSP00000379368; ENSG00000169981.
GeneID7584.
KEGGhsa:7584.
UCSCuc003cnq.3. human.

Organism-specific databases

CTD7584.
GeneCardsGC03P044690.
HGNCHGNC:13099. ZNF35.
HPAHPA051859.
HPA054738.
MIM194533. gene.
neXtProtNX_P13682.
PharmGKBPA37674.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidP13682.
OMAVPKTEIC.
PhylomeDBP13682.
TreeFamTF350849.

Gene expression databases

ArrayExpressP13682.
BgeeP13682.
CleanExHS_ZNF35.
GenevestigatorP13682.

Family and domain databases

Gene3D3.30.160.60. 11 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF35. human.
GeneWikiZNF35.
GenomeRNAi7584.
NextBio29649.
PROP13682.
SOURCESearch...

Entry information

Entry nameZNF35_HUMAN
AccessionPrimary (citable) accession number: P13682
Secondary accession number(s): B2RBU6, Q53Y54, Q96D01
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 13, 2010
Last modified: July 9, 2014
This is version 140 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM