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P13682

- ZNF35_HUMAN

UniProt

P13682 - ZNF35_HUMAN

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Protein

Zinc finger protein 35

Gene

ZNF35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. cellular response to retinoic acid Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: ProtInc
  3. spermatogenesis Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 35
Alternative name(s):
Zinc finger protein HF.10
Gene namesi
Name:ZNF35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:13099. ZNF35.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. cell Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Zinc finger protein 35PRO_0000047366Add
BLAST

Proteomic databases

MaxQBiP13682.
PaxDbiP13682.
PRIDEiP13682.

PTM databases

PhosphoSiteiP13682.

Expressioni

Gene expression databases

BgeeiP13682.
CleanExiHS_ZNF35.
ExpressionAtlasiP13682. baseline.
GenevestigatoriP13682.

Organism-specific databases

HPAiHPA051859.
HPA054738.

Interactioni

Protein-protein interaction databases

BioGridi113412. 3 interactions.
MINTiMINT-4720812.

Structurei

3D structure databases

ProteinModelPortaliP13682.
SMRiP13682. Positions 183-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 221213Globular domainAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 276Poly-Glu

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119358.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP13682.
OMAiVPKTEIC.
PhylomeDBiP13682.
TreeFamiTF350849.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13682-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAELREAMA LAPWGPVKVK KEEEEEENFP GQASSQQVHS ENIKVWAPVQ
60 70 80 90 100
GLQTGLDGSE EEEKGQNISW DMAVVLKATQ EAPAASTLGS YSLPGTLAKS
110 120 130 140 150
EILETHGTMN FLGAETKNLQ LLVPKTEICE EAEKPLIISE RIQKADPQGP
160 170 180 190 200
ELGEACEKGN MLKRQRIKRE KKDFRQVIVN DCHLPESFKE EENQKCKKSG
210 220 230 240 250
GKYSLNSGAV KNPKTQLGQK PFTCSVCGKG FSQSANLVVH QRIHTGEKPF
260 270 280 290 300
ECHECGKAFI QSANLVVHQR IHTGQKPYVC SKCGKAFTQS SNLTVHQKIH
310 320 330 340 350
SLEKTFKCNE CEKAFSYSSQ LARHQKVHIT EKCYECNECG KTFTRSSNLI
360 370 380 390 400
VHQRIHTGEK PFACNDCGKA FTQSANLIVH QRSHTGEKPY ECKECGKAFS
410 420 430 440 450
CFSHLIVHQR IHTAEKPYDC SECGKAFSQL SCLIVHQRIH SGDLPYVCNE
460 470 480 490 500
CGKAFTCSSY LLIHQRIHNG EKPYTCNECG KAFRQRSSLT VHQRTHTGEK
510 520
PYECEKCGAA FISNSHLMRH HRTHLVE
Length:527
Mass (Da):59,089
Last modified:July 13, 2010 - v4
Checksum:i9E7099A290ED938B
GO

Sequence cautioni

The sequence AAA85451.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG37343.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA30268.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti413 – 44028Missing in CAA30268. (PubMed:3380682)CuratedAdd
BLAST
Sequence conflicti432 – 4321C → S in AAA85451. (PubMed:1572646)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07289 mRNA. Translation: CAA30268.1. Different initiation.
L35269, M76702, M76703 Genomic DNA. Translation: AAA85451.1. Different initiation.
AK314821 mRNA. Translation: BAG37343.1. Different initiation.
AC099669 Genomic DNA. No translation available.
BC013597 mRNA. Translation: AAH13597.2.
BT006962 mRNA. Translation: AAP35608.1.
CCDSiCCDS2718.2.
PIRiA38073.
RefSeqiNP_003411.3. NM_003420.3.
XP_005265499.1. XM_005265442.1.
XP_005265500.1. XM_005265443.1.
XP_005265501.1. XM_005265444.1.
UniGeneiHs.288658.

Genome annotation databases

EnsembliENST00000396056; ENSP00000379368; ENSG00000169981.
GeneIDi7584.
KEGGihsa:7584.
UCSCiuc003cnq.3. human.

Polymorphism databases

DMDMi300669709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07289 mRNA. Translation: CAA30268.1 . Different initiation.
L35269 , M76702 , M76703 Genomic DNA. Translation: AAA85451.1 . Different initiation.
AK314821 mRNA. Translation: BAG37343.1 . Different initiation.
AC099669 Genomic DNA. No translation available.
BC013597 mRNA. Translation: AAH13597.2 .
BT006962 mRNA. Translation: AAP35608.1 .
CCDSi CCDS2718.2.
PIRi A38073.
RefSeqi NP_003411.3. NM_003420.3.
XP_005265499.1. XM_005265442.1.
XP_005265500.1. XM_005265443.1.
XP_005265501.1. XM_005265444.1.
UniGenei Hs.288658.

3D structure databases

ProteinModelPortali P13682.
SMRi P13682. Positions 183-501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113412. 3 interactions.
MINTi MINT-4720812.

PTM databases

PhosphoSitei P13682.

Polymorphism databases

DMDMi 300669709.

Proteomic databases

MaxQBi P13682.
PaxDbi P13682.
PRIDEi P13682.

Protocols and materials databases

DNASUi 7584.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396056 ; ENSP00000379368 ; ENSG00000169981 .
GeneIDi 7584.
KEGGi hsa:7584.
UCSCi uc003cnq.3. human.

Organism-specific databases

CTDi 7584.
GeneCardsi GC03P044690.
HGNCi HGNC:13099. ZNF35.
HPAi HPA051859.
HPA054738.
MIMi 194533. gene.
neXtProti NX_P13682.
PharmGKBi PA37674.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119358.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi P13682.
OMAi VPKTEIC.
PhylomeDBi P13682.
TreeFami TF350849.

Miscellaneous databases

ChiTaRSi ZNF35. human.
GeneWikii ZNF35.
GenomeRNAii 7584.
NextBioi 29649.
PROi P13682.
SOURCEi Search...

Gene expression databases

Bgeei P13682.
CleanExi HS_ZNF35.
ExpressionAtlasi P13682. baseline.
Genevestigatori P13682.

Family and domain databases

Gene3Di 3.30.160.60. 11 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 11 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation."
    Pannuti A., Lanfrancone L., Pascucci A., Pelicci P.-G., la Mantia G., Lania L.
    Nucleic Acids Res. 16:4227-4237(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22."
    Lanfrancone L., Pengue G., Pandolfi P.P., Salcini A.E., Giacomucci A., Longo L., Donti E., de Luca P., la Mantia G., Pelicci P.-G., Lania L.
    Genomics 12:720-728(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-527.

Entry informationi

Entry nameiZNF35_HUMAN
AccessioniPrimary (citable) accession number: P13682
Secondary accession number(s): B2RBU6, Q53Y54, Q96D01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3