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Protein

Serine/threonine-protein phosphatase PP1-1

Gene

dis2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Manganese 1By similarity1
Metal bindingi65Manganese 1By similarity1
Metal bindingi91Manganese 1By similarity1
Metal bindingi91Manganese 2By similarity1
Metal bindingi123Manganese 2By similarity1
Active sitei124Proton donorBy similarity1
Metal bindingi172Manganese 2By similarity1
Metal bindingi247Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • attachment of mitotic spindle microtubules to kinetochore Source: PomBase
  • cell division Source: UniProtKB-KW
  • deactivation of mitotic spindle assembly checkpoint Source: PomBase
  • negative regulation of mitotic chromosome condensation Source: PomBase
  • positive regulation of establishment of cell polarity regulating cell shape Source: PomBase
  • positive regulation of protein localization to cell tip Source: PomBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-1 (EC:3.1.3.16)
Gene namesi
Name:dis2
Synonyms:bws1
ORF Names:SPBC776.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC776.02c.
PomBaseiSPBC776.02c. dis2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi245R → Q: Cold-sensitive phenotype. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588181 – 327Serine/threonine-protein phosphatase PP1-1Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316Phosphothreonine; by CDC21 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP13681.
PRIDEiP13681.

PTM databases

iPTMnetiP13681.

Interactioni

Subunit structurei

Oligomer.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi277707. 92 interactors.
DIPiDIP-61473N.
IntActiP13681. 10 interactors.
MINTiMINT-4687271.
STRINGi4896.SPBC776.02c.1.

Structurei

3D structure databases

ProteinModelPortaliP13681.
SMRiP13681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172697.
InParanoidiP13681.
KOiK06269.
OMAiIFIQQPI.
OrthoDBiEOG092C37EX.
PhylomeDBiP13681.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P13681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPDVDLDS IIDRLLEVRG SRPGRQVQLS EDEIRFLCNK AREIFISQPI
60 70 80 90 100
LLELEAPLKI CGDIHGQYYD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL
110 120 130 140 150
EVICLLLAYK IKYPENFFIL RGNHECASIN RIYGFYDECK RRYNIKLWKT
160 170 180 190 200
FTDCFNCLPI AAIIDEKIFT MHGGLSPDLN SMDQIQRIMR PTDVPDTGLL
210 220 230 240 250
CDLLWSDPDK DLTGWGDNDR GVSFTFGPDV VSRFLHKHDM DLVCRAHQVV
260 270 280 290 300
EDGYEFFSKR QLVTLFSAPN YCGEFDNAGA MMSVDESLLC SFQILKPAEK
310 320
KQRYGYQGSS QNWHMTPPRK NKTGNSK
Length:327
Mass (Da):37,636
Last modified:January 1, 1990 - v1
Checksum:i1106BB9C7D6FDCFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17E → EGE (PubMed:2544298).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27075 Genomic DNA. Translation: AAA74731.1.
M27068 Genomic DNA. Translation: AAA89197.1.
CU329671 Genomic DNA. Translation: CAA22875.1.
PIRiA32550.
RefSeqiNP_596317.1. NM_001022239.2.

Genome annotation databases

EnsemblFungiiSPBC776.02c.1; SPBC776.02c.1:pep; SPBC776.02c.
GeneIDi2541193.
KEGGispo:SPBC776.02c.

Similar proteinsi

Entry informationi

Entry nameiPP11_SCHPO
AccessioniPrimary (citable) accession number: P13681
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 25, 2017
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families