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Protein

Signal peptidase complex catalytic subunit SEC11C

Gene

SEC11C

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.1 Publication

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-CFA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Protein family/group databases

MEROPSiS26.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11C (EC:3.4.21.89)
Alternative name(s):
Microsomal signal peptidase 21 kDa subunit
Short name:
SPase 21 kDa subunit
SEC11 homolog C
SEC11-like protein 3
SPC21
Gene namesi
Name:SEC11C
Synonyms:SEC11L3, SPC21
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2827CytoplasmicSequence analysisAdd
BLAST
Transmembranei29 – 4820Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini49 – 192144LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 192191Signal peptidase complex catalytic subunit SEC11CPRO_0000109547Add
BLAST

Proteomic databases

PaxDbiP13679.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000000138.

Structurei

3D structure databases

ProteinModelPortaliP13679.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiP13679.
KOiK13280.
OMAiMQIRQVL.
OrthoDBiEOG7V4B0P.
TreeFamiTF313648.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13679-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAGAVGTH LPASGLDIFG DLRKMNKRQL YYQVLNFAMI VSSALMIWKG
60 70 80 90 100
LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE
110 120 130 140 150
GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV
160 170 180 190
VGRARGFLPY VGMVTIIMND YPKFKYALLA VMGAYVLLKR ES
Length:192
Mass (Da):21,600
Last modified:January 23, 2007 - v3
Checksum:i3C4933EAEAB5E58E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05069 mRNA. Translation: AAA30896.1.
PIRiA34229.
RefSeqiNP_001003312.1. NM_001003312.1.
UniGeneiCfa.40272.

Genome annotation databases

EnsembliENSCAFT00000000158; ENSCAFP00000000138; ENSCAFG00000000100.
GeneIDi404003.
KEGGicfa:404003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05069 mRNA. Translation: AAA30896.1.
PIRiA34229.
RefSeqiNP_001003312.1. NM_001003312.1.
UniGeneiCfa.40272.

3D structure databases

ProteinModelPortaliP13679.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000000138.

Protein family/group databases

MEROPSiS26.010.

Proteomic databases

PaxDbiP13679.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000000158; ENSCAFP00000000138; ENSCAFG00000000100.
GeneIDi404003.
KEGGicfa:404003.

Organism-specific databases

CTDi90701.

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiP13679.
KOiK13280.
OMAiMQIRQVL.
OrthoDBiEOG7V4B0P.
TreeFamiTF313648.

Enzyme and pathway databases

ReactomeiR-CFA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A subunit of mammalian signal peptidase is homologous to yeast SEC11 protein."
    Greenburg G., Shelness G.S., Blobel G.
    J. Biol. Chem. 264:15762-15765(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-31 AND 69-89.
    Tissue: Liver.
  2. "Purification of microsomal signal peptidase as a complex."
    Evans E.A., Gilmore R., Blobel G.
    Proc. Natl. Acad. Sci. U.S.A. 83:581-585(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF SIGNAL PEPTIDASE COMPLEX.
  3. "Genetic complementation in yeast reveals functional similarities between the catalytic subunits of mammalian signal peptidase complex."
    Liang H., VanValkenburgh C., Chen X., Mullins C., Van Kaer L., Green N., Fang H.
    J. Biol. Chem. 278:50932-50939(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSC11C_CANLF
AccessioniPrimary (citable) accession number: P13679
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.