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Protein

Signal peptidase complex catalytic subunit SEC11C

Gene

SEC11C

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.1 Publication

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

ReactomeiR-CFA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Protein family/group databases

MEROPSiS26.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11C (EC:3.4.21.89)
Alternative name(s):
Microsomal signal peptidase 21 kDa subunit
Short name:
SPase 21 kDa subunit
SEC11 homolog C
SEC11-like protein 3
SPC21
Gene namesi
Name:SEC11C
Synonyms:SEC11L3, SPC21
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 28CytoplasmicSequence analysisAdd BLAST27
Transmembranei29 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini49 – 192LumenalSequence analysisAdd BLAST144

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001095472 – 192Signal peptidase complex catalytic subunit SEC11CAdd BLAST191

Proteomic databases

PaxDbiP13679.

Expressioni

Gene expression databases

BgeeiENSCAFG00000000100.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

Protein-protein interaction databases

CORUMiP13679.
STRINGi9615.ENSCAFP00000000138.

Structurei

3D structure databases

ProteinModelPortaliP13679.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiP13679.
KOiK13280.
OMAiWKGLIVI.
OrthoDBiEOG091G0X3D.
TreeFamiTF313648.

Family and domain databases

InterProiView protein in InterPro
IPR036286. LexA/Signal_pep-like_sf.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiView protein in Pfam
PF00717. Peptidase_S24. 1 hit.
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13679-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAGAVGTH LPASGLDIFG DLRKMNKRQL YYQVLNFAMI VSSALMIWKG
60 70 80 90 100
LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE
110 120 130 140 150
GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV
160 170 180 190
VGRARGFLPY VGMVTIIMND YPKFKYALLA VMGAYVLLKR ES
Length:192
Mass (Da):21,600
Last modified:January 23, 2007 - v3
Checksum:i3C4933EAEAB5E58E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05069 mRNA. Translation: AAA30896.1.
PIRiA34229.
RefSeqiNP_001003312.1. NM_001003312.1.
UniGeneiCfa.40272.

Genome annotation databases

EnsembliENSCAFT00000000158; ENSCAFP00000000138; ENSCAFG00000000100.
GeneIDi404003.
KEGGicfa:404003.

Similar proteinsi

Entry informationi

Entry nameiSC11C_CANLF
AccessioniPrimary (citable) accession number: P13679
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families