Reviewed,
UniProtKB/Swiss-Prot P13678 (KPC3_DROME)
Last modified
February 9, 2010.
Version 106.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein kinase C Short name=PKC EC=2.7.11.13 Alternative name(s): dPKC98F | ||||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 634 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Miscellaneous | This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. |
| Sequence similarities | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 phorbol-ester/DAG-type zinc fingers. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Domain | Repeat Zinc-finger |
| Ligand | ATP-binding Calcium Metal-binding Nucleotide-binding Zinc |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | intracellular signaling cascade Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylationNon-traceable author statement. Source: FlyBase |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion bindingInferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: IntAct protein kinase C activityInferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 634 | 634 | Protein kinase C | PRO_0000055732 | |||||
Regions | |||||||||
| Domain | 303 – 560 | 258 | Protein kinase | ||||||
| Domain | 561 – 632 | 72 | AGC-kinase C-terminal | ||||||
| Zinc finger | 71 – 121 | 51 | Phorbol-ester/DAG-type 1 | ||||||
| Zinc finger | 146 – 196 | 51 | Phorbol-ester/DAG-type 2 | ||||||
| Nucleotide binding | 309 – 317 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 427 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 332 | 1 | ATP By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | J04848 mRNA. Translation: AAA28818.1. AE014297 Genomic DNA. Translation: AAF56846.1. Different initiation. |
| PIR | B32392. |
| RefSeq | NP_524545.2. |
3D structure databases | |
| SMR | P13678. Positions 70-123, 137-199, 300-627. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P13678. 15 interactions. |
| STRING | P13678. |
Proteomic databases | |
| PRIDE | P13678. |
Genome annotation databases | |
| Ensembl | FBtr0085359; FBpp0084728; FBgn0003093; Drosophila melanogaster. [Genome view] |
| GeneID | 43428. |
| KEGG | dme:Dmel_CG1954. |
| NMPDR | fig|7227.3.peg.15160. |
Organism-specific databases | |
| CTD | 43428. |
| FlyBase | FBgn0003093. Pkc98E. |
Phylogenomic databases | |
| eggNOG | inNOG09283. |
| InParanoid | P13678. |
| PhylomeDB | P13678. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.13. 48. |
Gene expression databases | |
| GermOnline | CG1954. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR000961. AGC-kinase_C. IPR020454. DAG/PE_bd. IPR011009. Kinase-like_dom. IPR015745. PKC. IPR017892. Pkinase_C. IPR014376. Prot_kin_PKC_delta. IPR002219. Prot_Kinase_C-like_PE/DAG_bd. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view] |
| PANTHER | PTHR22985:SF86. PKC. 1 hit. |
| Pfam | PF00130. C1_1. 2 hits. PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view] |
| PIRSF | PIRSF000551. PKC_delta. 1 hit. |
| PRINTS | PR00008. DAGPEDOMAIN. |
| SMART | SM00109. C1. 2 hits. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS00479. ZF_DAG_PE_1. 2 hits. PS50081. ZF_DAG_PE_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 833872. |
Entry information
| Entry name | KPC3_DROME | ||||||||
| Accession | Primary (citable) accession number: P13678 Secondary accession number(s): Q9VAQ6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

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