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Protein

Protein kinase C

Gene

Pkc98E

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Miscellaneous

This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei437ATPPROSITE-ProRule annotation1
Active sitei532Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 226Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri251 – 301Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51
Nucleotide bindingi414 – 422ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein kinase C activity Source: FlyBase
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • dorsal/ventral axis specification Source: FlyBase
  • Golgi organization Source: FlyBase
  • intracellular signal transduction Source: InterPro
  • lipid particle organization Source: FlyBase
  • long-term memory Source: FlyBase
  • negative regulation of cell proliferation Source: FlyBase
  • peptidyl-serine phosphorylation Source: GO_Central
  • protein phosphorylation Source: FlyBase
  • response to ethanol Source: FlyBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.11.13 1994
ReactomeiR-DME-114508 Effects of PIP2 hydrolysis
R-DME-1489509 DAG and IP3 signaling
R-DME-2029485 Role of phospholipids in phagocytosis
SignaLinkiP13678

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C (EC:2.7.11.13)
Short name:
PKC
Alternative name(s):
dPKC98F
Gene namesi
Name:Pkc98E
Synonyms:Pkc3
ORF Names:CG1954
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003093 Pkc98E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557321 – 739Protein kinase CAdd BLAST739

Proteomic databases

PaxDbiP13678
PRIDEiP13678

Expressioni

Gene expression databases

BgeeiFBgn0003093
ExpressionAtlasiP13678 baseline and differential
GenevisibleiP13678 DM

Interactioni

Protein-protein interaction databases

BioGridi68299, 17 interactors
IntActiP13678, 1 interactor
STRINGi7227.FBpp0084728

Structurei

3D structure databases

ProteinModelPortaliP13678
SMRiP13678
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini408 – 665Protein kinasePROSITE-ProRule annotationAdd BLAST258
Domaini666 – 737AGC-kinase C-terminalAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 226Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri251 – 301Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0694 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00820000126964
InParanoidiP13678
KOiK18050
OMAiPCDQELK
OrthoDBiEOG091G0QRS
PhylomeDBiP13678

Family and domain databases

CDDicd00029 C1, 2 hits
cd05591 STKc_nPKC_epsilon, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR034669 nPKC_epsilon
IPR002219 PE/DAG-bd
IPR017892 Pkinase_C
IPR014376 Prot_kin_PKC_delta
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00168 C2, 1 hit
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000551 PKC_delta, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

P13678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTGKLQIKV CEASGLRPTD FQKRHNLTFG KLADEQLIDP YVSIDVDESH
60 70 80 90 100
FDRATTRPKT FDPVWNEQFV HDVTNVSNIN LTVFHDAALP PDDFVANCII
110 120 130 140 150
SFEDLMQSET AVQDLWVNLE PQGKIHVIIE LKNRTDKAKA EAVVEHTVAV
160 170 180 190 200
NKEFKERAGF NRRRGAMRRR VHQVNGHKFM ATFLRQPTFC SHCREFIWGI
210 220 230 240 250
GKQGYQCQVC TLVVHKKCHL SVVSKCPGMR DEQPAKVEMV PAGQRFNVNL
260 270 280 290 300
PHRFVVHSYK RFTFCDHCGS LLYGLIKQGL QCETCGMNVH KRCQKNVANT
310 320 330 340 350
CGINTKQMAE ILSSLGISPD KQQPRRSKYL NQQGGEDNYG ASLGADGDGA
360 370 380 390 400
PGQSFRSCAL SVDSLATSTT TMTSGYNSSS CMSLAVTGSG GVGATGETRP
410 420 430 440 450
GKCSLLDFNF IKVLGKGSFG KVMLAEKKGT DEIYAIKVLK KDAIIQDDDV
460 470 480 490 500
DCTMTEKRIL ALAANHPFLT ALHSCFQTPD RLFFVMEYVN GGDLMFQIQK
510 520 530 540 550
ARRFEASRAA FYAAEVTLAL QFLHTHGVIY RDLKLDNILL DQEGHCKLAD
560 570 580 590 600
FGMCKEGIMN GMLTTTFCGT PDYIAPEILK EQEYGASVDW WALGVLMYEM
610 620 630 640 650
MAGQPPFEAD NEDELFDSIM HDDVLYPVWL SREAVSILKG FLTKNPEQRL
660 670 680 690 700
GCTGDENEIR KHPFFAKLDW KELEKRNIKP PFRPKMKNPR DANNFDAEFT
710 720 730
KEDPVLTPIG NEVVRCINQD EFAGFSFVNP KFGPERKVY
Length:739
Mass (Da):83,107
Last modified:January 31, 2018 - v2
Checksum:iFB3322575FCE5BC5
GO

Sequence cautioni

The sequence AAA28818 differs from that shown. Reason: Frameshift at positions 13, 17 and 29.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04848 mRNA Translation: AAA28818.1 Frameshift.
AE014297 Genomic DNA Translation: AAF56846.1
AE014297 Genomic DNA Translation: AHN57576.1
PIRiB32392
RefSeqiNP_001287577.1, NM_001300648.1
NP_524545.2, NM_079821.4
UniGeneiDm.4053

Genome annotation databases

EnsemblMetazoaiFBtr0085359; FBpp0084728; FBgn0003093
FBtr0339150; FBpp0308295; FBgn0003093
GeneIDi43428
KEGGidme:Dmel_CG1954

Similar proteinsi

Entry informationi

Entry nameiKPC3_DROME
AccessioniPrimary (citable) accession number: P13678
Secondary accession number(s): A0A0B4LHW0, Q9VAQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 31, 2018
Last modified: May 23, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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