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P13678

- KPC3_DROME

UniProt

P13678 - KPC3_DROME

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Protein

Protein kinase C

Gene

Pkc98E

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei332 – 3321ATPPROSITE-ProRule annotation
Active sitei427 – 4271Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri71 – 12151Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 19651Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi309 – 3179ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein kinase C activity Source: FlyBase
  4. protein serine/threonine kinase activity Source: FlyBase

GO - Biological processi

  1. dorsal/ventral axis specification Source: FlyBase
  2. Golgi organization Source: FlyBase
  3. I-kappaB phosphorylation Source: FlyBase
  4. lipid particle organization Source: FlyBase
  5. long-term memory Source: FlyBase
  6. negative regulation of cell proliferation Source: FlyBase
  7. neuron projection morphogenesis Source: FlyBase
  8. protein phosphorylation Source: FlyBase
  9. response to ethanol Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.11.13. 1994.
ReactomeiREACT_181716. Role of phospholipids in phagocytosis.
REACT_209941. DAG and IP3 signaling.
SignaLinkiP13678.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C (EC:2.7.11.13)
Short name:
PKC
Alternative name(s):
dPKC98F
Gene namesi
Name:Pkc98E
Synonyms:Pkc3
ORF Names:CG1954
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003093. Pkc98E.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634Protein kinase CPRO_0000055732Add
BLAST

Proteomic databases

PaxDbiP13678.
PRIDEiP13678.

Expressioni

Gene expression databases

BgeeiP13678.
ExpressionAtlasiP13678. differential.

Interactioni

Protein-protein interaction databases

BioGridi68299. 16 interactions.
IntActiP13678. 1 interaction.
MINTiMINT-155042.

Structurei

3D structure databases

ProteinModelPortaliP13678.
SMRiP13678. Positions 70-196, 302-625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini303 – 560258Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini561 – 63272AGC-kinase C-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri71 – 12151Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 19651Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiP13678.
KOiK18050.
OrthoDBiEOG77M8QM.
PhylomeDBiP13678.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000551. PKC_delta. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13678-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSETAVQDL WVNLEPQGKI HVIIELKNRT DKAKAEAVVE HTVAVNKEFK
60 70 80 90 100
ERAGFNRRRG AMRRRVHQVN GHKFMATFLR QPTFCSHCRE FIWGIGKQGY
110 120 130 140 150
QCQVCTLVVH KKCHLSVVSK CPGMRDEQPA KVEMVPAGQR FNVNLPHRFV
160 170 180 190 200
VHSYKRFTFC DHCGSLLYGL IKQGLQCETC GMNVHKRCQK NVANTCGINT
210 220 230 240 250
KQMAEILSSL GISPDKQQPR RSKYLNQQGG EDNYGASLGA DGDGAPGQSF
260 270 280 290 300
RSCALSVDSL ATSTTTMTSG YNSSSCMSLA VTGSGGVGAT GETRPGKCSL
310 320 330 340 350
LDFNFIKVLG KGSFGKVMLA EKKGTDEIYA IKVLKKDAII QDDDVDCTMT
360 370 380 390 400
EKRILALAAN HPFLTALHSC FQTPDRLFFV MEYVNGGDLM FQIQKARRFE
410 420 430 440 450
ASRAAFYAAE VTLALQFLHT HGVIYRDLKL DNILLDQEGH CKLADFGMCK
460 470 480 490 500
EGIMNGMLTT TFCGTPDYIA PEILKEQEYG ASVDWWALGV LMYEMMAGQP
510 520 530 540 550
PFEADNEDEL FDSIMHDDVL YPVWLSREAV SILKGFLTKN PEQRLGCTGD
560 570 580 590 600
ENEIRKHPFF AKLDWKELEK RNIKPPFRPK MKNPRDANNF DAEFTKEDPV
610 620 630
LTPIGNEVVR CINQDEFAGF SFVNPKFGPE RKVY
Length:634
Mass (Da):71,157
Last modified:April 1, 1990 - v1
Checksum:i3AE3A3D6B7A276BA
GO

Sequence cautioni

The sequence AAF56846.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04848 mRNA. Translation: AAA28818.1.
AE014297 Genomic DNA. Translation: AAF56846.1. Different initiation.
PIRiB32392.
RefSeqiNP_524545.2. NM_079821.4.
UniGeneiDm.4053.

Genome annotation databases

GeneIDi43428.
KEGGidme:Dmel_CG1954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04848 mRNA. Translation: AAA28818.1 .
AE014297 Genomic DNA. Translation: AAF56846.1 . Different initiation.
PIRi B32392.
RefSeqi NP_524545.2. NM_079821.4.
UniGenei Dm.4053.

3D structure databases

ProteinModelPortali P13678.
SMRi P13678. Positions 70-196, 302-625.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 68299. 16 interactions.
IntActi P13678. 1 interaction.
MINTi MINT-155042.

Proteomic databases

PaxDbi P13678.
PRIDEi P13678.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 43428.
KEGGi dme:Dmel_CG1954.

Organism-specific databases

CTDi 43428.
FlyBasei FBgn0003093. Pkc98E.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi P13678.
KOi K18050.
OrthoDBi EOG77M8QM.
PhylomeDBi P13678.

Enzyme and pathway databases

BRENDAi 2.7.11.13. 1994.
Reactomei REACT_181716. Role of phospholipids in phagocytosis.
REACT_209941. DAG and IP3 signaling.
SignaLinki P13678.

Miscellaneous databases

ChiTaRSi Pkc98E. drosophila.
GenomeRNAii 43428.
NextBioi 833872.

Gene expression databases

Bgeei P13678.
ExpressionAtlasi P13678. differential.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000551. PKC_delta. 1 hit.
PRINTSi PR00008. DAGPEDOMAIN.
SMARTi SM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of two new Drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells."
    Schaeffer E., Smith D., Mardon G., Quinn W., Zuker C.
    Cell 57:403-412(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.

Entry informationi

Entry nameiKPC3_DROME
AccessioniPrimary (citable) accession number: P13678
Secondary accession number(s): Q9VAQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3