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Protein

Complement component C6

Gene

C6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement pathway, Cytolysis, Immunity, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000039537-MONOMER.
ReactomeiR-HSA-166665. Terminal pathway of complement.
R-HSA-977606. Regulation of Complement cascade.

Protein family/group databases

TCDBi1.C.39.3.3. the membrane attack complex/perforin (macpf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C6
Gene namesi
Name:C6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1339. C6.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • membrane attack complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane attack complex, Secreted

Pathology & Biotechi

Involvement in diseasei

Complement component 6 deficiency (C6D)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
See also OMIM:612446

Organism-specific databases

DisGeNETi729.
MalaCardsiC6.
MIMi612446. phenotype.
OpenTargetsiENSG00000039537.
Orphaneti169150. Immunodeficiency due to a late component of complements deficiency.
PharmGKBiPA25921.

Polymorphism and mutation databases

DMDMi146345396.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000002357922 – 934Complement component C6Add BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 61
Disulfide bondi24 ↔ 65
Glycosylationi29C-linked (Man)1 Publication1
Glycosylationi32C-linked (Man); partial1 Publication1
Disulfide bondi35 ↔ 73
Glycosylationi38O-linked (Fuc...)1 Publication1
Disulfide bondi39 ↔ 78
Disulfide bondi82 ↔ 117
Glycosylationi90C-linked (Man); partial1 Publication1
Disulfide bondi93 ↔ 127
Disulfide bondi96 ↔ 133
Disulfide bondi140 ↔ 151
Disulfide bondi146 ↔ 164
Disulfide bondi158 ↔ 173
Disulfide bondi180 ↔ 218
Glycosylationi324N-linked (GlcNAc...)2 Publications1
Glycosylationi392O-linked (Fuc...)1 Publication1
Disulfide bondi399 ↔ 420
Disulfide bondi499 ↔ 623
Disulfide bondi521 ↔ 570
Disulfide bondi523 ↔ 539
Disulfide bondi526 ↔ 541
Disulfide bondi543 ↔ 552
Glycosylationi568C-linked (Man); partial1 Publication1
Glycosylationi571C-linked (Man); partial1 Publication1
Glycosylationi574C-linked (Man); partial1 Publication1
Disulfide bondi577 ↔ 611
Disulfide bondi589 ↔ 601
Disulfide bondi644 ↔ 686
Disulfide bondi672 ↔ 699
Disulfide bondi704 ↔ 746
Disulfide bondi732 ↔ 761
Disulfide bondi773 ↔ 823
Disulfide bondi784 ↔ 801
Disulfide bondi786 ↔ 837
Disulfide bondi793 ↔ 816
Glycosylationi855N-linked (GlcNAc...)1 Publication1
Disulfide bondi862 ↔ 873
Disulfide bondi867 ↔ 919
Disulfide bondi880 ↔ 897
Disulfide bondi882 ↔ 932
Disulfide bondi888 ↔ 912

Post-translational modificationi

All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP13671.
PaxDbiP13671.
PeptideAtlasiP13671.
PRIDEiP13671.

PTM databases

iPTMnetiP13671.
PhosphoSitePlusiP13671.

Expressioni

Gene expression databases

BgeeiENSG00000039537.
CleanExiHS_C6.
ExpressionAtlasiP13671. baseline and differential.
GenevisibleiP13671. HS.

Organism-specific databases

HPAiCAB069427.
HPA043823.

Interactioni

Subunit structurei

Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1753221,EBI-389883

Protein-protein interaction databases

BioGridi107190. 8 interactors.
IntActiP13671. 5 interactors.
STRINGi9606.ENSP00000263413.

Structurei

Secondary structure

1934
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 26Combined sources3
Beta strandi38 – 40Combined sources3
Beta strandi42 – 48Combined sources7
Helixi54 – 58Combined sources5
Helixi61 – 64Combined sources4
Beta strandi68 – 73Combined sources6
Beta strandi95 – 97Combined sources3
Beta strandi100 – 104Combined sources5
Beta strandi106 – 108Combined sources3
Beta strandi121 – 125Combined sources5
Beta strandi130 – 133Combined sources4
Beta strandi141 – 145Combined sources5
Beta strandi151 – 153Combined sources3
Helixi154 – 156Combined sources3
Beta strandi157 – 161Combined sources5
Beta strandi164 – 167Combined sources4
Helixi168 – 170Combined sources3
Beta strandi179 – 182Combined sources4
Helixi190 – 194Combined sources5
Beta strandi195 – 198Combined sources4
Turni199 – 202Combined sources4
Beta strandi203 – 207Combined sources5
Beta strandi226 – 228Combined sources3
Beta strandi236 – 240Combined sources5
Helixi247 – 249Combined sources3
Beta strandi250 – 256Combined sources7
Helixi258 – 262Combined sources5
Beta strandi279 – 282Combined sources4
Turni287 – 289Combined sources3
Helixi298 – 307Combined sources10
Beta strandi309 – 327Combined sources19
Beta strandi329 – 331Combined sources3
Helixi336 – 341Combined sources6
Helixi351 – 361Combined sources11
Beta strandi363 – 365Combined sources3
Beta strandi367 – 382Combined sources16
Helixi383 – 389Combined sources7
Helixi393 – 407Combined sources15
Helixi418 – 420Combined sources3
Helixi426 – 429Combined sources4
Helixi434 – 436Combined sources3
Beta strandi437 – 442Combined sources6
Beta strandi445 – 447Combined sources3
Helixi449 – 455Combined sources7
Beta strandi461 – 465Combined sources5
Helixi466 – 478Combined sources13
Beta strandi481 – 486Combined sources6
Beta strandi487 – 489Combined sources3
Helixi490 – 493Combined sources4
Helixi500 – 516Combined sources17
Helixi520 – 522Combined sources3
Turni527 – 529Combined sources3
Beta strandi530 – 535Combined sources6
Beta strandi538 – 542Combined sources5
Beta strandi547 – 549Combined sources3
Helixi550 – 552Combined sources3
Beta strandi579 – 586Combined sources8
Beta strandi595 – 597Combined sources3
Beta strandi605 – 610Combined sources6
Beta strandi643 – 645Combined sources3
Beta strandi653 – 656Combined sources4
Beta strandi660 – 663Combined sources4
Beta strandi667 – 672Combined sources6
Beta strandi676 – 680Combined sources5
Beta strandi683 – 686Combined sources4
Beta strandi688 – 692Combined sources5
Beta strandi698 – 701Combined sources4
Beta strandi703 – 705Combined sources3
Beta strandi711 – 714Combined sources4
Beta strandi715 – 717Combined sources3
Beta strandi720 – 723Combined sources4
Beta strandi727 – 729Combined sources3
Beta strandi734 – 736Combined sources3
Beta strandi737 – 740Combined sources4
Beta strandi742 – 745Combined sources4
Beta strandi747 – 749Combined sources3
Beta strandi755 – 757Combined sources3
Turni772 – 776Combined sources5
Beta strandi778 – 783Combined sources6
Helixi789 – 792Combined sources4
Beta strandi798 – 804Combined sources7
Turni805 – 808Combined sources4
Beta strandi809 – 814Combined sources6
Helixi815 – 822Combined sources8
Helixi825 – 827Combined sources3
Beta strandi829 – 836Combined sources8
Helixi841 – 851Combined sources11
Beta strandi853 – 857Combined sources5
Beta strandi862 – 864Combined sources3
Beta strandi875 – 877Combined sources3
Beta strandi879 – 881Combined sources3
Helixi885 – 891Combined sources7
Beta strandi897 – 899Combined sources3
Beta strandi901 – 903Combined sources3
Beta strandi905 – 907Combined sources3
Helixi911 – 920Combined sources10
Beta strandi925 – 930Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T5OX-ray2.87A22-934[»]
4A5WX-ray3.50B22-934[»]
4E0SX-ray4.21B22-934[»]
ProteinModelPortaliP13671.
SMRiP13671.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 79TSP type-1 1PROSITE-ProRule annotationAdd BLAST58
Domaini81 – 134TSP type-1 2PROSITE-ProRule annotationAdd BLAST54
Domaini138 – 175LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Domaini176 – 522MACPFPROSITE-ProRule annotationAdd BLAST347
Domaini523 – 553EGF-likeAdd BLAST31
Domaini565 – 612TSP type-1 3PROSITE-ProRule annotationAdd BLAST48
Domaini642 – 701Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini702 – 763Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini780 – 839Kazal-like 1PROSITE-ProRule annotationAdd BLAST60
Domaini876 – 934Kazal-like 2PROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni611 – 688CCP 1Add BLAST78
Regioni642 – 934C5b-binding domainAdd BLAST293
Regioni689 – 765CCP 2Add BLAST77
Regioni766 – 840Factor I module (FIM) 1Add BLAST75
Regioni858 – 934Factor I module (FIM) 2Add BLAST77

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated
Contains 1 EGF-like domain.Curated
Contains 2 Kazal-like domains.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 1 MACPF domain.PROSITE-ProRule annotation
Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation
Contains 3 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
GeneTreeiENSGT00550000074478.
HOGENOMiHOG000111865.
HOVERGENiHBG005366.
InParanoidiP13671.
KOiK03995.
OMAiCVCQSGT.
OrthoDBiEOG091G07LK.
PhylomeDBiP13671.
TreeFamiTF330498.

Family and domain databases

CDDicd00033. CCP. 2 hits.
InterProiIPR003884. FacI_MAC.
IPR002350. Kazal_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF07648. Kazal_2. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS51465. KAZAL_2. 2 hits.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRSVLYFI LLNALINKGQ ACFCDHYAWT QWTSCSKTCN SGTQSRHRQI
60 70 80 90 100
VVDKYYQENF CEQICSKQET RECNWQRCPI NCLLGDFGPW SDCDPCIEKQ
110 120 130 140 150
SKVRSVLRPS QFGGQPCTAP LVAFQPCIPS KLCKIEEADC KNKFRCDSGR
160 170 180 190 200
CIARKLECNG ENDCGDNSDE RDCGRTKAVC TRKYNPIPSV QLMGNGFHFL
210 220 230 240 250
AGEPRGEVLD NSFTGGICKT VKSSRTSNPY RVPANLENVG FEVQTAEDDL
260 270 280 290 300
KTDFYKDLTS LGHNENQQGS FSSQGGSSFS VPIFYSSKRS ENINHNSAFK
310 320 330 340 350
QAIQASHKKD SSFIRIHKVM KVLNFTTKAK DLHLSDVFLK ALNHLPLEYN
360 370 380 390 400
SALYSRIFDD FGTHYFTSGS LGGVYDLLYQ FSSEELKNSG LTEEEAKHCV
410 420 430 440 450
RIETKKRVLF AKKTKVEHRC TTNKLSEKHE GSFIQGAEKS ISLIRGGRSE
460 470 480 490 500
YGAALAWEKG SSGLEEKTFS EWLESVKENP AVIDFELAPI VDLVRNIPCA
510 520 530 540 550
VTKRNNLRKA LQEYAAKFDP CQCAPCPNNG RPTLSGTECL CVCQSGTYGE
560 570 580 590 600
NCEKQSPDYK SNAVDGQWGC WSSWSTCDAT YKRSRTRECN NPAPQRGGKR
610 620 630 640 650
CEGEKRQEED CTFSIMENNG QPCINDDEEM KEVDLPEIEA DSGCPQPVPP
660 670 680 690 700
ENGFIRNEKQ LYLVGEDVEI SCLTGFETVG YQYFRCLPDG TWRQGDVECQ
710 720 730 740 750
RTECIKPVVQ EVLTITPFQR LYRIGESIEL TCPKGFVVAG PSRYTCQGNS
760 770 780 790 800
WTPPISNSLT CEKDTLTKLK GHCQLGQKQS GSECICMSPE EDCSHHSEDL
810 820 830 840 850
CVFDTDSNDY FTSPACKFLA EKCLNNQQLH FLHIGSCQDG RQLEWGLERT
860 870 880 890 900
RLSSNSTKKE SCGYDTCYDW EKCSASTSKC VCLLPPQCFK GGNQLYCVKM
910 920 930
GSSTSEKTLN ICEVGTIRCA NRKMEILHPG KCLA
Length:934
Mass (Da):104,786
Last modified:May 1, 2007 - v3
Checksum:iA88F4BED7CC349D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti567Q → H in BAD02321 (Ref. 4) Curated1
Sequence conflicti616M → I in BAD02321 (Ref. 4) Curated1
Sequence conflicti934A → T in BAD02321 (Ref. 4) Curated1

Polymorphismi

The sequence shown is that of allotype C6 B.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_006056119A → E in allotype C6 A. 5 PublicationsCorresponds to variant rs1801033dbSNPEnsembl.1
Natural variantiVAR_027647397K → E.Corresponds to variant rs6896011dbSNPEnsembl.1
Natural variantiVAR_027648470S → F.Corresponds to variant rs10462014dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05064 mRNA. Translation: AAA51860.1.
J05024 mRNA. Translation: AAA59668.1.
X72177 Genomic DNA. Translation: CAA50994.1.
AB126592 mRNA. Translation: BAD02321.1.
AC008863 Genomic DNA. No translation available.
AC091871 Genomic DNA. No translation available.
BC035723 mRNA. Translation: AAH35723.1.
J04506 mRNA. Translation: AAB59433.1.
CCDSiCCDS3936.1.
PIRiA34372.
RefSeqiNP_000056.2. NM_000065.3.
NP_001108603.2. NM_001115131.2.
UniGeneiHs.481992.

Genome annotation databases

EnsembliENST00000263413; ENSP00000263413; ENSG00000039537.
ENST00000337836; ENSP00000338861; ENSG00000039537.
GeneIDi729.
KEGGihsa:729.
UCSCiuc003jmk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

C6base

C6 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05064 mRNA. Translation: AAA51860.1.
J05024 mRNA. Translation: AAA59668.1.
X72177 Genomic DNA. Translation: CAA50994.1.
AB126592 mRNA. Translation: BAD02321.1.
AC008863 Genomic DNA. No translation available.
AC091871 Genomic DNA. No translation available.
BC035723 mRNA. Translation: AAH35723.1.
J04506 mRNA. Translation: AAB59433.1.
CCDSiCCDS3936.1.
PIRiA34372.
RefSeqiNP_000056.2. NM_000065.3.
NP_001108603.2. NM_001115131.2.
UniGeneiHs.481992.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T5OX-ray2.87A22-934[»]
4A5WX-ray3.50B22-934[»]
4E0SX-ray4.21B22-934[»]
ProteinModelPortaliP13671.
SMRiP13671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107190. 8 interactors.
IntActiP13671. 5 interactors.
STRINGi9606.ENSP00000263413.

Protein family/group databases

TCDBi1.C.39.3.3. the membrane attack complex/perforin (macpf) family.

PTM databases

iPTMnetiP13671.
PhosphoSitePlusiP13671.

Polymorphism and mutation databases

DMDMi146345396.

Proteomic databases

EPDiP13671.
PaxDbiP13671.
PeptideAtlasiP13671.
PRIDEiP13671.

Protocols and materials databases

DNASUi729.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263413; ENSP00000263413; ENSG00000039537.
ENST00000337836; ENSP00000338861; ENSG00000039537.
GeneIDi729.
KEGGihsa:729.
UCSCiuc003jmk.4. human.

Organism-specific databases

CTDi729.
DisGeNETi729.
GeneCardsiC6.
H-InvDBHIX0024838.
HGNCiHGNC:1339. C6.
HPAiCAB069427.
HPA043823.
MalaCardsiC6.
MIMi217050. gene.
612446. phenotype.
neXtProtiNX_P13671.
OpenTargetsiENSG00000039537.
Orphaneti169150. Immunodeficiency due to a late component of complements deficiency.
PharmGKBiPA25921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
GeneTreeiENSGT00550000074478.
HOGENOMiHOG000111865.
HOVERGENiHBG005366.
InParanoidiP13671.
KOiK03995.
OMAiCVCQSGT.
OrthoDBiEOG091G07LK.
PhylomeDBiP13671.
TreeFamiTF330498.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000039537-MONOMER.
ReactomeiR-HSA-166665. Terminal pathway of complement.
R-HSA-977606. Regulation of Complement cascade.

Miscellaneous databases

ChiTaRSiC6. human.
GeneWikiiComplement_component_6.
GenomeRNAii729.
PROiP13671.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000039537.
CleanExiHS_C6.
ExpressionAtlasiP13671. baseline and differential.
GenevisibleiP13671. HS.

Family and domain databases

CDDicd00033. CCP. 2 hits.
InterProiIPR003884. FacI_MAC.
IPR002350. Kazal_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF07648. Kazal_2. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS51465. KAZAL_2. 2 hits.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO6_HUMAN
AccessioniPrimary (citable) accession number: P13671
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 179 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.