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Protein

Mannosyl-D-glycerate transport/metabolism system repressor MngR

Gene

mngR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Represses mngA and mngB. Regulates its own expression.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi32 – 5120H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to heat Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD01103.
ECOL316407:JW0719-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-D-glycerate transport/metabolism system repressor MngR
Alternative name(s):
Fatty acyl-responsive regulator
Protein P30
Gene namesi
Name:mngR
Synonyms:farR, g30, ybgB
Ordered Locus Names:b0730, JW0719
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11109. mngR.

Pathology & Biotechi

Disruption phenotypei

In cells lacking this gene the expression of mngA and mngB increases by 9-fold and 23-fold, respectively.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Mannosyl-D-glycerate transport/metabolism system repressor MngRPRO_0000050641Add
BLAST

Proteomic databases

PaxDbiP13669.

Expressioni

Inductioni

Induced by mannosyl-D-glycerate.

Interactioni

Protein-protein interaction databases

BioGridi4261225. 5 interactions.
DIPiDIP-9565N.
IntActiP13669. 4 interactions.
STRINGi511145.b0730.

Structurei

3D structure databases

ProteinModelPortaliP13669.
SMRiP13669. Positions 5-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7269HTH gntR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH gntR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105FDP. Bacteria.
COG2188. LUCA.
HOGENOMiHOG000228717.
InParanoidiP13669.
KOiK11922.
OMAiYRISRAN.
PhylomeDBiP13669.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.1410.10. 1 hit.
InterProiIPR028978. Chorismate_lyase_/UTRA_dom.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011663. UTRA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00392. GntR. 1 hit.
PF07702. UTRA. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00345. HTH_GNTR. 1 hit.
SM00866. UTRA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF64288. SSF64288. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHKPLYRQI ADRIREQIAR GELKPGDALP TESALQTEFG VSRVTVRQAL
60 70 80 90 100
RQLVEQQILE SIQGSGTYVK EERVNYDIFQ LTSFDEKLSD RHVDTHSEVL
110 120 130 140 150
IFEVIPADDF LQQQLQITPQ DRVWHVKRVR YRKQKPMALE ETWMPLALFP
160 170 180 190 200
DLTWQVMENS KYHFIEEVKK MVIDRSEQEI IPLMPTEEMS RLLNISQTKP
210 220 230 240
ILEKVSRGYL VDGRVFEYSR NAFNTDDYKF TLIAQRKSSR
Length:240
Mass (Da):28,273
Last modified:January 1, 1990 - v1
Checksum:i69CBB5AFAB2DCDD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15790 Genomic DNA. Translation: CAA33791.1.
U00096 Genomic DNA. Translation: AAC73824.1.
AP009048 Genomic DNA. Translation: BAA35396.2.
D64014 Genomic DNA. No translation available.
PIRiS04645.
RefSeqiNP_415258.1. NC_000913.3.
WP_000509902.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73824; AAC73824; b0730.
BAA35396; BAA35396; BAA35396.
GeneIDi945371.
KEGGiecj:JW0719.
eco:b0730.
PATRICi32116655. VBIEscCol129921_0760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15790 Genomic DNA. Translation: CAA33791.1.
U00096 Genomic DNA. Translation: AAC73824.1.
AP009048 Genomic DNA. Translation: BAA35396.2.
D64014 Genomic DNA. No translation available.
PIRiS04645.
RefSeqiNP_415258.1. NC_000913.3.
WP_000509902.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP13669.
SMRiP13669. Positions 5-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261225. 5 interactions.
DIPiDIP-9565N.
IntActiP13669. 4 interactions.
STRINGi511145.b0730.

Proteomic databases

PaxDbiP13669.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73824; AAC73824; b0730.
BAA35396; BAA35396; BAA35396.
GeneIDi945371.
KEGGiecj:JW0719.
eco:b0730.
PATRICi32116655. VBIEscCol129921_0760.

Organism-specific databases

EchoBASEiEB1100.
EcoGeneiEG11109. mngR.

Phylogenomic databases

eggNOGiENOG4105FDP. Bacteria.
COG2188. LUCA.
HOGENOMiHOG000228717.
InParanoidiP13669.
KOiK11922.
OMAiYRISRAN.
PhylomeDBiP13669.

Enzyme and pathway databases

BioCyciEcoCyc:PD01103.
ECOL316407:JW0719-MONOMER.

Miscellaneous databases

PROiP13669.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.1410.10. 1 hit.
InterProiIPR028978. Chorismate_lyase_/UTRA_dom.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011663. UTRA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00392. GntR. 1 hit.
PF07702. UTRA. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00345. HTH_GNTR. 1 hit.
SM00866. UTRA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF64288. SSF64288. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMNGR_ECOLI
AccessioniPrimary (citable) accession number: P13669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Originally proposed to be involved in the regulation of the acid citric cycle in response to fatty acids. This was based on in vitro experiments showing that MngR was released from its DNA-binding sites by high concentration sof fatty acids and acyl-CoAs. These results could be explained by the fact that these high-concentrations of fatty acids could have denatured the MngR protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.