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Protein

Stathmin

Gene

Stmn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin
Alternative name(s):
Leukemia-associated phosphoprotein p18
Metablastin
Oncoprotein 18
Short name:
Op18
Phosphoprotein p19
Short name:
pp19
Pr22 protein
Prosolin
pp17
Gene namesi
Name:Stmn1
Synonyms:Lap18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2992 Stmn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001823922 – 149StathminAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei4PhosphoserineBy similarity1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei16PhosphoserineCombined sources1 Publication1
Modified residuei25Phosphoserine; by CDK1, MAPK1 and MAPK3Combined sources1 Publication1
Modified residuei29N6-methyllysineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei38Phosphoserine; by CDK1, MAPK1 and MAPK3Combined sources1 Publication1
Modified residuei63PhosphoserineCombined sources1
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei119N6-acetyllysineBy similarity1

Post-translational modificationi

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF (By similarity). Phosphorylation at Ser-16 is higher in the developing axons from hippocampal neurons and seems to be required for neuron polarization.By similarity2 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP13668
PRIDEiP13668

2D gel databases

World-2DPAGE0004:P13668

PTM databases

iPTMnetiP13668
PhosphoSitePlusiP13668

Expressioni

Gene expression databases

BgeeiENSRNOG00000016810
ExpressionAtlasiP13668 baseline and differential
GenevisibleiP13668 RN

Interactioni

Subunit structurei

Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247991, 1 interactor
IntActiP13668, 1 interactor
STRINGi10116.ENSRNOP00000022574

Structurei

3D structure databases

ProteinModelPortaliP13668
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 145SLDPROSITE-ProRule annotationAdd BLAST142

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 140Sequence analysisAdd BLAST100

Sequence similaritiesi

Belongs to the stathmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IN6S Eukaryota
ENOG4111KFP LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiP13668
KOiK04381
OMAiDAKSEFP
OrthoDBiEOG091G0Y2U
PhylomeDBiP13668
TreeFamiTF326935

Family and domain databases

InterProiView protein in InterPro
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 1 hit
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI
60 70 80 90 100
QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK
110 120 130 140
LTHKMEANKE NREAQMAAKL ERLREKDKHV EEVRKNKESK DPADETEAD
Length:149
Mass (Da):17,288
Last modified:January 23, 2007 - v2
Checksum:i316426E0617BCD01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04979 mRNA Translation: AAA42184.1
M27876 mRNA Translation: AAA81570.1
X94914 mRNA Translation: CAA64400.1
BC062234 mRNA Translation: AAH62234.1
PIRiA34294
RefSeqiNP_058862.1, NM_017166.1
XP_006239185.1, XM_006239123.3
XP_017448691.1, XM_017593202.1
UniGeneiRn.555

Genome annotation databases

EnsembliENSRNOT00000022574; ENSRNOP00000022574; ENSRNOG00000016810
ENSRNOT00000076052; ENSRNOP00000068006; ENSRNOG00000016810
GeneIDi29332
KEGGirno:29332
UCSCiRGD:2992 rat

Similar proteinsi

Entry informationi

Entry nameiSTMN1_RAT
AccessioniPrimary (citable) accession number: P13668
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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