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Protein

Stathmin

Gene

Stmn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin
Alternative name(s):
Leukemia-associated phosphoprotein p18
Metablastin
Oncoprotein 18
Short name:
Op18
Phosphoprotein p19
Short name:
pp19
Pr22 protein
Prosolin
pp17
Gene namesi
Name:Stmn1
Synonyms:Lap18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2992. Stmn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 149148StathminPRO_0000182392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei9 – 91N6-acetyllysineBy similarity
Modified residuei16 – 161PhosphoserineCombined sources1 Publication
Modified residuei25 – 251Phosphoserine; by CDK1, MAPK1 and MAPK3Combined sources1 Publication
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei38 – 381Phosphoserine; by CDK1, MAPK1 and MAPK3Combined sources1 Publication
Modified residuei63 – 631PhosphoserineCombined sources
Modified residuei100 – 1001N6-acetyllysineBy similarity
Modified residuei119 – 1191N6-acetyllysineBy similarity

Post-translational modificationi

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF (By similarity). Phosphorylation at Ser-16 is higher in the developing axons from hippocampal neurons and seems to be required for neuron polarization.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP13668.
PRIDEiP13668.

2D gel databases

World-2DPAGE0004:P13668.

PTM databases

iPTMnetiP13668.
PhosphoSiteiP13668.

Expressioni

Gene expression databases

ExpressionAtlasiP13668. baseline and differential.
GenevisibleiP13668. RN.

Interactioni

Subunit structurei

Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247991. 1 interaction.
IntActiP13668. 1 interaction.
STRINGi10116.ENSRNOP00000022574.

Structurei

3D structure databases

ProteinModelPortaliP13668.
SMRiP13668. Positions 6-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 145142SLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 140100Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IN6S. Eukaryota.
ENOG4111KFP. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP13668.
KOiK04381.
OMAiDAKSEFP.
OrthoDBiEOG744TBN.
PhylomeDBiP13668.
TreeFamiTF326935.

Family and domain databases

InterProiIPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI
60 70 80 90 100
QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK
110 120 130 140
LTHKMEANKE NREAQMAAKL ERLREKDKHV EEVRKNKESK DPADETEAD
Length:149
Mass (Da):17,288
Last modified:January 23, 2007 - v2
Checksum:i316426E0617BCD01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04979 mRNA. Translation: AAA42184.1.
M27876 mRNA. Translation: AAA81570.1.
X94914 mRNA. Translation: CAA64400.1.
BC062234 mRNA. Translation: AAH62234.1.
PIRiA34294.
RefSeqiNP_058862.1. NM_017166.1.
XP_006239185.1. XM_006239123.2.
UniGeneiRn.555.

Genome annotation databases

EnsembliENSRNOT00000022574; ENSRNOP00000022574; ENSRNOG00000016810.
ENSRNOT00000076052; ENSRNOP00000068006; ENSRNOG00000016810.
GeneIDi29332.
KEGGirno:29332.
UCSCiRGD:2992. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04979 mRNA. Translation: AAA42184.1.
M27876 mRNA. Translation: AAA81570.1.
X94914 mRNA. Translation: CAA64400.1.
BC062234 mRNA. Translation: AAH62234.1.
PIRiA34294.
RefSeqiNP_058862.1. NM_017166.1.
XP_006239185.1. XM_006239123.2.
UniGeneiRn.555.

3D structure databases

ProteinModelPortaliP13668.
SMRiP13668. Positions 6-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247991. 1 interaction.
IntActiP13668. 1 interaction.
STRINGi10116.ENSRNOP00000022574.

PTM databases

iPTMnetiP13668.
PhosphoSiteiP13668.

2D gel databases

World-2DPAGE0004:P13668.

Proteomic databases

PaxDbiP13668.
PRIDEiP13668.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022574; ENSRNOP00000022574; ENSRNOG00000016810.
ENSRNOT00000076052; ENSRNOP00000068006; ENSRNOG00000016810.
GeneIDi29332.
KEGGirno:29332.
UCSCiRGD:2992. rat.

Organism-specific databases

CTDi3925.
RGDi2992. Stmn1.

Phylogenomic databases

eggNOGiENOG410IN6S. Eukaryota.
ENOG4111KFP. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP13668.
KOiK04381.
OMAiDAKSEFP.
OrthoDBiEOG744TBN.
PhylomeDBiP13668.
TreeFamiTF326935.

Miscellaneous databases

PROiP13668.

Gene expression databases

ExpressionAtlasiP13668. baseline and differential.
GenevisibleiP13668. RN.

Family and domain databases

InterProiIPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A single cDNA encodes two isoforms of stathmin, a developmentally regulated neuron-enriched phosphoprotein."
    Doye V., Soubrier F., Bauw G., Boutterin M.-C., Beretta L., Koppel J., Vandekerckhove J., Sobel A.
    J. Biol. Chem. 264:12134-12137(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Homology between the cDNAs encoding phosphoprotein p19 and SCG10 reveals a novel mammalian gene family preferentially expressed in developing brain."
    Schubart U.K., Das Banerjee M., Eng J.
    DNA 8:389-398(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Hosoya H.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  5. Lubec G., Afjehi-Sadat L., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 15-28 AND 30-41, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.
  6. "The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18."
    Watabe-Uchida M., John K.A., Janas J.A., Newey S.E., Van Aelst L.
    Neuron 51:727-739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT SER-16.
  7. Lubec G., Chen W.-Q.
    Submitted (FEB-2007) to UniProtKB
    Cited for: ACETYLATION AT ALA-2, PHOSPHORYLATION AT SER-25 AND SER-38, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-25; SER-38 AND SER-63, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTMN1_RAT
AccessioniPrimary (citable) accession number: P13668
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.