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Protein

Sarcalumenin

Gene

SRL

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of calcium transport.

GO - Molecular functioni

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcalumenin
Gene namesi
Name:SRL
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002241320 – 908SarcalumeninAdd BLAST889

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi824N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000015642.

Structurei

3D structure databases

ProteinModelPortaliP13666.
SMRiP13666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini525 – 766Dynamin-type GAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 457Acidic domain, probably binds calciumAdd BLAST438

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1954. Eukaryota.
ENOG410XYGB. LUCA.
HOGENOMiHOG000290639.
HOVERGENiHBG017848.
InParanoidiP13666.

Family and domain databases

InterProiView protein in InterPro
IPR022812. Dynamin_SF.
IPR031692. EHD_N.
IPR030381. G_DYNAMIN_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00350. Dynamin_N. 1 hit.
PF16880. EHD_N. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51718. G_DYNAMIN_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13666-1) [UniParc]FASTAAdd to basket
Also known as: 160 kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALLLFCFV ASLLLSGQAE LQVPASGGTE DVGNLLENHF SAGDASLEEK
60 70 80 90 100
ERALYADAAP RDENLLLHYP DGREAESAER TTAGAPPAAP GPGSEPEASL
110 120 130 140 150
PNASATESAP PGDATGPREE QGPAAASALP PGGDEGSLQE ERQELSSGEG
160 170 180 190 200
PGEEAAGLGL PSEGAASGEM QGQAGGGKVP KEAEGVLGDS PVQGAAAETA
210 220 230 240 250
EPEASGIAPS SEDEQIHTLE GEGKGSPGPD HGPTELDGTP DGASAGEEPK
260 270 280 290 300
ADLDTEARER AEDQHQVHTL ETEGKGGPGP HQGPAEVDGG PDTVSVGESL
310 320 330 340 350
EAREGAEDQG KPSPSQEAGP AAAEAGTEPG GTKHSEEEGM EQDRPPEGQV
360 370 380 390 400
PVMRQDEGGE ASSEEEGDEE GGSEEEEGDP SEEDSGEDSG DGASSEEAGA
410 420 430 440 450
ASEEASGTAG LGEEETQPST EGLDSGPAGS QAQDTEAEEP EEGHQGPESP
460 470 480 490 500
ITAPQEETED VSEEVPMRDR SHIQKTLMLN EDKPTDDFSA VLQRLRKIYH
510 520 530 540 550
SSIKPLEQSY KYNELRQHEI TDGEITSKPM VLFLGPWSVG KSTMINYLLG
560 570 580 590 600
LENTRYQLYT GAEPTTSEFT VLMHGPKLKT IEGIVMAADS ARSFSPLEKF
610 620 630 640 650
GQNFLEKLIG IEVPHKLLER VTFVDTPGII ENRKQQERGY PFNDVCQWFI
660 670 680 690 700
DRADLIFVVF DPTKLDVGLE LETLFRQLKG RESQIRIILN KADNLATQML
710 720 730 740 750
MRVYGALFWS LAPLINVTEP PRVYVSSFWP QEYKPDTHRE LFLREEISLL
760 770 780 790 800
EDLNQVIENR LENKIAFIRQ HAIRVRIHAL LVDRYLQTYK DKMTFFSDGE
810 820 830 840 850
LVFKDIVEDP DKFYIFKTIL AKTNVSKFDL PNREAYKDFF GINPISSFKL
860 870 880 890 900
LSQQCSYMGG CFLEKIERAI TQELPSLLGS LGLGKNPGAL NCDKTGCGET

PKNRYKKH
Length:908
Mass (Da):97,921
Last modified:January 1, 1990 - v1
Checksum:iA48CAA221AE1418B
GO
Isoform 2 (identifier: P13666-2) [UniParc]FASTAAdd to basket
Also known as: 58 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     20-455: Missing.

Note: No experimental confirmation available.
Show »
Length:472
Mass (Da):54,450
Checksum:i71E95D3CD8ABB41A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti474Q → E in AAA60730 (PubMed:2521635).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00442920 – 455Missing in isoform 2. 1 PublicationAdd BLAST436

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25750 mRNA. Translation: AAA31189.1.
J04480 mRNA. Translation: AAA60730.1.
PIRiA33280.
A33312.
RefSeqiNP_001075750.1. NM_001082281.1. [P13666-1]
XP_008247813.1. XM_008249591.2.
UniGeneiOcu.595.

Genome annotation databases

GeneIDi100009112.
KEGGiocu:100009112.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSRCA_RABIT
AccessioniPrimary (citable) accession number: P13666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 10, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families