Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-lactamase OXA-1

Gene

bla

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71Acyl-ester intermediate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BRENDAi3.5.2.6. 2026.
SABIO-RKP13661.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-1 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
Synonyms:oxa1
Encoded oniPlasmid RGN2380 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001702426 – 276Beta-lactamase OXA-1Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74N6-carboxylysine1 Publication1

Interactioni

Subunit structurei

Monomer.1 Publication

Chemistry databases

BindingDBiP13661.

Structurei

Secondary structure

1276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 37Combined sources8
Beta strandi40 – 48Combined sources9
Turni49 – 51Combined sources3
Beta strandi54 – 58Combined sources5
Helixi60 – 63Combined sources4
Helixi70 – 72Combined sources3
Helixi73 – 83Combined sources11
Helixi103 – 105Combined sources3
Helixi111 – 117Combined sources7
Helixi120 – 130Combined sources11
Helixi132 – 142Combined sources11
Turni153 – 155Combined sources3
Helixi158 – 161Combined sources4
Beta strandi164 – 167Combined sources4
Helixi172 – 183Combined sources12
Beta strandi187 – 189Combined sources3
Helixi191 – 201Combined sources11
Beta strandi202 – 205Combined sources4
Beta strandi211 – 220Combined sources10
Beta strandi227 – 236Combined sources10
Beta strandi242 – 251Combined sources10
Helixi259 – 273Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M6KX-ray1.50A/B26-276[»]
3ISGX-ray1.40A/B26-276[»]
4MLLX-ray1.37A/B/C/D26-276[»]
ProteinModelPortaliP13661.
SMRiP13661.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13661.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni238 – 240Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK18790.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTIHINFA IFLIIANIIY SSASASTDIS TVASPLFEGT EGCFLLYDAS
60 70 80 90 100
TNAEIAQFNK AKCATQMAPD STFKIALSLM AFDAEIIDQK TIFKWDKTPK
110 120 130 140 150
GMEIWNSNHT PKTWMQFSVV WVSQEITQKI GLNKIKNYLK DFDYGNQDFS
160 170 180 190 200
GDKERNNGLT EAWLESSLKI SPEEQIQFLR KIINHNLPVK NSAIENTIEN
210 220 230 240 250
MYLQDLDNST KLYGKTGAGF TANRTLQNGW FEGFIISKSG HKYVFVSALT
260 270
GNLGSNLTSS IKAKKNAITI LNTLNL
Length:276
Mass (Da):30,880
Last modified:February 10, 2009 - v2
Checksum:i5ADF7626422BA124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02967 Genomic DNA. Translation: AAA91586.2.
PIRiA39880.
RefSeqiNP_957554.1. NC_005327.1.
WP_001334766.1. NZ_MAJK01000115.1.
YP_006953880.1. NC_019089.1.
YP_008574821.1. NC_022374.1.

Genome annotation databases

GeneIDi13906817.
17035637.
2716479.
KEGGiag:AAA91586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02967 Genomic DNA. Translation: AAA91586.2.
PIRiA39880.
RefSeqiNP_957554.1. NC_005327.1.
WP_001334766.1. NZ_MAJK01000115.1.
YP_006953880.1. NC_019089.1.
YP_008574821.1. NC_022374.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M6KX-ray1.50A/B26-276[»]
3ISGX-ray1.40A/B26-276[»]
4MLLX-ray1.37A/B/C/D26-276[»]
ProteinModelPortaliP13661.
SMRiP13661.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP13661.
ChEMBLiCHEMBL4951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13906817.
17035637.
2716479.
KEGGiag:AAA91586.

Phylogenomic databases

KOiK18790.

Enzyme and pathway databases

BRENDAi3.5.2.6. 2026.
SABIO-RKP13661.

Miscellaneous databases

EvolutionaryTraceiP13661.
PROiP13661.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBLO1_ECOLX
AccessioniPrimary (citable) accession number: P13661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 10, 2009
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid, Transposable element

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.