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Protein

Beta-lactamase OXA-1

Gene

bla

Organism
Escherichia coli
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71Acyl-ester intermediate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Enzyme and pathway databases

BRENDAi3.5.2.6 2026
SABIO-RKP13661

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-1 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
Synonyms:oxa1
Encoded oniPlasmid RGN2380 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4951
DrugBankiDB03801 Lysine Nz-Carboxylic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001702426 – 276Beta-lactamase OXA-1Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74N6-carboxylysine1 Publication1

Interactioni

Subunit structurei

Monomer.1 Publication

Chemistry databases

BindingDBiP13661

Structurei

Secondary structure

1276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 37Combined sources8
Beta strandi40 – 48Combined sources9
Turni49 – 51Combined sources3
Beta strandi54 – 58Combined sources5
Helixi60 – 63Combined sources4
Helixi70 – 72Combined sources3
Helixi73 – 83Combined sources11
Helixi103 – 105Combined sources3
Helixi111 – 117Combined sources7
Helixi120 – 130Combined sources11
Helixi132 – 142Combined sources11
Turni153 – 155Combined sources3
Helixi158 – 161Combined sources4
Beta strandi164 – 167Combined sources4
Helixi172 – 183Combined sources12
Beta strandi187 – 189Combined sources3
Helixi191 – 201Combined sources11
Beta strandi202 – 205Combined sources4
Beta strandi211 – 220Combined sources10
Beta strandi227 – 236Combined sources10
Beta strandi242 – 251Combined sources10
Helixi259 – 273Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M6KX-ray1.50A/B26-276[»]
3ISGX-ray1.40A/B26-276[»]
4MLLX-ray1.37A/B/C/D26-276[»]
ProteinModelPortaliP13661
SMRiP13661
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13661

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni238 – 240Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK18790

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR002137 Beta-lactam_class-D_AS
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00337 BETA_LACTAMASE_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTIHINFA IFLIIANIIY SSASASTDIS TVASPLFEGT EGCFLLYDAS
60 70 80 90 100
TNAEIAQFNK AKCATQMAPD STFKIALSLM AFDAEIIDQK TIFKWDKTPK
110 120 130 140 150
GMEIWNSNHT PKTWMQFSVV WVSQEITQKI GLNKIKNYLK DFDYGNQDFS
160 170 180 190 200
GDKERNNGLT EAWLESSLKI SPEEQIQFLR KIINHNLPVK NSAIENTIEN
210 220 230 240 250
MYLQDLDNST KLYGKTGAGF TANRTLQNGW FEGFIISKSG HKYVFVSALT
260 270
GNLGSNLTSS IKAKKNAITI LNTLNL
Length:276
Mass (Da):30,880
Last modified:February 10, 2009 - v2
Checksum:i5ADF7626422BA124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02967 Genomic DNA Translation: AAA91586.2
PIRiA39880
RefSeqiNP_957554.1, NC_005327.1
WP_001334766.1, NZ_PUDX01000080.1
YP_006953880.1, NC_019089.1
YP_008574821.1, NC_022374.1

Genome annotation databases

GeneIDi13906817
17035637
23335851
2716479
KEGGiag:AAA91586

Similar proteinsi

Entry informationi

Entry nameiBLO1_ECOLX
AccessioniPrimary (citable) accession number: P13661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid, Transposable element

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