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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Active sitei95 – 951Proton donorPROSITE-ProRule annotation
Binding sitei221 – 2211SubstrateBy similarity
Binding sitei239 – 2391SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: GO_Central
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  3. UMP biosynthetic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
ORF Names:CaO19.1716, CaO19.9284
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Orotidine 5'-phosphate decarboxylasePRO_0000134646Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0000783.

Structurei

3D structure databases

ProteinModelPortaliP13649.
SMRiP13649. Positions 7-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 633Substrate bindingBy similarity
Regioni93 – 10210Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0284.
InParanoidiP13649.
KOiK01591.
OrthoDBiEOG7CVQ76.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVNTKTYSE RAETHASPVA QRLFRLMESK KTNLCASIDV DTTKEFLELI
60 70 80 90 100
DKLGPYVCLI KTHIDIINDF SYESTIEPLL ELSRKHQFMI FEDRKFADIG
110 120 130 140 150
NTVKKQYIGG VYKISSWADI TNAHGVTGNG VVEGLKQGAK ETTTNQEPRG
160 170 180 190 200
LLMLAELSSV GSLAYGEYSQ KTVEIAKSDK EFVIGFIAQR DMGGQEEGFD
210 220 230 240 250
WLIMTPGVGL DDKGDGLGQQ YRTVDEVVST GTDIIIVGRG LFGKGRDPDI
260 270
EGKRYRDAGW NAYLKKTGQL
Length:270
Mass (Da):29,979
Last modified:March 3, 2009 - v3
Checksum:iBD35C5CA62DA0606
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571D → N in CAA32410 (PubMed:2574635).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14198 Genomic DNA. Translation: CAA32410.1.
AF109400 Genomic DNA. Translation: AAF13298.1.
AACQ01000014 Genomic DNA. Translation: EAL02877.1.
AACQ01000013 Genomic DNA. Translation: EAL03005.1.
PIRiA48331. DCCKA.
RefSeqiXP_721667.1. XM_716574.1.
XP_721787.1. XM_716694.1.

Genome annotation databases

GeneIDi3636649.
3636682.
KEGGical:CaO19.1716.
cal:CaO19.9284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14198 Genomic DNA. Translation: CAA32410.1.
AF109400 Genomic DNA. Translation: AAF13298.1.
AACQ01000014 Genomic DNA. Translation: EAL02877.1.
AACQ01000013 Genomic DNA. Translation: EAL03005.1.
PIRiA48331. DCCKA.
RefSeqiXP_721667.1. XM_716574.1.
XP_721787.1. XM_716694.1.

3D structure databases

ProteinModelPortaliP13649.
SMRiP13649. Positions 7-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0000783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3636649.
3636682.
KEGGical:CaO19.1716.
cal:CaO19.9284.

Phylogenomic databases

eggNOGiCOG0284.
InParanoidiP13649.
KOiK01591.
OrthoDBiEOG7CVQ76.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and transcript analysis of the C. albicans URA3 gene encoding orotidine-5'-phosphate decarboxylase."
    Ernst J.F., Losberger C.
    Curr. Genet. 16:153-157(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.
  2. "Construction and evaluation of a Candida albicans gene expression cassette."
    Hoyer L.L.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1177.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPYRF_CANAL
AccessioniPrimary (citable) accession number: P13649
Secondary accession number(s): Q5AJ76, Q9UVV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: March 3, 2009
Last modified: April 1, 2015
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.