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P13649

- PYRF_CANAL

UniProt

P13649 - PYRF_CANAL

Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Active sitei95 – 951Proton donorPROSITE-ProRule annotation
    Binding sitei221 – 2211SubstrateBy similarity
    Binding sitei239 – 2391SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: CGD

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    3. adhesion of symbiont to host Source: CGD
    4. cell migration Source: CGD
    5. filamentous growth Source: CGD
    6. filamentous growth of a population of unicellular organisms Source: CGD
    7. pathogenesis Source: CGD
    8. pyrimidine nucleobase biosynthetic process Source: CGD
    9. uridine biosynthetic process Source: CGD

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:URA3
    ORF Names:CaO19.1716, CaO19.9284
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Orotidine 5'-phosphate decarboxylasePRO_0000134646Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0000783.

    Structurei

    3D structure databases

    ProteinModelPortaliP13649.
    SMRiP13649. Positions 7-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni61 – 633Substrate bindingBy similarity
    Regioni93 – 10210Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0284.
    KOiK01591.
    OrthoDBiEOG7CVQ76.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13649-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVNTKTYSE RAETHASPVA QRLFRLMESK KTNLCASIDV DTTKEFLELI    50
    DKLGPYVCLI KTHIDIINDF SYESTIEPLL ELSRKHQFMI FEDRKFADIG 100
    NTVKKQYIGG VYKISSWADI TNAHGVTGNG VVEGLKQGAK ETTTNQEPRG 150
    LLMLAELSSV GSLAYGEYSQ KTVEIAKSDK EFVIGFIAQR DMGGQEEGFD 200
    WLIMTPGVGL DDKGDGLGQQ YRTVDEVVST GTDIIIVGRG LFGKGRDPDI 250
    EGKRYRDAGW NAYLKKTGQL 270
    Length:270
    Mass (Da):29,979
    Last modified:March 3, 2009 - v3
    Checksum:iBD35C5CA62DA0606
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti257 – 2571D → N in CAA32410. (PubMed:2574635)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14198 Genomic DNA. Translation: CAA32410.1.
    AF109400 Genomic DNA. Translation: AAF13298.1.
    AACQ01000014 Genomic DNA. Translation: EAL02877.1.
    AACQ01000013 Genomic DNA. Translation: EAL03005.1.
    PIRiA48331. DCCKA.
    RefSeqiXP_721667.1. XM_716574.1.
    XP_721787.1. XM_716694.1.

    Genome annotation databases

    GeneIDi3636649.
    3636682.
    KEGGical:CaO19.1716.
    cal:CaO19.9284.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14198 Genomic DNA. Translation: CAA32410.1 .
    AF109400 Genomic DNA. Translation: AAF13298.1 .
    AACQ01000014 Genomic DNA. Translation: EAL02877.1 .
    AACQ01000013 Genomic DNA. Translation: EAL03005.1 .
    PIRi A48331. DCCKA.
    RefSeqi XP_721667.1. XM_716574.1.
    XP_721787.1. XM_716694.1.

    3D structure databases

    ProteinModelPortali P13649.
    SMRi P13649. Positions 7-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000783.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3636649.
    3636682.
    KEGGi cal:CaO19.1716.
    cal:CaO19.9284.

    Phylogenomic databases

    eggNOGi COG0284.
    KOi K01591.
    OrthoDBi EOG7CVQ76.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and transcript analysis of the C. albicans URA3 gene encoding orotidine-5'-phosphate decarboxylase."
      Ernst J.F., Losberger C.
      Curr. Genet. 16:153-157(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.
    2. "Construction and evaluation of a Candida albicans gene expression cassette."
      Hoyer L.L.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 1177.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiPYRF_CANAL
    AccessioniPrimary (citable) accession number: P13649
    Secondary accession number(s): Q5AJ76, Q9UVV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3