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P13649 (PYRF_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
ORF Names:CaO19.1716, CaO19.9284
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Orotidine 5'-phosphate decarboxylase
PRO_0000134646

Regions

Region61 – 633Substrate binding By similarity
Region93 – 10210Substrate binding By similarity

Sites

Active site951Proton donor By similarity
Binding site391Substrate By similarity
Binding site2211Substrate By similarity
Binding site2391Substrate By similarity

Experimental info

Sequence conflict2571D → N in CAA32410. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P13649 [UniParc].

Last modified March 3, 2009. Version 3.
Checksum: BD35C5CA62DA0606

FASTA27029,979
        10         20         30         40         50         60 
MTVNTKTYSE RAETHASPVA QRLFRLMESK KTNLCASIDV DTTKEFLELI DKLGPYVCLI 

        70         80         90        100        110        120 
KTHIDIINDF SYESTIEPLL ELSRKHQFMI FEDRKFADIG NTVKKQYIGG VYKISSWADI 

       130        140        150        160        170        180 
TNAHGVTGNG VVEGLKQGAK ETTTNQEPRG LLMLAELSSV GSLAYGEYSQ KTVEIAKSDK 

       190        200        210        220        230        240 
EFVIGFIAQR DMGGQEEGFD WLIMTPGVGL DDKGDGLGQQ YRTVDEVVST GTDIIIVGRG 

       250        260        270 
LFGKGRDPDI EGKRYRDAGW NAYLKKTGQL 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and transcript analysis of the C. albicans URA3 gene encoding orotidine-5'-phosphate decarboxylase."
Ernst J.F., Losberger C.
Curr. Genet. 16:153-157(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.
[2]"Construction and evaluation of a Candida albicans gene expression cassette."
Hoyer L.L.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 1177.
[3]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14198 Genomic DNA. Translation: CAA32410.1.
AF109400 Genomic DNA. Translation: AAF13298.1.
AACQ01000014 Genomic DNA. Translation: EAL02877.1.
AACQ01000013 Genomic DNA. Translation: EAL03005.1.
PIRDCCKA. A48331.
RefSeqXP_721667.1. XM_716574.1.
XP_721787.1. XM_716694.1.

3D structure databases

ProteinModelPortalP13649.
SMRP13649. Positions 7-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0000783.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3636649.
3636682.
KEGGcal:CaO19.1716.
cal:CaO19.9284.

Phylogenomic databases

eggNOGCOG0284.
KOK01591.
OrthoDBEOG7CVQ76.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_CANAL
AccessionPrimary (citable) accession number: P13649
Secondary accession number(s): Q5AJ76, Q9UVV6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: March 3, 2009
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names