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Protein

Lamin-A

Gene

LMNA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lamin-A
Gene namesi
Name:LMNA
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 654653Lamin-APRO_0000063814Add
BLAST
Propeptidei655 – 6573Removed in mature formBy similarityPRO_0000403465

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei654 – 6541Cysteine methyl esterBy similarity
Lipidationi654 – 6541S-farnesyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PRIDEiP13648.

Interactioni

Protein-protein interaction databases

BioGridi676484. 1 interaction.
IntActiP13648. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP13648.
SMRiP13648. Positions 28-64, 312-385, 429-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini434 – 544111LTDAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 3231HeadAdd
BLAST
Regioni33 – 382350RodAdd
BLAST
Regioni33 – 6937Coil 1AAdd
BLAST
Regioni70 – 7910Linker 1
Regioni80 – 217138Coil 1BAdd
BLAST
Regioni218 – 24124Linker 2Add
BLAST
Regioni242 – 382141Coil 2Add
BLAST
Regioni383 – 657275TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated
Contains 1 LTD domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015.
InParanoidiP13648.
KOiK12641.
PhylomeDBiP13648.

Family and domain databases

Gene3Di2.60.40.1260. 1 hit.
InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR001322. Lamin_tail_dom.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF00932. LTD. 1 hit.
[Graphical view]
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF74853. SSF74853. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPSQRRSG RGGGPSGTPL SPTRITRLQE KEDLQELNDR LAVYIDKVRS
60 70 80 90 100
LELENAGLRL RITESEEVVS REVSGIKAAY EAELADARKT LDSVAKERAR
110 120 130 140 150
LQLELSKVRE EHKELKARNA KKEADLLAAQ ARLKDLEALL NSKEAALSTA
160 170 180 190 200
LGEKRNLENE VRDLRAQVAK LEGALSEAKK QLQDEMLRRV DAENRLQTLK
210 220 230 240 250
EELEFQKNIY SEELRETKRR HETRLVEIDN GRQQEFESKL AEALQDLRRQ
260 270 280 290 300
HEDQIRHYRD ELEKTYGAKL ENAKQSAERN SSMAGAAHEE LQQTHIRIDS
310 320 330 340 350
LSAELSQLQK QLAAKEAKLR EVEEALSRER EGGRRLLAEK EREMAEMRAR
360 370 380 390 400
MQQQLDEYQE LLDIKLALDM EINAYRKLLE GEEERLRLSP SPSSQRGARS
410 420 430 440 450
SGLQHSGAGS AKKRRLEDGE GREGREGRTS FSHHARTSGR VGVEEVDLEG
460 470 480 490 500
RFVRLRNKSN EDQALGNWQV KRQNGDDPPL TYRFPPKFTL KAGQAVTIWA
510 520 530 540 550
SGAGATHSPP SDVVWKAQSS WGSGDSLRTA LINSNGEEVA MRKLVRTVII
560 570 580 590 600
NDDDEDEEDD EVSIHHRHHH SGCSGSADPA EYNLRSRTVL CGTCGQPADK
610 620 630 640 650
GSAAAASSAS SASTVTVSRG YRSSGGGIGE GLLGRSYVLG GAGPRRQAPA

PQGCSIM
Length:657
Mass (Da):73,164
Last modified:January 1, 1990 - v1
Checksum:iFD0B31828A77AF08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16879 mRNA. Translation: CAA34762.1.
PIRiS05517.
RefSeqiNP_990618.1. NM_205287.1.
UniGeneiGga.715.

Genome annotation databases

GeneIDi396224.
KEGGigga:396224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16879 mRNA. Translation: CAA34762.1.
PIRiS05517.
RefSeqiNP_990618.1. NM_205287.1.
UniGeneiGga.715.

3D structure databases

ProteinModelPortaliP13648.
SMRiP13648. Positions 28-64, 312-385, 429-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676484. 1 interaction.
IntActiP13648. 1 interaction.

Proteomic databases

PRIDEiP13648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396224.
KEGGigga:396224.

Phylogenomic databases

HOVERGENiHBG013015.
InParanoidiP13648.
KOiK12641.
PhylomeDBiP13648.

Miscellaneous databases

PROiP13648.

Family and domain databases

Gene3Di2.60.40.1260. 1 hit.
InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR001322. Lamin_tail_dom.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF00932. LTD. 1 hit.
[Graphical view]
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF74853. SSF74853. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMNA_CHICK
AccessioniPrimary (citable) accession number: P13648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.