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Protein

Keratin, type I cytoskeletal 13

Gene

KRT13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 13
Alternative name(s):
Cytokeratin-13
Short name:
CK-13
Keratin-13
Short name:
K13
Gene namesi
Name:KRT13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6415. KRT13.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intermediate filament cytoskeleton Source: UniProtKB
  • keratin filament Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

White sponge nevus 2 (WSN2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
See also OMIM:615785
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016035108M → T in WSN2. 1 PublicationCorresponds to variant rs60364670dbSNPEnsembl.1
Natural variantiVAR_023924111L → P in WSN2. 1 PublicationCorresponds to variant rs59897026dbSNPEnsembl.1
Natural variantiVAR_016036112N → S in WSN2. 1 PublicationCorresponds to variant rs59970018dbSNPEnsembl.1
Natural variantiVAR_016037115L → P in WSN2. 1 PublicationCorresponds to variant rs60906702dbSNPEnsembl.1
Natural variantiVAR_003836119L → P in WSN2. 1 PublicationCorresponds to variant rs60440396dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3860.
MalaCardsiKRT13.
MIMi615785. phenotype.
OpenTargetsiENSG00000171401.
Orphaneti171723. White sponge nevus.
PharmGKBiPA30202.

Polymorphism and mutation databases

BioMutaiKRT13.
DMDMi269849755.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636471 – 458Keratin, type I cytoskeletal 13Add BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei27Omega-N-methylarginineCombined sources1
Modified residuei35Omega-N-methylarginineCombined sources1
Modified residuei50PhosphoserineBy similarity1
Modified residuei427PhosphoserineCombined sources1 Publication1

Post-translational modificationi

O-glycosylated; glycans consist of single N-acetylglucosamine residues.1 Publication

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP13646.
PeptideAtlasiP13646.
PRIDEiP13646.

PTM databases

iPTMnetiP13646.
PhosphoSitePlusiP13646.
SwissPalmiP13646.
UniCarbKBiP13646.

Expressioni

Tissue specificityi

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.1 Publication

Gene expression databases

BgeeiENSG00000171401.
CleanExiHS_KRT13.
ExpressionAtlasiP13646. baseline and differential.
GenevisibleiP13646. HS.

Organism-specific databases

HPAiCAB000133.
HPA030877.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4.

Protein-protein interaction databases

BioGridi110058. 57 interactors.
IntActiP13646. 26 interactors.
STRINGi9606.ENSP00000246635.

Structurei

3D structure databases

ProteinModelPortaliP13646.
SMRiP13646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 103HeadAdd BLAST103
Regioni104 – 412RodAdd BLAST309
Regioni104 – 139Coil 1AAdd BLAST36
Regioni140 – 158Linker 1Add BLAST19
Regioni159 – 250Coil 1BAdd BLAST92
Regioni251 – 273Linker 12Add BLAST23
Regioni274 – 412Coil 2Add BLAST139
Regioni413 – 458TailAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 102Gly-richAdd BLAST90

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP13646.
KOiK07604.
OMAiEEWFHSK.
OrthoDBiEOG091G087I.
PhylomeDBiP13646.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13646-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLRLQSSSA SYGGGFGGGS CQLGGGRGVS TCSTRFVSGG SAGGYGGGVS
60 70 80 90 100
CGFGGGAGSG FGGGYGGGLG GGYGGGLGGG FGGGFAGGFV DFGACDGGLL
110 120 130 140 150
TGNEKITMQN LNDRLASYLE KVRALEEANA DLEVKIRDWH LKQSPASPER
160 170 180 190 200
DYSPYYKTIE ELRDKILTAT IENNRVILEI DNARLAADDF RLKYENELAL
210 220 230 240 250
RQSVEADING LRRVLDELTL SKTDLEMQIE SLNEELAYMK KNHEEEMKEF
260 270 280 290 300
SNQVVGQVNV EMDATPGIDL TRVLAEMREQ YEAMAERNRR DAEEWFHTKS
310 320 330 340 350
AELNKEVSTN TAMIQTSKTE ITELRRTLQG LEIELQSQLS MKAGLENTVA
360 370 380 390 400
ETECRYALQL QQIQGLISSI EAQLSELRSE MECQNQEYKM LLDIKTRLEQ
410 420 430 440 450
EIATYRSLLE GQDAKMIGFP SSAGSVSPRS TSVTTTSSAS VTTTSNASGR

RTSDVRRP
Length:458
Mass (Da):49,588
Last modified:November 24, 2009 - v4
Checksum:iA51AECFD6195ACB4
GO
Isoform 2 (identifier: P13646-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-73: Missing.
     351-458: ETECRYALQL...GRRTSDVRRP → DPGTHQQHRGPAERAPQ

Note: No experimental confirmation available.
Show »
Length:355
Mass (Da):38,581
Checksum:i4961456B245B173B
GO
Isoform 3 (identifier: P13646-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-458: MIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP → KRQPP

Show »
Length:420
Mass (Da):45,867
Checksum:i2C1A7FAF2BD62DCD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46G → R in BAD96771 (Ref. 6) Curated1
Sequence conflicti46G → R in BAD96797 (Ref. 6) Curated1
Sequence conflicti58G → D in CAA32786 (PubMed:2475110).Curated1
Sequence conflicti58G → D (PubMed:2477803).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05937681F → Y.Corresponds to variant rs12150581dbSNPEnsembl.1
Natural variantiVAR_016035108M → T in WSN2. 1 PublicationCorresponds to variant rs60364670dbSNPEnsembl.1
Natural variantiVAR_023924111L → P in WSN2. 1 PublicationCorresponds to variant rs59897026dbSNPEnsembl.1
Natural variantiVAR_016036112N → S in WSN2. 1 PublicationCorresponds to variant rs59970018dbSNPEnsembl.1
Natural variantiVAR_016037115L → P in WSN2. 1 PublicationCorresponds to variant rs60906702dbSNPEnsembl.1
Natural variantiVAR_003836119L → P in WSN2. 1 PublicationCorresponds to variant rs60440396dbSNPEnsembl.1
Natural variantiVAR_024488146A → G.Corresponds to variant rs760134dbSNPEnsembl.1
Natural variantiVAR_060724187A → V.Combined sources7 PublicationsCorresponds to variant rs9891361dbSNPEnsembl.1
Natural variantiVAR_059377298T → A.7 PublicationsCorresponds to variant rs4796697dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01637662 – 73Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_016377351 – 458ETECR…DVRRP → DPGTHQQHRGPAERAPQ in isoform 2. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_038433416 – 458MIGFP…DVRRP → KRQPP in isoform 3. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14640 mRNA. Translation: CAA32786.1.
X52426 mRNA. Translation: CAA36673.1.
AF049259 Genomic DNA. Translation: AAC35754.1.
AK092276 mRNA. Translation: BAC03847.1.
AK223051 mRNA. Translation: BAD96771.1.
AK223077 mRNA. Translation: BAD96797.1.
AC019349 Genomic DNA. No translation available.
BC002661 mRNA. Translation: AAH02661.3.
BC077718 mRNA. Translation: AAH77718.2.
CCDSiCCDS11396.1. [P13646-1]
CCDS11397.1. [P13646-3]
PIRiA37343.
S06088. KRHU3.
RefSeqiNP_002265.2. NM_002274.3.
NP_705694.2. NM_153490.2.
UniGeneiHs.654550.

Genome annotation databases

EnsembliENST00000246635; ENSP00000246635; ENSG00000171401. [P13646-1]
ENST00000336861; ENSP00000336604; ENSG00000171401. [P13646-3]
GeneIDi3860.
KEGGihsa:3860.
UCSCiuc002hwu.2. human. [P13646-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-13 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14640 mRNA. Translation: CAA32786.1.
X52426 mRNA. Translation: CAA36673.1.
AF049259 Genomic DNA. Translation: AAC35754.1.
AK092276 mRNA. Translation: BAC03847.1.
AK223051 mRNA. Translation: BAD96771.1.
AK223077 mRNA. Translation: BAD96797.1.
AC019349 Genomic DNA. No translation available.
BC002661 mRNA. Translation: AAH02661.3.
BC077718 mRNA. Translation: AAH77718.2.
CCDSiCCDS11396.1. [P13646-1]
CCDS11397.1. [P13646-3]
PIRiA37343.
S06088. KRHU3.
RefSeqiNP_002265.2. NM_002274.3.
NP_705694.2. NM_153490.2.
UniGeneiHs.654550.

3D structure databases

ProteinModelPortaliP13646.
SMRiP13646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110058. 57 interactors.
IntActiP13646. 26 interactors.
STRINGi9606.ENSP00000246635.

PTM databases

iPTMnetiP13646.
PhosphoSitePlusiP13646.
SwissPalmiP13646.
UniCarbKBiP13646.

Polymorphism and mutation databases

BioMutaiKRT13.
DMDMi269849755.

Proteomic databases

PaxDbiP13646.
PeptideAtlasiP13646.
PRIDEiP13646.

Protocols and materials databases

DNASUi3860.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246635; ENSP00000246635; ENSG00000171401. [P13646-1]
ENST00000336861; ENSP00000336604; ENSG00000171401. [P13646-3]
GeneIDi3860.
KEGGihsa:3860.
UCSCiuc002hwu.2. human. [P13646-1]

Organism-specific databases

CTDi3860.
DisGeNETi3860.
GeneCardsiKRT13.
HGNCiHGNC:6415. KRT13.
HPAiCAB000133.
HPA030877.
MalaCardsiKRT13.
MIMi148065. gene.
615785. phenotype.
neXtProtiNX_P13646.
OpenTargetsiENSG00000171401.
Orphaneti171723. White sponge nevus.
PharmGKBiPA30202.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP13646.
KOiK07604.
OMAiEEWFHSK.
OrthoDBiEOG091G087I.
PhylomeDBiP13646.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiKRT13. human.
GeneWikiiKeratin_13.
GenomeRNAii3860.
PROiP13646.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171401.
CleanExiHS_KRT13.
ExpressionAtlasiP13646. baseline and differential.
GenevisibleiP13646. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C13_HUMAN
AccessioniPrimary (citable) accession number: P13646
Secondary accession number(s): Q53G54, Q6AZK5, Q8N240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 178 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.