ID K1C10_HUMAN Reviewed; 584 AA. AC P13645; Q14664; Q8N175; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 24-NOV-2009, sequence version 6. DT 25-JAN-2012, entry version 130. DE RecName: Full=Keratin, type I cytoskeletal 10; DE AltName: Full=Cytokeratin-10; DE Short=CK-10; DE AltName: Full=Keratin-10; DE Short=K10; GN Name=KRT10; Synonyms=KPP; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS SER-101 AND TYR-487. RC TISSUE=Foreskin; RX MEDLINE=89008465; PubMed=2459124; RA Zhou X.M., Idler W.W., Steven A.C., Roop D.R., Steinert P.M.; RT "The complete sequence of the human intermediate filament chain RT keratin 10. Subdomainal divisions and model for folding of end domain RT sequences."; RL J. Biol. Chem. 263:15584-15589(1988). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT TYR-487. RX MEDLINE=89125611; PubMed=2464696; DOI=10.1016/0022-2836(88)90045-9; RA Rieger M., Franke W.W.; RT "Identification of an orthologous mammalian cytokeratin gene. High RT degree of intron sequence conservation during evolution of human RT cytokeratin 10."; RL J. Mol. Biol. 204:841-856(1988). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in RT the human lineage."; RL Nature 440:1045-1049(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-101 AND RP TYR-487. RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 130-584, AND VARIANT TYR-487. RX MEDLINE=88122104; PubMed=2448602; DOI=10.1007/BF00444680; RA Darmon M.Y., Semat A., Darmon M.C., Vasseur M.; RT "Sequence of a cDNA encoding human keratin No 10 selected according to RT structural homologies of keratins and their tissue-specific RT expression."; RL Mol. Biol. Rep. 12:277-283(1987). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-161, AND VARIANTS BCIE RP HIS-156 AND ASN-160. RX MEDLINE=94117868; PubMed=7507150; DOI=10.1111/1523-1747.ep12371723; RA Rothnagel J.A., Longley M.A., Holder R.A., Kuster W., Roop D.R.; RT "Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene RT sequencing."; RL J. Invest. Dermatol. 102:13-16(1994). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-161, AND VARIANT BCIE RP CYS-156. RA Rothnagel J.J., Dominey A., Fisher M., Axtell S., Pittelkow M., RA Anton-Lamprecht I., Hohl D., Roop D.; RT "Identification of mutational hot spots in the suprabasal keratin RT genes from patients with epidermolytic hyperkeratosis."; RL Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 197-584. RX MEDLINE=92339897; PubMed=1378806; DOI=10.1016/0378-1119(92)90521-P; RA Tkachenko A.V., Buchman V.L., Bliskovsky V.V., Shvets Y.P., RA Kisselev L.L.; RT "Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo RT structural rearrangements within repeats."; RL Gene 116:245-251(1992). RN [9] RP PROTEIN SEQUENCE OF 180-184 AND 568-580. RC TISSUE=Keratinocyte; RX MEDLINE=93162043; PubMed=1286667; DOI=10.1002/elps.11501301199; RA Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., RA Vandekerckhove J.; RT "Microsequences of 145 proteins recorded in the two-dimensional gel RT protein database of normal human epidermal keratinocytes."; RL Electrophoresis 13:960-969(1992). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-42, AND MASS RP SPECTROMETRY. RC TISSUE=Cervix carcinoma; RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of RT the kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [11] RP INVOLVEMENT IN CRIE. RX PubMed=20798280; DOI=10.1126/science.1192280; RA Choate K.A., Lu Y., Zhou J., Choi M., Elias P.M., Farhi A., RA Nelson-Williams C., Crumrine D., Williams M.L., Nopper A.J., Bree A., RA Milstone L.M., Lifton R.P.; RT "Mitotic recombination in patients with ichthyosis causes reversion of RT dominant mutations in KRT10."; RL Science 330:94-97(2010). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [13] RP VARIANT BCIE HIS-156. RX MEDLINE=92386600; PubMed=1381287; DOI=10.1016/0092-8674(92)90314-3; RA Cheng J., Syder A.J., Yu Q.-C., Letai A., Paller A.S., Fuchs E.; RT "The genetic basis of epidermolytic hyperkeratosis: a disorder of RT differentiation-specific epidermal keratin genes."; RL Cell 70:811-819(1992). RN [14] RP VARIANTS. RX MEDLINE=92141228; PubMed=1371013; DOI=10.1073/pnas.89.3.910; RA Korge B.P., Gan S.-Q., McBridge O.W., Mischke D., Steinert P.M.; RT "Extensive size polymorphism of the human keratin 10 chain resides in RT the C-terminal V2 subdomain due to variable numbers and sizes of RT glycine loops."; RL Proc. Natl. Acad. Sci. U.S.A. 89:910-914(1992). RN [15] RP VARIANTS BCIE HIS-156 AND SER-161. RX MEDLINE=92376531; PubMed=1380725; DOI=10.1126/science.257.5073.1128; RA Rothnagel J.A., Dominey A.M., Dempsey L.D., Longley M.A., RA Greenhalgh D.A., Gagne T.A., Huber M., Frenk E., Hohl D., Roop D.R.; RT "Mutations in the rod domains of keratins 1 and 10 in epidermolytic RT hyperkeratosis."; RL Science 257:1128-1130(1992). RN [16] RP VARIANTS BCIE HIS-154; CYS-156; HIS-156; ASP-160 AND GLN-442. RX MEDLINE=94136477; PubMed=7508181; RA Chipev C.C., Yang J.-M., Digiovanna J.J., Steinert P.M., Marekov L., RA Compton J.G., Bale S.J.; RT "Preferential sites in keratin 10 that are mutated in epidermolytic RT hyperkeratosis."; RL Am. J. Hum. Genet. 54:179-190(1994). RN [17] RP VARIANTS BCIE ARG-150; CYS-156 AND GLU-439, AND VARIANT SER-126. RX MEDLINE=94216497; PubMed=7512983; DOI=10.1172/JCI117132; RA Syder A.J., Yu Q.-C., Paller A.S., Giudice G., Pearson R., Fuchs E.; RT "Genetic mutations in the K1 and K10 genes of patients with RT epidermolytic hyperkeratosis. Correlation between location and disease RT severity."; RL J. Clin. Invest. 93:1533-1542(1994). RN [18] RP VARIANTS BCIE PRO-156 AND SER-156. RX MEDLINE=94117870; PubMed=7507152; DOI=10.1111/1523-1747.ep12371726; RA McLean W.H.I., Eady R.A.J., Dopping-Hepenstal P.J.C., McMillan J.R., RA Leigh I.M., Navsaria H.A., Higgins C., Harper J.I., Paige D.G., RA Morley S.M.; RT "Mutations in the rod 1A domain of keratins 1 and 10 in bullous RT congenital ichthyosiform erythroderma (BCIE)."; RL J. Invest. Dermatol. 102:24-30(1994). RN [19] RP VARIANT THR-150. RX MEDLINE=95059228; PubMed=7526210; DOI=10.1056/NEJM199411243312103; RA Paller A.S., Syder A.J., Chan Y.-M., Yu Q.-C., Hutton M.E., Tadini G., RA Fuchs E.; RT "Genetic and clinical mosaicism in a type of epidermal nevus."; RL N. Engl. J. Med. 331:1408-1415(1994). RN [20] RP VARIANT AEI GLU-422. RX PubMed=9036939; DOI=10.1111/1523-1747.ep12286491; RA Joh G.-Y., Traupe H., Metze D., Nashan D., Huber M., Hohl D., RA Longley M.A., Rothnagel J.A., Roop D.R.; RT "A novel dinucleotide mutation in keratin 10 in the annular RT epidermolytic ichthyosis variant of bullous congenital ichthyosiform RT erythroderma."; RL J. Invest. Dermatol. 108:357-361(1997). RN [21] RP VARIANT AEI THR-446. RX MEDLINE=99072665; PubMed=9856845; RX DOI=10.1046/j.1523-1747.1998.00451.x; RA Suga Y., Duncan K.O., Heald P.W., Roop D.R.; RT "A novel helix termination mutation in keratin 10 in annular RT epidermolytic ichthyosis, a variant of bullous congenital RT ichthyosiform erythroderma."; RL J. Invest. Dermatol. 111:1220-1223(1998). RN [22] RP VARIANT BCIE SER-160. RX MEDLINE=99215719; PubMed=10201536; RX DOI=10.1046/j.1523-1747.1999.00557.x; RA Arin M.J., Longley M.A., Anton-Lamprecht I., Kurze G., Huber M., RA Hohl D., Rothnagel J.A., Roop D.R.; RT "A novel substitution in keratin 10 in epidermolytic hyperkeratosis."; RL J. Invest. Dermatol. 112:506-508(1999). CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins. CC keratin-10 is generally associated with keratin-1. CC -!- TISSUE SPECIFICITY: Seen in all suprabasal cell layers including CC stratum corneum. CC -!- POLYMORPHISM: A number of alleles are known that mainly differ in CC the Gly-rich region (positions 490-560). CC -!- DISEASE: Defects in KRT10 are a cause of bullous congenital CC ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as CC epidermolytic hyperkeratosis (EHK) or bullous erythroderma CC ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant CC skin disorder characterized by widespread blistering and an CC ichthyotic erythroderma at birth that persist into adulthood. CC Histologically there is a diffuse epidermolytic degeneration in CC the lower spinous layer of the epidermis. Within a few weeks from CC birth, erythroderma and blister formation diminish and CC hyperkeratoses develop. CC -!- DISEASE: Defects in KRT10 are a cause of ichthyosis annular CC epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis CC with epidermolytic hyperkeratosis. AEI is a skin disorder CC resembling bullous congenital ichthyosiform erythroderma. Affected CC individuals present with bullous ichthyosis in early childhood and CC hyperkeratotic lichenified plaques in the flexural areas and CC extensor surfaces at later ages. The feature that distinguishes CC AEI from BCIE is dramatic episodes of flares of annular polycyclic CC plaques with scale, which coalesce to involve most of the body CC surface and can persist for several weeks or even months. CC -!- DISEASE: Defects in KRT10 are the cause of reticular congenital CC ichthyosiform erythroderma (CRIE) [MIM:609165]; also called CC ichthyosis with confetti (IWC) or reticular erythrokeratoderma. CC CRIE is a rare skin condition characterized by slowly enlarging CC islands of normal skin surrounded by erythematous ichthyotic CC patches in a reticulated pattern. The condition starts in infancy CC as a lamellar ichthyosis, with small islands of normal skin CC resembling confetti appearing in late childhood and at puberty. CC Histopathologic findings include band-like parakeratosis, CC psoriasiform acanthosis, and vacuolization of keratinocytes with CC binucleated cells in the upper epidermis, sometimes associated CC with amyloid deposition in the dermis. Ultrastructural CC abnormalities include perinuclear shells formed from a network of CC fine filaments in the upper epidermis. CC -!- MISCELLANEOUS: There are two types of cytoskeletal and CC microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to CC basic; 56-70 kDa). CC -!- SIMILARITY: Belongs to the intermediate filament family. CC -!- SEQUENCE CAUTION: CC Sequence=AAA59468.1; Type=Erroneous initiation; Note=Translation N-terminally extended; CC -!- WEB RESOURCE: Name=Human Intermediate Filament Mutation Database; CC URL="http://www.interfil.org"; CC -!- WEB RESOURCE: Name=GeneReviews; CC URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KRT10"; CC -!- WEB RESOURCE: Name=Wikipedia; Note=Keratin-10 entry; CC URL="http://en.wikipedia.org/wiki/Keratin_10"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; J04029; AAA60544.1; -; mRNA. DR EMBL; X14487; CAA32649.1; -; Genomic_DNA. DR EMBL; AC090283; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BC034697; AAH34697.1; -; mRNA. DR EMBL; M19156; AAA59468.1; ALT_INIT; mRNA. DR EMBL; L20218; AAB59438.1; -; Genomic_DNA. DR EMBL; L20219; AAB59439.1; -; Genomic_DNA. DR EMBL; M77663; AAA59199.1; -; mRNA. DR IPI; IPI00009865; -. DR PIR; A31994; A31994. DR PIR; S02158; KRHU0. DR RefSeq; NP_000412.3; NM_000421.3. DR UniGene; Hs.99936; -. DR PDB; 3ASW; X-ray; 2.60 A; B=473-487. DR PDBsum; 3ASW; -. DR ProteinModelPortal; P13645; -. DR SMR; P13645; 144-181, 195-295, 313-455. DR IntAct; P13645; 16. DR MINT; MINT-1132575; -. DR STRING; P13645; -. DR PhosphoSite; P13645; -. DR DMDM; 269849769; -. DR SWISS-2DPAGE; P13645; -. DR Aarhus/Ghent-2DPAGE; 7405; IEF. DR REPRODUCTION-2DPAGE; P13645; -. DR PeptideAtlas; P13645; -. DR PRIDE; P13645; -. DR Ensembl; ENST00000269576; ENSP00000269576; ENSG00000186395. DR GeneID; 3858; -. DR KEGG; hsa:3858; -. DR UCSC; uc002hvi.1; human. DR CTD; 3858; -. DR GeneCards; GC17M038974; -. DR HGNC; HGNC:6413; KRT10. DR HPA; CAB000132; -. DR HPA; HPA012014; -. DR MIM; 113800; phenotype. DR MIM; 148080; gene. DR MIM; 607602; phenotype. DR MIM; 609165; phenotype. DR neXtProt; NX_P13645; -. DR Orphanet; 312; Congenital bullous ichthyosiform erythroderma. DR Orphanet; 313; Lamellar ichthyosis. DR PharmGKB; PA30200; -. DR eggNOG; prNOG05122; -. DR GeneTree; ENSGT00560000077101; -. DR HOGENOM; HBG715391; -. DR HOVERGEN; HBG013015; -. DR InParanoid; P13645; -. DR OMA; YSSSKHY; -. DR OrthoDB; EOG4P8FJH; -. DR PhylomeDB; P13645; -. DR NextBio; 15181; -. DR ArrayExpress; P13645; -. DR Bgee; P13645; -. DR CleanEx; HS_KRT10; -. DR Genevestigator; P13645; -. DR GermOnline; ENSG00000186395; Homo sapiens. DR GO; GO:0030280; F:structural constituent of epidermis; NAS:UniProtKB. DR GO; GO:0008544; P:epidermis development; TAS:ProtInc. DR InterPro; IPR016044; F. DR InterPro; IPR001664; IF. DR InterPro; IPR018039; Intermediate_filament_CS. DR InterPro; IPR002957; Keratin_I. DR KO; K07604; -. DR PANTHER; PTHR23239; IF; 1. DR Pfam; PF00038; Filament; 1. DR PRINTS; PR01248; TYPE1KERATIN. DR PROSITE; PS00226; IF; 1. PE 1: Evidence at protein level; KW 3D-structure; Coiled coil; Complete proteome; KW Direct protein sequencing; Disease mutation; Ichthyosis; KW Intermediate filament; Keratin; Phosphoprotein; Polymorphism; KW Reference proteome. FT CHAIN 1 584 Keratin, type I cytoskeletal 10. FT /FTId=PRO_0000063642. FT REGION 1 145 Head. FT REGION 146 456 Rod. FT REGION 146 181 Coil 1A. FT REGION 182 202 Linker 1. FT REGION 203 294 Coil 1B. FT REGION 295 317 Linker 12. FT REGION 318 456 Coil 2. FT REGION 457 584 Tail. FT COMPBIAS 17 575 Gly-rich. FT COMPBIAS 477 579 Ser-rich. FT MOD_RES 16 16 Phosphoserine. FT MOD_RES 42 42 Phosphoserine. FT MOD_RES 56 56 Phosphoserine (By similarity). FT VARIANT 101 101 I -> S (in dbSNP:rs4261597). FT /FTId=VAR_058202. FT VARIANT 126 126 G -> S. FT /FTId=VAR_010505. FT VARIANT 150 150 M -> R (in BCIE; dbSNP:rs58901407). FT /FTId=VAR_010506. FT VARIANT 150 150 M -> T (in a patient with epidermal nevi FT hyperkeratotic type due to genetic FT mosaicism). FT /FTId=VAR_010507. FT VARIANT 154 154 N -> H (in BCIE; dbSNP:rs57784225). FT /FTId=VAR_003826. FT VARIANT 156 156 R -> C (in BCIE). FT /FTId=VAR_003828. FT VARIANT 156 156 R -> H (in BCIE; dbSNP:rs58075662). FT /FTId=VAR_003827. FT VARIANT 156 156 R -> P (in BCIE). FT /FTId=VAR_003829. FT VARIANT 156 156 R -> S (in BCIE; dbSNP:rs58852768). FT /FTId=VAR_003830. FT VARIANT 160 160 Y -> D (in BCIE; severe phenotype; FT dbSNP:rs58414354). FT /FTId=VAR_003831. FT VARIANT 160 160 Y -> N (in BCIE; severe phenotype). FT /FTId=VAR_010508. FT VARIANT 160 160 Y -> S (in BCIE; severe phenotype; FT dbSNP:rs58735429). FT /FTId=VAR_010509. FT VARIANT 161 161 L -> S (in BCIE; dbSNP:rs60118264). FT /FTId=VAR_003832. FT VARIANT 422 422 R -> E (in AEI; requires 2 nucleotide FT substitutions; dbSNP:rs59075499). FT /FTId=VAR_033145. FT VARIANT 439 439 K -> E (in BCIE; mild phenotype; FT dbSNP:rs61434181). FT /FTId=VAR_010510. FT VARIANT 442 442 L -> Q (in BCIE; dbSNP:rs58026994). FT /FTId=VAR_003833. FT VARIANT 446 446 I -> T (in AEI). FT /FTId=VAR_010511. FT VARIANT 487 487 H -> Y. FT /FTId=VAR_060723. FT CONFLICT 9 11 KHY -> SKQF (in Ref. 1; AAA60544). FT CONFLICT 24 31 Missing (in Ref. 1; AAA60544). FT CONFLICT 86 86 R -> H (in Ref. 2; CAA32649). FT CONFLICT 106 106 S -> N (in Ref. 2; CAA32649). FT CONFLICT 181 184 WYEK -> RYDQ (in Ref. 1; AAA60544). FT CONFLICT 189 189 H -> R (in Ref. 1; AAA60544). FT CONFLICT 197 197 S -> G (in Ref. 8; AAA59199). FT CONFLICT 266 266 K -> Q (in Ref. 1; AAA60544). FT CONFLICT 279 280 EL -> YV (in Ref. 5; AAA59468). FT CONFLICT 287 287 H -> R (in Ref. 1; AAA60544). FT CONFLICT 293 293 D -> H (in Ref. 1; AAA60544). FT CONFLICT 312 312 V -> I (in Ref. 5; AAA59468). FT CONFLICT 323 323 S -> N (in Ref. 1; AAA60544). FT CONFLICT 340 340 F -> V (in Ref. 5; AAA59468). FT CONFLICT 374 374 A -> R (in Ref. 5; AAA59468). FT CONFLICT 408 408 Q -> H (in Ref. 2; CAA32649). FT CONFLICT 420 420 Q -> E (in Ref. 1; AAA60544). FT CONFLICT 436 436 L -> T (in Ref. 1; AAA60544). FT CONFLICT 451 451 S -> G (in Ref. 8; AAA59199). FT CONFLICT 460 461 GG -> RS (in Ref. 5; AAA59468). FT CONFLICT 477 477 S -> T (in Ref. 5; AAA59468). FT CONFLICT 482 482 S -> T (in Ref. 5; AAA59468). FT CONFLICT 487 490 Missing (in Ref. 8; AAA59199). FT CONFLICT 491 516 Missing (in Ref. 1; AAA60544). FT CONFLICT 503 503 S -> T (in Ref. 5; AAA59468). FT CONFLICT 508 508 S -> T (in Ref. 5; AAA59468). FT CONFLICT 513 519 YGGGSSS -> LRGELH (in Ref. 5; AAA59468). FT CONFLICT 523 527 GGSSS -> AHST (in Ref. 5; AAA59468). FT CONFLICT 524 524 G -> GGSSSGGHGG (in Ref. 2; CAA32649). FT CONFLICT 534 534 S -> N (in Ref. 5; AAA59468). FT CONFLICT 535 535 S -> F (in Ref. 1; AAA60544). FT CONFLICT 542 546 YGGGS -> LRGRH (in Ref. 5; AAA59468). FT CONFLICT 565 565 G -> GGYGGGSSSGG (in Ref. 1; AAA60544). FT STRAND 479 481 FT STRAND 483 486 SQ SEQUENCE 584 AA; 58827 MW; 4941ECD2AE46D417 CRC64; MSVRYSSSKH YSSSRSGGGG GGGGCGGGGG VSSLRISSSK GSLGGGFSSG GFSGGSFSRG SSGGGCFGGS SGGYGGLGGF GGGSFRGSYG SSSFGGSYGG IFGGGSFGGG SFGGGSFGGG GFGGGGFGGG FGGGFGGDGG LLSGNEKVTM QNLNDRLASY LDKVRALEES NYELEGKIKE WYEKHGNSHQ GEPRDYSKYY KTIDDLKNQI LNLTTDNANI LLQIDNARLA ADDFRLKYEN EVALRQSVEA DINGLRRVLD ELTLTKADLE MQIESLTEEL AYLKKNHEEE MKDLRNVSTG DVNVEMNAAP GVDLTQLLNN MRSQYEQLAE QNRKDAEAWF NEKSKELTTE IDNNIEQISS YKSEITELRR NVQALEIELQ SQLALKQSLE ASLAETEGRY CVQLSQIQAQ ISALEEQLQQ IRAETECQNT EYQQLLDIKI RLENEIQTYR SLLEGEGSSG GGGRGGGSFG GGYGGGSSGG GSSGGGHGGG HGGSSGGGYG GGSSGGGSSG GGYGGGSSSG GHGGSSSGGY GGGSSGGGGG GYGGGSSGGG SSSGGGYGGG SSSGGHKSSS SGSVGESSSK GPRY //