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Protein

Keratin, type I cytoskeletal 10

Gene

KRT10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the establishment of the epidermal barrier on plantar skin.By similarity
(Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.1 Publication

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

  • structural constituent of epidermis Source: CAFA

GO - Biological processi

  • cornification Source: Reactome
  • keratinization Source: Reactome
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: CAFA

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SIGNORiP13645

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 10
Alternative name(s):
Cytokeratin-10
Short name:
CK-10
Keratin-10
Short name:
K10
Gene namesi
Name:KRT10
Synonyms:KPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000186395.6
HGNCiHGNC:6413 KRT10
MIMi148080 gene
neXtProtiNX_P13645

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin, Secreted

Pathology & Biotechi

Involvement in diseasei

Epidermolytic hyperkeratosis (EHK)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
See also OMIM:113800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010506150M → R in EHK. 2 PublicationsCorresponds to variant dbSNP:rs58901407EnsemblClinVar.1
Natural variantiVAR_010507150M → T in EHK; also found in a patient with hyperkeratotic epidermal nevi due to genetic mosaicism. 2 PublicationsCorresponds to variant dbSNP:rs58901407EnsemblClinVar.1
Natural variantiVAR_003826154N → H in EHK. 1 PublicationCorresponds to variant dbSNP:rs57784225EnsemblClinVar.1
Natural variantiVAR_003828156R → C in EHK. 4 PublicationsCorresponds to variant dbSNP:rs58852768EnsemblClinVar.1
Natural variantiVAR_003827156R → H in EHK. 5 PublicationsCorresponds to variant dbSNP:rs58075662EnsemblClinVar.1
Natural variantiVAR_003829156R → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs58075662EnsemblClinVar.1
Natural variantiVAR_003830156R → S in EHK. 1 PublicationCorresponds to variant dbSNP:rs58852768EnsemblClinVar.1
Natural variantiVAR_003831160Y → D in EHK; severe phenotype. 1 PublicationCorresponds to variant dbSNP:rs58414354EnsemblClinVar.1
Natural variantiVAR_010508160Y → N in EHK; severe phenotype. 1 Publication1
Natural variantiVAR_010509160Y → S in EHK; severe phenotype. 1 PublicationCorresponds to variant dbSNP:rs58735429EnsemblClinVar.1
Natural variantiVAR_003832161L → S in EHK. 1 PublicationCorresponds to variant dbSNP:rs60118264EnsemblClinVar.1
Natural variantiVAR_010510439K → E in EHK; mild phenotype. 1 PublicationCorresponds to variant dbSNP:rs61434181EnsemblClinVar.1
Natural variantiVAR_003833442L → Q in EHK. 1 PublicationCorresponds to variant dbSNP:rs58026994EnsemblClinVar.1
Natural variantiVAR_071985449Y → C in EHK. 1 PublicationCorresponds to variant dbSNP:rs267607383EnsemblClinVar.1
Ichthyosis annular epidermolytic (AEI)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
See also OMIM:607602
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033145422R → E in AEI; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs59075499EnsemblClinVar.1
Natural variantiVAR_010511446I → T in AEI. 1 PublicationCorresponds to variant dbSNP:rs62651994EnsemblClinVar.1
Erythroderma, ichthyosiform, congenital reticular (CRIE)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare skin condition characterized by slowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. The condition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearing in late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis, and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloid deposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of fine filaments in the upper epidermis.
See also OMIM:609165

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNETi3858
MalaCardsiKRT10
MIMi113800 phenotype
607602 phenotype
609165 phenotype
OpenTargetsiENSG00000186395
Orphaneti281139 Annular epidermolytic ichthyosis
281190 Congenital reticular ichthyosiform erythroderma
312 Epidermolytic ichthyosis
PharmGKBiPA30200

Polymorphism and mutation databases

BioMutaiKRT10
DMDMi269849769

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636421 – 584Keratin, type I cytoskeletal 10Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Disulfide bondi401InterchainCombined sources1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP13645
PaxDbiP13645
PeptideAtlasiP13645
PRIDEiP13645
TopDownProteomicsiP13645

2D gel databases

REPRODUCTION-2DPAGEP13645
SWISS-2DPAGEP13645

PTM databases

iPTMnetiP13645
PhosphoSitePlusiP13645
SwissPalmiP13645

Expressioni

Tissue specificityi

Seen in all suprabasal cell layers including stratum corneum.

Gene expression databases

BgeeiENSG00000186395
CleanExiHS_KRT10
ExpressionAtlasiP13645 baseline and differential
GenevisibleiP13645 HS

Organism-specific databases

HPAiCAB000132
HPA012014

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Heterodimer with KRT1 (PubMed:27595935). Two heterodimers of KRT1 and KRT10 form a heterotetramer (PubMed:27595935). The KRT10 subunit in the heterotetramer is probably disulfide-linked (Probable).1 Publication1 Publication
(Microbial infection) Interacts (via C-terminal tail domain) with the S.aureus clumping factor, clfB; this interaction probably mediates S.aureus attachment to the keratinized squamous epithelial cells from the nasal cavity.3 Publications

Protein-protein interaction databases

BioGridi110056, 62 interactors
IntActiP13645, 19 interactors
MINTiP13645
STRINGi9606.ENSP00000269576

Structurei

Secondary structure

1584
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi348 – 455Combined sources108
Beta strandi479 – 481Combined sources3
Beta strandi483 – 486Combined sources4
Beta strandi500 – 508Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ASWX-ray2.60B473-487[»]
4F1ZX-ray2.30Q499-512[»]
4ZRYX-ray3.30A337-456[»]
ProteinModelPortaliP13645
SMRiP13645
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 460IF rodPROSITE-ProRule annotationAdd BLAST315

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 145HeadAdd BLAST145
Regioni146 – 181Coil 1AAdd BLAST36
Regioni182 – 202Linker 1Add BLAST21
Regioni203 – 294Coil 1BAdd BLAST92
Regioni295 – 317Linker 12Add BLAST23
Regioni318 – 456Coil 2Add BLAST139
Regioni457 – 584TailAdd BLAST128

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 575Gly-richAdd BLAST559
Compositional biasi477 – 579Ser-richAdd BLAST103

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJX Eukaryota
ENOG410YDXS LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiP13645
KOiK07604
OMAiQGQPRDY
OrthoDBiEOG091G087I
PhylomeDBiP13645
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 3 hits
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P13645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRYSSSKH YSSSRSGGGG GGGGCGGGGG VSSLRISSSK GSLGGGFSSG
60 70 80 90 100
GFSGGSFSRG SSGGGCFGGS SGGYGGLGGF GGGSFRGSYG SSSFGGSYGG
110 120 130 140 150
IFGGGSFGGG SFGGGSFGGG GFGGGGFGGG FGGGFGGDGG LLSGNEKVTM
160 170 180 190 200
QNLNDRLASY LDKVRALEES NYELEGKIKE WYEKHGNSHQ GEPRDYSKYY
210 220 230 240 250
KTIDDLKNQI LNLTTDNANI LLQIDNARLA ADDFRLKYEN EVALRQSVEA
260 270 280 290 300
DINGLRRVLD ELTLTKADLE MQIESLTEEL AYLKKNHEEE MKDLRNVSTG
310 320 330 340 350
DVNVEMNAAP GVDLTQLLNN MRSQYEQLAE QNRKDAEAWF NEKSKELTTE
360 370 380 390 400
IDNNIEQISS YKSEITELRR NVQALEIELQ SQLALKQSLE ASLAETEGRY
410 420 430 440 450
CVQLSQIQAQ ISALEEQLQQ IRAETECQNT EYQQLLDIKI RLENEIQTYR
460 470 480 490 500
SLLEGEGSSG GGGRGGGSFG GGYGGGSSGG GSSGGGHGGG HGGSSGGGYG
510 520 530 540 550
GGSSGGGSSG GGYGGGSSSG GHGGSSSGGY GGGSSGGGGG GYGGGSSGGG
560 570 580
SSSGGGYGGG SSSGGHKSSS SGSVGESSSK GPRY
Length:584
Mass (Da):58,827
Last modified:November 24, 2009 - v6
Checksum:i4941ECD2AE46D417
GO

Sequence cautioni

The sequence AAA59468 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 11KHY → SKQF in AAA60544 (PubMed:2459124).Curated3
Sequence conflicti24 – 31Missing in AAA60544 (PubMed:2459124).Curated8
Sequence conflicti86R → H in CAA32649 (PubMed:2464696).Curated1
Sequence conflicti106S → N in CAA32649 (PubMed:2464696).Curated1
Sequence conflicti181 – 184WYEK → RYDQ in AAA60544 (PubMed:2459124).Curated4
Sequence conflicti189H → R in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti197S → G in AAA59199 (PubMed:1378806).Curated1
Sequence conflicti266K → Q in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti279 – 280EL → YV in AAA59468 (PubMed:2448602).Curated2
Sequence conflicti287H → R in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti293D → H in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti312V → I in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti323S → N in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti340F → V in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti374A → R in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti408Q → H in CAA32649 (PubMed:2464696).Curated1
Sequence conflicti420Q → E in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti436L → T in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti451S → G in AAA59199 (PubMed:1378806).Curated1
Sequence conflicti460 – 461GG → RS in AAA59468 (PubMed:2448602).Curated2
Sequence conflicti477S → T in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti482S → T in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti487 – 490Missing in AAA59199 (PubMed:1378806).Curated4
Sequence conflicti491 – 516Missing in AAA60544 (PubMed:2459124).CuratedAdd BLAST26
Sequence conflicti503S → T in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti508S → T in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti513 – 519YGGGSSS → LRGELH in AAA59468 (PubMed:2448602).Curated7
Sequence conflicti523 – 527GGSSS → AHST in AAA59468 (PubMed:2448602).Curated5
Sequence conflicti524G → GGSSSGGHGG in CAA32649 (PubMed:2464696).Curated1
Sequence conflicti534S → N in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti535S → F in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti542 – 546YGGGS → LRGRH in AAA59468 (PubMed:2448602).Curated5
Sequence conflicti565G → GGYGGGSSSGG in AAA60544 (PubMed:2459124).Curated1

Polymorphismi

A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560).

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058202101I → S2 PublicationsCorresponds to variant dbSNP:rs4261597Ensembl.1
Natural variantiVAR_010505126G → S2 PublicationsCorresponds to variant dbSNP:rs77919366EnsemblClinVar.1
Natural variantiVAR_010506150M → R in EHK. 2 PublicationsCorresponds to variant dbSNP:rs58901407EnsemblClinVar.1
Natural variantiVAR_010507150M → T in EHK; also found in a patient with hyperkeratotic epidermal nevi due to genetic mosaicism. 2 PublicationsCorresponds to variant dbSNP:rs58901407EnsemblClinVar.1
Natural variantiVAR_003826154N → H in EHK. 1 PublicationCorresponds to variant dbSNP:rs57784225EnsemblClinVar.1
Natural variantiVAR_003828156R → C in EHK. 4 PublicationsCorresponds to variant dbSNP:rs58852768EnsemblClinVar.1
Natural variantiVAR_003827156R → H in EHK. 5 PublicationsCorresponds to variant dbSNP:rs58075662EnsemblClinVar.1
Natural variantiVAR_003829156R → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs58075662EnsemblClinVar.1
Natural variantiVAR_003830156R → S in EHK. 1 PublicationCorresponds to variant dbSNP:rs58852768EnsemblClinVar.1
Natural variantiVAR_003831160Y → D in EHK; severe phenotype. 1 PublicationCorresponds to variant dbSNP:rs58414354EnsemblClinVar.1
Natural variantiVAR_010508160Y → N in EHK; severe phenotype. 1 Publication1
Natural variantiVAR_010509160Y → S in EHK; severe phenotype. 1 PublicationCorresponds to variant dbSNP:rs58735429EnsemblClinVar.1
Natural variantiVAR_003832161L → S in EHK. 1 PublicationCorresponds to variant dbSNP:rs60118264EnsemblClinVar.1
Natural variantiVAR_033145422R → E in AEI; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs59075499EnsemblClinVar.1
Natural variantiVAR_010510439K → E in EHK; mild phenotype. 1 PublicationCorresponds to variant dbSNP:rs61434181EnsemblClinVar.1
Natural variantiVAR_003833442L → Q in EHK. 1 PublicationCorresponds to variant dbSNP:rs58026994EnsemblClinVar.1
Natural variantiVAR_010511446I → T in AEI. 1 PublicationCorresponds to variant dbSNP:rs62651994EnsemblClinVar.1
Natural variantiVAR_071985449Y → C in EHK. 1 PublicationCorresponds to variant dbSNP:rs267607383EnsemblClinVar.1
Natural variantiVAR_060723487H → Y4 PublicationsCorresponds to variant dbSNP:rs17855579Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04029 mRNA Translation: AAA60544.1
X14487 Genomic DNA Translation: CAA32649.1
AC090283 mRNA No translation available.
BC034697 mRNA Translation: AAH34697.1
M19156 mRNA Translation: AAA59468.1 Different initiation.
L20218 Genomic DNA Translation: AAB59438.1
L20219 Genomic DNA Translation: AAB59439.1
M77663 mRNA Translation: AAA59199.1
CCDSiCCDS11377.1
PIRiA31994
S02158 KRHU0
RefSeqiNP_000412.3, NM_000421.3
UniGeneiHs.99936

Genome annotation databases

EnsembliENST00000269576; ENSP00000269576; ENSG00000186395
GeneIDi3858
KEGGihsa:3858
UCSCiuc002hvi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiK1C10_HUMAN
AccessioniPrimary (citable) accession number: P13645
Secondary accession number(s): Q14664, Q8N175
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 24, 2009
Last modified: May 23, 2018
This is version 192 of the entry and version 6 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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