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P13645

- K1C10_HUMAN

UniProt

P13645 - K1C10_HUMAN

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Protein

Keratin, type I cytoskeletal 10

Gene

KRT10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of epidermis Source: UniProtKB

GO - Biological processi

  1. cellular response to calcium ion Source: Ensembl
  2. keratinocyte differentiation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 10
Alternative name(s):
Cytokeratin-10
Short name:
CK-10
Keratin-10
Short name:
K10
Gene namesi
Name:KRT10
Synonyms:KPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6413. KRT10.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular space Source: UniProt
  3. extracellular vesicular exosome Source: UniProtKB
  4. intermediate filament Source: UniProtKB
  5. keratin filament Source: Ensembl
  6. membrane Source: UniProtKB
  7. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

Epidermolytic hyperkeratosis (EHK) [MIM:113800]: An autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.8 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501M → R in EHK. 1 Publication
Corresponds to variant rs58901407 [ dbSNP | Ensembl ].
VAR_010506
Natural varianti154 – 1541N → H in EHK. 1 Publication
Corresponds to variant rs57784225 [ dbSNP | Ensembl ].
VAR_003826
Natural varianti156 – 1561R → C in EHK. 3 Publications
VAR_003828
Natural varianti156 – 1561R → H in EHK. 4 Publications
Corresponds to variant rs58075662 [ dbSNP | Ensembl ].
VAR_003827
Natural varianti156 – 1561R → P in EHK. 1 Publication
VAR_003829
Natural varianti156 – 1561R → S in EHK. 1 Publication
Corresponds to variant rs58852768 [ dbSNP | Ensembl ].
VAR_003830
Natural varianti160 – 1601Y → D in EHK; severe phenotype. 1 Publication
Corresponds to variant rs58414354 [ dbSNP | Ensembl ].
VAR_003831
Natural varianti160 – 1601Y → N in EHK; severe phenotype. 1 Publication
VAR_010508
Natural varianti160 – 1601Y → S in EHK; severe phenotype. 1 Publication
Corresponds to variant rs58735429 [ dbSNP | Ensembl ].
VAR_010509
Natural varianti161 – 1611L → S in EHK. 1 Publication
Corresponds to variant rs60118264 [ dbSNP | Ensembl ].
VAR_003832
Natural varianti439 – 4391K → E in EHK; mild phenotype. 1 Publication
Corresponds to variant rs61434181 [ dbSNP | Ensembl ].
VAR_010510
Natural varianti442 – 4421L → Q in EHK. 1 Publication
Corresponds to variant rs58026994 [ dbSNP | Ensembl ].
VAR_003833
Ichthyosis annular epidermolytic (AEI) [MIM:607602]: A skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti422 – 4221R → E in AEI; requires 2 nucleotide substitutions. 1 Publication
Corresponds to variant rs59075499 [ dbSNP | Ensembl ].
VAR_033145
Natural varianti446 – 4461I → T in AEI. 1 Publication
VAR_010511
Erythroderma, ichthyosiform, congenital reticular (CRIE) [MIM:609165]: A rare skin condition characterized by slowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. The condition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearing in late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis, and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloid deposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of fine filaments in the upper epidermis.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

MIMi113800. phenotype.
607602. phenotype.
609165. phenotype.
Orphaneti281139. Annular epidermolytic ichthyosis.
281190. Congenital reticular ichthyosiform erythroderma.
312. Epidermolytic ichthyosis.
PharmGKBiPA30200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Keratin, type I cytoskeletal 10PRO_0000063642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine1 Publication
Modified residuei42 – 421Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP13645.
PaxDbiP13645.
PeptideAtlasiP13645.
PRIDEiP13645.
ProMEXiP13645.

2D gel databases

REPRODUCTION-2DPAGEP13645.
SWISS-2DPAGEP13645.

PTM databases

PhosphoSiteiP13645.

Expressioni

Tissue specificityi

Seen in all suprabasal cell layers including stratum corneum.

Gene expression databases

BgeeiP13645.
CleanExiHS_KRT10.
GenevestigatoriP13645.

Organism-specific databases

HPAiCAB000132.
HPA012014.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.

Protein-protein interaction databases

BioGridi110056. 51 interactions.
IntActiP13645. 19 interactions.
MINTiMINT-1132575.
STRINGi9606.ENSP00000269576.

Structurei

Secondary structure

1
584
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi479 – 4813
Beta strandi483 – 4864
Beta strandi500 – 5089

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ASWX-ray2.60B473-487[»]
4F1ZX-ray2.30Q499-512[»]
ProteinModelPortaliP13645.
SMRiP13645. Positions 145-287, 313-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 145145HeadAdd
BLAST
Regioni146 – 456311RodAdd
BLAST
Regioni146 – 18136Coil 1AAdd
BLAST
Regioni182 – 20221Linker 1Add
BLAST
Regioni203 – 29492Coil 1BAdd
BLAST
Regioni295 – 31723Linker 12Add
BLAST
Regioni318 – 456139Coil 2Add
BLAST
Regioni457 – 584128TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 575559Gly-richAdd
BLAST
Compositional biasi477 – 579103Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG147548.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP13645.
KOiK07604.
OMAiRYSSSKH.
OrthoDBiEOG7FV3Q8.
PhylomeDBiP13645.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13645-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVRYSSSKH YSSSRSGGGG GGGGCGGGGG VSSLRISSSK GSLGGGFSSG
60 70 80 90 100
GFSGGSFSRG SSGGGCFGGS SGGYGGLGGF GGGSFRGSYG SSSFGGSYGG
110 120 130 140 150
IFGGGSFGGG SFGGGSFGGG GFGGGGFGGG FGGGFGGDGG LLSGNEKVTM
160 170 180 190 200
QNLNDRLASY LDKVRALEES NYELEGKIKE WYEKHGNSHQ GEPRDYSKYY
210 220 230 240 250
KTIDDLKNQI LNLTTDNANI LLQIDNARLA ADDFRLKYEN EVALRQSVEA
260 270 280 290 300
DINGLRRVLD ELTLTKADLE MQIESLTEEL AYLKKNHEEE MKDLRNVSTG
310 320 330 340 350
DVNVEMNAAP GVDLTQLLNN MRSQYEQLAE QNRKDAEAWF NEKSKELTTE
360 370 380 390 400
IDNNIEQISS YKSEITELRR NVQALEIELQ SQLALKQSLE ASLAETEGRY
410 420 430 440 450
CVQLSQIQAQ ISALEEQLQQ IRAETECQNT EYQQLLDIKI RLENEIQTYR
460 470 480 490 500
SLLEGEGSSG GGGRGGGSFG GGYGGGSSGG GSSGGGHGGG HGGSSGGGYG
510 520 530 540 550
GGSSGGGSSG GGYGGGSSSG GHGGSSSGGY GGGSSGGGGG GYGGGSSGGG
560 570 580
SSSGGGYGGG SSSGGHKSSS SGSVGESSSK GPRY
Length:584
Mass (Da):58,827
Last modified:November 24, 2009 - v6
Checksum:i4941ECD2AE46D417
GO

Sequence cautioni

The sequence AAA59468.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 113KHY → SKQF in AAA60544. (PubMed:2459124)Curated
Sequence conflicti24 – 318Missing in AAA60544. (PubMed:2459124)Curated
Sequence conflicti86 – 861R → H in CAA32649. (PubMed:2464696)Curated
Sequence conflicti106 – 1061S → N in CAA32649. (PubMed:2464696)Curated
Sequence conflicti181 – 1844WYEK → RYDQ in AAA60544. (PubMed:2459124)Curated
Sequence conflicti189 – 1891H → R in AAA60544. (PubMed:2459124)Curated
Sequence conflicti197 – 1971S → G in AAA59199. (PubMed:1378806)Curated
Sequence conflicti266 – 2661K → Q in AAA60544. (PubMed:2459124)Curated
Sequence conflicti279 – 2802EL → YV in AAA59468. (PubMed:2448602)Curated
Sequence conflicti287 – 2871H → R in AAA60544. (PubMed:2459124)Curated
Sequence conflicti293 – 2931D → H in AAA60544. (PubMed:2459124)Curated
Sequence conflicti312 – 3121V → I in AAA59468. (PubMed:2448602)Curated
Sequence conflicti323 – 3231S → N in AAA60544. (PubMed:2459124)Curated
Sequence conflicti340 – 3401F → V in AAA59468. (PubMed:2448602)Curated
Sequence conflicti374 – 3741A → R in AAA59468. (PubMed:2448602)Curated
Sequence conflicti408 – 4081Q → H in CAA32649. (PubMed:2464696)Curated
Sequence conflicti420 – 4201Q → E in AAA60544. (PubMed:2459124)Curated
Sequence conflicti436 – 4361L → T in AAA60544. (PubMed:2459124)Curated
Sequence conflicti451 – 4511S → G in AAA59199. (PubMed:1378806)Curated
Sequence conflicti460 – 4612GG → RS in AAA59468. (PubMed:2448602)Curated
Sequence conflicti477 – 4771S → T in AAA59468. (PubMed:2448602)Curated
Sequence conflicti482 – 4821S → T in AAA59468. (PubMed:2448602)Curated
Sequence conflicti487 – 4904Missing in AAA59199. (PubMed:1378806)Curated
Sequence conflicti491 – 51626Missing in AAA60544. (PubMed:2459124)CuratedAdd
BLAST
Sequence conflicti503 – 5031S → T in AAA59468. (PubMed:2448602)Curated
Sequence conflicti508 – 5081S → T in AAA59468. (PubMed:2448602)Curated
Sequence conflicti513 – 5197YGGGSSS → LRGELH in AAA59468. (PubMed:2448602)Curated
Sequence conflicti523 – 5275GGSSS → AHST in AAA59468. (PubMed:2448602)Curated
Sequence conflicti524 – 5241G → GGSSSGGHGG in CAA32649. (PubMed:2464696)Curated
Sequence conflicti534 – 5341S → N in AAA59468. (PubMed:2448602)Curated
Sequence conflicti535 – 5351S → F in AAA60544. (PubMed:2459124)Curated
Sequence conflicti542 – 5465YGGGS → LRGRH in AAA59468. (PubMed:2448602)Curated
Sequence conflicti565 – 5651G → GGYGGGSSSGG in AAA60544. (PubMed:2459124)Curated

Polymorphismi

A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti101 – 1011I → S.2 Publications
Corresponds to variant rs4261597 [ dbSNP | Ensembl ].
VAR_058202
Natural varianti126 – 1261G → S.1 Publication
Corresponds to variant rs77919366 [ dbSNP | Ensembl ].
VAR_010505
Natural varianti150 – 1501M → R in EHK. 1 Publication
Corresponds to variant rs58901407 [ dbSNP | Ensembl ].
VAR_010506
Natural varianti150 – 1501M → T in a patient with epidermal nevi hyperkeratotic type due to genetic mosaicism. 1 Publication
VAR_010507
Natural varianti154 – 1541N → H in EHK. 1 Publication
Corresponds to variant rs57784225 [ dbSNP | Ensembl ].
VAR_003826
Natural varianti156 – 1561R → C in EHK. 3 Publications
VAR_003828
Natural varianti156 – 1561R → H in EHK. 4 Publications
Corresponds to variant rs58075662 [ dbSNP | Ensembl ].
VAR_003827
Natural varianti156 – 1561R → P in EHK. 1 Publication
VAR_003829
Natural varianti156 – 1561R → S in EHK. 1 Publication
Corresponds to variant rs58852768 [ dbSNP | Ensembl ].
VAR_003830
Natural varianti160 – 1601Y → D in EHK; severe phenotype. 1 Publication
Corresponds to variant rs58414354 [ dbSNP | Ensembl ].
VAR_003831
Natural varianti160 – 1601Y → N in EHK; severe phenotype. 1 Publication
VAR_010508
Natural varianti160 – 1601Y → S in EHK; severe phenotype. 1 Publication
Corresponds to variant rs58735429 [ dbSNP | Ensembl ].
VAR_010509
Natural varianti161 – 1611L → S in EHK. 1 Publication
Corresponds to variant rs60118264 [ dbSNP | Ensembl ].
VAR_003832
Natural varianti422 – 4221R → E in AEI; requires 2 nucleotide substitutions. 1 Publication
Corresponds to variant rs59075499 [ dbSNP | Ensembl ].
VAR_033145
Natural varianti439 – 4391K → E in EHK; mild phenotype. 1 Publication
Corresponds to variant rs61434181 [ dbSNP | Ensembl ].
VAR_010510
Natural varianti442 – 4421L → Q in EHK. 1 Publication
Corresponds to variant rs58026994 [ dbSNP | Ensembl ].
VAR_003833
Natural varianti446 – 4461I → T in AEI. 1 Publication
VAR_010511
Natural varianti487 – 4871H → Y.4 Publications
Corresponds to variant rs17855579 [ dbSNP | Ensembl ].
VAR_060723

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04029 mRNA. Translation: AAA60544.1.
X14487 Genomic DNA. Translation: CAA32649.1.
AC090283 mRNA. No translation available.
BC034697 mRNA. Translation: AAH34697.1.
M19156 mRNA. Translation: AAA59468.1. Different initiation.
L20218 Genomic DNA. Translation: AAB59438.1.
L20219 Genomic DNA. Translation: AAB59439.1.
M77663 mRNA. Translation: AAA59199.1.
CCDSiCCDS11377.1.
PIRiA31994.
S02158. KRHU0.
RefSeqiNP_000412.3. NM_000421.3.
UniGeneiHs.99936.

Genome annotation databases

EnsembliENST00000269576; ENSP00000269576; ENSG00000186395.
GeneIDi3858.
KEGGihsa:3858.
UCSCiuc002hvi.3. human.

Polymorphism databases

DMDMi269849769.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-10 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04029 mRNA. Translation: AAA60544.1 .
X14487 Genomic DNA. Translation: CAA32649.1 .
AC090283 mRNA. No translation available.
BC034697 mRNA. Translation: AAH34697.1 .
M19156 mRNA. Translation: AAA59468.1 . Different initiation.
L20218 Genomic DNA. Translation: AAB59438.1 .
L20219 Genomic DNA. Translation: AAB59439.1 .
M77663 mRNA. Translation: AAA59199.1 .
CCDSi CCDS11377.1.
PIRi A31994.
S02158. KRHU0.
RefSeqi NP_000412.3. NM_000421.3.
UniGenei Hs.99936.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ASW X-ray 2.60 B 473-487 [» ]
4F1Z X-ray 2.30 Q 499-512 [» ]
ProteinModelPortali P13645.
SMRi P13645. Positions 145-287, 313-455.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110056. 51 interactions.
IntActi P13645. 19 interactions.
MINTi MINT-1132575.
STRINGi 9606.ENSP00000269576.

PTM databases

PhosphoSitei P13645.

Polymorphism databases

DMDMi 269849769.

2D gel databases

REPRODUCTION-2DPAGE P13645.
SWISS-2DPAGE P13645.

Proteomic databases

MaxQBi P13645.
PaxDbi P13645.
PeptideAtlasi P13645.
PRIDEi P13645.
ProMEXi P13645.

Protocols and materials databases

DNASUi 3858.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269576 ; ENSP00000269576 ; ENSG00000186395 .
GeneIDi 3858.
KEGGi hsa:3858.
UCSCi uc002hvi.3. human.

Organism-specific databases

CTDi 3858.
GeneCardsi GC17M038974.
HGNCi HGNC:6413. KRT10.
HPAi CAB000132.
HPA012014.
MIMi 113800. phenotype.
148080. gene.
607602. phenotype.
609165. phenotype.
neXtProti NX_P13645.
Orphaneti 281139. Annular epidermolytic ichthyosis.
281190. Congenital reticular ichthyosiform erythroderma.
312. Epidermolytic ichthyosis.
PharmGKBi PA30200.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147548.
GeneTreei ENSGT00760000118808.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi P13645.
KOi K07604.
OMAi RYSSSKH.
OrthoDBi EOG7FV3Q8.
PhylomeDBi P13645.
TreeFami TF332742.

Miscellaneous databases

GeneWikii Keratin_10.
GenomeRNAii 3858.
NextBioi 15181.
PROi P13645.
SOURCEi Search...

Gene expression databases

Bgeei P13645.
CleanExi HS_KRT10.
Genevestigatori P13645.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
SUPFAMi SSF46579. SSF46579. 1 hit.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences."
    Zhou X.M., Idler W.W., Steven A.C., Roop D.R., Steinert P.M.
    J. Biol. Chem. 263:15584-15589(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-101 AND TYR-487.
    Tissue: Foreskin.
  2. "Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10."
    Rieger M., Franke W.W.
    J. Mol. Biol. 204:841-856(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-487.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-101 AND TYR-487.
    Tissue: Skin.
  5. "Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression."
    Darmon M.Y., Semat A., Darmon M.C., Vasseur M.
    Mol. Biol. Rep. 12:277-283(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-584, VARIANT TYR-487.
  6. "Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing."
    Rothnagel J.A., Longley M.A., Holder R.A., Kuster W., Roop D.R.
    J. Invest. Dermatol. 102:13-16(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-161, VARIANTS EHK HIS-156 AND ASN-160.
  7. "Identification of mutational hot spots in the suprabasal keratin genes from patients with epidermolytic hyperkeratosis."
    Rothnagel J.J., Dominey A., Fisher M., Axtell S., Pittelkow M., Anton-Lamprecht I., Hohl D., Roop D.
    Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-161, VARIANT EHK CYS-156.
  8. "Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats."
    Tkachenko A.V., Buchman V.L., Bliskovsky V.V., Shvets Y.P., Kisselev L.L.
    Gene 116:245-251(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 197-584.
  9. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
    Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
    Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 180-184 AND 568-580.
    Tissue: Keratinocyte.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-42, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10."
    Choate K.A., Lu Y., Zhou J., Choi M., Elias P.M., Farhi A., Nelson-Williams C., Crumrine D., Williams M.L., Nopper A.J., Bree A., Milstone L.M., Lifton R.P.
    Science 330:94-97(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CRIE.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes."
    Cheng J., Syder A.J., Yu Q.-C., Letai A., Paller A.S., Fuchs E.
    Cell 70:811-819(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT EHK HIS-156.
  14. "Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops."
    Korge B.P., Gan S.-Q., McBridge O.W., Mischke D., Steinert P.M.
    Proc. Natl. Acad. Sci. U.S.A. 89:910-914(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS.
  15. "Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis."
    Rothnagel J.A., Dominey A.M., Dempsey L.D., Longley M.A., Greenhalgh D.A., Gagne T.A., Huber M., Frenk E., Hohl D., Roop D.R.
    Science 257:1128-1130(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS EHK HIS-156 AND SER-161.
  16. "Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis."
    Chipev C.C., Yang J.-M., Digiovanna J.J., Steinert P.M., Marekov L., Compton J.G., Bale S.J.
    Am. J. Hum. Genet. 54:179-190(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS EHK HIS-154; CYS-156; HIS-156; ASP-160 AND GLN-442.
  17. "Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity."
    Syder A.J., Yu Q.-C., Paller A.S., Giudice G., Pearson R., Fuchs E.
    J. Clin. Invest. 93:1533-1542(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS EHK ARG-150; CYS-156 AND GLU-439, VARIANT SER-126.
  18. "Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE)."
    McLean W.H.I., Eady R.A.J., Dopping-Hepenstal P.J.C., McMillan J.R., Leigh I.M., Navsaria H.A., Higgins C., Harper J.I., Paige D.G., Morley S.M.
    J. Invest. Dermatol. 102:24-30(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS EHK PRO-156 AND SER-156.
  19. Cited for: VARIANT THR-150.
  20. "A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma."
    Joh G.-Y., Traupe H., Metze D., Nashan D., Huber M., Hohl D., Longley M.A., Rothnagel J.A., Roop D.R.
    J. Invest. Dermatol. 108:357-361(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AEI GLU-422.
  21. "A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma."
    Suga Y., Duncan K.O., Heald P.W., Roop D.R.
    J. Invest. Dermatol. 111:1220-1223(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AEI THR-446.
  22. Cited for: VARIANT EHK SER-160.

Entry informationi

Entry nameiK1C10_HUMAN
AccessioniPrimary (citable) accession number: P13645
Secondary accession number(s): Q14664, Q8N175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 24, 2009
Last modified: October 29, 2014
This is version 157 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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