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Protein

Keratin, type I cytoskeletal 10

Gene

KRT10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of epidermis Source: UniProtKB

GO - Biological processi

  • keratinocyte differentiation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 10
Alternative name(s):
Cytokeratin-10
Short name:
CK-10
Keratin-10
Short name:
K10
Gene namesi
Name:KRT10
Synonyms:KPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6413. KRT10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • intermediate filament Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

Epidermolytic hyperkeratosis (EHK)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
See also OMIM:113800
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501M → R in EHK. 2 Publications
Corresponds to variant rs58901407 [ dbSNP | Ensembl ].
VAR_010506
Natural varianti150 – 1501M → T in EHK; also found in a patient with hyperkeratotic epidermal nevi due to genetic mosaicism. 2 Publications
Corresponds to variant rs58901407 [ dbSNP | Ensembl ].
VAR_010507
Natural varianti154 – 1541N → H in EHK. 1 Publication
Corresponds to variant rs57784225 [ dbSNP | Ensembl ].
VAR_003826
Natural varianti156 – 1561R → C in EHK. 4 Publications
Corresponds to variant rs58852768 [ dbSNP | Ensembl ].
VAR_003828
Natural varianti156 – 1561R → H in EHK. 5 Publications
Corresponds to variant rs58075662 [ dbSNP | Ensembl ].
VAR_003827
Natural varianti156 – 1561R → P in EHK. 1 Publication
Corresponds to variant rs58075662 [ dbSNP | Ensembl ].
VAR_003829
Natural varianti156 – 1561R → S in EHK. 1 Publication
Corresponds to variant rs58852768 [ dbSNP | Ensembl ].
VAR_003830
Natural varianti160 – 1601Y → D in EHK; severe phenotype. 1 Publication
Corresponds to variant rs58414354 [ dbSNP | Ensembl ].
VAR_003831
Natural varianti160 – 1601Y → N in EHK; severe phenotype. 1 Publication
VAR_010508
Natural varianti160 – 1601Y → S in EHK; severe phenotype. 1 Publication
Corresponds to variant rs58735429 [ dbSNP | Ensembl ].
VAR_010509
Natural varianti161 – 1611L → S in EHK. 1 Publication
Corresponds to variant rs60118264 [ dbSNP | Ensembl ].
VAR_003832
Natural varianti439 – 4391K → E in EHK; mild phenotype. 1 Publication
Corresponds to variant rs61434181 [ dbSNP | Ensembl ].
VAR_010510
Natural varianti442 – 4421L → Q in EHK. 1 Publication
Corresponds to variant rs58026994 [ dbSNP | Ensembl ].
VAR_003833
Natural varianti449 – 4491Y → C in EHK. 1 Publication
Corresponds to variant rs267607383 [ dbSNP | Ensembl ].
VAR_071985
Ichthyosis annular epidermolytic (AEI)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
See also OMIM:607602
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti422 – 4221R → E in AEI; requires 2 nucleotide substitutions. 1 Publication
Corresponds to variant rs59075499 [ dbSNP | Ensembl ].
VAR_033145
Natural varianti446 – 4461I → T in AEI. 1 Publication
Corresponds to variant rs62651994 [ dbSNP | Ensembl ].
VAR_010511
Erythroderma, ichthyosiform, congenital reticular (CRIE)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare skin condition characterized by slowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. The condition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearing in late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis, and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloid deposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of fine filaments in the upper epidermis.
See also OMIM:609165

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

MalaCardsiKRT10.
MIMi113800. phenotype.
607602. phenotype.
609165. phenotype.
Orphaneti281139. Annular epidermolytic ichthyosis.
281190. Congenital reticular ichthyosiform erythroderma.
312. Epidermolytic ichthyosis.
PharmGKBiPA30200.

Polymorphism and mutation databases

BioMutaiKRT10.
DMDMi269849769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Keratin, type I cytoskeletal 10PRO_0000063642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineCombined sources
Modified residuei16 – 161PhosphoserineCombined sources
Modified residuei42 – 421PhosphoserineCombined sources
Modified residuei53 – 531PhosphoserineCombined sources
Modified residuei56 – 561PhosphoserineCombined sources
Modified residuei170 – 1701PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP13645.
MaxQBiP13645.
PaxDbiP13645.
PeptideAtlasiP13645.
PRIDEiP13645.
TopDownProteomicsiP13645.

2D gel databases

REPRODUCTION-2DPAGEP13645.
SWISS-2DPAGEP13645.

PTM databases

iPTMnetiP13645.
PhosphoSiteiP13645.
SwissPalmiP13645.

Expressioni

Tissue specificityi

Seen in all suprabasal cell layers including stratum corneum.

Gene expression databases

BgeeiENSG00000186395.
CleanExiHS_KRT10.
GenevisibleiP13645. HS.

Organism-specific databases

HPAiCAB000132.
HPA012014.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.

Protein-protein interaction databases

BioGridi110056. 59 interactions.
IntActiP13645. 19 interactions.
MINTiMINT-1132575.
STRINGi9606.ENSP00000269576.

Structurei

Secondary structure

1
584
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi479 – 4813Combined sources
Beta strandi483 – 4864Combined sources
Beta strandi500 – 5089Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ASWX-ray2.60B473-487[»]
4F1ZX-ray2.30Q499-512[»]
4ZRYX-ray3.30A337-456[»]
ProteinModelPortaliP13645.
SMRiP13645. Positions 145-287, 313-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 145145HeadAdd
BLAST
Regioni146 – 456311RodAdd
BLAST
Regioni146 – 18136Coil 1AAdd
BLAST
Regioni182 – 20221Linker 1Add
BLAST
Regioni203 – 29492Coil 1BAdd
BLAST
Regioni295 – 31723Linker 12Add
BLAST
Regioni318 – 456139Coil 2Add
BLAST
Regioni457 – 584128TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 575559Gly-richAdd
BLAST
Compositional biasi477 – 579103Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJX. Eukaryota.
ENOG410YDXS. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP13645.
KOiK07604.
OMAiHGNSHQG.
OrthoDBiEOG091G087I.
PhylomeDBiP13645.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRYSSSKH YSSSRSGGGG GGGGCGGGGG VSSLRISSSK GSLGGGFSSG
60 70 80 90 100
GFSGGSFSRG SSGGGCFGGS SGGYGGLGGF GGGSFRGSYG SSSFGGSYGG
110 120 130 140 150
IFGGGSFGGG SFGGGSFGGG GFGGGGFGGG FGGGFGGDGG LLSGNEKVTM
160 170 180 190 200
QNLNDRLASY LDKVRALEES NYELEGKIKE WYEKHGNSHQ GEPRDYSKYY
210 220 230 240 250
KTIDDLKNQI LNLTTDNANI LLQIDNARLA ADDFRLKYEN EVALRQSVEA
260 270 280 290 300
DINGLRRVLD ELTLTKADLE MQIESLTEEL AYLKKNHEEE MKDLRNVSTG
310 320 330 340 350
DVNVEMNAAP GVDLTQLLNN MRSQYEQLAE QNRKDAEAWF NEKSKELTTE
360 370 380 390 400
IDNNIEQISS YKSEITELRR NVQALEIELQ SQLALKQSLE ASLAETEGRY
410 420 430 440 450
CVQLSQIQAQ ISALEEQLQQ IRAETECQNT EYQQLLDIKI RLENEIQTYR
460 470 480 490 500
SLLEGEGSSG GGGRGGGSFG GGYGGGSSGG GSSGGGHGGG HGGSSGGGYG
510 520 530 540 550
GGSSGGGSSG GGYGGGSSSG GHGGSSSGGY GGGSSGGGGG GYGGGSSGGG
560 570 580
SSSGGGYGGG SSSGGHKSSS SGSVGESSSK GPRY
Length:584
Mass (Da):58,827
Last modified:November 24, 2009 - v6
Checksum:i4941ECD2AE46D417
GO

Sequence cautioni

The sequence AAA59468 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 113KHY → SKQF in AAA60544 (PubMed:2459124).Curated
Sequence conflicti24 – 318Missing in AAA60544 (PubMed:2459124).Curated
Sequence conflicti86 – 861R → H in CAA32649 (PubMed:2464696).Curated
Sequence conflicti106 – 1061S → N in CAA32649 (PubMed:2464696).Curated
Sequence conflicti181 – 1844WYEK → RYDQ in AAA60544 (PubMed:2459124).Curated
Sequence conflicti189 – 1891H → R in AAA60544 (PubMed:2459124).Curated
Sequence conflicti197 – 1971S → G in AAA59199 (PubMed:1378806).Curated
Sequence conflicti266 – 2661K → Q in AAA60544 (PubMed:2459124).Curated
Sequence conflicti279 – 2802EL → YV in AAA59468 (PubMed:2448602).Curated
Sequence conflicti287 – 2871H → R in AAA60544 (PubMed:2459124).Curated
Sequence conflicti293 – 2931D → H in AAA60544 (PubMed:2459124).Curated
Sequence conflicti312 – 3121V → I in AAA59468 (PubMed:2448602).Curated
Sequence conflicti323 – 3231S → N in AAA60544 (PubMed:2459124).Curated
Sequence conflicti340 – 3401F → V in AAA59468 (PubMed:2448602).Curated
Sequence conflicti374 – 3741A → R in AAA59468 (PubMed:2448602).Curated
Sequence conflicti408 – 4081Q → H in CAA32649 (PubMed:2464696).Curated
Sequence conflicti420 – 4201Q → E in AAA60544 (PubMed:2459124).Curated
Sequence conflicti436 – 4361L → T in AAA60544 (PubMed:2459124).Curated
Sequence conflicti451 – 4511S → G in AAA59199 (PubMed:1378806).Curated
Sequence conflicti460 – 4612GG → RS in AAA59468 (PubMed:2448602).Curated
Sequence conflicti477 – 4771S → T in AAA59468 (PubMed:2448602).Curated
Sequence conflicti482 – 4821S → T in AAA59468 (PubMed:2448602).Curated
Sequence conflicti487 – 4904Missing in AAA59199 (PubMed:1378806).Curated
Sequence conflicti491 – 51626Missing in AAA60544 (PubMed:2459124).CuratedAdd
BLAST
Sequence conflicti503 – 5031S → T in AAA59468 (PubMed:2448602).Curated
Sequence conflicti508 – 5081S → T in AAA59468 (PubMed:2448602).Curated
Sequence conflicti513 – 5197YGGGSSS → LRGELH in AAA59468 (PubMed:2448602).Curated
Sequence conflicti523 – 5275GGSSS → AHST in AAA59468 (PubMed:2448602).Curated
Sequence conflicti524 – 5241G → GGSSSGGHGG in CAA32649 (PubMed:2464696).Curated
Sequence conflicti534 – 5341S → N in AAA59468 (PubMed:2448602).Curated
Sequence conflicti535 – 5351S → F in AAA60544 (PubMed:2459124).Curated
Sequence conflicti542 – 5465YGGGS → LRGRH in AAA59468 (PubMed:2448602).Curated
Sequence conflicti565 – 5651G → GGYGGGSSSGG in AAA60544 (PubMed:2459124).Curated

Polymorphismi

A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti101 – 1011I → S.2 Publications
Corresponds to variant rs4261597 [ dbSNP | Ensembl ].
VAR_058202
Natural varianti126 – 1261G → S.2 Publications
Corresponds to variant rs77919366 [ dbSNP | Ensembl ].
VAR_010505
Natural varianti150 – 1501M → R in EHK. 2 Publications
Corresponds to variant rs58901407 [ dbSNP | Ensembl ].
VAR_010506
Natural varianti150 – 1501M → T in EHK; also found in a patient with hyperkeratotic epidermal nevi due to genetic mosaicism. 2 Publications
Corresponds to variant rs58901407 [ dbSNP | Ensembl ].
VAR_010507
Natural varianti154 – 1541N → H in EHK. 1 Publication
Corresponds to variant rs57784225 [ dbSNP | Ensembl ].
VAR_003826
Natural varianti156 – 1561R → C in EHK. 4 Publications
Corresponds to variant rs58852768 [ dbSNP | Ensembl ].
VAR_003828
Natural varianti156 – 1561R → H in EHK. 5 Publications
Corresponds to variant rs58075662 [ dbSNP | Ensembl ].
VAR_003827
Natural varianti156 – 1561R → P in EHK. 1 Publication
Corresponds to variant rs58075662 [ dbSNP | Ensembl ].
VAR_003829
Natural varianti156 – 1561R → S in EHK. 1 Publication
Corresponds to variant rs58852768 [ dbSNP | Ensembl ].
VAR_003830
Natural varianti160 – 1601Y → D in EHK; severe phenotype. 1 Publication
Corresponds to variant rs58414354 [ dbSNP | Ensembl ].
VAR_003831
Natural varianti160 – 1601Y → N in EHK; severe phenotype. 1 Publication
VAR_010508
Natural varianti160 – 1601Y → S in EHK; severe phenotype. 1 Publication
Corresponds to variant rs58735429 [ dbSNP | Ensembl ].
VAR_010509
Natural varianti161 – 1611L → S in EHK. 1 Publication
Corresponds to variant rs60118264 [ dbSNP | Ensembl ].
VAR_003832
Natural varianti422 – 4221R → E in AEI; requires 2 nucleotide substitutions. 1 Publication
Corresponds to variant rs59075499 [ dbSNP | Ensembl ].
VAR_033145
Natural varianti439 – 4391K → E in EHK; mild phenotype. 1 Publication
Corresponds to variant rs61434181 [ dbSNP | Ensembl ].
VAR_010510
Natural varianti442 – 4421L → Q in EHK. 1 Publication
Corresponds to variant rs58026994 [ dbSNP | Ensembl ].
VAR_003833
Natural varianti446 – 4461I → T in AEI. 1 Publication
Corresponds to variant rs62651994 [ dbSNP | Ensembl ].
VAR_010511
Natural varianti449 – 4491Y → C in EHK. 1 Publication
Corresponds to variant rs267607383 [ dbSNP | Ensembl ].
VAR_071985
Natural varianti487 – 4871H → Y.4 Publications
Corresponds to variant rs17855579 [ dbSNP | Ensembl ].
VAR_060723

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04029 mRNA. Translation: AAA60544.1.
X14487 Genomic DNA. Translation: CAA32649.1.
AC090283 mRNA. No translation available.
BC034697 mRNA. Translation: AAH34697.1.
M19156 mRNA. Translation: AAA59468.1. Different initiation.
L20218 Genomic DNA. Translation: AAB59438.1.
L20219 Genomic DNA. Translation: AAB59439.1.
M77663 mRNA. Translation: AAA59199.1.
CCDSiCCDS11377.1.
PIRiA31994.
S02158. KRHU0.
RefSeqiNP_000412.3. NM_000421.3.
UniGeneiHs.99936.

Genome annotation databases

EnsembliENST00000269576; ENSP00000269576; ENSG00000186395.
GeneIDi3858.
KEGGihsa:3858.
UCSCiuc002hvi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-10 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04029 mRNA. Translation: AAA60544.1.
X14487 Genomic DNA. Translation: CAA32649.1.
AC090283 mRNA. No translation available.
BC034697 mRNA. Translation: AAH34697.1.
M19156 mRNA. Translation: AAA59468.1. Different initiation.
L20218 Genomic DNA. Translation: AAB59438.1.
L20219 Genomic DNA. Translation: AAB59439.1.
M77663 mRNA. Translation: AAA59199.1.
CCDSiCCDS11377.1.
PIRiA31994.
S02158. KRHU0.
RefSeqiNP_000412.3. NM_000421.3.
UniGeneiHs.99936.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ASWX-ray2.60B473-487[»]
4F1ZX-ray2.30Q499-512[»]
4ZRYX-ray3.30A337-456[»]
ProteinModelPortaliP13645.
SMRiP13645. Positions 145-287, 313-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110056. 59 interactions.
IntActiP13645. 19 interactions.
MINTiMINT-1132575.
STRINGi9606.ENSP00000269576.

PTM databases

iPTMnetiP13645.
PhosphoSiteiP13645.
SwissPalmiP13645.

Polymorphism and mutation databases

BioMutaiKRT10.
DMDMi269849769.

2D gel databases

REPRODUCTION-2DPAGEP13645.
SWISS-2DPAGEP13645.

Proteomic databases

EPDiP13645.
MaxQBiP13645.
PaxDbiP13645.
PeptideAtlasiP13645.
PRIDEiP13645.
TopDownProteomicsiP13645.

Protocols and materials databases

DNASUi3858.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269576; ENSP00000269576; ENSG00000186395.
GeneIDi3858.
KEGGihsa:3858.
UCSCiuc002hvi.4. human.

Organism-specific databases

CTDi3858.
GeneCardsiKRT10.
HGNCiHGNC:6413. KRT10.
HPAiCAB000132.
HPA012014.
MalaCardsiKRT10.
MIMi113800. phenotype.
148080. gene.
607602. phenotype.
609165. phenotype.
neXtProtiNX_P13645.
Orphaneti281139. Annular epidermolytic ichthyosis.
281190. Congenital reticular ichthyosiform erythroderma.
312. Epidermolytic ichthyosis.
PharmGKBiPA30200.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGJX. Eukaryota.
ENOG410YDXS. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP13645.
KOiK07604.
OMAiHGNSHQG.
OrthoDBiEOG091G087I.
PhylomeDBiP13645.
TreeFamiTF332742.

Miscellaneous databases

ChiTaRSiKRT10. human.
GeneWikiiKeratin_10.
GenomeRNAii3858.
PROiP13645.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186395.
CleanExiHS_KRT10.
GenevisibleiP13645. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C10_HUMAN
AccessioniPrimary (citable) accession number: P13645
Secondary accession number(s): Q14664, Q8N175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 24, 2009
Last modified: September 7, 2016
This is version 178 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.