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P13640

- MT1G_HUMAN

UniProt

P13640 - MT1G_HUMAN

Protein

Metallothionein-1G

Gene

MT1G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi5 – 51Divalent metal cation; cluster B
    Metal bindingi7 – 71Divalent metal cation; cluster B
    Metal bindingi14 – 141Divalent metal cation; cluster B
    Metal bindingi16 – 161Divalent metal cation; cluster B
    Metal bindingi20 – 201Divalent metal cation; cluster B
    Metal bindingi22 – 221Divalent metal cation; cluster B
    Metal bindingi25 – 251Divalent metal cation; cluster B
    Metal bindingi27 – 271Divalent metal cation; cluster B
    Metal bindingi30 – 301Divalent metal cation; cluster B
    Metal bindingi34 – 341Divalent metal cation; cluster A
    Metal bindingi35 – 351Divalent metal cation; cluster A
    Metal bindingi37 – 371Divalent metal cation; cluster A
    Metal bindingi38 – 381Divalent metal cation; cluster A
    Metal bindingi42 – 421Divalent metal cation; cluster A
    Metal bindingi45 – 451Divalent metal cation; cluster A
    Metal bindingi49 – 491Divalent metal cation; cluster A
    Metal bindingi51 – 511Divalent metal cation; cluster A
    Metal bindingi58 – 581Divalent metal cation; cluster A
    Metal bindingi60 – 601Divalent metal cation; cluster A
    Metal bindingi61 – 611Divalent metal cation; cluster A

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to cadmium ion Source: UniProtKB
    2. cellular response to copper ion Source: UniProtKB
    3. cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
    4. cellular response to zinc ion Source: UniProtKB
    5. monocyte activation Source: UniProtKB
    6. monocyte differentiation Source: UniProtKB
    7. negative regulation of growth Source: UniProtKB

    Keywords - Ligandi

    Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-1G
    Short name:
    MT-1G
    Alternative name(s):
    Metallothionein-1K
    Short name:
    MT-1K
    Metallothionein-IG
    Short name:
    MT-IG
    Gene namesi
    Name:MT1G
    Synonyms:MT1K, MT1M
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:7399. MT1G.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31204.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6262Metallothionein-1GPRO_0000197238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP13640.
    PaxDbiP13640.
    PRIDEiP13640.

    PTM databases

    PhosphoSiteiP13640.

    Expressioni

    Gene expression databases

    ArrayExpressiP13640.
    BgeeiP13640.
    CleanExiHS_MT1G.
    HS_MT1M.
    GenevestigatoriP13640.

    Interactioni

    Subunit structurei

    Monomer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SPINK7P580623EBI-1182473,EBI-1182445

    Protein-protein interaction databases

    BioGridi110601. 3 interactions.
    IntActiP13640. 2 interactions.
    STRINGi9606.ENSP00000391397.

    Structurei

    3D structure databases

    ProteinModelPortaliP13640.
    SMRiP13640. Positions 1-62.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929BetaAdd
    BLAST
    Regioni31 – 6232AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG138665.
    HOGENOMiHOG000236262.
    InParanoidiP13640.
    KOiK14739.
    OMAiGCICKEP.
    OrthoDBiEOG7PZS1X.
    PhylomeDBiP13640.
    TreeFamiTF336054.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P13640-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPNCSCAAA GVSCTCASSC KCKECKCTSC KKSCCSCCPV GCAKCAQGCI   50
    CKGASEKCSC CA 62
    Length:62
    Mass (Da):6,141
    Last modified:February 7, 2006 - v2
    Checksum:iA1B390F5899DD040
    GO
    Isoform 2 (identifier: P13640-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         10-10: Missing.

    Show »
    Length:61
    Mass (Da):6,070
    Checksum:i7B0A61FF89CA94CC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei10 – 101Missing in isoform 2. 1 PublicationVSP_017230

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03910 Genomic DNA. Translation: AAA59873.1.
    BC020757 mRNA. Translation: AAH20757.1.
    S68954 mRNA. Translation: AAB30083.1.
    CCDSiCCDS10766.1. [P13640-2]
    PIRiA29236. SMHU1G.
    RefSeqiNP_005941.1. NM_005950.1. [P13640-2]
    UniGeneiHs.433391.

    Genome annotation databases

    EnsembliENST00000379811; ENSP00000369139; ENSG00000125144. [P13640-1]
    ENST00000444837; ENSP00000391397; ENSG00000125144. [P13640-2]
    GeneIDi4495.
    KEGGihsa:4495.
    UCSCiuc002eju.1. human. [P13640-2]

    Polymorphism databases

    DMDMi90109444.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03910 Genomic DNA. Translation: AAA59873.1 .
    BC020757 mRNA. Translation: AAH20757.1 .
    S68954 mRNA. Translation: AAB30083.1 .
    CCDSi CCDS10766.1. [P13640-2 ]
    PIRi A29236. SMHU1G.
    RefSeqi NP_005941.1. NM_005950.1. [P13640-2 ]
    UniGenei Hs.433391.

    3D structure databases

    ProteinModelPortali P13640.
    SMRi P13640. Positions 1-62.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110601. 3 interactions.
    IntActi P13640. 2 interactions.
    STRINGi 9606.ENSP00000391397.

    PTM databases

    PhosphoSitei P13640.

    Polymorphism databases

    DMDMi 90109444.

    Proteomic databases

    MaxQBi P13640.
    PaxDbi P13640.
    PRIDEi P13640.

    Protocols and materials databases

    DNASUi 4495.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379811 ; ENSP00000369139 ; ENSG00000125144 . [P13640-1 ]
    ENST00000444837 ; ENSP00000391397 ; ENSG00000125144 . [P13640-2 ]
    GeneIDi 4495.
    KEGGi hsa:4495.
    UCSCi uc002eju.1. human. [P13640-2 ]

    Organism-specific databases

    CTDi 4495.
    GeneCardsi GC16M056700.
    H-InvDB HIX0021664.
    HGNCi HGNC:7399. MT1G.
    MIMi 156353. gene.
    neXtProti NX_P13640.
    PharmGKBi PA31204.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG138665.
    HOGENOMi HOG000236262.
    InParanoidi P13640.
    KOi K14739.
    OMAi GCICKEP.
    OrthoDBi EOG7PZS1X.
    PhylomeDBi P13640.
    TreeFami TF336054.

    Miscellaneous databases

    ChiTaRSi MT1G. human.
    GeneWikii Metallothionein_1G.
    GenomeRNAii 4495.
    NextBioi 17383.
    PROi P13640.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13640.
    Bgeei P13640.
    CleanExi HS_MT1G.
    HS_MT1M.
    Genevestigatori P13640.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals."
      Foster R., Jahroudi N., Varshney U., Gedamu L.
      J. Biol. Chem. 263:11528-11535(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Structure and expression of the human metallothionein genes."
      Gedamu L., Varshney U., Jahroudi N., Foster R., Shworak N.W.
      Experientia Suppl. 52:361-372(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Hunziker P.E.
      Submitted (NOV-1993) to UniProtKB
      Cited for: PROTEIN SEQUENCE (ISOFORM 1).
      Tissue: Liver.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver.
    5. "Induction by zinc of specific metallothionein isoforms in human monocytes."
      Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M.
      Eur. J. Biochem. 220:105-110(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31 (ISOFORM 2), ACETYLATION AT MET-1.

    Entry informationi

    Entry nameiMT1G_HUMAN
    AccessioniPrimary (citable) accession number: P13640
    Secondary accession number(s): P80296
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Metallothioneins
      Classification of metallothioneins and list of entries
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3