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P13640

- MT1G_HUMAN

UniProt

P13640 - MT1G_HUMAN

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Protein

Metallothionein-1G

Gene
MT1G, MT1K, MT1M
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster B
Metal bindingi7 – 71Divalent metal cation; cluster B
Metal bindingi14 – 141Divalent metal cation; cluster B
Metal bindingi16 – 161Divalent metal cation; cluster B
Metal bindingi20 – 201Divalent metal cation; cluster B
Metal bindingi22 – 221Divalent metal cation; cluster B
Metal bindingi25 – 251Divalent metal cation; cluster B
Metal bindingi27 – 271Divalent metal cation; cluster B
Metal bindingi30 – 301Divalent metal cation; cluster B
Metal bindingi34 – 341Divalent metal cation; cluster A
Metal bindingi35 – 351Divalent metal cation; cluster A
Metal bindingi37 – 371Divalent metal cation; cluster A
Metal bindingi38 – 381Divalent metal cation; cluster A
Metal bindingi42 – 421Divalent metal cation; cluster A
Metal bindingi45 – 451Divalent metal cation; cluster A
Metal bindingi49 – 491Divalent metal cation; cluster A
Metal bindingi51 – 511Divalent metal cation; cluster A
Metal bindingi58 – 581Divalent metal cation; cluster A
Metal bindingi60 – 601Divalent metal cation; cluster A
Metal bindingi61 – 611Divalent metal cation; cluster A

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cellular response to cadmium ion Source: UniProtKB
  2. cellular response to copper ion Source: UniProtKB
  3. cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
  4. cellular response to zinc ion Source: UniProtKB
  5. monocyte activation Source: UniProtKB
  6. monocyte differentiation Source: UniProtKB
  7. negative regulation of growth Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1G
Short name:
MT-1G
Alternative name(s):
Metallothionein-1K
Short name:
MT-1K
Metallothionein-IG
Short name:
MT-IG
Gene namesi
Name:MT1G
Synonyms:MT1K, MT1M
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:7399. MT1G.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31204.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6262Metallothionein-1GPRO_0000197238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP13640.
PaxDbiP13640.
PRIDEiP13640.

PTM databases

PhosphoSiteiP13640.

Expressioni

Gene expression databases

ArrayExpressiP13640.
BgeeiP13640.
CleanExiHS_MT1G.
HS_MT1M.
GenevestigatoriP13640.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
SPINK7P580623EBI-1182473,EBI-1182445

Protein-protein interaction databases

BioGridi110601. 3 interactions.
IntActiP13640. 2 interactions.
STRINGi9606.ENSP00000391397.

Structurei

3D structure databases

ProteinModelPortaliP13640.
SMRiP13640. Positions 1-62.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929BetaAdd
BLAST
Regioni31 – 6232AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG138665.
HOGENOMiHOG000236262.
InParanoidiP13640.
KOiK14739.
OMAiGCICKEP.
OrthoDBiEOG7PZS1X.
PhylomeDBiP13640.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P13640-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDPNCSCAAA GVSCTCASSC KCKECKCTSC KKSCCSCCPV GCAKCAQGCI   50
CKGASEKCSC CA 62
Length:62
Mass (Da):6,141
Last modified:February 7, 2006 - v2
Checksum:iA1B390F5899DD040
GO
Isoform 2 (identifier: P13640-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: Missing.

Show »
Length:61
Mass (Da):6,070
Checksum:i7B0A61FF89CA94CC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei10 – 101Missing in isoform 2. VSP_017230

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03910 Genomic DNA. Translation: AAA59873.1.
BC020757 mRNA. Translation: AAH20757.1.
S68954 mRNA. Translation: AAB30083.1.
CCDSiCCDS10766.1. [P13640-2]
PIRiA29236. SMHU1G.
RefSeqiNP_005941.1. NM_005950.1. [P13640-2]
UniGeneiHs.433391.

Genome annotation databases

EnsembliENST00000379811; ENSP00000369139; ENSG00000125144. [P13640-1]
ENST00000444837; ENSP00000391397; ENSG00000125144. [P13640-2]
GeneIDi4495.
KEGGihsa:4495.
UCSCiuc002eju.1. human. [P13640-2]

Polymorphism databases

DMDMi90109444.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03910 Genomic DNA. Translation: AAA59873.1 .
BC020757 mRNA. Translation: AAH20757.1 .
S68954 mRNA. Translation: AAB30083.1 .
CCDSi CCDS10766.1. [P13640-2 ]
PIRi A29236. SMHU1G.
RefSeqi NP_005941.1. NM_005950.1. [P13640-2 ]
UniGenei Hs.433391.

3D structure databases

ProteinModelPortali P13640.
SMRi P13640. Positions 1-62.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110601. 3 interactions.
IntActi P13640. 2 interactions.
STRINGi 9606.ENSP00000391397.

PTM databases

PhosphoSitei P13640.

Polymorphism databases

DMDMi 90109444.

Proteomic databases

MaxQBi P13640.
PaxDbi P13640.
PRIDEi P13640.

Protocols and materials databases

DNASUi 4495.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379811 ; ENSP00000369139 ; ENSG00000125144 . [P13640-1 ]
ENST00000444837 ; ENSP00000391397 ; ENSG00000125144 . [P13640-2 ]
GeneIDi 4495.
KEGGi hsa:4495.
UCSCi uc002eju.1. human. [P13640-2 ]

Organism-specific databases

CTDi 4495.
GeneCardsi GC16M056700.
H-InvDB HIX0021664.
HGNCi HGNC:7399. MT1G.
MIMi 156353. gene.
neXtProti NX_P13640.
PharmGKBi PA31204.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG138665.
HOGENOMi HOG000236262.
InParanoidi P13640.
KOi K14739.
OMAi GCICKEP.
OrthoDBi EOG7PZS1X.
PhylomeDBi P13640.
TreeFami TF336054.

Miscellaneous databases

ChiTaRSi MT1G. human.
GeneWikii Metallothionein_1G.
GenomeRNAii 4495.
NextBioi 17383.
PROi P13640.
SOURCEi Search...

Gene expression databases

ArrayExpressi P13640.
Bgeei P13640.
CleanExi HS_MT1G.
HS_MT1M.
Genevestigatori P13640.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals."
    Foster R., Jahroudi N., Varshney U., Gedamu L.
    J. Biol. Chem. 263:11528-11535(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Structure and expression of the human metallothionein genes."
    Gedamu L., Varshney U., Jahroudi N., Foster R., Shworak N.W.
    Experientia Suppl. 52:361-372(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Hunziker P.E.
    Submitted (NOV-1993) to UniProtKB
    Cited for: PROTEIN SEQUENCE (ISOFORM 1).
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  5. "Induction by zinc of specific metallothionein isoforms in human monocytes."
    Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M.
    Eur. J. Biochem. 220:105-110(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31 (ISOFORM 2), ACETYLATION AT MET-1.

Entry informationi

Entry nameiMT1G_HUMAN
AccessioniPrimary (citable) accession number: P13640
Secondary accession number(s): P80296
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 7, 2006
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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