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P13640 (MT1G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-1G

Short name=MT-1G
Alternative name(s):
Metallothionein-1K
Short name=MT-1K
Metallothionein-IG
Short name=MT-IG
Gene names
Name:MT1G
Synonyms:MT1K, MT1M
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length62 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Subunit structure

Monomer.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SPINK7P580623EBI-1182473,EBI-1182445

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P13640-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P13640-2)

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6262Metallothionein-1G
PRO_0000197238

Regions

Region1 – 2929Beta
Region31 – 6232Alpha

Sites

Metal binding51Divalent metal cation; cluster B
Metal binding71Divalent metal cation; cluster B
Metal binding141Divalent metal cation; cluster B
Metal binding161Divalent metal cation; cluster B
Metal binding201Divalent metal cation; cluster B
Metal binding221Divalent metal cation; cluster B
Metal binding251Divalent metal cation; cluster B
Metal binding271Divalent metal cation; cluster B
Metal binding301Divalent metal cation; cluster B
Metal binding341Divalent metal cation; cluster A
Metal binding351Divalent metal cation; cluster A
Metal binding371Divalent metal cation; cluster A
Metal binding381Divalent metal cation; cluster A
Metal binding421Divalent metal cation; cluster A
Metal binding451Divalent metal cation; cluster A
Metal binding491Divalent metal cation; cluster A
Metal binding511Divalent metal cation; cluster A
Metal binding581Divalent metal cation; cluster A
Metal binding601Divalent metal cation; cluster A
Metal binding611Divalent metal cation; cluster A

Amino acid modifications

Modified residue11N-acetylmethionine Ref.5

Natural variations

Alternative sequence101Missing in isoform 2.
VSP_017230

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 7, 2006. Version 2.
Checksum: A1B390F5899DD040

FASTA626,141
        10         20         30         40         50         60 
MDPNCSCAAA GVSCTCASSC KCKECKCTSC KKSCCSCCPV GCAKCAQGCI CKGASEKCSC 


CA 

« Hide

Isoform 2 [UniParc].

Checksum: 7B0A61FF89CA94CC
Show »

FASTA616,070

References

« Hide 'large scale' references
[1]"Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals."
Foster R., Jahroudi N., Varshney U., Gedamu L.
J. Biol. Chem. 263:11528-11535(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Structure and expression of the human metallothionein genes."
Gedamu L., Varshney U., Jahroudi N., Foster R., Shworak N.W.
Experientia Suppl. 52:361-372(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Hunziker P.E.
Submitted (NOV-1993) to UniProtKB
Cited for: PROTEIN SEQUENCE (ISOFORM 1).
Tissue: Liver.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Liver.
[5]"Induction by zinc of specific metallothionein isoforms in human monocytes."
Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M.
Eur. J. Biochem. 220:105-110(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31 (ISOFORM 2), ACETYLATION AT MET-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03910 Genomic DNA. Translation: AAA59873.1.
BC020757 mRNA. Translation: AAH20757.1.
S68954 mRNA. Translation: AAB30083.1.
CCDSCCDS10766.1. [P13640-2]
PIRSMHU1G. A29236.
RefSeqNP_005941.1. NM_005950.1. [P13640-2]
UniGeneHs.433391.

3D structure databases

ProteinModelPortalP13640.
SMRP13640. Positions 1-62.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110601. 3 interactions.
IntActP13640. 2 interactions.
STRING9606.ENSP00000391397.

PTM databases

PhosphoSiteP13640.

Polymorphism databases

DMDM90109444.

Proteomic databases

MaxQBP13640.
PaxDbP13640.
PRIDEP13640.

Protocols and materials databases

DNASU4495.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379811; ENSP00000369139; ENSG00000125144. [P13640-1]
ENST00000444837; ENSP00000391397; ENSG00000125144. [P13640-2]
GeneID4495.
KEGGhsa:4495.
UCSCuc002eju.1. human. [P13640-2]

Organism-specific databases

CTD4495.
GeneCardsGC16M056700.
H-InvDBHIX0021664.
HGNCHGNC:7399. MT1G.
MIM156353. gene.
neXtProtNX_P13640.
PharmGKBPA31204.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG138665.
HOGENOMHOG000236262.
InParanoidP13640.
KOK14739.
OMAGCICKEP.
OrthoDBEOG7PZS1X.
PhylomeDBP13640.
TreeFamTF336054.

Gene expression databases

ArrayExpressP13640.
BgeeP13640.
CleanExHS_MT1G.
HS_MT1M.
GenevestigatorP13640.

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. SSF57868. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMT1G. human.
GeneWikiMetallothionein_1G.
GenomeRNAi4495.
NextBio17383.
PROP13640.
SOURCESearch...

Entry information

Entry nameMT1G_HUMAN
AccessionPrimary (citable) accession number: P13640
Secondary accession number(s): P80296
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 7, 2006
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Metallothioneins

Classification of metallothioneins and list of entries

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM