Reviewed, UniProtKB/Swiss-Prot P13634 (CAH1_MOUSE)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 1
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase I
      Short name=CA-I
    Carbonate dehydratase I

Gene names

Name:	Ca1
Synonyms:	Car1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 261	260	Carbonic anhydrase 1		PRO_0000077413
Sites
	Metal binding	95	1	Zinc; catalytic
	Metal binding	97	1	Zinc; catalytic
	Metal binding	120	1	Zinc; catalytic
Experimental info
	Sequence conflict	238	1	S → P Ref.3
	Sequence conflict	238	1	S → P Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P13634-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 814AAA7BA38EDF0C	FASTA	261	28,321
	10 20 30 40 50 60 MASADWGYGS ENGPDQWSKL YPIANGNNQS PIDIKTSEAN HDSSLKPLSI SYNPATAKEI 70 80 90 100 110 120 VNVGHSFHVI FDDSSNQSVL KGGPLADSYR LTQFHFHWGN SNDHGSEHTV DGTRYSGELH 130 140 150 160 170 180 LVHWNSAKYS SASEAISKAD GLAILGVLMK VGPANPSLQK VLDALNSVKT KGKRAPFTNF 190 200 210 220 230 240 DPSSLLPSSL DYWTYFGSLT HPPLHESVTW VICKDSISLS PEQLAQLRGL LSSAEGESAV 250 260 PVLSNHRPPQ PLKGRTVRAS F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular evolution of the carbonic anhydrase genes: calculation of divergence time for mouse carbonic anhydrase I and II." Fraser P.J., Curtis P.J. J. Mol. Evol. 23:294-299(1986) [PubMed: 3104601] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The mouse carbonic anhydrase I gene contains two tissue-specific promoters." Fraser P.J., Cummings P., Curtis P.J. Mol. Cell. Biol. 9:3308-3313(1989) [PubMed: 2571923] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Spleen.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M32452 mRNA. Translation: AAA37354.1. L36655 , M28197, L36650, L36651, L36652, L36653, L36654 Genomic DNA. Translation: AAA50291.1. AK003066 mRNA. Translation: BAB22544.1. BC011223 mRNA. Translation: AAH11223.1.
IPI	IPI00230320.
PIR	A26344.
RefSeq	NP_001077426.1. NP_033929.2.
UniGene	Mm.273195
3D structure databases
HSSP	HSSP built from PDB template 1BZM based on UniProtKB P00915.
SMR	P13634. Positions 5-261.
ModBase	Search...
Protein-protein interaction databases
STRING	P13634.
PTM databases
PhosphoSite	P13634.
Proteomic databases
PRIDE	P13634.
Genome annotation databases
Ensembl	ENSMUST00000094365; ENSMUSP00000091925; ENSMUSG00000027556; Mus musculus. [Genome view]
GeneID	12346.
KEGG	mmu:12346.
Organism-specific databases
CTD	12346.
MGI	MGI:88268. Car1.
Phylogenomic databases
HOGENOM	P13634.
HOVERGEN	P13634.
Enzyme and pathway databases
BRENDA	4.2.1.1. 244.
Gene expression databases
ArrayExpress	P13634.
Bgee	P13634.
CleanEx	MM_CAR1.
Genevestigator	P13634.
GermOnline	ENSMUSG00000027556. Mus musculus.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018442. Carbonic_anhydrase_CA1. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF30. Carbonic_anhydrase_CA1. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
ProDom	PD000865. Euk_COanhd. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	280986.
SOURCE	Search...

Entry information

Entry name

CAH1_MOUSE

Accession

Primary (citable) accession number: P13634
Secondary accession number(s): Q9DC84

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 23, 2007
Last modified:	October 13, 2009
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)