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Protein

C4-dicarboxylate transport transcriptional regulatory protein DctD

Gene

dctD

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system DctB/DctD involved in the transport of C4-dicarboxylates. When activated by DctB acts in conjunction with sigma-54 to activate the transcription of dctA.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi173 – 180ATPPROSITE-ProRule annotation8
Nucleotide bindingi236 – 245ATPPROSITE-ProRule annotation10
DNA bindingi417 – 436H-T-H motifAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C4-dicarboxylate transport transcriptional regulatory protein DctD
Gene namesi
Name:dctD
Ordered Locus Names:RB1525
ORF Names:SMb20613
Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymB

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB04077. Glycerol.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810891 – 460C4-dicarboxylate transport transcriptional regulatory protein DctDAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by DctB.1 Publication

Keywords - PTMi

Phosphoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-1506790.

Structurei

Secondary structure

1460
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 10Combined sources5
Helixi14 – 26Combined sources13
Beta strandi30 – 35Combined sources6
Helixi37 – 42Combined sources6
Beta strandi50 – 56Combined sources7
Beta strandi59 – 61Combined sources3
Helixi63 – 73Combined sources11
Beta strandi79 – 83Combined sources5
Helixi85 – 87Combined sources3
Helixi88 – 96Combined sources9
Beta strandi101 – 106Combined sources6
Helixi109 – 142Combined sources34

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L5YX-ray2.10A/B2-143[»]
1L5ZX-ray2.00A2-143[»]
1QKKX-ray1.70A2-143[»]
ProteinModelPortaliP13632.
SMRiP13632.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13632.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 120Response regulatoryPROSITE-ProRule annotationAdd BLAST115
Domaini145 – 374Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST230

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni332 – 345Inter-domain linkerSequence analysisAdd BLAST14

Phylogenomic databases

KOiK10126.
OMAiMPISMQV.

Family and domain databases

CDDicd00156. REC. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011006. CheY-like_superfamily.
IPR009057. Homeobox-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
PfamiView protein in Pfam
PF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00448. REC. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS50110. RESPONSE_REGULATORY. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.

Sequencei

Sequence statusi: Complete.

P13632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAPSVFLI DDDRDLRKAM QQTLELAGFT VSSFASATEA LAGLSADFAG
60 70 80 90 100
IVISDIRMPG MDGLALFRKI LALDPDLPMI LVTGHGDIPM AVQAIQDGAY
110 120 130 140 150
DFIAKPFAAD RLVQSARRAE EKRRLVMENR SLRRAAEAAS EGLPLIGQTP
160 170 180 190 200
VMERLRQTLK HIADTDVDVL VAGETGSGKE VVATLLHQWS RRRTGNFVAL
210 220 230 240 250
NCGALPETVI ESELFGHEPG AFTGAVKKRI GRIEHASGGT LFLDEIEAMP
260 270 280 290 300
PATQVKMLRV LEAREITPLG TNLTRPVDIR VVAAAKVDLG DPAARGDFRE
310 320 330 340 350
DLYYRLNVVT LSIPPLRERR DDIPLLFSHF LARASERFGR EVPAISAAMR
360 370 380 390 400
AYLATHSWPG NVRELSHFAE RVALGVEGNL GVPAAAPASS GATLPERLER
410 420 430 440 450
YEADILKQAL TAHCGDVKET LQALGIPRKT FYDKLQRHGI NRADYVERAG
460
PGRPNAISKT
Length:460
Mass (Da):50,061
Last modified:October 24, 2001 - v3
Checksum:iF6B9356EA089B38C
GO

Sequence cautioni

The sequence AAA63514 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43G → E in AAA63513 (PubMed:2134335).Curated1
Sequence conflicti43G → E in AAA63514 (PubMed:2134335).Curated1
Sequence conflicti68R → G (PubMed:2134335).Curated1
Sequence conflicti70I → V (PubMed:2134335).Curated1
Sequence conflicti151V → A in AAA63513 (PubMed:2134335).Curated1
Sequence conflicti151V → A in AAA63514 (PubMed:2134335).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03683 Genomic DNA. Translation: AAA63513.1.
J03683 Genomic DNA. Translation: AAA63514.1. Different initiation.
M26531 Genomic DNA. Translation: AAA26250.1.
AL591985 Genomic DNA. Translation: CAC49925.1.
PIRiC33586.
E96032.
RefSeqiNP_438065.1. NC_003078.1.
WP_003529421.1. NC_003078.1.

Genome annotation databases

EnsemblBacteriaiCAC49925; CAC49925; SM_b20613.
GeneIDi1237857.
KEGGisme:SM_b20613.
PATRICifig|266834.11.peg.6450.

Similar proteinsi

Entry informationi

Entry nameiDCTD_RHIME
AccessioniPrimary (citable) accession number: P13632
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 24, 2001
Last modified: August 30, 2017
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references