Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P13631

- RARG_HUMAN

UniProt

P13631 - RARG_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Retinoic acid receptor gamma

Gene

RARG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi90 – 15566Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri90 – 11021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri126 – 15025NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: BHF-UCL
  2. retinoic acid receptor activity Source: Ensembl
  3. retinoid X receptor binding Source: BHF-UCL
  4. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  5. sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  6. steroid hormone receptor activity Source: InterPro
  7. zinc ion binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. canonical Wnt signaling pathway Source: BHF-UCL
  3. cellular response to retinoic acid Source: Ensembl
  4. embryonic camera-type eye development Source: Ensembl
  5. embryonic eye morphogenesis Source: BHF-UCL
  6. embryonic hindlimb morphogenesis Source: BHF-UCL
  7. face development Source: Ensembl
  8. gene expression Source: Reactome
  9. glandular epithelial cell development Source: Ensembl
  10. growth plate cartilage chondrocyte growth Source: Ensembl
  11. Harderian gland development Source: Ensembl
  12. multicellular organism growth Source: Ensembl
  13. negative regulation of apoptotic process Source: Ensembl
  14. negative regulation of cartilage development Source: Ensembl
  15. negative regulation of cell proliferation Source: BHF-UCL
  16. negative regulation of chondrocyte differentiation Source: Ensembl
  17. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  18. neural tube closure Source: Ensembl
  19. positive regulation of apoptotic process Source: BHF-UCL
  20. positive regulation of cell proliferation Source: Ensembl
  21. positive regulation of programmed cell death Source: BHF-UCL
  22. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  23. prostate gland epithelium morphogenesis Source: Ensembl
  24. regulation of cell size Source: BHF-UCL
  25. regulation of myelination Source: Ensembl
  26. response to retinoic acid Source: BHF-UCL
  27. retinal pigment epithelium development Source: Ensembl
  28. retinoic acid receptor signaling pathway Source: BHF-UCL
  29. trachea cartilage development Source: Ensembl
  30. transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiP13631.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor gamma
Short name:
RAR-gamma
Alternative name(s):
Nuclear receptor subfamily 1 group B member 3
Gene namesi
Name:RARG
Synonyms:NR1B3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9866. RARG.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: BHF-UCL
  2. nuclear chromatin Source: Ensembl
  3. nucleoplasm Source: Reactome
  4. nucleus Source: UniProtKB
  5. transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34227.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Retinoic acid receptor gammaPRO_0000053472Add
BLAST

Proteomic databases

MaxQBiP13631.
PaxDbiP13631.
PRIDEiP13631.

PTM databases

PhosphoSiteiP13631.

Expressioni

Gene expression databases

BgeeiP13631.
CleanExiHS_RARG.
ExpressionAtlasiP13631. baseline and differential.
GenevestigatoriP13631.

Organism-specific databases

HPAiHPA053883.

Interactioni

Subunit structurei

Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SORBS3O60504-22EBI-2568901,EBI-1222956

Protein-protein interaction databases

BioGridi111851. 32 interactions.
IntActiP13631. 13 interactions.
MINTiMINT-3007936.
STRINGi9606.ENSP00000332695.

Structurei

Secondary structure

1
454
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi184 – 20017Combined sources
Helixi204 – 2063Combined sources
Helixi224 – 24623Combined sources
Helixi251 – 2533Combined sources
Helixi256 – 27722Combined sources
Turni281 – 2844Combined sources
Beta strandi285 – 2873Combined sources
Beta strandi292 – 2954Combined sources
Helixi296 – 3027Combined sources
Helixi305 – 3073Combined sources
Helixi308 – 31811Combined sources
Helixi319 – 3213Combined sources
Helixi325 – 33612Combined sources
Helixi347 – 36822Combined sources
Helixi375 – 40127Combined sources
Beta strandi404 – 4063Combined sources
Helixi410 – 4167Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EXAX-ray1.59A178-423[»]
1EXXX-ray1.67A178-423[»]
1FCXX-ray1.47A183-417[»]
1FCYX-ray1.30A183-417[»]
1FCZX-ray1.38A183-417[»]
1FD0X-ray1.38A183-417[»]
2LBDX-ray2.06A178-423[»]
3LBDX-ray2.40A178-423[»]
4LBDX-ray2.50A178-423[»]
ProteinModelPortaliP13631.
SMRiP13631. Positions 89-419.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13631.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8989ModulatingAdd
BLAST
Regioni156 – 20146HingeAdd
BLAST
Regioni202 – 421220Ligand-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri90 – 11021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri126 – 15025NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG297448.
GeneTreeiENSGT00760000118837.
HOVERGENiHBG005606.
InParanoidiP13631.
KOiK08529.
OMAiRSPQPDQ.
OrthoDBiEOG738053.
PhylomeDBiP13631.
TreeFamiTF328382.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Isoforms differ only in their N-terminal regions.

Isoform 1 (identifier: P13631-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATNKERLFA AGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG
60 70 80 90 100
QPDLPKEMAS LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY
110 120 130 140 150
HYGVSSCEGC KGFFRRSIQK NMVYTCHRDK NCIINKVTRN RCQYCRLQKC
160 170 180 190 200
FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY ELSPQLEELI TKVSKAHQET
210 220 230 240 250
FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK IVEFAKRLPG
260 270 280 290 300
FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH
310 320 330 340 350
NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV
360 370 380 390 400
DKLQEPLLEA LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL
410 420 430 440 450
KMEIPGPMPP LIREMLENPE MFEDDSSQPG PHPNASSEDE VPGGQGKGGL

KSPA
Length:454
Mass (Da):50,342
Last modified:January 1, 1990 - v1
Checksum:i1EE27B22772D4AFD
GO
Isoform 2 (identifier: P13631-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MATNKERLFA...PDLPKEMASL → MYDCMETFAP...FAWPQPASLQ

Show »
Length:443
Mass (Da):49,308
Checksum:i4D709194F5111E86
GO
Isoform 3 (identifier: P13631-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.

Show »
Length:382
Mass (Da):42,926
Checksum:i37AF909319A4B140
GO
Isoform 4 (identifier: P13631-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: MATNKERLFA...YGVSSCEGCK → MLALPLPPCW...LPGRNPPACN

Note: No experimental confirmation available.

Show »
Length:432
Mass (Da):47,931
Checksum:iAA332A06D720ADB8
GO

Sequence cautioni

The sequence CAA40548.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181I → T in CAB60726. 1 PublicationCurated
Sequence conflicti172 – 1721K → R in AAG41594. 1 PublicationCurated
Sequence conflicti252 – 2521T → A in CAB60726. 1 PublicationCurated
Sequence conflicti342 – 3421M → V in BAH12478. (PubMed:14702039)Curated
Sequence conflicti421 – 4211M → L in CAB60726. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti427 – 4271S → L.
Corresponds to variant rs2229774 [ dbSNP | Ensembl ].
VAR_038554
Natural varianti430 – 4301G → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_036061

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111MATNK…CEGCK → MLALPLPPCWSGAPPGEEGE SAAGPWCFQHPVSLQAGSRC TTVWKRLPRVRDGCTGRPGP GPACCAEPPAAPVSPDLNLL PGRNPPACN in isoform 4. 1 PublicationVSP_044776Add
BLAST
Alternative sequencei1 – 7272Missing in isoform 3. 1 PublicationVSP_044777Add
BLAST
Alternative sequencei1 – 6161MATNK…EMASL → MYDCMETFAPGPRRLYGAAG PGAGLLRRATGGSCFAGLES FAWPQPASLQ in isoform 2. 2 PublicationsVSP_031080Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24857 mRNA. Translation: AAA52692.1.
M57707 mRNA. Translation: AAA63254.1.
M38258 mRNA. Translation: AAA60254.1.
AK297023 mRNA. Translation: BAH12478.1.
AK297277 mRNA. Translation: BAH12537.1.
AK316259 mRNA. Translation: BAH14630.1.
AC021072 Genomic DNA. No translation available.
AC073573 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96676.1.
BC093727 mRNA. Translation: AAH93727.1.
BC093729 mRNA. Translation: AAH93729.1.
M32074 mRNA. Translation: AAA60253.1.
X57280 Genomic DNA. Translation: CAA40548.1. Sequence problems.
AJ250835 Genomic DNA. Translation: CAB60726.1.
AY013703 Genomic DNA. Translation: AAG41594.2.
AY013704 Genomic DNA. Translation: AAG41595.1.
CCDSiCCDS41790.1. [P13631-2]
CCDS58236.1. [P13631-3]
CCDS58237.1. [P13631-4]
CCDS8850.1. [P13631-1]
PIRiA33903.
C35991.
RefSeqiNP_000957.1. NM_000966.5. [P13631-1]
NP_001036193.1. NM_001042728.2. [P13631-2]
NP_001230659.1. NM_001243730.1. [P13631-3]
NP_001230661.1. NM_001243732.1. [P13631-4]
XP_005269113.1. XM_005269056.2. [P13631-1]
XP_005269114.1. XM_005269057.1. [P13631-1]
UniGeneiHs.1497.
Hs.733399.

Genome annotation databases

EnsembliENST00000338561; ENSP00000343698; ENSG00000172819. [P13631-2]
ENST00000394426; ENSP00000377947; ENSG00000172819. [P13631-3]
ENST00000425354; ENSP00000388510; ENSG00000172819. [P13631-1]
ENST00000543726; ENSP00000444335; ENSG00000172819. [P13631-4]
GeneIDi5916.
KEGGihsa:5916.
UCSCiuc001sce.3. human. [P13631-1]
uc010sob.2. human.

Polymorphism databases

DMDMi133498.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Retinoic acid receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24857 mRNA. Translation: AAA52692.1 .
M57707 mRNA. Translation: AAA63254.1 .
M38258 mRNA. Translation: AAA60254.1 .
AK297023 mRNA. Translation: BAH12478.1 .
AK297277 mRNA. Translation: BAH12537.1 .
AK316259 mRNA. Translation: BAH14630.1 .
AC021072 Genomic DNA. No translation available.
AC073573 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96676.1 .
BC093727 mRNA. Translation: AAH93727.1 .
BC093729 mRNA. Translation: AAH93729.1 .
M32074 mRNA. Translation: AAA60253.1 .
X57280 Genomic DNA. Translation: CAA40548.1 . Sequence problems.
AJ250835 Genomic DNA. Translation: CAB60726.1 .
AY013703 Genomic DNA. Translation: AAG41594.2 .
AY013704 Genomic DNA. Translation: AAG41595.1 .
CCDSi CCDS41790.1. [P13631-2 ]
CCDS58236.1. [P13631-3 ]
CCDS58237.1. [P13631-4 ]
CCDS8850.1. [P13631-1 ]
PIRi A33903.
C35991.
RefSeqi NP_000957.1. NM_000966.5. [P13631-1 ]
NP_001036193.1. NM_001042728.2. [P13631-2 ]
NP_001230659.1. NM_001243730.1. [P13631-3 ]
NP_001230661.1. NM_001243732.1. [P13631-4 ]
XP_005269113.1. XM_005269056.2. [P13631-1 ]
XP_005269114.1. XM_005269057.1. [P13631-1 ]
UniGenei Hs.1497.
Hs.733399.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EXA X-ray 1.59 A 178-423 [» ]
1EXX X-ray 1.67 A 178-423 [» ]
1FCX X-ray 1.47 A 183-417 [» ]
1FCY X-ray 1.30 A 183-417 [» ]
1FCZ X-ray 1.38 A 183-417 [» ]
1FD0 X-ray 1.38 A 183-417 [» ]
2LBD X-ray 2.06 A 178-423 [» ]
3LBD X-ray 2.40 A 178-423 [» ]
4LBD X-ray 2.50 A 178-423 [» ]
ProteinModelPortali P13631.
SMRi P13631. Positions 89-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111851. 32 interactions.
IntActi P13631. 13 interactions.
MINTi MINT-3007936.
STRINGi 9606.ENSP00000332695.

Chemistry

BindingDBi P13631.
ChEMBLi CHEMBL2363071.
DrugBanki DB00459. Acitretin.
DB00210. Adapalene.
DB00523. Alitretinoin.
DB00799. Tazarotene.
DB00755. Tretinoin.
GuidetoPHARMACOLOGYi 592.

PTM databases

PhosphoSitei P13631.

Polymorphism databases

DMDMi 133498.

Proteomic databases

MaxQBi P13631.
PaxDbi P13631.
PRIDEi P13631.

Protocols and materials databases

DNASUi 5916.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338561 ; ENSP00000343698 ; ENSG00000172819 . [P13631-2 ]
ENST00000394426 ; ENSP00000377947 ; ENSG00000172819 . [P13631-3 ]
ENST00000425354 ; ENSP00000388510 ; ENSG00000172819 . [P13631-1 ]
ENST00000543726 ; ENSP00000444335 ; ENSG00000172819 . [P13631-4 ]
GeneIDi 5916.
KEGGi hsa:5916.
UCSCi uc001sce.3. human. [P13631-1 ]
uc010sob.2. human.

Organism-specific databases

CTDi 5916.
GeneCardsi GC12M053604.
H-InvDB HIX0129677.
HGNCi HGNC:9866. RARG.
HPAi HPA053883.
MIMi 180190. gene.
neXtProti NX_P13631.
PharmGKBi PA34227.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297448.
GeneTreei ENSGT00760000118837.
HOVERGENi HBG005606.
InParanoidi P13631.
KOi K08529.
OMAi RSPQPDQ.
OrthoDBi EOG738053.
PhylomeDBi P13631.
TreeFami TF328382.

Enzyme and pathway databases

Reactomei REACT_15525. Nuclear Receptor transcription pathway.
SignaLinki P13631.

Miscellaneous databases

ChiTaRSi RARG. human.
EvolutionaryTracei P13631.
GeneWikii Retinoic_acid_receptor_gamma.
GenomeRNAii 5916.
NextBioi 23030.
PROi P13631.
SOURCEi Search...

Gene expression databases

Bgeei P13631.
CleanExi HS_RARG.
ExpressionAtlasi P13631. baseline and differential.
Genevestigatori P13631.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A functional retinoic acid receptor encoded by the gene on human chromosome 12."
    Ishikawa T., Umesono K., Mangelsdorf D.J., Aburatani H., Stanger B.Z., Shibasaki Y., Imawari M., Evans R.M., Takaku F.
    Mol. Endocrinol. 4:837-844(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Genomic organization of the retinoic acid receptor gamma gene."
    Lehmann J.M., Hoffmann B., Pfahl M.
    Nucleic Acids Res. 19:573-578(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Brain, Tongue and Umbilical cord blood.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  8. "Murine isoforms of retinoic acid receptor gamma with specific patterns of expression."
    Kastner P., Krust A., Mendelsohn C., Garnier J.-M., Zelent A., Leroy P., Staub A., Chambon P.
    Proc. Natl. Acad. Sci. U.S.A. 87:2700-2704(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-63 (ISOFORM 2).
  9. "RAR-gamma-2 expression is regulated through a retinoic acid response element embedded in Sp1 sites."
    Lehmann J.M., Zhang X.K., Pfahl M.
    Mol. Cell. Biol. 12:2976-2985(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-55, ALTERNATIVE SPLICING.
    Tissue: Placenta.
  10. Gebhard W.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 74-454.
    Tissue: Lung carcinoma.
  11. "Genomic organization of the human retinoic acid receptor gamma gene."
    Xu H., Clifford J.L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-191 AND 394-411.
  12. "Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid."
    Renaud J.-P., Rochel N., Ruff M., Vivat V., Chambon P., Gronemeyer H., Moras D.
    Nature 378:681-689(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 178-423.
  13. "Conformational adaptation of agonists to the human nuclear receptor RAR gamma."
    Klaholz B.P., Renaud J.-P., Mitschler A., Zusi C., Chambon P., Gronemeyer H., Moras D.
    Nat. Struct. Biol. 5:199-202(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 178-423.
  14. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-430.

Entry informationi

Entry nameiRARG_HUMAN
AccessioniPrimary (citable) accession number: P13631
Secondary accession number(s): B7Z492
, B7Z4F1, B7ZAE4, J3KNP6, P22932, Q15281, Q52LZ8, Q9BYX8, Q9H1I3, Q9UJ38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 26, 2014
This is version 180 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3