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Protein

ATP synthase F(0) complex subunit B1, mitochondrial

Gene

ATP5F1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-163210 Formation of ATP by chemiosmotic coupling
R-BTA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit B1, mitochondrial
Alternative name(s):
ATP synthase subunit b
Short name:
ATPase subunit b
Gene namesi
Name:ATP5F1
Synonyms:ATP5F
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:26303 ATP5PB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42Mitochondrion2 PublicationsAdd BLAST42
ChainiPRO_000007167143 – 256ATP synthase F(0) complex subunit B1, mitochondrialAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131N6-succinyllysineBy similarity1
Modified residuei139N6-acetyllysineBy similarity1
Modified residuei154N6-acetyllysineBy similarity1
Modified residuei162N6-acetyllysineBy similarity1
Modified residuei221N6-acetyllysineBy similarity1
Modified residuei233N6-acetyllysineBy similarity1
Modified residuei244N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP13619
PeptideAtlasiP13619
PRIDEiP13619

Expressioni

Gene expression databases

BgeeiENSBTAG00000006441

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68.1 Publication

Protein-protein interaction databases

CORUMiP13619
DIPiDIP-38983N
IntActiP13619, 10 interactors
MINTiP13619
STRINGi9913.ENSBTAP00000008447

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi122 – 159Combined sources38
Helixi161 – 163Combined sources3
Helixi164 – 223Combined sources60

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CLYX-ray2.80A/D43-256[»]
2WSSX-ray3.20T/X141-256[»]
4B2Qelectron microscopy37.00T/t121-249[»]
5ARAelectron microscopy6.70T76-249[»]
5AREelectron microscopy7.40T76-249[»]
5ARHelectron microscopy7.20T76-249[»]
5ARIelectron microscopy7.40T76-249[»]
5FIJelectron microscopy7.40T76-249[»]
5FIKelectron microscopy6.40T76-249[»]
5FILelectron microscopy7.10T76-249[»]
ProteinModelPortaliP13619
SMRiP13619
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13619

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ATPase B chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410INNH Eukaryota
ENOG4111WYE LUCA
GeneTreeiENSGT00390000001958
HOGENOMiHOG000007163
HOVERGENiHBG050604
InParanoidiP13619
KOiK02127
OMAiIYVINHE
OrthoDBiEOG091G0DPN
TreeFamiTF313250

Family and domain databases

InterProiView protein in InterPro
IPR008688 ATP_synth_Bsub_B/MI25
IPR013837 ATP_synth_F0_suB
PANTHERiPTHR12733 PTHR12733, 1 hit
PfamiView protein in Pfam
PF05405 Mt_ATP-synt_B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRVVLSAA AAAAPSLKNA ALLGPGVLQA TRIFHTGQPS LAPVPPLPEH
60 70 80 90 100
GGKVRFGLIP EEFFQFLYPK TGVTGPYVLG TGLILYLLSK EIYVITPETF
110 120 130 140 150
SAISTIGFLV YIVKKYGASV GEFADKLNEQ KIAQLEEVKQ ASIKQIQDAI
160 170 180 190 200
DMEKSQQALV QKRHYLFDVQ RNNIAMALEV TYRERLHRVY REVKNRLDYH
210 220 230 240 250
ISVQNMMRQK EQEHMINWVE KRVVQSISAQ QEKETIAKCI ADLKLLSKKA

QAQPVM
Length:256
Mass (Da):28,822
Last modified:July 25, 2006 - v2
Checksum:i5766369D254B3D9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53K → Y AA sequence (PubMed:1827992).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110212 mRNA Translation: AAI10213.1
X06088 mRNA Translation: CAA29472.1
PIRiS00763
RefSeqiNP_001033590.1, NM_001038501.2
UniGeneiBt.3867
Bt.61189

Genome annotation databases

EnsembliENSBTAT00000008447; ENSBTAP00000008447; ENSBTAG00000006441
GeneIDi282701
KEGGibta:282701

Similar proteinsi

Entry informationi

Entry nameiAT5F1_BOVIN
AccessioniPrimary (citable) accession number: P13619
Secondary accession number(s): Q2TBH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 25, 2006
Last modified: April 25, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health